• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2793-2800
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• 2015

In molecular-targeted cancer therapy, acquired resistance to gemcitabine is a major clinical problem that reduces its effectiveness, resulting in recurrence and metastasis of cancers. In spite of great efforts to reveal the overall mechanism of acquired gemcitabine resistance, no definitive genetic factors have been identified that are absolutely responsible for the resistance process. Therefore, we performed a cross-platform meta-analysis of three publically available microarray datasets for cancer cell lines with acquired gemcitabine resistance, using the R-based RankProd algorithm, and were able to identify a total of 158 differentially expressed genes (DEGs; 76 up- and 82 down-regulated) that are potentially involved in acquired resistance to gemcitabine. Indeed, the top 20 up- and down-regulated DEGs are largely associated with a common process of carcinogenesis in many cells. For the top 50 up- and down-regulated DEGs, we conducted integrated analyses of a gene regulatory network, a gene co-expression network, and a protein-protein interaction network. The identified DEGs were functionally enriched via Gene Ontology hierarchy and Kyoto Encyclopedia of Genes and Genomes pathway analyses. By systemic combinational analysis of the three molecular networks, we could condense the total number of DEGs to final seven genes. Notably, GJA1, LEF1, and CCND2 were contained within the lists of the top 20 up- or down-regulated DEGs. Our study represents a comprehensive overview of the gene expression patterns associated with acquired gemcitabine resistance and theoretical support for further clinical therapeutic studies.

• Journal of Contemporary Eastern Asia
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• v.18 no.2
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• pp.90-117
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• 2019

How is science advice integrated in environmental policymaking? This is an increasingly pertinent question that is being raised since the nuclear catastrophe of Fukushima, Japan, in 2011. Global re-evaluation of energy policies and climate mitigation measures include discussions on how to better integrate science advice in policymaking, and at the same time keeping science independent from political influence. This paper addressed the policy discourse of setting up a national CO2 reduction target in Japanese policymaking between 2009 and 2012. The target proposed by the former DPJ government was turned down, and Japan lacked a clear strategy for long-term climate mitigation. The analysis provides explanations from a quantitative actor-network perspective. Centrality measures from social network analysis for policy actors in an environmental policy network of Japan were calculated to identify those actors that control the discourse. Data used for analysis comes from the Global Environmental Policy Actor Network 2 (GEPON 2) survey conducted in Japan (2012-13). Science advice in Japan was kept independent from political influence and was mostly excluded from policymaking. One of the two largest discourse coalitions in the environmental policy network promoted a higher CO2 reduction target for international negotiations but favored lowering the target after a new international agreement would have been set. This may explain why Japan struggled to commit to long-term mitigation strategies. Applying social network analysis to quantitatively calculate discourse coalitions was a feasible methodology for investigating "discursive power." But limited in discussing the "practice" (e.g. meetings, telephone, or email conversations) among the actors in discourse coalitions.

• The Transactions of the Korea Information Processing Society
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• v.7 no.8S
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• pp.2608-2619
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• 2000

This paper proposes the Handover Scheme for the mobile and describes the result of the performance analysis. In the conventional scheme of handover request, the withdrawal of terminal may occur because handover request is performed based on fixed signal level without considering network load and terminal mobility. The proposed scheme offers the minimization of withdrawal and handover blocking probability by means of the handover request of terminal based on the network load and terminal mobility. Conventional handover scheme has the sequential procedure that network performs resource check and path rerouting on the handover by MT(Mobile Terminal). Proposed handover scheme pre-processes the resource check before the handover request by predicting the handover request timo so that handover latency can be reduced. Moreover, path optimization is executed after the completion of handover in order to reduce handover latency. The rdduction of handover latency prevents the dropping of service by minimizing backward handover blocking. In summary, we propose the prediction of handover request time and decision method based on terminal, validating the performance of proposed scheme considering various cases of simulation.

• Journal of the HCI Society of Korea
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• v.1 no.2
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• pp.59-64
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• 2006

This paper describes UPnP AV System which provides various multimedia services in home network composed of diverse multimedia devices. It is difficult to build home network where various multimedia services can be provided because there are a lot of difference devices, platforms, and network technologies. However, UPnP middleware can make up multimedia service environment in that home network. Therefore this paper describes how the multimedia service environment is built with UPnP middleware. We analyze and modify MediaServer, MediaRenderer, and Control Point, which these are the components of UPnP AV archtecture. Additionally we provide some efficient GUI to use different kind of multimedia in any place of home networks. We propose UPnP AV Framework of playback module that consist of MediaServer providing contents, MediaRenderer using contents, and Control Point providing GUI. Especially, MediaRenderer and Control Point are integrated in set-top.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.5B
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• pp.287-294
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• 2005

It is impossible to replace overnight the present Internet Protocol Version 4(IPv4)-based Internet with Internet Protocol Version 6(IPv6). These two protocols are expected to coexist for a number of years during the transition period. A number of transition mechanisms are proposed by Internet Engineering Task Force(IETF) Next Generation Transition Working Group(Ngtrans WG). However, most of them provide only the mechanism to initiate sessions from hosts within the IPv6 network to those within the IPv4 network, but do not support the initiation from IPv4 hosts to IPv6 ones. In this paper, we propose the IPv4-to-IPv6 Dual Stack Transition Mechanism(4to6 DSTM) which can operate even in the case that IPv4 clients in the IPv4 network initiate connections with dual stack servers in the IPv6 network.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.46 no.5
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• pp.168-177
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• 2009

This paper proposes the EAP-AKA scheme without UICC for extending its usage to existing WLAN/WiBro devices. To apply the current EAP-AKA scheme, the WLAN/WiBro devices require an external Universal Integrated Circuit Card (UICC) reader. If they don't use UICC due to cost overhead and architectural problem of device, the EAP-AKA scheme loses its own advantages in security and portability aspects. The proposed scheme uses the DH key algorithm and a password for non-UICC devices instead of using the long-term key stored in UICC. The main contribution is to maintain the security and portability of the EAP-AKA while being applied to non-3GPP network devices not equipped with UICC. Furthermore, it does not require major modifications of authentication architecture in 3GPP.

• The Journal of the Korea Contents Association
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• v.14 no.10
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• pp.189-197
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• 2014

The purpose of this study is to examine factors influencing adolescents' suicidal ideation and provide foundational data to reduce adolescents' suicidal ideation and prevent their suicide based on that. According to the research results, there was no significant difference found in demographic characteristics. And depression, stress, and social support exerted significant influence on suicidal ideation. As depression and stress became higher, suicidal ideation increased. When other factors were controlled, suicidal ideation increased if social support was provided less. Based on the study results, the study has made political suggestions as follows: first, regarding the family support system, it is needed to adopt institutional approaches so that they can participate in many different types of education to improve relationship between parents and children. Second, about the school support system, it is necessary to develop programs to form teacher and peer support relations and build the friend support resource system. Third, in terms of the community support system, it is required to build an integrated support system to form diverse local networks.

• Journal of the Korea Society of Computer and Information
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• v.17 no.7
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• pp.97-106
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• 2012

Management of biosignal data in mobile devices causes many problems in real-time transmission of large volume of multimedia data or storage devices. Therefore, this research paper intends to suggest an m-Health system, a clinical data processing system using mobile in order to provide quick medical service. This system deployed health system on IP network, compounded outputs from many bio sensing in remote sites and performed integrated data processing electronically on various bio sensors. The m-health system measures and monitors various biosignals and sends them to data servers of remote hospitals. It is an Android-based mobile application which patients and their family and medical staff can use anywhere anytime. Medical staff access patient data from hospital data servers and provide feedback on medical diagnosis and prescription to patients or users. Video stream for patient monitoring uses a scalable transcoding technique to decides data size appropriate for network traffic and sends video stream, remarkably reducing loads of mobile systems and networks.

• Korean Journal of Optics and Photonics
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• v.26 no.4
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• pp.203-208
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• 2015

Wavelength filters are essential components for selecting a certain wavelength channel of a WDM optical communication system. To realize wavelength filters with narrow bandwidth and high reflectivity, an apodized grating structure with length of 15 mm and index modulation of $5{\times}10^{-4}$ was designed. The device exhibited a reflectivity of 95%, 3-dB bandwidth of 0.28 nm, and 20-dB bandwidth of 0.70 nm on an 18 mm grating length.

• Journal of Korean Society of Water and Wastewater
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• v.26 no.5
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• pp.609-617
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• 2012

A dynamic water quality model is presented in order to simulate water quality under slowly varying flow conditions over time. To improve numerical accuracy, the proposed model uses a lumped system approach instead of extended period simulation, unlike the other available models. This approach can achieve computational efficiency by assuming liquid and pipe walls to be rigid, unlike the method of characteristics, which has been successfully implemented in rapidly varying flows. The discrete volume method is applied to resolve the advection and reaction terms of the transport equation for water quality constituents in pipes. Numerical applications are implemented to the pipe network examples under steady and unsteady conditions as well as hydraulic and water quality simulations. The numerical results are compared with EPANET2, which is a widely used simulation model for a water distribution system. The model results are in good agreement with EPANET2 for steady-state simulation. However, the hydraulic simulation results under unsteady flows differ from those of EPANET2, which causes a deviation in water quality prediction. The proposed model is expected to be a component of an integrated operation model for a water distribution system if it is combined with a computational model for rapidly varying flows to estimate leakage, pipe roughness, and intensive water quality.