• Journal of Microbiology and Biotechnology
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• v.32 no.5
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• pp.657-662
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• 2022

Glycosyltransferase (GT)-specific degenerate PCR screening followed by in silico sequence analyses of the target clone was used to isolate a member of family1 GT-encoding genes from the established fosmid libraries of soil actinomycetes Micromonospora echinospora ATCC 27932. A recombinant MeUGT1 was heterologously expressed as a His-tagged protein in E. coli, and its enzymatic reaction with semi-synthetic phenoxodiol isoflavene (as a glycosyl acceptor) and uridine diphosphate-glucose (as a glycosyl donor) created two different glycol-attached products, thus revealing that MeUGT1 functions as an isoflavonoid glycosyltransferase with regional flexibility. Chromatographic separation of product glycosides followed by the instrumental analyses, clearly confirmed these previously unprecedented glycosides as phenoxodiol-4'-α-O-glucoside and phenoxodiol-7-α-O-glucoside, respectively. The antioxidant activities of the above glycosides are almost the same as that of parental phenoxodiol, whereas their anti-proliferative activities are all superior to that of cisplatin (the most common platinum chemotherapy drug) against two human carcinoma cells, ovarian SKOV-3 and prostate DU-145. In addition, they are more water-soluble than their parental aglycone, as well as remaining intractable to the simulated in vitro digestion test, hence demonstrating the pharmacological potential for the enhanced bio-accessibility of phenoxodiol glycosides. This is the first report on the microbial enzymatic biosynthesis of phenoxodiol glucosides.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.12
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• pp.8691-8699
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• 2015

With the technology of our time growing sophisticated everyday, softwares advance rapidly in accordance. Reflecting this trend, researches on Usability of S/W GUI(Graphical User Interface) is actively taking place. However, despite the active researches on such topic, Usability study of S/W GUI for weapon system remains insufficient. For such reason, this paper intends to focus on drawing evaluation factors as well as priority of design factors for Usability of S/W GUI for weapon system. For an accurate and reliable result, Usability evaluation attributes & design factors were assessed by professionals. Moreover, by incorporating AHP(Analytical Hierarchy Process) and Matrix analysis, each evaluation attributes' level of importance and relation between design factors & usability attributes were assessed to draw final design priority. As a result, the importance of Informativity, Accessibility, and Visibility were derived as 0.127, 0.121, 0.108, and selected to be the foremost priority for evaluating. This research could be utilized as foundation for usability evaluation of S/W GUI on weapon system.

• Journal of Advanced Navigation Technology
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• v.28 no.3
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• pp.369-374
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• 2024

This study aims to improve the accessibility and efficiency of sign language education for both hearing impaired and non-deaf people. To this end, we developed VR realistic sign language education content that integrates hand tracking technology and conversational AI. Through this content, users can learn sign language in real time and experience direct communication in a virtual environment. As a result of the study, it was confirmed that this integrated approach significantly improves immersion in sign language learning and contributes to lowering the barriers to sign language learning by providing learners with a deeper understanding. This presents a new paradigm for sign language education and shows how technology can change the accessibility and effectiveness of education.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.15 no.6
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• pp.24-35
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• 2016

This paper developed social equity indicators for evaluation of bus networks. This paper divided the social equity is into 4 categories such as horizontal equity, horizontal accessibility, vertical equity, and vertical accessibility and social equity was defined as integrated concept of these individual indicators. A simulation was performed by using the newly developed indicators to the toy network. On the basis of the simulation result, the social equity indicators are significant to the relative comparison for each zone. And, it was proved that optimal bus network alternative could be different depending on inclusion of the social equity indicators. Thus, it enabled to evaluate the bus network, as a public resource, considering not only the economic efficiency but also social equity. This paper suggested evaluation method for bus network considering social equity using indicators newly developed.

• Journal of KIISE:Software and Applications
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• v.31 no.9
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• pp.1180-1195
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• 2004

Due to the exponential increase of information, search and access for the Web information or service takes much time. Web information is represented through several web pages using hyperlinks and each web page is contains several topics. However. most existing web tools don't reflect such web authoring tendencies and treat it as an independent information unit. This inconsistency yields inherent problems in web browsing and searching. In this paper, we propose a web surfing assistant called LinkBroker that provides collodion pages. They are composed of relevant information extracted from several web pages that have table and frame structure in order to improve accessibility to web information. Especially, the system extracts a set of web pages that are logically connected and groups those pages using table and frame tags. Then, essential information blocks in each page of a group are extracted to construct an integrated summary page. It Provides a comprehensive view to user and one cut way to access distributed information. Experimental results show the effectiveness and usefulness of LinkBroker system.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.15 no.5
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• pp.62-70
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• 2016

Ensuring walkability in a city where pedestrians and vehicles coexist is an issue of critical importance. The relative relationship between vehicle transit and walkability improvements complicates the evaluation of walkability, which thus necessitates the formation of a quantitative standard by which a methodological measurement of walkability can be achieved inside the pedestrian network. Therefore, a model is determined whereby quantitative indices such as, but not limited to, experiences of accessibility, mobility, and convenience within the network are estimated. This research proposes the integration of space syntax theory and the logit path choice model in the evaluation of walkability. Space syntax theory assesses adequacy of the constructed pedestrian network through calculation of the link integration value, while the logit model estimates its safety, mobility, and accessibility using probability. The advantage of the integrated model hence lies in its ability to sufficiently reflect such evaluation measures as the integration value, mobility convenience, accessibility potential, and safety experienced by the demand in a quantitative manner through probability computation. In this research, the Dial Algorithm is used to arrive at a solution to the logit model. This process requires that the physical distance of the pedestrian network and the perceptive distance of space syntax theory be made equivalent. In this, the research makes use of network expansion to reflect wait times. The evaluation index calculated through the integrated model is reviewed and using the results of this sample network, the applicability of the model is assessed.

• Convergence Security Journal
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• v.8 no.1
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• pp.67-78
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• 2008

A prototyping means the way to improve system better from add, modify and delete in the middle of System's working with making model of system simply to offer users in the first develop which the first model is similar in the real model. but there are virtual prototyping and real prototyping in the skills of prototyping but there is some limitation for simulating variety and detail product in the real prototyping and hard to make a simulation of environment elements of the target model in the virtual prototyping. Integrated prototyping system is improved to make up for their defects of environment in the real or virtual prototyping. In this theory, to have flexibility, reusability, scalability and accessibility we build environment of integrated prototyping improvement which is based on component with linkage method between virtual and real.

• Journal of the Korean Recycled Construction Resources Institute
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• v.4 no.2
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• pp.125-135
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• 2016

The objective of this paper is to provide integrated Korea industrial standards(KS) for concrete aggregates, which has been separately provided with ten kinds of KS, in order to improve the way of quality management of concrete aggregate and to prevent distribution of unsuitable aggregates. For the sequences of the paper, typical foreign standards related to concrete aggregates including ASTM for US, EN for EU, JIS for Japan are reviewed and compared to provide necessities and feasibilities of the paper. Based on the analysis above results, existing KS for concrete aggregates, which have been separately provided with ten kinds being lack of correlation between each KS is integrated to KS F 2526 "Aggregates for concrete" in this paper. By doing this, in terms of terminology, the expression of the aggregate, which has been currently classified into specified terminologies of aggregates depending on sources, manufacturing methods of each aggregates, is able to be integrated to single expression of the aggregate for concrete. It is believed that integrated KS presented herein provides more desirable way in terms of its better accessibility, easier revision and closer connection between each aggregate kinds.

• Journal of Korean Public Health Nursing
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• v.35 no.1
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• pp.5-18
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• 2021

Purpose: This study aimed to develop a client-centered integrated home nursing care model for rural areas by analyzing public health nursing, hospital-based home care services, and long-term nursing care in Korea. Methods: The literature review performed included data from the National Assembly Library, DBpia, RISS, and KISS, Google Scholar, the Ministry of Government Legislation, Statistics Korea, and the Ministry of Health and Welfare. Results: The client-centered and integrated home nursing care model in a rural area was opened as the Home Nursing Care Center in a public health center operating directly or on consignment. This model provides both a hospital-based home care services as well as long-term care, in accordance with the health status of the client and difficulty of nursing services. Moreover, the nurse who worked in a sub-organization (Centers for Supporting Healthy Living, Public Health Units, and etc.) of the public health center as care coordinator and case manager facilitates to connect home nursing care services and social welfare services. Conclusions: Our data indicates that the client-centered integrated home nursing care model in rural areas effectively combines professional services, regional accessibility, and social welfare services.

• Journal of Preventive Medicine and Public Health
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• v.52 no.3
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• pp.200-204
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• 2019

On September 12, 2018, President Jae-In Moon announced the Comprehensive Plan for Lifelong Care for People with Developmental Disabilities, with representatives from the associated government branches (Ministry of Health and Welfare, Ministry of Education, and Ministry of Employment and Labor) in attendance. The goals of this plan are to provide health, medical, rehabilitative, special education, and social welfare services according to the life-stages of the affected individuals; to reduce parental pressure; to promote social interventions; and to enhance community-level participation in order to create a 'welfare society in harmony.' However, in order for the plan to succeed, additional efforts must be made in the following areas. First, an epidemiological survey is needed to understand the scale, prevalence, and incidence of developmental disabilities and to establish an evidence base to support policy development. Second, accurate definitions of developmental disabilities must be established in order to avoid policy discrimination based on impairment type and age. Third, personal evaluations to assess disabled individuals' unmet needs and customized service designs to deliver those needs are required. Fourth, the plan must fulfill the goals of accessibility and fairness that the government intends to provide. Fifth, the government should consider an integrated financial support system and to propose a detailed plan for monetary distributions. Finally, an integrated system that links health, medical, employment, educational, and welfare services must be constructed.