• Journal of the Korean Chemical Society
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• v.60 no.2
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• pp.125-130
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• 2016

With the goal of developing Alzheimer’s disease therapeutics, we have designed and synthesized new triazole linked decursinol derivatives having potency inhibitory activities against cholinesterase [acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)]. Since inhibition of cholinesterase (ChE) is still considered to be one of the most effective targets to treat AD patients, many new classes of ChE inhibitors have been synthesized. In an effort of identifying new type of cholinergic drug, decursinol derivatives 11-17 have been synthesized between decursinol and other biological interesting compounds such as lipoic acid, polyphenols, etc by using the click reaction and then evaluated their biological activities. Compound 12 (IC₅₀ = 5.89 ± 0.31 mM against BuChE) showed more effective inhibitory activity against BuChE than galantamine (IC₅₀ = 9.4 ± 2.5 mM). Decursinol derivatives can be considered a new class inhibitor for BuChE and can be applied to be a novel drug candidate to treat AD patients.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.05a
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• pp.487-490
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• 2011

As international standards of ICT were recently recognized as a essential strategy to penetrate into global markets in advance, the competition for international standardization among advanced countries and companies has been intensified. Also, the convergence of ICT and other industry as well as that of ICT and broadcasting has caused the expansion of range and importance in standardization. It is necessary to set up the strategy of standardization on essential technology and implement it systematically in order to take leading position in global market of IC in smart information society of the 21th century. Therefore, in this paper, I'll suggest constructive strategies of standardization through analyzing the trend and environment of IC standardization.

• Proceedings of the IEEK Conference
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• 1999.06a
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• pp.861-864
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• 1999

We designed and fabricated microstrip line fed QMSAs(Quarter-Wavelength Microstrip Antenna) for 850〔MHz〕 band on the CGP-500 Copper-clad Laminates substrate (CHUKOH company) with $\varepsilon$$_{r}$＝2.6, H＝1.6〔mm〕( $\pm$0.08), where the width of the radiation patch is identical with that of the ground plane. The resonant frequencies and the return losses were measured by reducing the PSW(Partially Shorted Width) to 0〔mm〕, step by step, when the microstrip line width was 1.47〔mm〕, 2.93〔mm〕and 4.4〔mm〕separately. As a result, a good characterized antenna with a 11% reduced resonant length and a return loss -29.44〔㏈〕 was obtained when the total PSW was in the range of 70% of radiated patch width, compared to the conventional QMSA.A.

• Design & Manufacturing
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• v.10 no.3
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• pp.1-7
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• 2016

In the semiconductor industry the memory and chip were developed to high density memory and high performance chip, so circuit design was also high integrated and the test bed was needed to be thin and fine pitch socket. LGA(Land Grid Array) IC socket with thin wall thickness was designed to satisfy this requirement. The LGA IC socket plastic part was manufacture by injection molding process, it was needed accuracy, stiffness and suit resin with high flowability. After injection molding process the side gates were needed to remove for further assembly process. ln this study, the cold press cutting process was applied to remove the gates. For design of punch and die, the cold press cutting analysis was implemented by$DEFORM-2D^{TM}$ ln consideration of the simulation results, an adequate punch and die was designed and made for the cutting unit. In order to verify the performance of cutting process, the roughness of cutting section of the part was measured and was satisfied in requirement.

• Journal of IKEEE
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• v.22 no.3
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• pp.767-773
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• 2018

This paper proposes the simple structure LED-driving power converter with high power factor. As the proposed power converter combines the PFC boost converter and the conventional flyback converter into only one power conversion circuit, it simplifies the structure of LED-driving power converter. Thus the proposed converter is controlled using only one PWM controller IC, and it achieves high power factor, constant output voltage/current and cost-effectiveness. Therefore the proposed converter is suitable for the industry production and utilization of LED-light-system. In this paper, the operation analysis and design example of the proposed converter are explained, briefly. Also experimental results of the prototype that is implemented based on the designed circuit parameters are shown to validate operation characteristics of the proposed converter.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.10a
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• pp.745-748
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• 2003

This paper presents a study on pull cord switch system which is employed in various industry for emergency stop of the equipments. By using power line communication(PLC) technique, in this paper, a new method for operation position detection of pull cord switch is suggested without complicated wiring of separate cables which utilize only 2 lines. Also, using control function of PLC IC, a reset signal for each switch reset can be implemented in the switch status control/sensing device. Finally, this paper shows validity and practical applicability of the proposed operating position sensing system of pull cord switch by implementing the system and revealing the response time and signal through the PLC line.

• Journal of information and communication convergence engineering
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• v.14 no.4
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• pp.258-267
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• 2016

Three-dimensional integrated circuits (3D ICs) experience die-to-die variations in addition to the already challenging within-die variations. This adds an additional design complexity and makes variation estimation and full-chip optimization even more challenging. In this paper, we show that the industry standard on-chip variation (AOCV) tables cannot be applied directly to 3D paths that are spanning multiple dies. We develop a new machine learning-based model and methodology for an accurate variation estimation of logic paths in 3D designs. Our model makes use of key parameters extracted from existing GDSII 3D IC design and sign-off simulation database. Thus, it requires no runtime overhead when compared to AOCV analysis while achieving an average accuracy of 90% in variation evaluation. By using our model in a full-chip variation-aware 3D IC physical design flow, we obtain up to 16% improvement in critical path delay under variations, which is verified with detailed Monte Carlo simulations.

• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1035-1038
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• 2009

Phytochemical investigation of the methanolic extract of Diospyros kaki leaves led to the isolation of osmanthuside H (1) and a new phenol glycoside, named gamnamoside [4-(3-hydroxypropyl)-2-methoxyphenol $\beta$-D-apiofuranosyl( 1 $\rightarrow$ 6)$\beta$-D-glucopyranoside] (2) along with (-) catechin (3) through a series of reversed phase column chromatography and preparative C18 HPLC. The structures of the isolates were determined by spectroscopic methods including IR, UV, HRTOFMS, and 2D NMR. Compounds 1, 2, and 3, showed good inhibitory activities ($IC_{50}$) of 175.4, 94.4, and 126.6 ${\mu}g/mL$ respectively, whereas a reversible ADH inhibitor, 4-methylpyrazole, showed the $IC_{50}$ of 326.6 ${\mu}g/mL$ against alcohol dehydrogenase (ADH).

• Fashion & Textile Research Journal
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• v.8 no.3
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• pp.326-330
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• 2006

The results of the research for the whitening effect and functional machanism of 1-(2-cyclohexylmethoxy-6-hydroxyphenyl)-3-(4-hydroxymethylphenyl)-propenone are as follow : 1. Propenone inhibited concentration-dependently the generation of melanin increased by the stimulation of ${\alpha}$-MSH and protoporphyrin IX, and $IC_{50}$ value was six to eight ${\mu}M$. This was five to seven times superior in the inhibiting effect, compared with kojic acid used as positive control group. 2. Propenone did not have a decolorizing effect on melanin already generated. 3. Propenone was observed to have toxicity of over $100{\mu}M$ for the mouse melanoma B16 cells.

• Design & Manufacturing
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• v.10 no.2
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• pp.50-54
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• 2016

In the semiconductor industry the final products were checked for several environments before sell the products. The burning test of memory and chip was implemented in reliability for all of parts. The memory and chip were developed to high density memory and high performance chip, so circuit design was also high integrated and the test bed was needed to be thin and fine pitch socket. LGA(Land Grid Array) IC socket with thin wall thickness was designed to satisfy this requirement. The LGA IC socket plastic part was manufacture by injection molding process, it was needed accuracy, stiffness and suit resin with high flowability. In this study, injection molding process analysis was executed for 2 and 4 cavities moldings with runner, gate and sprue. The warpage analysis was also implemented for further gate removal process. Through the analyses the total deformations of the moldings were predicted within maximum 0.05mm deformation. Finally in consideration of these results, 2 and 4 cavities molds were designed and made and tested in injection molding process.