• Cartoon and Animation Studies
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• s.44
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• pp.183-209
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• 2016

Hayao Miyazaki's product, , is evaluated that his work until present that product point of view and commercial point of view are highly filled at the same time. Miyazaki's showed new public entertainment possibility in genre that is animation inventing highest-grossing domestic film in Japan's history until it was taken over by another Miyazaki work. Also, it can high evaluate that not that see for interest simply beam about environment and human who writer has to spectator deep self-examination and way of problem pulling comprehension without burden through resected reflex which is not exigent delivery sympathy form. Analyzing his product, , ,, , , , this research allowed purpose to recognize that he present the alternative after arranges intent subject how and institute problem. And do to study whether his though and ideology met with viewpoints of ecologism and environment(environmentalism) in work how. There are his countenance have theme that is certain in Miyazaki director's works. If summarize had handled subject meantime, it is , , , etc. This subjects are that go first at importance order among problems which we face, it is that human desires essentially. If balance of society system that regulate various economical, moral value system and desire to our society is set, our society is that can become little more near in nature mode of life.

• Nutrition Research and Practice
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• v.14 no.5
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• pp.438-452
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• 2020

BACKGROUND/OBJECTIVES: Brain senescence causes cognitive impairment and neurodegeneration. It has also been demonstrated that curcumin (Cur) and hesperetin (Hes), both antioxidant polyphenolic compounds, mediate anti-aging and neuroprotective effects. Therefore, the objective of this study was to investigate whether Cur, Hes, and/or their combination exert anti-aging effects in D-galactose (Dg)-induced aged neuronal cells and rats. MATERIALS/METHODS: SH-SY5Y cells differentiated in response to retinoic acid were treated with Cur (1 μM), Hes (1 μM), or a combination of both, followed by 300 mM Dg. Neuronal loss was subsequently evaluated by measuring average neurite length and analyzing expression of β-tubulin III, phosphorylated extracellular signal-regulated kinases, and neurofilament heavy polypeptide. Cellular senescence and related proteins, p16 and p21, were also investigated, including their regulation of antioxidant enzymes. In vivo, brain aging was induced by injecting 250 mg/kg body weight (b.w.) Dg. The effects of supplementing this model with 50 mg/kg b.w. Cur, 50 mg/kg b.w. Hes, or a combination of both for 3 months were subsequently evaluated. Brain aging was examined with a step-through passive avoidance test and apoptosis markers were analyzed in brain cortex tissues. RESULTS: Cur, Hes, and their combination improved neuron length and cellular senescence by decreasing the number of β-gal stained cells, down-regulated expression of p16 and p21, and up-regulated expression of antioxidant enzymes, including superoxide dismutase 1, glutathione peroxidase 1, and catalase. Administration of Cur, Hes, or their combination also tended to ameliorate cognitive impairment and suppress apoptosis in the cerebral cortex by down-regulating Bax and poly (ADP-ribose) polymerase expression and increasing Bcl-2 expression. CONCLUSIONS: Cur and Hes appear to attenuate Dg-induced brain aging via regulation of antioxidant enzymes and apoptosis. These results suggest that Cur and Hes may mediate neuroprotective effects in the aging process, and further study of these antioxidant polyphenolic compounds is warranted.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.2
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• pp.77-89
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• 2020

Objectives: The purpose of this study is to analyse current status and treatment of the Korean medicine hospital after chemotherapy in patients with breast cancer. Methods: We investigated the medical records of 21 patients who admitted to Korean medicine hospital after chemotherapy in patients with breast cacner from March 1, 2017 to December 31, 2019. We searched medical records retrospectively and analyzed current status and treatment of Korean medicine hospital. Results: The average age of 21 participants was 52.81±8.38 years and 40s and 50s accounted for 85.6% of the total. After receiving chemotherapy, the average time to hospitalization was 1.87±3.13days and average hospital stay was 9.78±4.14 days. The subjects were classified as 28.6% of stage I, 52.4% of stage II, 9.5% of stage III, and 9.5% of stage IV. The analysis according to the presence of metastasis was 57.1% without metastasis, 33.3% with axillary lymph node metastasis, and 9.5% with distant metastasis. The main symptoms complained when hospitalized by 21 subjects were nausea (54.2%), fatigue (54.2%), and anorexia (50.8%) in over 50%, pantalgia (47.5%), and insomnia (47.5%), dizziness (44.1%), cold sweating (42.4%), lower extremity pain (40.7%), 37.5~37.9℃ fever (39.0%), headache (37.3%), hot flush (37.3%), pruritus (30.5%) are 30% or more. Korean medicine treatment was performed in 87.4% of all hospitalizations and Gwakhyangjunggi-san-gami was the most administered prescription. Extracts of Korean medicine was performed in 100.0% of all patients and Eunkyo-san was most administered extracts medicine. Acupuncture, moxibustion, and cupping treatments were performed in all 21 study subjects. Other treatments was performed at a frequency of hyperthermia (90.5%), lymph massage (23.8%), air compression therapy (23.8%), and Interference current therapy (19.0%) Conclusion: Korean traditional medicine can be used as a countermeasure for side effects after chemotherapy in breast cancer patients.

• Journal of Dental Rehabilitation and Applied Science
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• v.18 no.2
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• pp.81-91
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• 2002

Dental implant systems have shown many post-surgical problems and One of the most frequent problem is screw loosening. To reduce screw loosening, a number of methods have been tried and recently fundamental modification of fixture-abutment connection structure was developed and used the most frequently. Former implant system structure, such as Br${\aa}$nemark, had external hex with the height of 0.7 mm and later, fixture with external hex of 1.0 mm height and internal hex structure were developed. In addition, the method of morse taper application was introduced to reduce screw loosening. In this study, the level of screw loosening of each implant systems was compared based on the vibration loosening measurement of abutment screw of each implant systems. Analysis of measured value was performed using 3 kinds of methods, (i) Percentage of average of initial 3 times loosening-torque value(initial loosening value) to tightening-torque of 30 Ncm, (ii) Percentage of loosening-torque value after 200 N strength loaded(experimental value) to initial loosening value and (iii) Percentage of experimental value to 30 Ncm of tightening-torque. Each result of analyses shows the value of initial loosening, loosening by repetitive load and final loosening level. The results of this study were as follows. (1) Percentage of initial loosening value to tightening-torque was increased in order of 0.7 mm external hex, 1.0 mm external hex, internal hex and internal taper and all values between each groups showed statistical significance (p<0.05). (2) Percentage of experimental value to initial loosening value was increased in order of internal hex, 0.7 mm external hex, 1.0 mm external hex and internal taper. Value of internal taper showed significant difference with that of 0.7 mm external hex and internal hex (p<0.05). (3) Percentage of experimental value to tightening torque was increased in order of 0.7 mm external hex, 1.0 mm external hex, internal hex and internal taper. Values of all groups showed statistical significance (p<0.05) except between the groups of 1.0 mm external hex and internal hex. Based on those results, there was no significant difference of loosening-torque by repetitive loading except internal taper. It is supposed that implant system with high resistant capability against initial loosening could be recommended for clinical use. In addition, in case of single implant restoration, 1.0 mm external hex or internal hex could be recommended rather than 0.7 mm external hex, and the use of internal taper would be the most useful way to reduce screw loosening.

• Journal of Environmental Health Sciences
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• v.31 no.5 s.86
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• pp.398-403
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• 2005

This study is undertaken to find the optimal method to make the decision on the degree of water pollution by comparison of K-WQI, KOE-WQI that is made for index with the water quality index and water quality environment standard of the Frame Act on Environment Policy as the result of survey for water quality reality on the major point of the Yeongsan river from 2002 to 2004. The water quality of major rivers has some differences depending on seasons. however, under the water quality standard by the $BOD_5$ density, most of rivers displayed the water quality level of $II{\sim}III$ grading, and on K-WQI that is classified by indexing for 10 categories of pH, DO, $BOD_5,\;COD,\;SS,\;T-N,\;NH_3-N,\;NO_{3^-}$ N, T-P, and E-Coli and classified into 5 groups from 100 points to 40 points, they displayed the score distribution of the first grade in water quality for $85{\sim}100$ points to the second grade in water quality for $70{\sim}84$ points. On KOE-WQI that is classified by indexing for 5 categories of pH, DO, $BOD_5$, COD and T-coli and classified into 5 groups from 90 points or above for outstanding and 29 points or below for very bad, and the water quality distribution is made ranged from the first grade in water quality for 90 points or more to the third grade in water quality for $69{\sim}50$ points. In addition, for the contribution of the water quality decline, the Environmental standard has significant dependency on the $BOD_5$ density, with K-WQI contributing in various water quality decline depending on the environment around the river area of $BOD_5,\;T-N,\;NH_3-N,\;NO_3-N,\;T-P$, and E-Coli, and KOE-WQI acting os the factor contributing to lower the water quality decline by $BOD_5$, COD, and T-coli. As such, the current water quality environment standard has high dependency on $BOD_5$ and KOE-WQI excludes some nitrogen and phosphorus that considers the river environment that the grade in water quality is set by some category, and K-WQI reflected well of the ecology environment of rivers with the diversity of the assessment factor as well as to have the low dependency of specific factor to be objective.

• Biomedical Science Letters
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• v.24 no.1
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• pp.43-49
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• 2018

Electrocardiogram (ECG) is a widely used method to diagnose electrical activity of heart. Although it is a reliable and easy method, ECG could be interfered by electrical signals. One of the interfering signals is electromyogram (EMG) that is caused by muscle contraction in any parts of the body except heart. To avoid the EMG noise, an examinee is advised to be relaxed on supine position while measuring ECG. Sometimes, patients who can't put their arms and legs down on bed due to some reasons such as cast on arms or legs necessarily have the EMG noise. But detailed information about how much of the noise could be induced by positional change of arms and legs has not been reported. Here we examined the noise by analyzing ECG data from 14 candidates, 7 males and 7 females. The ECG data was obtained using the standard 12 lead ECG. EMG noise was induced by raising arms and legs at $90^{\circ}$, $60^{\circ}$ or $30^{\circ}$. Because arms are located close to the heart, noise by the raised arms was analyzed toward left or right arm separately. All of the examinees showed similar pattern of the EMG noise. EMG noise by positional change of left or right arm was clearly monitored in different limb leads. Change of leg positions induced the noise that was monitored in aVF of augmented leads and II and III of limb leads. There was a difference in degree of the noise between male and female examinees. In addition to the EMG noise, decrease of PR interval was monitored in particular positional changes, which was prominent in male examinees. These results will enlarge fundamental understanding about EMG noise in ECG.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3955-3960
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• 2012

Objective: To investigate the effects of $CD4^+$, IL17 and Foxp3 expression on prognosis of operable non-small cell lung cancer (NSCLC) with different pTNM stages. Methods: Expression of $CD4^+$, IL17 and Foxp3 in 102 cases of NSCLC tissues and adjacent cancer tissues was detected by immunohistochemistry and associations with prognosis with different pTNM stages were analyzed. The Chi-square test was used to compare count data. Survival differences were evaluated by Kaplan-Meier single factor analysis and the COX regression model was used to analyze the relationship between influential factors and the disease prognosis. The significance level was ${\alpha}$=0.05. Results: Expression of CD4, IL-17 and Foxp3 significantly varied in different pTNM stages of NSCLC tissues (P < 0.05). The same was true for CD4 expression (P < 0.05). The median survival time (MST) in the positive CD4 expression group was evidently higher than that in the negative group (25.8/23.9 months). Compared with stage III, the MST difference of stages I and II in the positive CD4 expression group were statistically significant (P < 0.05). The MST in positive IL-17 and Foxp3 expression groups was obviously lower than that in the corresponding negative group (P < 0.05) (25.6/35.1 months and 24/35.3 months, respectively). There was a significant difference of MST between any two of three stages of positive IL-17 expression group (P < 0.05), and it was the same with positive Foxp3 expression group. TNM stage, negative CD4 expression, and positive IL-17 and Foxp3 expression were the main risk factors for the prognosis of NSCLC. Conclusion: Surgical prognosis of NSCLC can be better assessed by the combination of clinical staging and expression of IL17 and Foxp3.

• Economic and Environmental Geology
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• v.40 no.1 s.182
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• pp.29-45
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• 2007

Biogeochemical characteristics involving redox processes in groundwater from a riverine alluvial aquifer was investigated using multi-level monitoring wells (up to 30m in depth). Anaerobic conditions were predominant and high Fe ($14{\sim}37mg/L$) and Mn ($1{\sim}4mg/L$) concentrations were observed at 10 to 20 m in depth. Below 20 m depth, dissolved sulfide was detected. Presumably, these high Fe and Mn concentrations were derived from the reduction of Fe- and Mn-oxides because dissolved oxygen and nitrate were nearly absent and Fe and Mn contents were considerable in the sediments. The depth range of high Mn concentration is wider than that of high Fe concentration. Dissolved organics may be derived from the upper layers. Sulfate reduction is more active than Fe and Mn reduction below 20 m in depth. Disparity of calculated redox potential from the various redox couples indicates that redox states are in disequilibrium condition in groundwater. Carbonate minerals such as siderite and rhodochrosite may control the dissolved concentrations of Fe(II) and Mn(II), and iron sulfide minerals control for Fe(II) where sulfide is detected because these minerals are near saturation from the calculation of solubility equilibria.

• Journal of Chest Surgery
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• v.33 no.6
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• pp.494-501
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• 2000

Background: Transmyocardial laser revascularization(TMLR) for revascularizing ischemic myocardium in patients was originally based on the assumption that laser channels remain their patency much longer. But recent studies show that laser channels did not remain open and that TMLR could achieve treatment benefits without long-term channel patency. The angiongencesis is currently thought to be induced by non-specific inflammatory response to mechanical tissue injury. This study is to evaluate hypothesis that various transmyocaridal mechanical revascularization(TMMR) may induce the angiogenic responses similar to that seen with TMLR, and transmyocaridal polymer stent revascularization(TMSR), the polymer stent in the myocardial tissue is hydrolyzed in 2 weeks, may enhance the non-specific inflammatory reaction resulting angiogenesis. Furthermore, polymer myocaridal stent channels remain long-term patency. Material and Method: Eight domestic pigs underwent ligation of the proximal circumflex artery, and 2 weeks later they were randomized to undergo transmycardial acupunctural revascularization (TMPR, Group I) of the left lateral wall with 18-G needle(n=2), to undergo transmyocardial (TMDR, Group II) with industrial 2mm steel drill(n=2), to undergo transmyocardial polymer stent revascularization (TMSR, Group III) after drilling the infarcted myocardium(n=2), the stent is poly(lactic acid-co-glycolic acid), which is self-degradated in the myocardium, and to a control group the ischemic zone was unterated(n=2). All the pigs were sacrificed after 4 weeks TMMR. Sections from the ischemic zone were submitted for vascular endothelial growth factor (VEGF) ELISA and histology. Result: There were makedly increase in the VEGF immunoassay in the ischemic zone of the TMMR group compared to the ischemic zone of the control group(control: each 30.85 and 43.15pg/mg protein, TMPR: each 44.14 and 68.61 pg/mg protein, TMDR: each 65.92 and 78.65 pg/mg protein, TMSR: each 177.39 and 168.87 pg/mg protein). TMSR channels caused greatest VEGF expression than channels made by other group and the polymer stent channels remained vacuole after 4 weeks. Conclusion: Transmyocardial polymer stent revascularization promoted the most angiogenci response by the VEGF immunoassay, although our study did not show the statistical significancy. The channels remained but the flow patency was not verified. Transmyocardial polymer stent revascularization (TMSR) is desirable in future experimental trials and in view of the significant cost implications comparable to that of laser.

• Journal of the korean academy of Pediatric Dentistry
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• v.36 no.4
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• pp.550-555
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• 2009

Distribution of orthodontic patients in pediatric dental clinics has increased recently. So it is worth to study about the present status of orthodontic patients in pediatric dental clinics. The purpose of this study was to recognize the characteristics and orthodontic patterns of orthodontic patients in pediatric dental clinics. The material consisted of distribution and orthodontic analysis records of 792 new patients in the department of pediatric dentistry, Seoul National University Dental Hospital, from 2006 to 2008. Results were as follows 1. In age distribution, 8-year-olds group comprised 22%, 7-year-olds 19%, 9-year-olds 16%, 10-year olds 15%, 11-year-olds 11%, and other age groups comprised 18%. 2. In skeletal patterns, skeletal class I patients comprised 52%, class II 29%, and class III 19%. 3. In vertical facial types mesofacial comprised 41%, brachyfacial 35%, and dolichofacial 24%. 4. Out of 792 patients 218 patients(28%) showed anterior cross-bite, and the occurrence ratio of anterior cross-bite increased as the age decreased.