• Title/Summary/Keyword: I-kBa

Search Result 397, Processing Time 0.033 seconds

The Serum and Immunohistochemical Analysis on the Anti-infammatory Effect of Aqueous Extract from Artemisia capillaris in the Liver of Lipopolysaccharide-injected Rat (인진추출물이 lipopolysaccharide주입에 의한 흰쥐 간의 염증반응에 미치는 혈청학적 및 면역조직화학적 영향)

  • 길영기;이준혁;최병태
    • Journal of Life Science
    • /
    • v.14 no.2
    • /
    • pp.215-220
    • /
    • 2004
  • We investigated the anti-inflammatory effects of aqueous extract of Artemisia capillaris Thunb. (AEAC), a traditional Korean herb for remedying liver disease, for suppression in the process of lipopolysaccharide (LPS)-induced inflammation in the liver of rat. Level of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) was increased in the serum of LPS-treated rats compared to normal, however, in the rats pretreated with AEAC, the increase of GOT, GPT and LDH value was arrested. More severe histological changes of liver such as cloudy swelling, hydropic degeneration, Kupffer cell reaction and inflammatory cells infiltration were demonstrated in the rats challenged with LPS compared with normal. Fewer scores of these changes were observed in rats pretreated with AEAC. Immunohistochemical analysis showed that while the expression of the nuclear factor (NF)-kBp65, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-$\alpha$ and COX (cyclooxygenase)-2 tended to increase, that of inhibitory (I)-kBa was decreased in the hepatocytes of rats challenged with LPS. A slight decline of NF-kBp65, TNF-$\alpha$ and COX-2, but increase of I-kB$\alpha$ were observed in the hepatocytes of the rats pretreated with AEAC. These results suggest that AEAC may act as a therapeutic agent for liver disease through a regulation of inflammation-related proteins.

Induction of Somatic Hybrid by Protoplast Fusion between Populus koreana × P. nigra var. italica and P. euramericana cv. Guardi (수원포플러와 구아디 포플러 원형질체(原形質體) 융합(融合)에 의한 체세포잡종체(體細胞雜種體) 유도(誘導))

  • Park, Young Goo;Kim, Jung Hee;Son, Sung Ho
    • Journal of Korean Society of Forest Science
    • /
    • v.81 no.3
    • /
    • pp.273-279
    • /
    • 1992
  • Protoplasts isolated from leaf mesophyll tissues of Populus koreana ${\times}$ P. nigra var. italica were fused with those of P. euramericana cv. Guardi. Well expended healthy leaves of 5 to 7 week-old-plantlet grown in vitro were used as source materials. Leaves from P. koreana ${\times}$ P. nigra var. italica and P. euramericana cv. Guardi were digested in enzyme solution I (2.0% Cellulase, 1.2% Hemicellulase, 0.4% Macrozyme, 2.0% Driselase, 0.05% Pectolyase ; w/v) and enzyme solution II (1.0% Cellulase, 1.2% Hemicellulase, 0.4% Macrozyme, 2.0% Driselase, 0.05% Pectolyase ; w/v), respectively, The highest frequency of fusion among the protoplasts originated from the two source materials was approximately 21% using 40% PEG or 15% dextran. In addition, fusion frequency was enhanced by incorporating 30mM of $Ca^{2+}$ in eluting solution at pH 10.5. Dividing cells and/or mint-calli were obtained by culturing the fusion products in a liquid 8p-KM medium supplemented with 0.6M sucrose, $0.45{\mu}M$ 2, 4-D, and $0.5{\mu}M$ BA. Shoots were regenerated from the fusion product-derived calli after culture on MS medium containing $5.0{\mu}M$ zeatin. To verify the putative hybrid or cybrid, SDS-PAGE was carried out. From the 24 regenerants, just two plants showed intermediate protein band patterns compared with those of the original source plants.

  • PDF

Demonstration of rapid single-flux-quantum RS flip-flop using YBCO/Co-YBCO/YBCO ramp-edge Josephson junction with and without ground plane (YBCO/Co-YBCO/YBCO ramp-edge 접합을 이용한 RS flip-flop 회로 제작과 동작)

  • Kim, Jun-Ho;Sung, Geon-Yong;Park, Jong-Hyeok;Kim, Chang-Hun;Jung, Gu-Rak;Hahn, Taek-Sang;Kang, Jun-Hui
    • 한국초전도학회:학술대회논문집
    • /
    • v.10
    • /
    • pp.189-192
    • /
    • 2000
  • We fabricated rapid single-flux-quantum RS flip-flop circuits with and without Y$_1$Ba$_2$Cu$_3$O$_{7-{\delta}}$(YBCO) ground plane. The circuit consists of SNS-type ramp-edge Josephson junctions that have cobalt-doped YBCO and Sr$_2$AITaO$_6$(SAT) for barrier layer and insulator layer, respectively. The fabricated Josephson junction showed a typical RSJ-like current-voltage(I-V) characteristics above 50K. We sucessfuly demonstrated RS flip-flop at temperatures around 50K. The RS flip-flop fabricated on ground plane showed more definite set and reset state in voltage-flux(V-${\phi}$) modulation curve for read SQUID, which may be attributed to a shielding effect of the YBCO ground plane.

  • PDF

Fabrication of YBCO films in MOD processing via chemically modified precursor solution (화학적으로 변형된 전구용액을 이용한 YBCO 박막 제조)

  • Kim, Y.K.;Yoo, J.M.;Chung, K.C.;Ko, J.W.;Kim, Y.J.;Han, B.S.
    • Progress in Superconductivity
    • /
    • v.7 no.2
    • /
    • pp.158-161
    • /
    • 2006
  • Superconducting YBCO films were successfully fabricated by MOD process using chemically modified precursor solution. In this study, a chemically modified precursor solution for MOD processing was synthesized using metal-organic salts and organic additives. It was shown that crack-free and uniform precursor films were formed after calcination in humidified Oxygen atmosphere. Less than 3 hours are required to finish the calcination process. XRD measurement shows that $BaF_2,\;CuO,\;Y_2O_3$ are major constituent of precursor films. Furthermore, YBCO films without any secondary phases were successfully fabricated after annealing in wet $Ar/O_2$ atmosphere. The YBCO film prepared on a $LaAlO_3$ single crystal substrate ($10mm{\times}10mm$) gives transport $I_c$ of 10A at 77K. This chemical modification approach is a possible candidate for improving MOD-processing of YBCO coated conductor.

  • PDF

Micropropagation of Hypericum erectum Thunberg by using Thidiazuron

  • Kim, Ok-Tae;Bang, Kyong-Hwan;In, Dong-Soo;Kim, Tae-Soo;Seong, Nak-Sul;Cha, Seon-Woo;Ahn, Jun-Cheul;Hwang, Baik
    • Korean Journal of Medicinal Crop Science
    • /
    • v.14 no.5
    • /
    • pp.278-281
    • /
    • 2006
  • The effect of plant growth regulators was investigated on in vitro shoot proliferation from axillary bud explants of Hypericum erectum. To determine the optimal cytokinin for proliferation of axillay buds, we carried out screening four cytokinins (BA, kinetin, 2iP, TDZ). When nodal segments were cultured on MS medium supplemented with $4.5\;{\mu}M$ TDZ (thidiazuron), a number of shoots were induced. Our results indicated that the addition of TDZ to culture medium resulted in the induction of significantly more axillary buds than in the addition of other cytokinins. The optimal concentration of TDZ for proliferation of axillary buds was $10\;{\mu}M$. 92% of shoots spontaneously rooted without any plant growth regulator (PGR) and formed whole plantlets within one month. More than 95% of these regenerants survived and they did not show any detectable variation in morphology or growth characteristics compared to their donor plants.

Sedimentary Geochemical Characteristics and Environmental Impact of Sediments in Tamjin River and Doam Bay (탐진강 및 도암만 지역 퇴적물의 퇴적지구화학적 특성과 환경영향)

  • Hong, Jin-Taek;Na, Bum-Soo;Kim, Joo-Yong;Koh, Yeong-Koo;Youn, Seok-Tai;Shin, Sang-Eun;Kim, Hai-Gyoung;Moon, Byoung-Chan;Oh, Kang-Ho
    • Journal of Environmental Impact Assessment
    • /
    • v.16 no.6
    • /
    • pp.393-405
    • /
    • 2007
  • To examine the sedimentary geochemical characteristics of sediment in the Tamjin River and Doam bay, the analysis was conducted, using the sample obtained in February 2000, on the grain size and the contents of metallic elements and organic carbon. The factors that influence the geochemical behavior of metallic elements in the surface sediment are grain size, organism, surrounding soil and $CaCO_3$. To find out the pollution level of metallic elements, the enrichment factor (EF) and the index of geoaccumulation ($I_{geo}$) were researched. The majority of metallic elements sustain their values in natural state. The elements such as K, Ba, Zr, etc. appear to be rich in some places. The EF and $I_{geo}$ of P, Cu, Zn, and Pb, which belong to toxic heavy metals, are partly related with man-made pollution. P and Cu have a high EF, Pb has a high $I_{geo}$ and Zn is high in both EF and $I_{geo}$. The low contents of P and Cu are not likely to be related with the pollution of water environment. However, given the development of relative pollution, the research and the management regarding the pollutants are needed. Because Pb, naturally enriched by geological characteristics, has a large influence on water environment along with Zn, the adequate measures against man-made pollution should be worked out.

Analyses of the Output Characteristics and the Internal Impedance of Dye-sensitized Solar Cell according to the Fabrication of the Blocking layer (Blocking layer 제작에 따른 염료감응형 태양전지 출력특성 및 내부 임피던스 분석)

  • Kim, Jin-Kyoung;Son, Min-Kyu;Choi, Jin-Ho;Kim, Soo-Kyoung;Hong, Na-Yeong;Kim, Hee-Jae
    • Proceedings of the KIEE Conference
    • /
    • 2011.07a
    • /
    • pp.1471-1472
    • /
    • 2011
  • 최근 경재적인 한계를 드러내고 있는 실리콘 태양전지의 대안으로 주목받고 있는 염료감응형 태양전지는 식물의 광합성 원리에 기초하여 빛이 입사하면 염료 분자가 포톤을 흡수해 여기하면서 전자를 방출함으로써 기전력을 발생시키는 원리로 동작한다. 염료에서 발생된 전자는 $TiO_2$의 conduction band로 주입되어 확산을 통해 TCO 기판으로 이동한다. 이때 다공성 나노구조의 $TiO_2$ 표면과 전해질의 접촉이 발생하게 되고 이로 인해 $TiO_2$ conduction band의 전자와 전해질의 $I_3{^-}$ 간의 재결합이 발생하게 되는데 이것은 DSC의 기능을 저하시키는 요인 중의 하나이다. 이러한 문제점은 $Al_2O_3$, ZnO, MgO, $BaTiO_2$ 등의 표면처리에 의한 core-shell 나노구조를 형성함으로써 해결할 수 있다. 본 연구에서는 aluminum isopropoxidee와 magnesium chloride 혼합 용액을 사용하여 core-shell 나노구조를 형성하여 셀을 제작하고, 완성된 셀의 출력특성과 내부 임피던스의 변화를 측정, 분석함으로써 단일 용액을 사용하였을 때에 비해 효과적인 재결합 감소와 광전압의 상승효과를 확인할 수 있었다.

  • PDF

Electrical Characterization of BST Thin Film by IDC pattern (IDC 패턴에 따른 BST 전기적 특성)

  • Roh, Ji-Hyoung;Kim, Sung-Su;Song, Sang-Woo;Kim, Ji-Hong;Koh, Jung-Hyuk;Moon, Byung-Moo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
    • /
    • 2008.11a
    • /
    • pp.200-200
    • /
    • 2008
  • This paper reports on electrical characterization by IDC pattern using BST$(Ba_{0.5}Sr_{0.5}TiO_3)$ thin film. BST thin films have been deposited on $Al_2O_3$ Substrates by Nd-YAG pulsed laser deposition with a 355nm wavelength at $700^{\circ}C$. The post deposition annealing at $750^{\circ}C$ in flowing $O_2$ atmosphere for I hours. The capacitance of IDC patterns have been measured from 1 to 10 GHz as a function fo electric field (${\pm}40$ KV/cm) at room temperature using interdiigitated Au electrodes deposited on top of BST. The IDC patterns have three type of fingers number. For the finger paris was increased onto $Al_2O_3$, the capacitance increased. The capacitance of 5 pairs finger was 0.3pF and 10 pairs finger was 0.9pF.

  • PDF

Mechanical and Magnetic Properties Variation of YBCO Superconductors with Resin and Ag Impregnation (Resin, Ag를 첨가한 YBCO 초전도체의 기계, 자기적 특성 변화)

  • Lee, N.I.;Jang, G.E.;Kim, C.J.;Jung, S.Y.;Han, Y.H.;Sung, T.H.
    • Progress in Superconductivity
    • /
    • v.8 no.1
    • /
    • pp.119-121
    • /
    • 2006
  • We studied the mechanical and magnetic properties of Y-Ba-Cu-O superconductor with and without resin and Ag impregnation. Bulk YBCO superconductor was manufactured with the top-seeded melt-growth method. Typical sample of 40mm X 20mm X 3mm was made and then 8 holes with 0.5mm diameter were drilled arbitrally. Epoxy resin and $AgNO_3$ were systematically added into the holes to compare the mechanical and magnetic properties of YBCO superconductor before and after reinforcement of resin and Ag. Based on the result of 3 point bending, bending strength increased with increasing amounts of resin and carbon nano-tube. However, it was found that the levitation force decreased after making hole, compared with virgin sample without hole.

  • PDF

Comparison of microstructures in T1-1223/Ag tapes with different chemical compositions and J$_c$'s

  • Jeong, D.Y.;Kim, H.K.;Lee, H.Y.;Cha, M.K.;Ha, H.S.;Oh, S.S.;Tsuruta, T.;Horiuchi, S.
    • 한국초전도학회:학술대회논문집
    • /
    • v.9
    • /
    • pp.280-290
    • /
    • 1999
  • The microstructures of a Tl$_{0.8}Pb_{0.2}Bi_{0.2}Sr_{1.6}Ca_2Cu_3O_{9+{\delta}}$/Ag tape (tape I ) with J$_c$ of 17,600 A/cm$^2$ at 77 K and 0 T and three Tl$_{0.8}Pb_{0.2}Bi_{0.2}Sr_{1.8}Ba_{0.2}Ca_{2.2}Cu_3O_{9+{\delta}}$/Ag tapes with J$_c$'s of 9,300 (tape II), 16,700 (tape III) and 25,200 A/cm$^2$ (tape IV)prepared using the powder-in-tube method and an in-situ reaction method, were investigated using scanning electron microscopy and high-resolution transmission electron microscopy, and compared each other. ln the tape preparation, an intermediate rolling process was incorporated during final heat-treatment for the last tape, but not for the rest of the tapes. The microstructural analysis revealed clear differences in grain-texturing, crystallographic defects and impurity phases, depending on the chemical composition of the tape. Tendency of directional grain-alignment increased in an order of tapes I, II III and IV. In tape IV, T1-1223 grains are textured, at least in local regions. In crystallographic defects, while stacking faults were prevalent in the former composition, dislocations and voids were frequently observed in the latter. Also impurity phases were appeared to be more abundant in the former than in the latter. The relationship between 1,and the microstructure in the tapes was attempted to explain in a term of grain-linking.

  • PDF