• Natural Product Sciences
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• v.18 no.4
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• pp.221-226
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• 2012

Hesperidin (HES) is a bioflavonoid with antioxidant, anti-inflammatory and anti-diabetic properties. IL-6 is well known as a primary proinflammatory cytokine that contributes to impaired insulin signaling in liver. This study was to investigate whether HES improves IL-6-mediated impairment of insulin sensitivity in liver. Hepa-1c1c7 cells were pre-treated with 50 and $100{\mu}M$ HES in complete media for 1 h and then cultured in the presence or absence of IL-6 (20 ng/ml). These results demonstrated that HES restored IL-6-suppressed expression of IRS-1 protein, downregulated IL-6-increased expression of CRP and SOCS-3 mRNA, and inhibited LPS-induced production of IL-6 in Hepa-1c1c7 cells. These findings indicate that HES may ameliorate hepatic insulin resistance via improvement of IL-6-mediated impaired insulin signaling in hepatocytes.

• Natural Product Sciences
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• v.19 no.4
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• pp.360-365
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• 2013

Baicalin has antioxidant, anti-inflammatory and anti-diabetic properties. IL-6 is a primary proinflammatory cytokine that contributes to impaired insulin signaling in liver. This study was carried out to investigate whether baicalin improves IL-6-mediated insulin resistance in liver. Hepa-1c1c7 cells were pre-treated with 50 and 100 ${\mu}M$ baicalin in complete media for 1 h and then cultured in the presence or absence of IL-6 (20 ng/ml). These results demonstrated that baicalin restored IL-6-suppressed expression of insulin receptor substrate (IRS)-1 protein, downregulated IL-6-increased gene expression of C-reactive protein (CRP) and suppressor of cytokine signaling (SOCS)-3, and inhibited LPS-induced production of IL-6 in Hepa-1c1c7 cells. These findings indicate that baicalin may ameliorate hepatic insulin resistance via improvement of IL-6-mediated impaired insulin signaling in hepatocytes.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.58.2-58.2
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• 2010

L1251B, which was revealed as a small group of protostars by the Spitzer Space Telescope (SST), presents a great site of studying chemical evolution in gas and ice as well as various dynamical processes associated with star formation (infall, rotation, and outflow). We have mapped L1251B with the Infrared Spectrograph (IRS) aboard the SST to study the chemical distribution in the phases of gas and ice and the dynamical feature related to shock in the region. Various atomic lines and the $H_2$ pure rotational lines, which trace different shock velocities, were detected. In addition, the distribution of the water and $CO_2$ ices hints variety of the ice desorption mechanism in L1251B.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.44.3-45
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• 2018

Magnetic fields affect star formation in a broad range of scales from parsec to hundreds au. In particular, interferometric observations and ideal magneto-hydrodynamic (MHD) simulations have reported that formation of a rotation-supported disk at the earliest young stellar objects (YSOs) is largely suppressed by magnetic fields aligned to the rotational axis of YSOs: magnetic braking. Our recent ALMA observations toward L1448 IRS 2, which has a rotation detected and its magnetic fields aligned to the rotation axis (poloidal fields) in ~500 au scales, show that the fields switch to toroidal at the center in ~100 au scales. This result suggests that magnetic braking may not be so catastrophic for early disk formation even in YSOs with magnetic fields aligned to the rotational axis.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.14 no.3
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• pp.171-180
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• 2014

In this paper, a multiple sliding surface (MSS) controller for a twin rotor multi-input-multioutput system (TRMS) with mismatched model uncertainties is proposed. The nonlinear terms in the model are regarded as model uncertainties, which do not satisfy the standard matching condition, and an MSS control technique is adopted to overcome them. In order to control the position of the TRMS, the system dynamics are pseudo-decomposed into horizontal and vertical subsystems, and two MSSs are separately designed for each subsystem. The stability of the TRMS with the proposed controller is guaranteed by the Lyapunov stability theory. Some simulation results are given to verify the proposed scheme, and the real time performances of the TRMS with the MSS controller show the effectiveness of the proposed controller.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.1
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• pp.83.2-83.2
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• 2011

I present results from the Spitzer/IRS study to identify massive young stellar objects (YSOs) in the Galactic Center (GC). Our sample of 107 YSO candidates was selected based on Spitzer/IRAC colors in the central 300 pc region of the Milky Way Galaxy. We obtained IRS spectra over $5{\mu}m$ to $35{\mu}m$, and identified massive YSOs by the presence of a $15.4{\mu}m$ shoulder on the absorption profile of $15{\mu}m$ $CO_2$ ice, suggestive of high $CH_3OH$ abundance on $CO_2$ ice grains. This $15.4{\mu}m$ shoulder is clearly observed in 16 sources and possibly observed in an additional 19 sources. We further show that 9 massive YSOs reveal molecular gas-phase absorption from $CO_2$, $C_2H_2$, and/or HCN, which traces warm and dense gas in YSOs. Our results provide the first spectroscopic census of the massive YSO population in the GC.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.697-699
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• 2003

We present a simple algorithm for detection of red patches by remote sensing in coastal waters of Korea. The red tide patches can by identified by the relative intensity of red band signal with respect to the blue-green background signal, provided the radiometric signals only in the sea area are properly stretched. We tested our algorithm by Ocean COlor Monitor(OCM) data of Indian Satellite IRS-P4, which has been received from 2001 by National Fisheries Research and Development Institute of Korea. A comparison of our results with observation shows that the locations of red tides derived from remote sending imagery by our algorithm are in accordance with observations.

• Proceedings of the Optical Society of Korea Conference
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• 2004.02a
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• pp.236-237
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• 2004

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.968-968
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• 2003

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.10
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• pp.4411-4417
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• 2012

The present study proposes the optimization of wing structure base on reduced model which assures the solution accuracy and computational efficiency. Well-constructed reduced model assures the accurate result in the eigenvalue problem, dynamic analysis or sensitivity of design optimization. Reduced system is classified into the reduce-order model based on structural modes and the reduced system based on degrees of freedom. Because this study uses the reduced system based on degrees of freedom, it is important to select the dominant degrees of freedom properly. For this work, robust selection method, two-level selection scheme, is employed and IRS(Improved Reduced System) is applied to construct the final reduced system. In the optimization process based on the reduced system, all of the equivalent stress, eigenvalue and design sensitivities are calculated from the reduced system. Through a numerical example, it is shown that the present optimization methodology based on the reduction method can provide an optimal results for objective function satisfying constraint condition.