• Nuclear Engineering and Technology
• /
• 제54권6호
• /
• pp.2077-2083
• /
• 2022

In the unlikely event of core disruptive accident in sodium cooled fast reactors, the reactor containment building would be bottled up with sodium and fission product aerosols. The behavior of these aerosols is crucial to estimate the in-containment source term as a part of nuclear reactor safety analysis. In this work, the evolution of sodium aerosol characteristics (mass concentration and size) is simulated using HAARM-S code. The code is based on the method of moments to solve the integro-differential equation. The code is updated to FORTRAN-77 and run in Microsoft FORTRAN PowerStation 4.0 (on Desktop). The sodium aerosol characteristics simulated by HAARM-S code are compared with the measured values at Aerosol Test Facility. The maximum deviation between measured and simulated mass concentrations is 30% at initial period (up to 60 min) and around 50% in the later period. In addition, the influence of humidity on aerosol size growth for two different aerosol mass concentrations is studied. The measured and simulated growth factors of aerosol size (ratio of saturated size to initial size) are found to be matched at reasonable extent. Since sodium is highly reactive with atmospheric constituents, the aerosol growth factor depends on the hygroscopic growth, chemical transformation and density variations besides coagulation. Further, there is a scope for the improvement of the code to estimate the aerosol dynamics in confined environment.

• 한국산림과학회지
• /
• 제86권3호
• /
• pp.365-377
• /
• 1997

미국 테네시주 컴벌랜드 고원의 대부분은 혼합 침엽수림으로 되어 있어 기존의 성장과 산출 예측 방식을 적용하기 어렵다. 또한 그들의 역사가 알려져 있지 않을 뿐더러 많은 부분이 동령림이 아니기 때문에 성장과 수확 예측 모델을 만드는데 있어서 지위지수를 변수로 사용하는 것이 제한되어 있다. 임지형(landtype)은 거의 같은 수확을 내는 임지를 포함하도록 고안되어 있기 때문에 이런 혼효림에서 지위지수 대산 사용될 수 있다. 임지형을 사용한 식생 결정을 위해, Chi-square로 임지형과 임형(forest type)과의 의존성을 검사하였다. 임지형 사이에서 수확의 유의성은 회귀분석과 분산분석을 이용하여 검사되었다. 흉고단면적성장(basal area growth)은 Moser and Hall(l969)이 개발한 비선형 모델에 적용되었다. 또한 흉고단면적성장과 재적성장은, 임지형과 임지형급(landtype class)에 의한 선형 회귀분석을 통해 최초 총 흉고단면적과 최초 재적에 관한 하나의 함수로서 예측되었다. 분산분석으로 임지형에 따른 흉고단면적성장과 재적성장의 유의성을 검사하였다. 지위급(site class)과 임지형의 유의성은 Chi-square로 검사되었다. 표본 강도가 낮아 검증이 의심스러웠음에도 불구하고, 식생형 (vegetation type)은 연구 지역 내 임지형과 관계된 것으로 보인다. 본 연구에서 임지형 간의 수확은 통계학적인 유의성이 발견되지 않았다.

• Journal of Microbiology and Biotechnology
• /
• 제6권4호
• /
• pp.295-298
• /
• 1996

Under glutamine-limited condition, $2\times10^6$ (viable cells/ml) of maximum cell density and 13.5 ($\mu g$/ml) of tissue-type Plasminogen Activators (tPA) production were maintained by spike feeding fresh medium in fed-batch cultivation of human recombinant melanoma cells. It showed that tPA production was much seriously affected than cell growth according to initial glutamine concentrations. Above 3.4 (mmol/I) of glutamine concentration both cell growth and tPA production were not much affected by increasing initial glutamine concentration. Glutamine depleted situation was occurred at latter periods of batch and fed-batch cultivations below 5.4 (mmole/I) of initial glutamine concentration. It also showed that maximum glutamine consumption and ammonia evolution rates were closely related to initial glutamine concentrations. Maximum specific tPA production rate was estimated as $8.1\times19^{-6}$ ($\mu g$/cells/h) at 3.4(mmol/I) of glutamine concentration, which is higher than that from other batch and fed-batch processes.

• 한국보육지원학회지
• /
• 제12권5호
• /
• pp.137-155
• /
• 2016

The purpose of the present study was to investigate the longitudinal relationship between main caregivers' life satisfaction and depression and self-esteem of school-aged children, and to provide plans for improving the lives of the school-aged children. For this purpose, we analyzed the three years'longitudinal panel data (2011-2013) of the Korean Children and Youth Panel Survey (KCYPS) including 2,342 first grade elementary school children employing the latent growth model using SPSS 18.0 and AMOS 22.0. Analysis results were as follows. First, main caregivers'life satisfaction and school-aged children's depression increased as time passes and linear change model was selected. Second, the initial status of main caregivers'life satisfaction had effects on the initial status of their children's depression, but initial status and rates of change of life satisfaction did not have an influence on the rates of change of the depression. However, it was found that the main caregivers' life satisfaction had effects on the school-aged children's self-esteem and it worked as a mediator on the longitudinal relationship between the main caregivers'life satisfaction and the children's depression. School-aged children's self-esteem was a partial mediator on the initial status of their depression and full mediator on these rates of change. These findings suggests that programs improving school-aged children's self-esteem should be developed.

• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2002년도 생물공학의 동향 (X)
• /
• pp.325-328
• /
• 2002

Sucrose 의 경우 저농도에서는 후반부로 갈수록 세포생장 속도는 현저히 감소하는데 비해 hGM-CSF 생산은 후반부에 급격히 증가함을 확인하였다. 고농도 sucrose를 사용하는 경우에는 lag phase가 길어지는 동안에 hGM-CSF의 생산이 증가하였다. 따라서 배양 초기에는 고농도 sucrose가, 배양 후반에는 저농도 sucrose로 존재하는 경우에 hGM-CSF를 많이 얻을 수 있었다. Nitrogen source의 농도는 60.52 mM과 121.04 mM일 때가 세포의 생장이나 hGM-CSF의 생산을 증가시켰으며, phosphate의 경우에는 4.96 mM 일 때가 대조구인 2.48 mM 일 때보다 hGM-CSF의 생산을 3 배 증가시켰다.

• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2000년도 추계학술발표대회 및 bio-venture fair
• /
• pp.69-72
• /
• 2000

Chlorella vulgaris를 이용하여 기본배지에서 초기 주입농도 $0.7{\times}10^4\;cells/mL$ 상태에서 300시간 배양 후 $1.21{\times}10^5\;cells/mL$의 생체수를 얻었으며, 초기 cell 농도가 0.30g/L인 경우가 성장률이 $0.162g/L\;{\cdot}\;day$로 우수하였다. Glucose 초기농도가 2.00g/L인 경우 초기 cell 농도 0.025g/L에서 140시간 후 0.874g/L이 되었으며 비성장속도는 $0.243h^{-1}$을 나타내었고, 72시간내에 가스를 268mL를 생성하였으며 이후로는 수소 생성이 종료으나 순수 소소를 19.87mol% 함유하고 있었다. Chlorella vulgaris의 조성을 원소분석기로 분석한 결과 $C_{1.000}\;H_{1.774}\;N_{0.125}\;O_{0.557}$가 되었으며 이산화탄소 전환율은 $0.616cells/\;g\;CO_2$가 됨을 알 수 있었다.

• 한국미생물·생명공학회지
• /
• 제18권4호
• /
• pp.394-400
• /
• 1990

유전자 조작된 세포 발효공정의 생산수율을 최대화하기 위하여 세포의 성장속도와 제품 생성속도간의 상반관계를 고려하여야 한다. 유전자 조작된 E.coli 발효에 있어, 최적화 이론을 적용하여 두 속도의 가중치를 결정함으로써 생산수율의 최대화를 꾀하였다. 성장저해제의 농도는 비 성장속도를 조절하고 결국 융합된 유전자의 발현 속도를 조절하는 변수로 사용되다. 이런 system의 특성을 위하여 간단한 unstructured model를 사용하였다.

• Clinical and Experimental Pediatrics
• /
• 제57권9호
• /
• pp.379-383
• /
• 2014

Recombinant growth hormone (GH) is an effective treatment for short children who are born small for gestational age (SGA). Short children born SGA who fail to demonstrate catch-up growth by 2-4 years of age are candidates for GH treatment initiated to achieve catch-up growth to a normal height in early childhood, maintain a normal height gain throughout childhood, and achieve an adult height within the normal target range. GH treatment at a dose of $35-70{\mu}g/kg/day$ should be considered for those with very marked growth retardation, as these patients require rapid catch-up growth. Factors associated with response to GH treatment during the initial 2-3 years of therapy include age and height standard deviation scores at the start of therapy, midparental height, and GH dose. Adverse events due to GH treatment are no more common in the SGA population than in other conditions treated with GH. Early surveillance in growth clinics is strongly recommended for children born SGA who have not caught up. Although high dose of up to 0.067 mg/kg/day are relatively safe for short children with growth failure, clinicians need to remain aware of long-term mortality and morbidity after GH treatment.

• KSBB Journal
• /
• 제6권3호
• /
• pp.255-261
• /
• 1991

The effect of concentration of yeast extract and NH4Cl in the mediun of alcohol fermentation of S. cerevisiae ATCC 24858 on the fermentation characteristics, specific growth rate, sugar conversion, alcohol productivity was experimentally investigated. Regardless of initial sugar concentrations, the values of the above three characteristics increased with augument of concentration of yeast extract. However, the increasing tendency ceased above a certain concentration. The concentration of NH4Cl had little effect on the change of the three characteristics. The functional relationships between the concentration of yeast extract and the characteristics were different according to the initial sugar concentrations, but those between the ratio of yeast extract concentration to initial sugar concentration and the characteristics could be expressed as same forms respectively regardless of initial sugar concentrations. Also the values of the three characteristics approached to the maximum values around 0.085 of the ratio, but did not increase any more above 0.1 of the ratio. We have come to conclusion that the optimum ratio of the yeast extract concentration to the initial sugar concentration was about 0.085 and the ratio should not be decided as greater than 0.1 in the medium of alcohol fermentation of S. cerevisiae ATCC 24858.

• 한국재료학회지
• /
• 제23권11호
• /
• pp.625-630
• /
• 2013

In this study, intermediate-mixed powders were prepared by loading zirconia powders initially in a ball-mill jar and loading alumina powders afterward; the initial-mixed powders were produced by loading zirconia and alumina powders together in the ball-mill jar. The effect of such differences in mixing method on the mechanical properties was investigated. In intermediate-mixed powders, the volume fraction of large particles slightly increased and, simultaneously, zirconia particles formed agglomerates that, due to early ball-mill loading of the zirconia powders only, were more dispersed than were the initial-mixed powders. For the intermediate-mixed powders, zirconia agglomerates were destroyed more quickly than were initial-mixed powders, so the number of dispersed zirconia particles rose and the inhibitory effect of densification due to the addition of a second phase was more obvious. In the microstructure of intermediate-mixed powders, zirconia grains were homogeneously dispersed and grain growth by coalescence was found to occur with increasing sintering temperature. For the initial-mixed powders, large zirconia grains formed by localized early-densification on the inside contacts of some zirconia agglomerates were observed in the early stages of sintering. The intermediate-mixed powders had slightly lower hardness values as a whole but higher fracture toughness compared to that of the initial-mixed powders.