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Antibody Engineering for the Development of Therapeutic Antibodies

  • Kim, Sang Jick;Park, Youngwoo;Hong, Hyo Jeong
    • Molecules and Cells
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    • v.20 no.1
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    • pp.17-29
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    • 2005
  • Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical product category after vaccines. Antibodies have been engineered by a variety of methods to suit a particular therapeutic use. This review describes the structural and functional characteristics of antibody and the antibody engineering for the generation and optimization of therapeutic antibodies.

An Analysis of Physical Load of the Shipping Work in Cold Storage Warehouses (냉동창고 출하작업의 신체부담 분석에 관한 연구)

  • 장성록
    • Journal of the Korean Society of Safety
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    • v.14 no.4
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    • pp.192-198
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    • 1999
  • Work-related musculoskeletal disorders constitute a major source of employee disability and lost wages. Cumulative Trauma Disorders(CTD) refers to a category of physical conditions which result from chronic musculoskeletal injury. Assessment of CTD risk in industry at early stage allows for early control, a safe environment, and a healthier workforce. In this study, the physical load of the shipping work in the cold storage warehouse were especially investigated. Employees were working with almost unnatural posture in a very restricted work space. The questionnaire and biomechanical analysis were used to evaluate the physical load. Results from analyses showed that they were sufficiently exposed to CTD due to repetition and unnatural posture. Based on the analysis, ways for improving working conditions are proposed. The analysis and proposals in this paper will serve as a basic tool for designing/redesigning working environment such as improvement of tools and equipments, design of times for work/rest cycle.

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Analysis about Korean Enterprise through China Excellence Performance Model and Comparison with China Enterprise

  • Ree, Sang-Bok;Ma, Yizhong
    • International Journal of Quality Innovation
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    • v.10 no.2
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    • pp.77-96
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    • 2009
  • Industry competition environment is not being meaning of internal and external distinction. This may be phenomenon of globalization progress. In this time, we wish to examine present level in our enterprise and also analyze cause relation between 7 category of China Excellence Performance model which is modified Malcolm Baldridge Model and compare with China enterprise by using the same questionnaire with China. It is right opportunity to obtain information by comparing China enterprise with the Korea. This questionnaire composition and contents used as it is questionnaire contents that enforce in 2007 in China CAQ. The survey on Korea enterprises' is 509 by KSA in 2008, China is surveyed 1679 by CAQ in 2007. In Korea 'leadership', 'strategy planning', 'customer and market', 'measurement, analysis and improvement' 'resources management' and 'process management' stronger than China, but in China 'performance results' is stronger than Korea.

A Study on Organic Solvent Exposure in Painting Operation of Automobile Manufacturing Industry (자동차 도장 작업장에서의 유기용제 폭로에 관한 연구)

  • 김영식
    • Journal of Environmental Health Sciences
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    • v.20 no.4
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    • pp.10-16
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    • 1994
  • A Study was performed in order to measure mixed organic solvent concentrations in air of painting operations during January 5-28, 1991. The mixed organic solvent concentrations were analyzed by the gas chromatography. The results were as follows: 1. The detection of organic solvent was highest in aromatic hydrocarbon(68%), and followed by aliphatic hydrocarbon (18%), and ketone (14%). 2. The detection of organic solvent by component category was highest in the grid class solvent (79.4%), and followed by the 3rd class solvent (20.6%). 3. Number of cases exceeding TLVS of mixed solvent level in air was highest on dipping operation (44%), and followed by spray operation (40%), dry and washing operation (33%), and adhensive operation (12%).

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A Comparative Study on the Job Requirements and Curricula for Food Coordinators and Food Stylists (푸드 코디네이터와 푸드 스타일리스트의 직무 요건 및 교과 과정에 관한 비교 연구)

  • Kang, Eun-Sook;Chun, Byung-Gil
    • Culinary science and hospitality research
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    • v.14 no.4
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    • pp.317-328
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    • 2008
  • A food coordinator and a food stylist have become one of the prospective jobs in the food industry. Nonetheless, they have not been definitely classified, even regarded as the same meaning. This study was conducted to investigate the different characteristics and job requirements between food coordinators and food stylists by examining the curricula for food coordinators and food stylists of related departments in 13 colleges. According to the result of this study, the definitions of them in the job category have not been clearly distinguished. It was also showed that the job domain of food coordinators was broader than that of food stylists. Therefore, education curricula related to this field need to be reviewed to cultivate the human resources who fit the job requirements for food coordinators and food stylists respectively.

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Comparative Analysis of Value Added to Personnel Expenses between General Hospitals and Regional Public Hospitals (민간종합병원과 지방의료원의 인건비 투자효율성 비교분석)

  • Lim, Jeong-Do
    • The Korean Journal of Health Service Management
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    • v.11 no.4
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    • pp.67-76
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    • 2017
  • Objectives : This study compared Value added to personnel expenses between 12 private general hospitals and 12 regional public hospitals, based on location and size, to examine industry competitiveness in terms of management. Methods : From 2011 to 2015, the value added and value added to personnel expenses were calculated by year. and a SPSS statistical program was used to determine and influential factors between private general hospitals and regional public hospitals. Results : The total value added to personnel expenses was 26.85 percent lower than general hospitals compared to regional public hospitals. The product category most influenced by the value added to personnel expenses was Stationeries & expendables at general hospitals and Outsourcing at regional public hospitals. Conclusions : Regional public hospitals have relatively low value added to personnel expenses compared to the general hospitals. Therefore, it is necessary for hospital management to reexamine gross revenue relative to total manpower.

A Study on the In-depth Analysis of Cause and Characteristic for Recent Electric Shock Accident (최근 감전재해의 발생특성과 재해원인 분석연구)

  • Choi, Sang-Won
    • Journal of the Korean Society of Safety
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    • v.29 no.2
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    • pp.7-11
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    • 2014
  • The electric shock victims were predominantly male, and more than half of the victims were found in companies with less than five employees in terms of the scale of company, and also more than half of victims had less than one month of experience for work experience. Considering the category of industry, more than half of the victims were engaged in construction, and considering the subcategory of industries, more than 60% of electric shock victims were found in building and other construction works. This study intended to conduct an in-depth analysis on the cause of electric shock accidents to provide basic data for policy proposing taking into considering the characteristics such as the electric shock path, low voltage, grounding and protection of workers. Also this study conducted an in-depth analysis of electric shock accidents for the past eleven years taking into account the necessity of a long-term plan.

Prediction of Some Moving-Body Problems Using Overlapped Grid System (중첩된 격자계를 사용한 움직이는 물체의 해석)

  • Lee Jin-Gyu;Chang Keun-Shik
    • 한국전산유체공학회:학술대회논문집
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    • 1998.05a
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    • pp.82-89
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    • 1998
  • There are many moving-body problems to be solved, the solution of which necessary for proper design of flight vehicles in aerospace industry. Since a body moves relative to other bodies in the category of these problems, difficulty arises regarding both generation of computational grid around the body in motion and conservation of flow properties in the moving grid system. A few example could be store separation from the aircraft and relative vibration of multiple bodies in the high-speed flow passage. In this paper we report on the progress made in computing moving-body aerodynamics related with sabot separation characteristics. Conservative overlapping grid together with cell-merging-unmerging technique is used to solve the Euler equations for a body in high-speed motion. Carbuncle errors has to be removed before we obtain physically adequate solution. Two-dimensional application is reported here.

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Development of Risk Analysis System for Integrated Environmental Management in Korea

  • Shin, Dong-Chun;Kim, Ye-Shin;Park, Sung-Eun;Yang, Ji-Yeon;Lim, Young-Wook
    • Proceedings of the Korea Society of Environmental Toocicology Conference
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    • 2003.10a
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    • pp.162-163
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    • 2003
  • The Eco-2 Project presents a win-win strategy for the environment and for the economy (ECO-2 is an abbreviation of Ecology and Economy), The project was initiated by the Korean Ministry of the Environment to promote the development of an environmental industry technology as a means of driving national development in this sector. Our project work belongs to the category of integrated environment management technology, and is described as a development and utilization of risk assessment and analysis system for integrated environmental management in municipal and industrial areas. The goal of our project is to develop available system software in health and ecological risk assessment and to offer it as Decision Support System (DSS) to aid the effective management of environmental risk in municipal and industrial areas in Korea.

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The Analysis the Certification Policy of Light Sport Aircraft (경량항공기 인증제도 분석)

  • Shin, Dai-Won;Kim, Woong-Yi
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.21 no.1
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    • pp.57-61
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    • 2013
  • In the present study, which is currently operating domestically and internationally, from the Technical Standards for Flight Safety of Light Sport Aircraft and certification system through a comparative analysis of the LSA Category Airworthiness Certifications documents. In particular, an aircraft type analysis of FAA certified S-LSA that the speed greater than 120 knots LSA manufactured without United States of America. Through the analysis, we presented a revised plan to activation of the domestic aviation leisure sports and the development of the Light Sport Aircraft industry in reality.