• Journal of Korean Society of Neurocognitive Rehabilitation
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• v.10 no.2
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• pp.45-52
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• 2018

The purpose of the present study was to determine correlations between the Berg Balance Scale (BBS), Montreal Cognitive Assessment-Korean (MoCA-K) and Modified Barthel Index (MBI) targeting stroke patients, and it seeks to analyze the influence among each factor to establish the fundamental research in evaluating the functional performance capability of stroke patients. The study was conducted between December 2017 and March 2018 and the target of the study was 34 stroke patients who are hospitalized and treated in Y rehabilitation hospital located in Goyang city. Following in criteria of how participants were selected. First, a person without the onset of 6months or more. Second, a person who can communicate and score over 20 points on MMSE-K. Third, a person without unilateral neglect. Fourth, a person without lower motor neuron lesion and orthopedic disease on the bilateral lower extremity. Fifth, a person without audiovisual problem and history of using drug or surgery that influence athletic function. sixth, patients who agreed on participating in the study. The evaluation was processed by measuring BBS, MoCA-K, and MBI with the occupational therapist and physical therapist. Also, one assistant was participated in measuring balanced ability for the safety reason. It was found that significantly correlates (p<.01) with BBS and MoCA-K (r=.459), BBS and MBI (r=.550), MoCA-K and MBI (r=.565). This study is meaningful that it provided the basis for the active use of BBS, MoCA-K and MBI as a clinical evaluation tool and its usefulness.

• Journal of Ginseng Research
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• v.45 no.1
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• pp.66-74
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• 2021

Background: Abnormal chloride (Cl-) transport has a detrimental impact on mucociliary clearance in both cystic fibrosis (CF) and non-CF chronic rhinosinusitis. Ginseng is a medicinal plant noted to have anti-inflammatory and antimicrobial properties. The present study aims to assess the capability of red ginseng aqueous extract (RGAE) to promote transepithelial Cl- secretion in nasal epithelium. Methods: Primary murine nasal septal epithelial (MNSE) [wild-type (WT) and transgenic CFTR-/-], fisher-rat-thyroid (FRT) cells expressing human WT CFTR, and TMEM16A-expressing human embryonic kidney cultures were utilized for the present experiments. Ciliary beat frequency (CBF) and airway surface liquid (ASL) depth measurements were performed using micro-optical coherence tomography (μOCT). Mechanisms underlying transepithelial Cl- transport were determined using pharmacologic manipulation in Ussing chambers and whole-cell patch clamp analysis. Results: RGAE (at 30㎍/mL of ginsenosides) significantly increased Cl- transport [measured as change in short-circuit current (ΔISC = ㎂/㎠)] when compared with control in WT and CFTR-/- MNSE (WT vs control = 49.8±2.6 vs 0.1+/-0.2, CFTR-/- = 33.5±1.5 vs 0.2±0.3, p < 0.0001). In FRT cells, the CFTR-mediated ΔISC attributed to RGAE was small (6.8 ± 2.5 vs control, 0.03 ± 0.01, p < 0.05). In patch clamp, TMEM16A-mediated currents were markedly improved with co-administration of RGAE and uridine 5-triphosphate (8406.3 +/- 807.7 pA) over uridine 5-triphosphate (3524.1 +/- 292.4 pA) or RGAE alone (465.2 +/- 90.7 pA) (p < 0.0001). ASL and CBF were significantly greater with RGAE (6.2+/-0.3 ㎛ vs control, 3.9+/-0.09 ㎛; 10.4+/-0.3 Hz vs control, 7.3 ± 0.2 Hz; p < 0.0001) in MNSE. Conclusion: RGAE augments ASL depth and CBF by stimulating Cl- secretion through CaCC, which suggests therapeutic potential in both CF and non-CF chronic rhinosinusitis.

• Korean Journal of Environmental Biology
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• v.39 no.1
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• pp.1-5
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• 2021

Radish is one of the major vegetable crops and has been damaged economically by the causal agent of Fusarium wilt disease, Fusarium oxysporum f. sp. raphani (FO) in the highlands of Gangwon province, Korea. Recently, clover cyst nematode, Heterodera trifolii(HT), occurred in highland of Jeongseon area and poses a threat to radish plants. The nematodes, besides causing direct damage to radish plants, possess the capability to synergize with other plant pathogens, leading to the development of a disease complex. The aim of this study was to investigate the interaction between FO and HT in radish plants. The length of plants co-infected with both FO and HT was shorter than that of plants infected with FO alone, but there was no statistically significant difference. However, the disease severity was much higher in the plants co-infected with both FO and HT(1.60±0.97) compared to FO alone(0.20±0.42)(df=3, F=10.17, p<0.001). Disease incidence was also about two-fold higher in plants co-infected with both FO and HT (80%) compared to FO alone (44%). These results suggested that the clover cyst nematode should be considered in the management of Fusarium wilt disease in the highlands of Gangwon province.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.81-88
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• 2021

Structural health monitoring (SHM) systems have attracted considerable interest owing to the frequent earthquakes over the last decade. Smart concrete is a technology that can analyze the state of structures based on their electro-mechanical behavior. On the other hand, most research on the self-sensing response of smart concrete generally investigated the electro-mechanical behavior of smart concrete under a static loading rate, even though the loading rate under an earthquake would be much faster than the static rate. Thus, this study evaluated the electro-mechanical behavior of smart ultra-high-performance concrete (S-UHPC) at three different loading rates (1, 4, and 8 mm/min) using a Universal Testing Machine (UTM). The stress-sensitive coefficient (SC) at the maximum compressive strength of S-UHPC was -0.140 %/MPa based on a loading rate of 1 mm/min but decreased by 42.8% and 72.7% as the loading rate was increased to 4 and 8 mm/min, respectively. Although the sensing capability of S-UHPC decreased with increased load speed due to the reduced deformation of conductive materials and increased microcrack, it was available for SHM systems for earthquake detection in structures.

• Journal of Navigation and Port Research
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• v.46 no.6
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• pp.525-529
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• 2022

In the eLoran system, the Loran Data Channel (LDC) is used to provide precise timing and positioning. The LDC message can be modulated with the Eurofix method, which modulates the transmission time of the 3rd-8th pulse not used for navigation, and the 9th pulse method, which modulates data using the 9th additional pulse after the existing 8 Loran pulses. In this paper, we analyzed the reception performance of the LDC message transmitted from the eLoran transmitter according to the modulation method. The eLoran testbed transmitter in Incheon was set to transmit LDC messages simultaneously with the 9th pulse modulation method and the Eurofix modulation method. Then, the LDC messages stored in the databases of the eLoran differential stations in Incheon and Pyeongtaek were analyzed in terms of the message reception rate according to the modulation method. Using the navigation aid management ship Inseong No. 1, the range of LDC message reception of actual sea users near Incheon Port was also analyzed. The results of this study are expected to be utilized in the full operational capability service after the eLoran pilot service.

• Composites Research
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• v.35 no.6
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• pp.394-401
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• 2022

Two polymer precursors, polyvinylidene chloride-resin (PVDC-resin) and polyvinylidene fluoride (PVDF), are assembled into the microporous carbon by pyrolysis. Microporous carbon is advantageous as an electrode for supercapacitors that store electric charges through ion adsorption/desorption. The pyrolysis also turns the various heteroatoms of two precursors into functional groups, contributing to the additional charge storage. The analysis of the porous structure and function group during carbonization are important to develop the carbon for energy storage. Here, we analyzed the functional groups of two polymer-derived carbons through X-ray photoelectron spectroscopy. The electrochemical properties of the functional groups were explored in various pH electrolytes. The specific capacitance of two carbons in the acidic electrolyte (1 M H₂SO₄) was improved compared to that in the neutral electrolyte (0.5 M Na₂SO₄) due to the faradaic charge/discharge reaction of the quinone functional group. In particular, the carbon electrode derived from PVDC-resin exhibits a lower capacity than the carbon from PVDF due to the small micropores. In the alkaline electrolyte (6 M KOH), the highest specific capacitance and rate capability were obtained among the three electrolytes for both electrodes based on the facile adsorption of the constituent electrolyte ions (K⁺, OH^-).

• Journal of Korea Water Resources Association
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• v.55 no.5
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• pp.345-356
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• 2022

A severe flooding occured at a small urban catchment in Daejeon-si South Korea on July 30, 2020 causing significant loss of property (inundated 78 vehicles and two apartments) and life (one casualty and 56 victims). In this study, a retrospective analysis of the inundation event was implemented using a physically-based urban flood model, H12 with high-resolution data. H12 is an integrated 1-dimensional sewer network and 2-dimensional surface flow model supported by hybrid parallel techniques to efficiently deal with high-resolution data. In addition, we evaluated the impact of the flooding barriers which were installed after the flood disaster. As a result, it was found that the inundation was affected by a combination of multiple components including the shape of the basin, the low terrain of the inundation area located in the downstream part of the basin, and lack of pipe capacity to drain discharge from the upstream during heavy rain. The impact of the flooding barriers was analyzed by modeling with and without barriers on the high-resolution terrain input data. It was evaluated that the flood barriers effectively lower the water depth in the apartment complex. This study demonstrates capability of high-resolution physically-based urban modeling to quantitatively assess the past inundation event and the impact of the reduction measures.

• BMB Reports
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• v.55 no.2
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• pp.98-103
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• 2022

Increased mRNA levels of cancer upregulated gene (CUG)2 have been detected in many different tumor tissues using Affymetrix microarray. Oncogenic capability of the CUG2 gene has been further reported. However, the mechanism by which CUG2 overexpression promotes cancer stem cell (CSC)-like phenotypes remains unknown. With recent studies showing that pyruvate kinase muscle 2 (PKM2) is overexpressed in clinical tissues from gastric, lung, and cervical cancer patients, we hypothesized that PKM2 might play an important role in CSC-like phenotypes caused by CUG2 overexpression. The present study revealed that PKM2 protein levels and translocation of PKM2 into the nucleus were enhanced in CUG2-overexpressing lung carcinoma A549 and immortalized bronchial BEAS-2B cells than in control cells. Expression levels of c-Myc, CyclinD1, and PKM2 were increased in CUG2-overexpressing cells than in control cells. Furthermore, EGFR and ERK inhibitors as well as suppression of Yap1 and NEK2 expression reduced PKM2 protein levels. Interestingly, knockdown of β-catenin expression failed to reduce PKM2 protein levels. Furthermore, reduction of PKM2 expression with its siRNA hindered CSC-like phenotypes such as faster wound healing, aggressive transwell migration, and increased size/number of sphere formation. The introduction of mutant S37A PKM2-green fluorescence protein (GFP) into cells without ability to move to the nucleus did not confer CSC-like phenotypes, whereas forced expression of wild-type PKM2 promoted such phenotypes. Overall, CUG2-induced increase in the expression of nuclear PKM2 contributes to CSC-like phenotypes by upregulating c-Myc and CyclinD1 as a co-activator.

• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.179-193
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• 2022

Amid the explosive growth of various metaverse platforms, there is no unified indicator to measure, analyze, and evaluate based on customer experience. Therefore, the usability evaluation factors in metaverse were identified through a heuristic methodology and literature review, to evaluate the metaverse, a two-to three-dimensional virtual world platform. A measurable system was established by subdividing 20 items in 5 fields, including user control, information structure, design and content, and usage environment, derived through Delphi technique. Based on this, after experiencing the actual contents of major metaverse platforms such as Roblox and Zepeto, usability was evaluated and comparative verification was conducted. As a result, it was estimated that metaverse user experience could be improved as its utility was derived relatively high in terms of user control and content. This study constitutes a theoretical contribution by extending the usability evaluation system, which has been widely used in the field of service design, to the fields of extended reality and mixed reality. At the same time, it has practical key findings of providing basic judgment standards to stakeholders in the metaverse field, as well as policy implications for digital capability enhancement and industry revitalization.

• Journal of Technology Innovation
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• v.30 no.4
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• pp.1-28
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• 2022

Arguably many studies point out that regional innovation capabilities are accepted as a major source of growth for the sustainable regional economy. Recently, a smart specialisation strategy that should reflect regional characteristics in the policy implementation process of the regional innovation system has been proposed, but empirical studies have only presented limited results. This study attempts to overcome limitations by approaching smart specialisation as a supplementary strategy for existing regional innovation research. To this end, smart specialisation was not an alternative strategy for the regional innovation system, but rather the institutional elements of regional innovation capabilities, and the relationship between regional innovation capabilities and the local economy was analyzed to identify the impact of smart specialisation on the local economy. A study was conducted through a panel model consisting of 16 cities and provinces in Korea and 10 years from 2009-2018, and the FGLS model was finally used through the process of searching for an appropriate panel model. As a result of the study, smart specialisation consisting of industry related variety and non-related variety had a positive effect on the local economy. In addition, other regional innovation capabilities measured by dividing them into base and facilitating factors also had a positive effect on the local economy, reaffirming the results of positive research between existing regional innovation and the local economy. This study is meaningful in that smart specialisation lacking in domestic research was viewed as an institutional element of regional innovation capabilities, and it was measured through regional industry-related variety and non-related variety.