• 대한금속재료학회지
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• 제50권12호
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• pp.891-896
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• 2012

Nanopowders of MgO and $TiO_2$ were made by high energy ball milling. The rapid synthesis and sintering of the nanostructured $MgTiO_3$ compound was investigated by the high-frequency induction heated sintering process. The advantage of this process is that it allows very quick densification to near theoretical density and inhibition grain growth. Nanocrystalline materials have received much attention as advanced engineering materials with improved physical and mechanical properties. As nanomaterials possess high strength, high hardness, excellent ductility and toughness, undoubtedly, more attention has been paid for the application of nanomaterials. A highly dense nanostructured $MgTiO_3$ compound was produced with simultaneous application of 80 MPa pressure and induced current within 2 min. The sintering behavior, gain size and mechanical properties of $MgTiO_3$ compound were investigated.

• 대한금속재료학회지
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• 제46권4호
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• pp.223-226
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• 2008

The comparison of sintering behavior and mechanical properties of ultra-fine WC-10wt.%Co and WC-10wt.%Fe hard materials produced by high-frequency induction heated sintering (HFIHS) was accomplished using ultra fine powder of WC and binders(Co, Fe). The advantage of this process allows very quick densification to near theoretical density and prohibition of grain growth in nano-structured materials. Highly dense WC-10Co and WC-10Fe with a relative density of up to 99% could be obtained with simultaneous application of 60 MPa pressure and induced current within 1 minute without significant change in grain size. The hardness and fracture toughness of the dense WC-10Co and WC-10Fe composites produced by HFIHS were investigated.

• Wind and Structures
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• 제32권1호
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• pp.55-69
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• 2021

Ultrapure ferritic stainless steel provides a new generation of long-span metal roof systems with continuous welding technology, which exhibits many unknown behaviors during wind excitation. This study focuses on the wind-resistant capacity of a new continuous welding stainless steel roof (CWSSR) system. Full-scale testing on the welding joints and the CWSSR system is performed under uniaxial tension and static ultimate wind uplift loadings, respectively. A finite element model is developed with mesh refinement optimization and is further validated with the testing results, which provides a reliable way of investigating the parameter effect on the wind-induced structural responses, namely, the width and thickness of the roof sheeting and welding height. Research results show that the CWSSR system has predominant wind-resistant performance and can bear an ultimate wind uplift loading of 10.4 kPa without observable failures. The welding joints achieve equivalent mechanical behaviors as those of base material is produced with the current of 65 A. Independent structural responses can be found for the roof sheeting of the CWSSR system, and the maximum displacement appears at the middle of the roof sheeting, while the maximum stress appears at the connection supports between the roof sheeting with a significant stress concentration effect. The responses of the CWSSR system are greatly influenced by the width and thickness of the roof sheeting but are less influenced by the welding height.

• 수면정신생리
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• 제28권1호
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• pp.18-26
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• 2021

Sleep is essential to brain function and mental health. Insomnia and obstructive sleep apnea (OSA) are the two most common sleep disorders, and are major public health concerns. Proton magnetic resonance spectroscopy (¹H-MRS) is a non-invasive method of quantifying neurometabolite concentrations. Therefore, ¹H-MRS studies on individuals with sleep disorders may enhance our understanding of the pathophysiology of these disorders. In this article, we reviewed ¹H-MRS studies in insomnia and OSA that reported changes in neurometabolite concentrations. Previous studies have consistently reported insomnia-related reductions in γ-aminobutyric acid (GABA) levels in the frontal and occipital regions, which suggest that changes in GABA are important to the etiology of insomnia. These results may support the hyperarousal theory that insomnia is associated with increased cognitive and physiological arousal. In addition, the severity of insomnia was associated with low glutamate and glutamine levels. Previous studies of OSA have consistently reported reduced N-acetylaspartate (NAA) levels in the frontal, parieto-occipital, and temporal regions. In addition, OSA was associated with increased myo-inositol levels. These results may provide evidence that intermittent hypoxia induced by OSA may result in neuronal damage in the brain, which can be related to neurocognitive dysfunction in patients with OSA. The current review summarizes findings related to neurochemical changes in insomnia and OSA. Future well-designed studies using ¹H-MRS have the potential to enhance our understanding of the pathophysiology of sleep disorders including insomnia and OSA.

• Current Photovoltaic Research
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• 제9권1호
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• pp.17-21
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• 2021

In this study, the effect of water level and temperature on the power generation was investigated in a water tank with an aquavoltaic PV module to perform feasibility research for the development of salt farm aquavoltaic system. The silicon solar cell attached to the bottom of each water tank is a 1-cell mini module, and the underwater effects of the crystal phase (19.0~19.9% of single- & 17.9~19.9% of poly-crystalline) of the PV module were investigated, and power generation characteristics for water level (0~10 cm) and temperature (10~40℃) were analyzed. The deterioration coefficients according to the water level and temperature of each single- and poly-crystalline module were investigated at very similar levels such as, -2.01 %/cm and -2.02 %/cm, -0.50 %/℃ and -0.48 %/℃, respectively. Therefore, in salt farm aquavoltaic system, water levels need to maintain as low as possible, and heat-induced degradation is similar to those shown in general land, and no factors have been found to be affected by the underwater environment depending on the determination.

• Journal of Microbiology and Biotechnology
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• 제30권12호
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• pp.1896-1904
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• 2020

Muscle atrophy, characterized by a reduced number and size of myofibers, occurs due to immobilization, aging, and several chronic diseases. Leonurus japonicus, belonging to the Labiatae family, is widely used as a traditional medicine in Korea, China, and Japan. Previous studies have reported that L. japonicus has various physiological activities, such as anti-bacteria, anti-cancer, and liver protection. Leonurine, which is a major bioactive in L. japonicas, is known to possess biological effects including anti-inflammation, anti-fibrosis, anti-angiogenesis, and anti-diabetes. However, the preventive effects of L. japonicas and leonurine on muscle have not been reported. The current study aimed to determine the inhibitory effects of standardized L. japonicus extract (LJE) and leonurine on muscle atrophy by clarifying their underlying molecular mechanisms in tumor necrosis factor-alpha (TNF-α)-stimulated L6 myotubes. LJE and leonurine stimulated the phosphatidylinositol 3-kinase/Akt pathway that was reduced by TNF-α treatment. LJE and leonurine not only increased the mammalian target of rapamycin pathway for protein anabolism but also decreased the mRNA expression of E3 ubiquitin ligases by blocking the translocation of Forkhead box O, which is closely linked with proteolysis. Additionally, LJE and leonurine alleviated inflammatory responses by downregulating TNF-α and interleukin-6 mRNA expression and reducing the protein expression of nuclear factor-kappa B, a major transcriptional factor of proinflammatory cytokines. Collectively, LJE and leonurine have potential as therapeutic candidates for inhibiting the development of skeletal muscle atrophy by activating the PI3K/Akt pathway and reducing inflammatory responses.

• Journal of Microbiology and Biotechnology
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• 제31권12호
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• pp.1632-1642
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• 2021

Tuberculosis is a highly contagious disease caused by Mycobacterium tuberculosis. It affects about 10 million people each year and is still one of the leading causes of death worldwide. About 2 to 3 billion people (equivalent to 1 in 3 people in the world) are infected with latent tuberculosis. Moreover, as the number of multidrug-resistant, extensively drug-resistant, and totally drug-resistant strains of M. tuberculosis continues to increase, there is an urgent need to develop new anti-tuberculosis drugs that are different from existing drugs to combat antibiotic-resistant M. tuberculosis. Against this background, we aimed to develop new anti-tuberculosis drugs using probiotics. Here, we report the anti-tuberculosis effect of Pediococcus acidilactici PMC202 isolated from young radish kimchi, a traditional Korean fermented food. Under coculture conditions, PMC202 inhibited the growth of M. tuberculosis. In addition, PMC202 inhibited the growth of drug-sensitive and -resistant M. tuberculosis- infected macrophages at a concentration that did not show cytotoxicity and showed a synergistic effect with isoniazid. In a 2-week, repeated oral administration toxicity study using mice, PMC202 did not cause weight change or specific clinical symptoms. Furthermore, the results of 16S rRNA-based metagenomics analysis confirmed that dysbiosis was not induced in bronchoalveolar lavage fluid after oral administration of PMC202. The anti-tuberculosis effect of PMC202 was found to be related to the reduction of nitric oxide. Our findings indicate that PMC202 could be used as an anti-tuberculosis drug candidate with the potential to replace current chemical-based drugs. However, more extensive toxicity, mechanism of action, and animal efficacy studies with clinical trials are needed.

• 한국정보시스템학회지:정보시스템연구
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• 제31권1호
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• pp.289-304
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• 2022

Purpose The development of the network and mobile industries has induced companies to invest in information systems, leading a new industrial revolution. The Journal of Information Systems, which developed the information system field into a theoretical and practical study in the 1990s, retains a 30-year history of information systems. This study aims to identify academic values and research trends of JIS by analyzing the trends. Design/methodology/approach This study aims to analyze the trend of JIS by compounding various methods, named as TLS mining analysis. TLS mining analysis consists of a series of analysis including Term Frequency-Inverse Document Frequency (TF-IDF) weight model, Latent Dirichlet Allocation (LDA) topic modeling, and a text mining with Semantic Network Analysis. Firstly, keywords are extracted from the research data using the TF-IDF weight model, and after that, topic modeling is performed using the Latent Dirichlet Allocation (LDA) algorithm to identify issue keywords. Findings The current study used the summery service of the published research paper provided by Korea Citation Index to analyze JIS. 714 papers that were published from 2002 to 2012 were divided into two periods: 2002-2011 and 2012-2021. In the first period (2002-2011), the research trend in the information system field had focused on E-business strategies as most of the companies adopted online business models. In the second period (2012-2021), data-based information technology and new industrial revolution technologies such as artificial intelligence, SNS, and mobile had been the main research issues in the information system field. In addition, keywords for improving the JIS citation index were presented.

• 문화기술의 융합
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• 제7권4호
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• pp.659-665
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• 2021

최근 폭발적인 인기를 끌고있는 짧은 동영상 애플리케이션(e.g., TikTok, YouTube Shorts)은 광고집행을 위한 새로운 SNS 플랫폼으로 관심을 받고 있다. 이러한 배경에서 본 연구는 짧은 동영상 애플리케이션에서 집행되고 있는 스토리텔링 광고를 분류하고 그 효과를 측정하는 것을 목적으로 한다. 상술 하면, 전통적 광고 분류기준인 허구성을 기준으로 스토리텔링 광고를 리얼리티, 패러디, 창의형식으로 구분하였다. 또한 인지심리학 정보처리 맥락에서 높은 수준과 낮은 수준의 메시지가치가(MSV)로 광고들을 분류하였다. 전 세계적으로 가장 많은 이용자를 보유한 틱톡을 대상으로 총 784명 중국인 이용자의 응답을 수집하였다. 연구결과 두 개의 주요 변인(허구성과 MSV) 간에 유의미한 조절효과가 발생하였다. 가장 주목할 만한 결과는 정보처리 리소스의 사용을 높게 요구하는 높은 허구성의 창의적 기법이 높은 메시지자극가를 사용하게 되면 인지과부하(cognitive overload)를 야기하여 광고효과가 낮아지는 것으로 나타났다. 보다 자세한 이론적 논의와 효과적인 짧은 동영상 스토리텔링 광고제작을 위한 제언들을 본문에서 상세히 소개하였다.

• Current Optics and Photonics
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• 제6권3호
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• pp.227-235
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• 2022

To investigate the aging-related physiological functions of organic light-emitting diodes (OLEDs), we examined mRNA expression changes in aging-related genes due to oxidative stress inhibition by 630-nm red light OLEDs. As a result of irradiating 630-nm OLED with an intensity of 5 mW/cm² for 15 min, the viability of dermal fibroblasts significantly increased by 1.3-fold. In addition, reactive oxygen species generated by H₂O₂ were significantly reduced about 4.9-fold by irradiation with 630-nm OLED. Quantitative reverse-transcription polymerase chain reaction results showed that 630-nm OLEDs altered aging-related gene mRNA expression levels through antioxidant activity. The mRNA expression levels of matrix metalloproteinase1 (MMP1) and MMP9 decreased significantly, by about 2.2- and 2.5-fold, compared to the control group, whereas those of collagen, type I, and alpha 1 increased significantly, by 4.9-fold. The mRNA expression levels of cancer suppression genes p16 and p53 in dermal fibroblasts were also significantly reduced by 630-nm OLED irradiation, by about 1.4- and three-fold, respectively, compared to the control. Overall, it was confirmed that 630-nm OLED irradiation lowered the level of ROS formation induced by H₂O₂ in dermal fibroblasts, and that this antioxidant effect could regulate the mRNA expression levels of aging- and tumor suppression-related genes. This study shows a link between 630-nm OLED irradiation and anti-aging physiological functions such as antioxidant function, and suggests the potential of OLEDs as a useful light source for skin care.