• Biomolecules & Therapeutics
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• 제4권2호
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• pp.167-173
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• 1996

This study was undertaken to evaluate a behavior-electroencephalogram (EEG) pattern relationship in pilocarpine- and kainic acid-induced convulsions of rats. Also we intended to examine the effect of a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, and diazepam on the pilocarpine-induced behavioral and electrical seizures in rats. The electrical activities at frontal and hippocampal areas and behavior activities were measured in freely moving rats. At the beginning of the experiments, the rats displayed an exploratory behavior. This awake and moving phase with a low amplitude, irregular, 4-10 Hz wave was followed by a still phase. Pilocarpine (400 mg/kg, i.p.) and kainic acid (0.5 mg/kg, i.c.v.) induced tonic and clonic seizures. The pilocarpine-induced change in electrical activities exhibited a weak correlation with behavioral convulsion at all stages. The amplitude and duration of the electrical response were not linear with the degree of behavioral score. An application of MK-801 (dizocilpine, 7.5 mg/kg) did not affect the amplitudes of the convulsant-induced electrical activities, though the same dose of this drug caused the deformation of the electrical pattern. There was no effect of MK-801 on the behavioral and electrical activities as expected. Diazepam (1 mg/kg) did not affect the amplitude of the electrical activities induced by pilocarpine but changed the pattern of these activities. Our study shows that there is no linear relationship between degree of behavior and amplitude of electrical activities of convulsants. This may indicate that the NMDA receptor stimulation can be processed by the neocortical or hippocampal network in a different way between behavioral and electrical activities.

• The Korean Journal of Physiology and Pharmacology
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• 제1권2호
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• pp.117-125
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• 1997

The N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission is involved in synaptic plasticity, developmental processes, learning and memory and many neuropathological disorders including age-related diseases. In the present study, regulation of the NMDA receptor properties by various ligands was investigated using $[^3H]MK-801$ binding studies in the synaptic membranes of young and aged rat forebrains. The binding in the presence of glutamate and glycine increased dramatically with growth between 1 and 6 weeks old, and thereafter declined gradually with aging. Glutamate, glycine or spermine respectively increased the binding with growth. Glutamate maintained the binding during aging, while glycine or spermine significantly decreased the binding in the aged brain. The maximum stimulation by glycine varied depending on the ages of brains. Greater sensitivity to glycine was observed at 1 week and 3 months and the sensitivity was significantly reduced in the aged brain. In contrast, spermine showed similar stimulation patterns in young and aged rats. These results indicated that the functional properties of the NMDA receptor-ion channel complex in young and aged rat forebrains are differentially regulated by agonists, and the reduction of the receptor function with normal aging may be, in some degree, due to the reduction of the receptor sensitivity to glycine.

• 한국항해학회지
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• 제19권2호
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• pp.107-113
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• 1995

Since the most of the mal-functions in the industrial equipments controlled by processors have been occured by the Electrical Fast Transient(EFT), the International Electrotechnical Commision(IEC) prepare the dummy signal to test the immunity level of the equipments controlled by processors and recommend it for the measuring. In this paper, the defined dummy EFT signal by IEC are analyzed by the spectrum analyzer in the frequency domain and studied the developed countermeasuring parts. The new developed parts are consist of the feedthrough capacitors ( $C_y$ type ) in the input and materials with high permeaility which was wound or inserted in the second layer of the Power Cable in order to increase Common Mode inductance. And it is compared inserted Permalloy to material with high permeability increasing Common Mode inductance. We could gotten a excellent insertion loss on the wide band against EFT signal. Especially, we confirm that countermeasuring Power Cable have been an excellent dynamic characteristics in computer system above the 3.6Kv. This new parts could be effectively used for industrial, MIL, and medical equipments to reduce a mal-functions on the site. Furthermore, these parts also have a good characteristics for EMI countermeasuring over the 60MHz up to several GHz band, they are also expected to be used for all kind of EMS test with IEC801-2, 3, 5 and 6 on the power distributed line.

• 한국소음진동공학회논문집
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• 제14권9호
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• pp.801-810
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• 2004

Parameter modification of a linear finite element model(FEM) based on modal sensitivity matrix is usually performed through an effort to match FEM modal data to experimental ones. However, there are cases where this method can't be applied successfully; lack of reliable modal data and ill-conditioning of the modal sensitivity matrix constitute such cases. In this research, a novel concept of introducing feedback loops to the conventional modal test setup is proposed. This method uses closed-loop natural frequency data for parameter modification to overcome the problems associated with the conventional method based on modal sensitivity matrix. We proposed the whole procedure of parameter modification using the closed-loop natural frequency data including the modal sensitivity modification and controller design method. Proposed controller design method is efficient in changing modes. Numerical simulation of parameter estimation based on time-domain input/output data is provided to demonstrate the estimation performance of the proposed method.

• Bulletin of the Korean Chemical Society
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• 제25권6호
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• pp.801-805
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• 2004

In this work, the fundamental study of on-line monitoring of $SiO_2$ particles in the size range of 40 nm to 725 nm was carried out using turbidimetry. The size of particle was measured using a field emission scanning electron microscope (FE-SEM). The factors affecting on the turbidity were discussed, for example, wavelength, size, and concentration. In order to observe the dependence of turbidity on the wavelength, a turbidimetric system equipped with charged coupled detector (CCD) was built. The shape of the transmitted peak was changed and the peak maximum was shifted to the red when the concentration of particle was increased. This result indicates that the turbidity is related to the wavelength, which corresponds to the characteristic of the Mie extinction coefficient, Q, that is a function of not only particle diameter and refractive index but also wavelength. It is clear that a linear calibration curve for each particle in different size can be obtained at an optimized wavelength.

• Structural Engineering and Mechanics
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• 제55권4호
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• pp.801-813
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• 2015

Flexural stiffness of bridge spans has become even more important parameter since Eurocode 1 introduced for railway bridges the serviceability limit state of resonance. For simply supported bridge spans it relies, in general, on accurate assessment of span moment of inertia that governs span flexural stiffness. The paper presents three methods of estimation of the equivalent moment of inertia for such spans: experimental, analytical and numerical. Test loading of the twin truss bridge spans and test results are presented. Recorded displacements and the method of least squares are used to find an "experimental" moment of inertia. Then it is computed according to the analytical method that accounts for joint action of truss girders and composite deck as well as limited span shear stiffness provided by diagonal bracing. Finally a 3D model of finite element method is created to assess the moment of inertia. Discussion of results is given. The comparative analysis proves efficiency of the analytical method.

• 한국항해항만학회지
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• 제29권9호
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• pp.801-806
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• 2005

The world of container shipping and container terminal business is changing and container ports need to know what the changes are in order to plan how to respond. In particular, the container transport industry has noticed two major developments such as globalization and consolidation. The purpose of this paper is to review the current trend towards globalization and consolidation of container liner shipping and container terminal business. It also investigates the impact of these market developments on container ports and presents its implications for port development, management and operation, and port competition policy. According to the discussion of this paper a greater exercise of market power of container terminal operators will have negative impacts on international trade and national economy, especially port users, including container lines, exporters and importers. An empirical evidence on the exercise of market power is required to develop competition rules on market dominance at a national and international level. This paper suggests 'port coopetition' as a solution for smaller and regional container terminal operators to survive in a competitive business environment.

• BMB Reports
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• 제40권5호
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• pp.801-804
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• 2007

The products of reactions catalyzed by Methanococcus. jannaschii (Mj) aldolase using various substrates were identified by gas chromatography (GC). Although Mj aldolase is considered a fuculose-1-phosphate aldolase based on homology searching after gene sequencing, it has not been proven to be a fuculose-1-phosphate aldolase based on its reaction products. Mj aldolase was found to catalyze reactions between glycoaldehyde or D, L-glyceraldehyde and DHAP (dihydroxyacetone phosphate). Before performing GC the ketoses produced were converted into peracetylated alditol derivatives by sequential reactions, i.e., dephosphorylation, $NaBH_4$ reduction, and acetylation. By comparing the GC data of final products with those of standard alditol samples, it was found that the enzymatic reactions with glycoaldehyde, D-glyceraldehyde, and D, L-glyceraldehyde produced D-ribulose-1-phosphate, D-psicose-1-phosphate, and a mixture of D-psicose and L-tagatose-1-phosphate, respectively. These results provide direct evidence that Mj aldolase is a fuculose-1-phosphate aldolase.

• 한국산학기술학회논문지
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• 제13권2호
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• pp.801-807
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• 2012

본 논문에서는 LC 필터 기술을 기반으로 하는 주파수 단일 하향 변환기를 설계 및 제작하였다. 설계한 단일 하향 변환기는 저잡음 증폭기, 혼합기 IF 증폭기, LC 필터로 구성하였으며 DC block 커패시터와 RF bypass 커패시터로 구성된다. 설계한 변환기는 IC를 LC 필터로 대치하여 전력을 감소시키고 제작비용을 낮추어주는 효과를 보인다. 본 논문에서 설계, 제작한 단일 하향 변환기는 이득이 약 10dBm이고 70MHz에서 18MHz의 대역폭을 실현하였다.

• 제어로봇시스템학회논문지
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• 제18권9호
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• pp.801-805
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• 2012

This paper proposes dynamic thresholding scheme for fingerprint identification. As a user authentication method by fingerprint recognition technology, verification method based on 1:1 matching was mainly used in the past, but identification method based on 1:N matching is generally used recently. The control of the value of FAR is very important in the application areas such as access control and time attendance systems. This paper proposes dynamic thresholding scheme which could properly control the value of FAR according to the field of applications and size of the fingerprints database.