• Journal of Veterinary Science
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• 제22권5호
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• pp.59.1-59.13
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• 2021

Background: Antimicrobial peptides (AMPs) have been identified as promising compounds for consideration as novel antimicrobial agents. Objectives: This study analyzed the efficacy of cecropin B against Haemophilus parasuis isolates through scanning electron microscopy (SEM) and atomic force microscopy (AFM) experiments. Results: Cecropin B exhibited broad inhibition activity against 15 standard Haemophilus parasuis (HPS) strains and 5 of the clinical isolates had minimum inhibition concentrations (MICs) ranging from 2 to 16 ㎍/mL. Microelectrophoresis and hexadecane adsorption assays indicated that the more hydrophobic and the higher the isoelectric point (IEP) of the strain, the more sensitive it was to cecropin B. Through SEM, multiple blisters of various shapes and dents on the cell surface were observed. Protrusions and leakage were detected by AFM. Conclusions: Based on the results, cecropin B could inhibit HPS via a pore-forming mechanism by interacting with the cytoplasmic membrane of bacteria. Moreover, as cecropin B concentration increased, the bacteria membrane was more seriously damaged. Thus, cecropin B could be developed as an effective anti-HPS agent for use in clinical applications.

• Bulletin of the Korean Chemical Society
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• 제23권1호
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• pp.93-97
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• 2002

Poly(ethylene glycol)-phosphatidylethanolamine conjugate (PEG-PE) has been used in preparing longcirculating liposomes. As a substitute for PEG-PE which can also be used in the long-circulating liposome formualtions, but can be prepared more readily with a lower cost, PEG-Phe-Chol was synthesized from PEG, phenylalanine, and cholesterol. The addition of the PEG derivative to distearoylphosphatidylcholine (DSPC) led to the formation of mixed micelles as well as liposomes when the derivative content was 10 mol% or greater. On the other hand, the addition of just 5 mol% PEG-Phe-Chol to dioleoylphosphatidylethanolamine (DOPE) generated mixed micelles as well as liposomes, but the formation of mixed micelles was completely inhibited by the addition of cholesterol. The leakage of entrapped calcein out of DOPE/cholesterol (7/3) liposomes containing 5 mol% PEG-Phe-Chol was about 45% during the incubation time for 24 h in 50% rabbit plasma, which was similar to that of the same liposomes containing 5 mol% PEG-dipalmitoylphosphatidylethanolamine (DPPE) under the identical conditions.

• 한국산학기술학회논문지
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• 제20권9호
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• pp.175-181
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• 2019

수소연료전지차(FCEV)의 수소연료 공급시스템에서 대용량 감압에 사용되는 기존의 1단 감압 구조 레귤레이터(Regulator)의 경우 높은 감압에 따른 맥동과 느린 응답, 수소 취성, 누설, 고중량, 고비용 등의 문제점이 있다. 이러한 문제점은 2번에 걸친 감압 메커니즘(2단 구조)을 가지는 2단 레귤레이터 개발을 통해 극복될 수 있으며, 2번째 감압시점에 전자식 솔레노이드 밸브를 적용한다면 폭넓은 출구압력의 제어가 가능하다. 이에 따라 2단 전자식 솔레노이드 밸브를 가지는 레귤레이터의 출구압력 정밀도 향상과 누설방지, 내구성, 경량화, 가격저감 등의 기술개발이 필요한 실정이다. 이중에서도 레귤레이터의 필수적인 성능인 출구압력 정밀도 향상과 누설 방지를 위해 감압 전과 감압 후의 구조부분을 나누어 각각의 초기 내압 적용 후 Valve part가 닫힌 상태(Open Ratio : 0 %)로 가정하여 해석 연구를 진행하였다. 1차감압부의 기밀성과 관련하여 Aluminum Alloy 소재의 사용은 부적절하다고 판단되었고, 서로 다른 금속으로 구성되었을 때는 응력의 변화와 함께 변위 또한 같이 증가하므로 이종 소재를 사용하는 접촉부 구성은 부적절하다고 판단되었다. 2차 감압부의 기밀성과 관련된 변위 측면에서는 Young's Modulus 값이 큰 TPU(Thermoplastic Polyurethane)를 사용하는 것이 비교적 변위량이 작으므로 적절하다고 판단하였고, 기밀성에 대한 기준으로 Case 분석을 진행한 결과 최적 형상을 설계할 수 있었다.

• 한국산업정보학회논문지
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• 제17권3호
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• pp.27-34
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• 2012

This paper presents the impact of time dependent dielectric breakdown (TDDB, also called as gate oxide breakdown) failure on nanoscale digital CMOS Circuits. Recently, TDDB for ultra-thin gate oxides has been considered as one of the critical reliability issues which can lead to performance degradation or logic failures in nanoscale CMOS devices. Also, leakage power in the standby mode can be increased significantly. In this paper, TDDB aging effects on large CMOS digital circuits in the 45nm technology are analyzed. Simulation results show that TDDB effect on MOSFET circuits can result in more significant increase of power consumption compared to delay increase.

• 디지털산업정보학회논문지
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• 제18권3호
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• pp.25-32
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• 2022

DID(Decentralized Identity Identification) is a system in which users voluntarily manage their identity, etc., and control the scope and subject of submission of identity information based on a block chain. In the era of the 4th industrial revolution, where the importance of protecting personal information is increasing day by day, DID will surely be positioned as the industrial center of the Internet and e-business. However, when managing personal information, DID is highly likely to cause a large amount of personal information leakage due to electronic infringement, such as hacking and invasion of privacy caused by the concentration of user's identity information on global service users. Therefore, there are a number of challenges to be solved before DID settles into a stable standardization. Therefore, in this paper, we try to examine what problems exist in order to positively apply the development of DID technology, and analyze the improvement plan to become a stable service in the future.

• 품질경영학회지
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• 제41권4호
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• pp.649-657
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• 2013

Purpose: In this study, the actual situation of domestic firms vulnerable to industrial security competence will be discussed. And accordingly be discussed for effective response measures. Methods: Using a structured questionnaire by mail, fax, e-mail and fill method was used respondents. By the end of '10 R&D Center, which holds 15,247 companies(population) among the 95% level of confidence, tolerance ${\pm}3%$ p-level corporate type, sector, region extraction method stratified multi-level companies were investigated through the final 1529. Results: The average level of industrial security capabilities 43.8%(out of 100) is very weak, so urgent and positive response measures also need to be investigated sought. Conclusion: we propose the effective management framework and improvement plans to prevent illegal industrial leakage are to be made.

• Journal of Electrical Engineering and Technology
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• 제10권4호
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• pp.1566-1577
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• 2015

A novel high step-up converter is presented herein, which combines the conventional buck-boost converter, the charge pump capacitor and the coupling inductor. By doing so, a quite high voltage conversion ratio due to not only the turns ratio but also the duty cycle, so as to increase design feasibility. It is noted that the denominator of the voltage conversion ratio is the square of one minus duty cycle. Above all, there is no voltage spike across the switch due to the leakage inductance and hence no passive or active snubber is needed, and furthermore, the used switch is driven without isolation and hence the gate driving circuit is relatively simple, thereby upgrading the industrial application capability of this converter. In this paper, the basic operating principles and the associated mathematical deductions are firstly described in detail, and finally some experimental results are provided to demonstrate the effectiveness of the proposed high step-up converter.

• 한국산학기술학회논문지
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• 제20권7호
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• pp.291-298
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• 2019

논문에서는 국내에서 운용되는 수중유도무기(어뢰) 중 추진전지(리튬이차전지)의 전해질 누액에 의한 발연현상을 방지하기 위하여 추진전지의 절연블록 추가를 통한 절연성능 강화 및 단전지 전해액 누액 방지 개선방법에 관해 기술하였다. 국내에서 리튬이차전지를 주전원공급원(추진전지)으로 사용하고 있는 어뢰에 발열 및 발연 현상이 발생하여 해군의 장비 운용에 불편함이 초래되었다. 발연현상에 대한 유의 항목 확인 및 모사시험 결과 전지팩 단위에서 일부 전지셀의 전해질이 누액되어 고전압부분의 주전원 회로와 단자탭간에 단락현상이 발생하여 해당 현상이 발생하였다. 발열 및 발연현상 시 리튬이차전지 특성 및 메커니즘 분석을 통하여 원인분석을 진행하였다. 리튬 이차전지의 전해질 누액 방지를 위해 근본적 개선책(단자 탭 강화)과 보완책(절연블록 선정 및 설치) 등 설계 개선을 수행하였고, 개선 전 후의 성능시험 비교 결과 탭 단자의 인장강도가 약 2배 향상, 내압 특성 또한 향상되었으며, 절연성능 강화로 어뢰의 추진전지 품질을 대폭 개선하였다. 또한 품질개선 방안이 적용되어 3년 이상 야전 운용 결과 이상발연 현상은 발생하지 않았다. 이로써 어뢰 추진전지의 운용 및 저장 안정성 기대된다.

• 대한안전경영과학회지
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• 제17권4호
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• pp.297-304
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• 2015

This study concerns the integrated gas sensor system of wire and wireless communication by using IoT(Internet of Things) technology. First, communication part is that it delivers the detection information, which transferred by wire or wireless communication and required control procedure based on a wireless module that receives the gas leakage information from wired or wireless detector, to administrator or user's terminal. Second, receiver part is that it shows the location and information, which received from the wired detector formed by a detecting sensor's node as linking with the communication part, and transfers these to the communication part. Third, wireless detector formed as a communication module of a detecting sensor node is that it detects gas leakage and transfers the information through wireless as a packet.Fourth, wired detector communicated with the receiver part and formed as a communication module of a detecting sensor node is that it detects gas leakage, transfers and shows the information as a packet. Fifth, administrator's terminal is that it receives gas leakage information by the communication part, transfers the signal by remote-control, and shut off a gas valve as responding the information. Sixth, database is that it is connected with the communication part; it sets and stores the default values for detecting smoke, CO., and temperature; it transfers this information to the communication part or sends a gas detecting signal to user's terminal. Seventh, user's terminal is that it receives each location's default value which stored and set at the database; it manages emergency situation as shutting off a gas valve through remote control by corresponding each location's gas leakage information, which transferred from the detector to the communication part by wireless.It is possible to process a high quality data regarding flammable or toxic gas by transferring the data, which measured by a sensor module of detector, to the communication part through wire and wireless. And, it allows a user to find the location by a smart phone where gas leaks. Eventually, it minimizes human life or property loss by having stability on gas leakage as well as corresponding each location's information quickly.

• Tribology and Lubricants
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• 제28권4호
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• pp.178-183
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• 2012

The fuel system of a vehicle is a very important compotent, as it provides the firing resources to the combustion chamber of the engine. However, improper operation of the system can generate bad condition or start-off during engine revolution. This study analyzed several examples of failure that had originated in the field. In the first example, the driver operated a vehicle containing both gasoline and LPG in the fuel tank, but the gasoline fuel remained unused for a few months. Therefore the fuel pump was clogged because of gasoline congelation. The second example, dealt with fuel leakage that occurred from the slightly torn O-ring connecting the fuel lines. The third example, pertained to engine damage and power-down owing to the usage of proor-quality fuel and ingredient. Therefore, it is necessary to take adequate measures to prevent the failure of the fuel system of vehicle.