• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.46-46
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• 2003

Interleukin-10 (IL-10) is a homodimeric protein with a wide spectrum of anti-inflammatory and immune activities. It inhibits cytokine production and expression of immune surface molecules in various cell types. The transgenic mice carrying the human IL-10 gene in conjunction with the bovine $\beta$-casein promoter produced the human IL-10 in milk during lactation. Transgenic mice were generated using a standard method as described previously. To screen transgenic mice, PCR was carried out using chromosomal DNA extracted from tail or toe tissues with a primer set. In this study, stability of germ line transmission and expression of IL-10 gene integrated into host chromosome were monitored up to generation F15 of a transgenic line. When female mouse of generation F9 was crossbred with normal male, generation F9 to F15 mice showed similar transmission rates (66.0$\pm$20.13%, 61.5$\pm$16.66%, 41.1$\pm$8.40%, 40.7$\pm$20.34%, 61.3$\pm$10.75%, 49.2$\pm$18.82%, and 43.8$\pm$25.91%, respectively), implying that the IL-10 gene can be transmitted stably up to long term generation in the transgenic mice. For ELISA analysis, IL-10 expression levels were determined with an hIL-10 ELISA and a mIL-10 ELISA kit in accordance with the supplier's protocol. Expression levels of human IL-10 from milk of generation F9 to F13 mice were 3.6$\pm$1.20 mg/ml, 4.2$\pm$0.93 mg/ml, 5.7$\pm$1.46 mg/ml, 6.3$\pm$3.46 mg/ml, and 6.8$\pm$4.52 mg/ml, respectively. These expression levels are higher than in generation F1 (1.6 mg/ml) mice. We concluded that transgenic mice faithfully passed the transgene on their progeny and successively secreted target proteins into their milk through several generations, although there was a little fluctuation in the transmission frequency and expression level between the generations.

• Journal of Service Research and Studies
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• v.13 no.1
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• pp.76-95
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• 2023

As information and communications technology-based "smart hospitals" and "digital healthcare" have become a hot topic in the healthcare field, hospital mobile apps are gaining attention; but, the utilization rate is low due to lack of publicity, unstable systems, and late updates. In this situation, systematic research is needed to increase the utilization rate of hospital mobile apps, but related research has been rare. Therefore, this study integrates the information systems success model (ISSM) from the technical perspective and the expectation-confirmation model (ECM) from the cognitive perspective to demonstrate the influence mechanism on the continuous use intention of hospital mobile apps. For this purpose, an online survey was conducted among 181 Korean adults who have used hospital mobile apps. The results of the structual equation modeling showed that most of the quality factors have significant effects on expectation confirmation, perceived usefulness, and satisfaction. Additionally, expectation confirmation significantly affects perceived usefulness and satisfaction, and both perceived usefulness and satisfaction significantly affect the continuous use intention of hospital mobile apps. This study is of importance in that it integrates the ISSM and ECM and applies them to the context of using hospital mobile apps, which are underutilized in the healthcare field, and provides practical implications for increasing the utilization rate of hospital mobile apps and operating effective and efficient services through the findings.

• Journal of Service Research and Studies
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• v.13 no.2
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• pp.99-113
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• 2023

In a customer-based industry, customer retention is the competitiveness of a company, and improving customer retention improves the competitiveness of the company. Therefore, accurate prediction and management of potential dormant customers is paramount to increasing the competitiveness of the enterprise. In particular, there are numerous competitors in the domestic card industry, and the government is introducing an automatic closing system for dormant card management. As a result of these social changes, the card industry must focus on better predicting and managing potential dormant cards, and better predicting dormant customers is emerging as an important challenge. In this study, the Recurrent Neural Network (RNN) methodology was used to predict potential dormant customers in the card industry, and in particular, Long-Short Term Memory (LSTM) was used to efficiently learn data for a long time. In addition, to redefine the variables needed to predict dormant customers in the card industry, Unified Theory of Technology (UTAUT), an integrated technology acceptance theory, was applied to redefine and group the variables used in the model. As a result, stable model accuracy and F-1 score were obtained, and Hit-Ratio proved that models using LSTM can produce stable results compared to other algorithms. It was also found that there was no moderating effect of demographic information that could occur in UTAUT, which was pointed out in previous studies. Therefore, among variable selection models using UTAUT, dormant customer prediction models using LSTM are proven to have non-biased stable results. This study revealed that there may be academic contributions to the prediction of dormant customers using LSTM algorithms that can learn well from previously untried time series data. In addition, it is a good example to show that it is possible to respond to customers who are preemptively dormant in terms of customer management because it is predicted at a time difference with the actual dormant capture, and it is expected to contribute greatly to the industry.

• Korean Journal of Environmental Biology
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• v.40 no.1
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• pp.70-86
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• 2022

A survey was conducted to analyze seasonal dynamics of the phytoplankton community at 22 stations on the surface and bottom layers in the Anma Islands of Yeonggwang(AIY) in the southern West Sea, Korea from the spring of 2020 to the winter of 2021, using a marine survey vessel Ed Ocean. Based on the survey results, there were 87 phytoplankton species in 52 genera, diatoms accounted for 67.8%, dinoflagellates 26.5%, silicoflagellates 3.5%, and cryptomonads and euglenoids accounted for 1.1% each. By season, it was simple in spring and relatively varied in winter. The phytoplankton standing crop on the surface was low (28.8±30.1 cells mL^-1) in summer and high (87.0±65.1 cells mL^-1) in spring. In the phytoplankton community, diatoms showed a high share (over 80%) throughout the year, and Skeletonema costatum-ls was the dominant species with a dominance of more than 60% in spring and winter, and 34.6% and 24.2% in summer and autumn, respectively. The diversity expressing the characteristics of the community structure was high (2.79±0.45) in autumn and low (1.82±0.18) in spring, unlike the phytoplankton standing crop. However, the dominance was high at (0.86±0.08) in spring and low (0.44j0.13) in autumn. Based on the results of principal component analysis (PCA) using environmental and phytoplankton-related factors, it was estimated that the biological oceanographic environmental characteristics seen through the phytoplankton community in the AIY were dominated by nutrients supplied from open seawater and surface sediments by seawater mixing, such as tidal mixing.

• Korean Journal of Environmental Biology
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• v.40 no.1
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• pp.25-53
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• 2022

In this study, trends in research methods and topics of seabird and marine fish migration were examined. Based on the framework of existing animal migration studies, future research directions were proposed in relation to the migration of seabirds and fish. In terms of research methodology, with the development of science and technology, tracking techniques using radio telemetry, acoustic telemetry, RFID (radio-frequency identification), satellite tracking, and geolocators are widely used to study seabird and fish migration. Research is also conducted indirectly through a population survey and the analysis of substances in the body. Research contents are largely classified into extrinsic factors that affect migration(such as environmental variables and interspecific competition), intrinsic factors such as hormones, anthropogenic activities including fishery and offshore wind farm, and the effect of global climate change. In future studies, physiological factors that influence or cause migration and dispersal should be identified concerning intrinsic factors. For the analysis of migration ability, it is necessary to study effects of changes in the magnetic field on the migration ability of seabirds and fish, interspecific differences in spatiotemporal migration ability, and factors that influence the migration success rate. Regarding extrinsic factors, research studies on effects of anthropogenic disturbances such as fishery and offshore wind farm and global climate change on the migration and dispersal patterns of marine animals are needed. Finally, integrated studies on the migration of seabirds and fish directly or indirectly affecting each other in various ecological aspects are required.

• Journal of Internet of Things and Convergence
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• v.9 no.3
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• pp.69-74
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• 2023

Smart museums based on the growth of online exhibition can be seen as in line with the movement of the 4th Industrial Revolution. By combining art and technologies, they enable viewers to experience culture and art. This study examined the cases of the Dunhuang Museum, the Palace Museum, and the China Arts and Crafts Master Museum to assess or identify how China is leading by accepting the technology of the fourth industry and applying the technology. In common, Chinese smart museums are widely used for collecting enviromental data, establishing integrated digital applications, and preserving collections, services, management, and exhibitions through VR, and AR. Through the case of the Chinese Smart Museum, this study identified the online exhibition as a space that exists in another dimension rather than an image replica with excellent operational utility. Therefore, online exhibitions are the best medium to expand the space, and viewers can explorethe museum's exhibition room and engage with all the contents of the museum without visiting the museum in person. Through the online exhibition of smart museums, visitors and viewers can be transformed into more active cultural consumers and develop collective capabilities.

• Journal of Internet of Things and Convergence
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• v.9 no.3
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• pp.27-33
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• 2023

In this study, it was analyzed with the dyeing pattern of Diospyros kaki Thunb (persimmon) and was tried to numerically evaluate how the dyeing pattern in silk fabrics and cells was changed by different mordants. When the dyed silk fabrics were sufficiently dried, the silk fabrics were found to have a pale yellow color. Interestingly, iron II sulfate mordant changed the color change the most, silk fabrics were dyed with a color close to brown or dark purple. For numerical analysis, 19% and 62.5% color changes could be induced by sodium tartrate plus citric acid and copper acetate, respectively. Iron II sulfate induced the greatest difference than that of untreated mordants at 88%. About 5% and 10% of Chinese hamster ovary (CHO) cells were stained by sodium tartrate plus citric acid and copper acetate, respectively. The staining effect induced by iron II sulfate was about 2.4 times higher than the staining effect by sodium tartrate plus citric acid. In previous studies, staining results have been visually confirmed. However, this results not only visually confirmed the dyeing, but also quantified the color change. In particular, if numerical results are continuously integrated into big data, any researcher will be able to easily obtain similar results even if the method, time, volume, etc. are changed. In addition, the numerical data of this study is considered to be an important basis for building a database for IoT construction and computer analysis.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.8 no.5
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• pp.893-903
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• 2018

Rental housing complex is the complex built up for stable supply of residence for low income class and it offers significant implication to the Korean society in the residential welfare aspect, and as it has been the continuous subject of dispute and interest, such an issue has stirred significant interest on residential environment of low income class. It has made along with the residence history of Korea, but in the aspect of quality of life for low income class, there is a significant difference with generally supplied residence, and it ultimately continues with the disputes with the rights on quality of life for low income class. For this study, a total of six rental housing complexes were implemented with the field survey and it also had the survey on facility utility and physical environment. Use of facilities is influenced by the arrangement plan on physical environment of the complex, and in particular, it is influenced by the relationship of the main entry to the complex and surrounding complexes. In addition, following the level of design and facility plan of community space and it has confirmed the need to accommodate the request of users through securing the integrated function of community facilities.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.7 no.9
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• pp.289-296
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• 2017

Anger cause heart disease and domestic violence and recently there have been an increasing number of media reports of crimes committed because of their inability to control their anger. Anger has been reported to cause massive financial losses due to heart disease and domestic violence. Therefore, since anger raises serious social problems and social costs, it is necessary to take active intervention methods to alleviate inappropriate anger coping. A variety of methods such as cognitive and emotional approach, psycho-mechanical approach, psycho-educational approach, relaxation therapy, cognitive behavior-art therapy, and stress immunization are being explored and utilized for presenting effective anger-coping intervention alternatives. In this manner, information and communication technology is likely to be used as an effective means for this, and various researches are being conducted. The purpose of this study is to develop an anger coping service technology using ICT (Information & Communication Technology) technology as an effort to improve anger coping ability. In other words, the goal is to develop a technology that delays anger and evokes the surroundings by providing location-based services to recognize anger situations and facilitate anger. This research is about the technology which intervene directly the anger situation to resolve it using location information and introduce the base technology to realize it.

• Journal of Korean Academy of Nursing
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• v.53 no.3
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• pp.295-308
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• 2023

Purpose: This study evaluated the validity and reliability of Shively and colleagues' self-efficacy for HIV disease management skills (HIV-SE) among Korean participants. Methods: The original HIV-SE questionnaire, comprising 34 items, was translated into Korean using a translation and back-translation process. To enhance clarity and eliminate redundancy, the author and expert committee engaged in multiple discussions and integrated two items with similar meanings into a single item. Further, four HIV nurse experts tested content validity. Survey data were collected from 227 individuals diagnosed with HIV from five Korean hospitals. Construct validity was verified through confirmatory factor analysis. Criterion validity was evaluated using Pearson's correlation coefficients with the new general self-efficacy scale. Internal consistency reliability and test-retest were examined for reliability. Results: The Korean version of HIV-SE (K-HIV-SE) comprises 33 items across six domains: "managing depression/mood," "managing medications," "managing symptoms," "communicating with a healthcare provider," "getting support/help," and "managing fatigue." The fitness of the modified model was acceptable (minimum value of the discrepancy function/degree of freedom = 2.49, root mean square error of approximation = .08, goodness-of-fit index = .76, adjusted goodness-of-fit index = .71, Tucker-Lewis index = .84, and comparative fit index = .86). The internal consistency reliability (Cronbach's α = .91) and test-retest reliability (intraclass correlation coefficient = .73) were good. The criterion validity of the K-HIV-SE was .59 (p < .001). Conclusion: This study suggests that the K-HIV-SE is useful for efficiently assessing self-efficacy for HIV disease management.