The Korean Journal of Physiology and Pharmacology
- Volume 1 Issue 2
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- Pages.117-125
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- 1997
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
[${^3H}MK-801$ Binding to the Synaptic Membranes of Rat Forebrains: Age-related Regulation by Glutamate, Glycine and Spermine
- Cho, Jung-Sook (Department of Pharmacology, College of Medicine, Dongguk University) ;
- Kong, Jae-Yang (Pharmaceutical Screening Division, Korea Research Institute of Chemical Technology)
- Published : 1997.04.21
Abstract
The N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission is involved in synaptic plasticity, developmental processes, learning and memory and many neuropathological disorders including age-related diseases. In the present study, regulation of the NMDA receptor properties by various ligands was investigated using