• Molecules and Cells
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• 제27권1호
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• pp.39-45
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• 2009

Ligand-dependent or independent oligomerization of receptor protein tyrosine kinase (RPTK) is often an essential step for receptor activation and intracellular signaling. The novel oncogene with kinase-domain (NOK) is a unique RPTK that almost completely lacks an ectodomain, expresses intracellularly and activates constitutively. However, it is unknown whether NOK can form oligomer or what function oligomerization would have. In this study, two NOK deletion mutants were generated by either removing the ectodomain ($NOK{\Delta}ECD$) or including the endodomain (NOK-ICD). Co-immunoprecipitation demonstrated that the transmembrane (TM) domain of NOK was essential for its intermolecular interaction. The results further showed that NOK aggregated more closely as lower order oligomers (the dimer- and trimer-sized) than either deletion mutant did since NOK could be crosslinked by both Sulfo-EGS and formaldehyde, whereas either deletion mutant was only sensitive to Sulfo-EGS. Removing the NOK TM domain (NOK-ICD) not only markedly promoted higher order oligomerization, but also altered the subcellular localization of NOK and dramatically elevated the NOK-mediated constitutive activation of extracellular signal-regulated kinase (ERK). Moreover, NOK-ICD but not NOK or $NOK{\Delta}ECD$ was co-localized with the upstream signaling molecule RAS on cell membrane. Thus, TM-mediated intermolecular contacting may be mainly responsible for the constitutive activation of NOK and contribute to the autoinhibitory effect on RAS/MAPK signaling.

• 한국환경과학회지
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• 제19권7호
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• pp.861-869
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• 2010

The present study aims to evaluate the characteristics of atmospheric polycyclic aromatic hydrocarbons (PAHs) pollution in roadside and residential areas of two Korean metropolitan cities (Seoul and Incheon) and a background area (Seokmolee). This purpose was established by analyzing temporal and spacial concentration distribution of total and 7 individual PAHs, which were extracted from ambient particulate matters, and by utilizing a multivariate statistical method (principal component analysis, PCA) for the qualitative determination of potential PAH sources. Target PAHs included benzo(a)anthracene (BaA), benzo(a)pyrene (BaP), benzo(b)fluoranthene (BbF), benzo(k)fluoranthene (BkF), chrysene (Chr), dibenzo(a,h)anthracene (DahA), and indeno(1,2,3-cd)pyrene (IcdP). For all surveyed sites, the concentrations of total PAHs were higher in winter season than in other seasons. However, the concentrations of individual PAHs varied with surveyed sites. In both residential and roadside sites of Seoul and Incheon, BbF revealed the highest atmospheric levels. For all 7 target PAHs, the ambient concentrations were higher in Seoul and Incheon than in a background area (Seokmolee). In both residential and roadside areas, the concentrations of 4 target PAHs (BaA, BbF, BkF, DahA) were higher in Incheon than in Seoul. However, both the residential and roadside Chr concentrations were comparable in Seoul and Incheon. In addition, the residential IcdP concentrations were higher in Incheon than in Seoul, whereas the roadside concentrations were higher in Seoul. The roadside and residential BaP concentrations exhibited the reverse result to the IcdP concentrations. An PCA analysis suggested that atmospheric PAHs in both residential and roadside areas would be due to combined effects of several potential sources such as gasoline- and diesel-fueled vehicles, coal/oil combustion, and waste incineration.

• 산업경영시스템학회지
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• 제41권4호
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• pp.238-247
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• 2018

This paper considers the problem of scheduling loading and unloading operations of a crane in a railway terminal motivated from rail-road container transshipment operations at Uiwang Inland Container Depot (ICD). Unlike previous studies only considering the total handling time of containers, this paper considers a bi-criteria objective of minimizing the weighted sum of the total handling time and tenant service time. The tenant service time is an important criterion in terms of terminal tenants who are private logistics companies in charge of moving containers from/to the terminal using their trucks. In the rail-road container shipment yard, the tenant service time of a tenant can be defined by a time difference between beginning and finishing loading and unloading operations of a crane. Thus, finding a set of sequences and time of the crane operations becomes a crucial decision issue in the problem. The problem is formulated as a nonlinear program which is improved by linearizing a nonlinear constraint in the model. This paper develops a genetic algorithm to solve the problem and performs a case study on the Uiwang ICD terminal. Computational experiment results show that the genetic algorithm shows better performance than commercial optimization solvers. Operational implications in terms of tenants are drawn through sensitivity analyses.

• 보건의료산업학회지
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• 제8권3호
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• pp.13-25
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• 2014

This research was performed to investigate the characteristics and determination factors on tertiary hospital inpatients. The used data was the four waves of Korea Health Panel(2008, 2009, 2010, 2011), and the number of subjects was 4,430 cases of tertiary and general hospital admission. The statistical methodology used in the study is the logistic regression model. The significant affecting factors in utilizing tertiary hospital admission were gender, marital status, education, household income, residence region and ICD-10 classification. Man, graduating college/university, married, high-income were socio-economic affecting factors in tertiary hospital admission. Medical need factor of ICD-10 classification and residence region of inpatients was also significant affecting factors in tertiary hospital admission. The 81.4% of inpatients at tertiary hospital had chronic disease and the 12.9% of inpatients readmitted, the 68.2% had a selecting doctor and the only 26.7% of inpatients reinforced by private medical insurance. This study recommended the Korean government to provide proper rule for tertiary hospital admission in order to improve the equity and efficiency of health care system.

• 대한한방내과학회지
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• 제31권1호
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• pp.1-10
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• 2010

Objectives : It is necessary that the international classification of diseases (ICD) be examined in order to comprise the third revision of the Korean Classification of Disease on Oriental Medicine (KCD-OM) and disease classification in the oriental internal medicine field. It is essential that the selection, classification and definition of disease and pattern names of oriental concepts in internal medicine be clear. Since 2008, the fifth revision of the Korean Classification of Disease (KCD-5) has been used in Korea. It was required to use the reference classification from the Oriental medicine area based on the ICD-10. Methods : In this review, the necessity for, meaning of and content of the third revision are briefly described. The ICD system was reviewed and KCD-OM was reconstructed. How diagnosis in the oriental internal medicine area had changed is discussed. Review and Results : In 1973, the disease classification of oriental medicine was established the basis on the contents of Dongeuibogam. It was irrespective of the ICD. As to the classification system in the Oriental internal medicine field, systemic disease was comprised of wind, cold, warm, wet, dryness, heat, spirit, ki, blood, phlegm and retained fluid, consumptive disease, etc. Diseases of internal medicine comprised a system according to the five viscera and the six internal organs and followed the classification system of Dongeuibogam. The first and second revisions were of the classification system based on the curriculum in 1979 and 1995. In 1979, in the first revision, geriatric disease and idiopathic types of disease were deleted, and skin disease was included among surgery diseases. This classification was expanded to 792 small classification items and 1,535 detailed classification items to the dozen disease classes. In 1995, in the second revision, it was adjusted to 644 small classes and 1,784 detailed classification items in the dozen disease classes. KCD-OM3 did KCD from this basis. It added and comprised the oriental medical doctor's concept names of diseases considering the special conditions in Korea. KCD-OM3 examined the KCD-OMsecond revised edition (1994). It improved the duplex classification, improper classifications, etc. It is difficult for us to separate the disease names and pattern names in oriental medicine. We added to the U code and made one classification system. By considering the special conditions in Korea, 169 codes (83 disease name codes, 86 pattern name codes) became the pre-existence classification and links among 306 U codes of KCD-OM3. 137 codes were newly added in the third revision. U code added 3 domains. These are composed of the disease name (U20-U33, 97 codes), the disease pattern name (U50-U79, 191 codes) and the constitution pattern name of each disease (U95-U98, 18 codes). Conclusion : The introduction of KCD-OM3 conforms to the diagnostic system by which oriental medical doctors examine classes used with the basic structure of the reference classification of WHO and raises the clinical study and academic activity of the Korean oriental medicine and makes the production of all kinds of nation statistical indices possible. The introduction of KCD-OM3 promotes the diagnostic system by which doctors of Oriental medicine examine classes using the association with KCD-5. It will raise the smoothness and efficiency of oriental medical treatment payments in the health insurance, automobile insurance, industrial accident compensation insurance, etc. In addition, internationally, the eleventh revision work of the ICD has been initiated. It needs to consider incorporating into the International Classification of Diseases some of every country's traditional medicine.

• Childhood Kidney Diseases
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• 제13권1호
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• pp.63-74
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• 2009

목 적 : 경제 발전과 생활양식의 변화는 보건환경에 많은 영향을 끼쳤고, 이로 인해 소아청소년기의 비뇨생식기질환의 질병양상에도 영향을 주었을 것으로 생각된다. 소아청소년의 비뇨생식기질환의 양상의 변화를 파악하기 위해서 한국의 소아 입원환자에 대한 단면적 연구(cross-sectional survey date)를 이용해 역학적 분석을 하였다. 방 법 : 전국 소아청소년과 85개 수련병원을 대상으로 2004년부터 2006년까지 신 요로 질환으로 퇴원한 환자의 자료를 수집하였다. 수집자료의 지표는 ICD-10 의 진단체계를 사용한 최종진단명, 나이, 성별, 입원기간 등을 고려하여 비뇨생식기 질환의 퇴원 환자 현황을 분석하였다. 의료비와 소득손실을 나타내는 지표로 질병부담을 선택하였고, 이는 입원건수와 평균 재원일수를 곱하여 산정하였다. 결 과 : 총 826,896명의 퇴원 환자 중 비뇨생식기 질환으로 퇴원한 환자는 33,876명으로 전체의 4.1%로 1970년대와 비교할 때 감소하는 경향을 나타내었다. 남녀 성비는 1.8:1이었고, 가장 많은 연령대는 생후 4주부터 1세까지의 영아기로 전체 소아 신질환의 32.3%를 차지하였는데. 이후 유아기, 청소년기, 학동기, 신생아기 순이었다. 가장 많은 질환은 요로감염으로 전체 비뇨생식기질환중 42%로 가장 많았고, 음낭수종이 13.2%, 신증후군이 5.1%의 순이었다. 결 론: 소아 비뇨생식기질환은 전체 입원환자에서 차지하는 비중이 높지는 않지만 요로감염의 경우 영유아기에 높은 빈도수를 차지하는 중요질환이며, 본 연구에서는 확인이 되지는 않았지만 요로감염이 신 반흔을 초래하게 되면 말기신부전증으로 이어지기 때문에 중요한 건강문제라고 볼 수 있다. 본 연구는 ICD-10에 의한 전국적인 자료 분석이기 때문에 효율적인 보건 정책의 수립에 있어 중요한 기초자료가 될 수 있지만, 더 실용적이고 정확한 소아청소년 비뇨생식기질환의 질병추이 관찰을 위해서는 입원 진단기준을 포함한 자료수집체계의 수정보완과 지속적인 조사연구가 필요하다.

• 한국항해항만학회지
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• 제40권6호
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• pp.459-468
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• 2016

국내 컨테이너 화물의 수출이 수입에 비해 감소하면서 특히, 경인지역 내 공 컨테이너의 순환 문제가 심각한 수준에 이르렀다. 이에 경인지역 내 공 컨테이너 반납지(의왕 ICD 및 인천항)에는 공 컨테이너가 계속해서 쌓여 가고, 일부 선사들은 공 컨테이너의 부산 반납을 의무화하여 업계 내 마찰까지 발생하는 상황이다. 본 연구는 이와 같은 경인지역 내 공 컨테이너 반납처리 문제를 개선하기 위하여 경인지역의 공 컨테이너의 반납처리 실태를 파악하고, 그에 대한 개선 방안을 제시하였다. 이때, 개선방안을 선사 입장이 아닌 컨테이너 이용 주체 입장에서 제시하고자 화주 및 운송업체, 컨테이너 운송기사 등 실질적인 이용자를 대상으로 반납지에 대한 문제점 및 선호도를 파악하고, 종합물류기업 A사의 운영 자료를 바탕으로 비효율적인 비용 구조를 분석하여 경인지역 내 공 컨테이너 반납처리 문제가 심화될 수밖에 없는 근본적인 원인을 도출하였다. 경인지역 내 문제점을 해결하기 위해서는 인천항 기능의 재정립, 경인지역 내 제3의 신규 장치장 확보, 효율적인 공 컨테이너 순환체계 확립 등이 필요함을 제시하였고, 이를 위한 국가 차원의 법 제도 마련 등이 시급함을 시사하였다.

• 한국정보전자통신기술학회논문지
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• 제11권3호
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• pp.290-294
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• 2018

현재 미래전은 신속한 전투상황 공유 및 정확한 전투지휘/통제를 통한 네트워크 중심전 양상을 나타내며, 다양한 전술 데이터링크(Tactical Data Link, TDL)에서 전술메시지가 운용되고 있다. 데이터 링크 처리기(Data Link Processor, DLP)가 처리하는 TDL 메시지를 모니터링하기 위해, 메시지 분석기는 일반적으로 시스템 개발 중에 하나의 구성품으로 개발된다. 또한 DLP가 처리하는 TDL 메시지를 메시지 분석기로 전달하기 위해 DLP와 메시지 분석기 사이의 인터페이스 메시지는 인터페이스 규격(Interface Control Documents, ICD)에 정의되어야 한다. 본 논문에서는 DLP와 직접 통신하지 않고 DLP로 전달되는 TDL 계층에서 제공하는 UDP 또는 TCP 패킷을 이용한 방법을 제시한다. JREAP-C와 같은 전술데이터 응용메시지 표준의 헤더정보를 이용, 수집된 패킷을 대상으로 후보패킷을 빠르게 필터링하고, 헤더에 포함된 전체 데이터 크기 정보를 이용하여, 완성된 메시지를 검증한다. 기존 방법은 시스템 구성 및 ICD에 반영되어야 하는 제약사항이 존재하지만, 본 논문에서 제안한 방법은 DLP와 직접 통신하지 않기 때문에 기존 방법이 갖는 제약사항 없이 JREAP-C, Link-K와 같은 전술데이터 응용 메시지를 분석하는 것이 가능하다.

• 동의신경정신과학회지
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• 제14권2호
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• pp.15-25
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• 2003

Objectives : This study aimed investigation of clinical development to child neuropsychiatry through the oriental western medical approach of child neuropsychiatric disorders Methods : As DSM-IV and ICD-10 set a standard for clinical expression. According to this standard and oriental medical diseases, child neuropsychiatric disorders are divided into six symptoms Results and Conclusion : 1. View point of oriental medicine, Psycho Somatic stroke(inclusive of the spasm) place under the category 'Epilepsy(癎)', 'Children's fit(驚風)' and 'Chi-Kyeung(?痙)'. 2. View point of oriental medicine, Mental Retardation place under the category 'Dementia(?)', 'Amnesia(健忘)' and 'Speech Disorder(語遲)' 3. View point of oriental medicine, Emotional Disorder place under the category 'Adjustment Disorder(客?)', 'Cry with anxiety at night(夜啼症)', 'Gi-Byung(?病)' and 'Child depressive Disorder(小兒癲症)' 4. View point of oriental medicine, Conduct development Disorder place under the category 'Physical frail of five part(五軟)' and 'Physical stiff of five part(五硬)'. 5. View point of oriental medicine, Childhood Psychosis place under the category 'Insanity(癲狂)'. 6. View point of oriental medicine, Somatoform Disorder place under the category 'Palpitation of the heart(驚悸)', 'Vomiting and Diarrhea(吐瀉)', 'Asthma(喘)', 'Headache(頭痛)' and 'Enuresis(遺尿)'

• 산경연구논집
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• 제8권4호
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• pp.15-21
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• 2017

Purpose - In this work, we examined the causal relationship between credit loans from households (CLH), loan collateralized with housing (LCH) and an interest of certificate of deposit (ICD) among others in South Korea. Furthermore, the optimal forecasts on the underlying model will be obtained and have the potential for applications in the economic field. Research design, data, and methodology - A total of 31 realizations sampled from the 4th quarter in 2008 to the 4th quarter in 2016 was chosen for this research. To achieve the purpose of this study, a regression model with correlated errors was exploited. Furthermore, goodness-of-fit measures was used as tools of optimal model-construction. Results - We found that by applying the regression model with errors component ARMA(1,5) to CLH, the steep and lasting rise can be expected over the next year, with moderate increase of LCH and ICD. Conclusions - Based on 2017-2018 forecasts for CLH, the precipitous and lasting increase can be expected over the next two years, with gradual rise of two major explanatory variables. By affording the assumption that the feedback among variables can exist, we can, in the future, consider more generalized models such as vector autoregressive model and structural equation model, to name a few.