• Korean Journal of Veterinary Research
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• v.39 no.4
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• pp.673-678
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• 1999

The distribution and relative frequency of insulin-immunoreactive cells in the pancreas was studied during developmental stages (fetus, neonate, 1-month-old, 6-month-old and adult) of the Korean native goat by immunohistochemical methods. The different distribution and relative frequency of glucagon-immunoreactive cells in the pancreas of the Korean native goat was observed during development. Insulin-immunoreactive cells were detected in the exocrine and endocrine portions (pancreatic islets) of the all ages, and in the duct of the 6-month-old. The relative frequencies of these cells were increased in the pancreatic islets with ages but decreased in the exocrine portions. Generally, they were distributed in the interacinar spaces or central zone of the pancreatic islets in all ages. However, the distributions and relative frequencies in the pancreatic islets of the neonate Korean native goat were divided into three patterns : 1) located in the inner zone with numerous frequencies, 2) the peripheral zone of the pancreatic islet with moderate frequencies and 3) the peripheral zone of the pancreatic islet with a few frequencies patterns.

• IMMUNE NETWORK
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• v.13 no.6
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• pp.235-239
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• 2013

Encapsulation of tissue has been an area of intense research with a myriad number of therapeutic applications as diverse as cancer, tissue regeneration, and diabetes. In the case of diabetes, transplantation of pancreatic islets of Langerhans containing insulin-producing beta cells has shown promise toward a cure. However, anti-rejection therapy that is needed to sustain the transplanted tissue has numerous adverse effects, and the islets might still be damaged by immune processes. Furthermore, the profound scarcity of healthy human donor organs restricts the availability of islets for transplant. Islet encapsulation allows the protection of this tissue without the use of toxic medications, while also expanding the donor pool to include animal sources. Before the widespread application of this therapy, there are still issues that need to be resolved. There are many materials that can be used, differing shapes and sizes of capsules, and varied sources of islets to name a few variables that need to be considered. In this review, the current options for capsule generation, past animal and human studies, and future directions in this area of research are discussed.

• Diabetes and Metabolism Journal
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• v.42 no.6
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• pp.451-464
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• 2018

Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by a less intensive autoimmune process and a broad clinical phenotype compared to classical type 1 diabetes mellitus (T1DM), sharing features with both type 2 diabetes mellitus (T2DM) and T1DM. Since patients affected by LADA are initially insulin independent and recognizable only by testing for islet-cell autoantibodies, it could be difficult to identify LADA in clinical setting and a high misdiagnosis rate still remains among patients with T2DM. Ideally, islet-cell autoantibodies screening should be performed in subjects with newly diagnosed T2DM, ensuring a closer monitoring of those resulted positive and avoiding treatment of hyperglycaemia which might increase the rate of ${\beta}-cells$ loss. Thus, since the autoimmune process in LADA seems to be slower than in classical T1DM, there is a wider window for new therapeutic interventions that may slow down ${\beta}-cell$ failure. This review summarizes the current understanding of LADA, by evaluating data from most recent studies, the actual gaps in diagnosis and management. Finally, we critically highlight and discuss novel findings and future perspectives on the therapeutic approach in LADA.

• Korean Journal of Veterinary Research
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• v.43 no.3
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• pp.339-347
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• 2003

The regional distribution and relative frequency of some endocrine cells in the pancreas of the Korean aucha perch, Coreoperca herzi Herzenstein belonging to the family Serranidae in order Perciformis, were observed using specific mammalian antisera against serotonin, insulin, glucagon, somatostatin and human pancreatic polypeptide (hPP) by peroxidase antiperoxidase (PAP) method. The pancreas was divided into four portions (principal and secondary islets, exocrine and pancreatic duct regions). In addition, the pancreatic islet regions were further subdivided into three regions (central, mantle and peripheral regions). Spherical to spindle or occasionally round to oval immunoreactive (IR) cells were demonstrated in the pancreatic islets and exoccrine portions, but no cells were detected in the pancreatic duct portions. In the principal islets, serotonin-IR cells were not detected but most of insulin-IR cells were located in the central regions and they were also demonstrated in the mantle and peripheral regions in moderate and rare frequencies, respectively. Glucagon- and hPP-IR cells were mainly situated in the mantle regions but the cells were also demonstrated in the peripheral regions in relatively lower frequency. Somatostatin-IR cells were evenly distributed in the central and mantle regions in a few frequency and cells were also demonstrated in the peripheral regions in rare frequency. Cell clusters were consisted of hPP-IR cells that were situated in the peripheral to mantle regions. In the secondary islet portions, serotonin-IR cells were randomly distributed throughout the whole pancreatic islet regions but lower frequency was detected in the peripheral regions compared to that in central and mantle regions where cells were detected in a few frequency, respectively. Insulin-IR cells were restricted to the central regions in numerous frequency and glucagon-IR cells were evenly distributed in the mantle and peripheral regions in moderate frequencies, respectively. Somatostatin-IR cells were observed in the central and mantle regions in moderate and a few frequencies, respectively. In addition, hPP-IR cells showed similar distributional patterns to those of glucagon-IR cells except cells were also located in the central regions in rare frequency. In the exocrine portions, only glucagon- and hPP-IR cells were demonstrated in rare and a few frequencies, respectively. In conclusion, the regional distribution and relative frequency of pancreatic endocrine cells of the Korean aucha perch showed general patterns, which were observed in other teleost. However, some species-dependent different distributional patterns and/or relative frequencies were also demonstrated especially to serotonin-IR cells. In pancreas of the Korean aucha perch, insulin-IR cells were the most predominant cell type followed by glucagon-, somatostatin-, hPP- and serotonin-IR cells.

• Korean Journal of Agricultural and Forest Meteorology
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• v.7 no.3
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• pp.201-210
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• 2005

This study was conducted to prepare efficient and systematic measures for nature conservation and management in Beomseom Islet, and to provide for basic data to investigate the process of vegetation change in the future. The vegetation of Beomseom Islet was classified to six vegetation type; i.e., Miscanthus sinensis community, Pinus thunbergii community, Iythophyte vegetation, evergreen broad leaf community, shrub community, and Pseudosasa japonica community. The size of each vegetation type was 40,230 $m^2$ ($23.3\%$) for shrub community, 39,366 $m^2$($22.8\%$) for Iythophyte vegetation, 30,012 $m^2$ ($17.4\%$) fur Pinus thunbergii community, 29,853 $m^2$ ($17.3\%$) for Miscanthus sinensis community, 5,564 $m^2$ ($3.2\%$) for evergreen broad leaf community, and 3,325 $m^2$ ($1.9\%$) for Pseudosasa japonica community. The area of non-vegetated sea cliff Bone that composed of bare rocks is 24,246 $m^2$($14.1\%$). We estimated that these distribution patterns of vegetation were the result of various environmental factors such as the steepness of slope and shallowness of soil as well as the cultivation of exotic plants causing disruption of native vegetation.

• Journal of the Economic Geographical Society of Korea
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• v.16 no.3
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• pp.423-444
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• 2013

Tourism in Thoi Son Islet has been the advanced model for rural tourism in the Mekong Delta region since the 1990s. The continuously rising number of tourists, however, has also created problems that affect sustainable rural development. To understand these problems, this research analyzed how rural tourism has been operated through the methodology of a stakeholder network. After investigating the network among key stakeholders (Ho Chi Minh travel agencies (HCMTAs), local travel agencies (LTAs), and local residents, the result showed that in the current model, HCMTAs and LTAs have played the role of connectors, working as hubs to shift tourists (demand) to match local residents (supply), with the networking being dominated by signed contracts (formal networks). The networks between LTAs and local residents are both formal and informal. Inter- and intra-networks among local residents are dominated by informal networks of established working relationships based on networks of family, friends, and neighbors. Moreover, this research has found that there is no cooperating network among LTAs. Among owners of tourist sites was not also found cooperating network. The primary motivating factor for these stakeholders is price competition; this has led to a disproportionately small share of revenue for local stakeholders, with most tourism revenue going to HCMTAs. Additionally, because of the high competition among local stakeholders, this results in local stakeholders having little or no negotiating power when conducting business with HCMTAs. Meanwhile the Tien Giang Tourism Association is inefficient in fostering cooperation among local stakeholders to increase their negotiating power.

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.6
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• pp.1107-1111
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• 2002

This study has been carried out to investigate the effects of the Phenolic compound on the hyperglycemic mice induced with strentozotocin (STZ). The effects of the phenolic compound were assayed by the changes of the blood glucose creatinine and blood urea nitrogen (BUN ) levels, and insulin-immunohistochemical staining and electron microscopical observation for $\beta$ -cells of the Langerhan's islet, under the same experimental conditions. For this purpose male mice were fed with phenolic compound (PA group, IS mg/kg/day; PB group, 90 mg/kg/day)in their diet while the control group received the same commercial diet, for 6 weeks. The blood glucose contents was examined by tail vein blood once a week for 6 weeks. Samples of the pancreas removed after that period were processed for the immunohistochemical identification of $\beta$ -cells as well as for measuring ultrastructural changes of $\beta$-cells. The levels of serum glucose were decreased significantly (p<0.05) on the PB group compared with the control and PA group. The blood BUN and creatinine levels are slightly decreased in the phenolic compound feeding groups compared with control group. The $\beta$-cells on Langerhnan's islet were destructed by administration of STZ, so that a few of insulin-positive cells were observed in the control group. A lot of insulin-positive cells were observed in the PB group compared with the control group. According to the electron microscopical observation $\beta$-cells are recovered from the damage in the PA group. The $\beta$-cell contained a lot of electron dense and pale granules compared with control group. These results suggest that administration of the pear phenolic compound to the mice helped recovery from the damage induced by STZ.

• Economic and Environmental Geology
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• v.54 no.2
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• pp.187-197
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• 2021

The Hyeongjeseom (Islet) is an erosional remnant of volcano which is located about 2 km northeast of sea shore of the Songaksan tuff ring, and is composed of volcaniclastic deposit, agglomerate and scoria deposit, ponded lava, aa lava flows, reworked deposit and beach deposit in ascending order from the base. The volcano is formed by volcaniclastic deposits and lava flows that recorded a transition from initial phreatomagmatic to magmatic explosions followed by lava effusion. It is interpreted that the outcropped volcaniclastic deposit may be a remaining portion of outer ring of a tuff cone. A bomb and a ponded lava yield geochemically basaltic trachyandesite compositions (SiO2 51.3 wt%, Na2O+K2O 6.0 wt%) and belong to olivine basalt with scarce (<5 %) phenocrysts of olivine, petrographically. By incremental heating Ar-Ar dating method, the plateau age of lava flow in the Heongjesom is 9.2±3.6(2σ) ka, implying that the volcanism of Heongjeseom may have occurred earlier than the Songaksan tuff ring which erupted ca. 3.7 ka. It still remains a task to find a volcano which matches with a historical record of volcanic activity that occurred a thousand years ago.

• Bulletin of the Korean Chemical Society
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• v.32 no.5
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• pp.1751-1753
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• 2011

• The Korean Journal of Malacology
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• v.14 no.2
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• pp.161-166
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• 1998

Mollusks were collected with Ponar grab from seven stations in lower part of Han river, Korea from June 1995 through May 1996. Basket sampler with artificial substrate was also employed to collect the adhesive mollusks. In addition to above mentioned sampling stations, Bam islet was surveyed. A total of species, Corbicula fluminea, Anodonta woodiana, Unio douglasiae, Limnoperna fortunei, corbicula fenouilliana and Physa acuta, were collected in lower part of Han river. Author reviewed the literatures on the ecological survey of molluscan fauna in Han river.