• Title/Summary/Keyword: Hyung-Min Kim

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Inhibition of Immediate Allergic Reaction by Eugenol (유제놀에 의한 즉시형 알레르기 반응의 억제)

  • Kim, Sang-Hyun;Shin, Tae-Yong;Kim, Hyung-Yong;Lee, Young-Mi;Lee, Eun-Hee;Shin, Bo-Kyoung;Kim, Youn-Chul;An, Nyeon-Hyoung;Kim, Hyung-Min
    • YAKHAK HOEJI
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    • v.40 no.6
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    • pp.679-683
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    • 1996

  • The current study evaluates the capacity of eugenol to regulate immediate allergic reaction by control of histamine release. Administrations of eugenol (1M/kg, i.p.) at 60 min b efore and 5, 10 min after the compound 48/80 treatment (8mg/kg, i.p.) were shown the mortality rates as 0, 44.4, and 77.8%, respectively. A 60 min before administered group revealed a significant inhibition of serum histamine release compared with those of 5 and 10 min after the compound 48/80 injection. Eugenol (6-48mM) was also showed a dose-dependent activity on the compound 48/80-induced histamine release from the highly purified population of Alcian Blue-positive peritonea] mast cells. These results indicate that in vitro treatment with exogenous eugenol inhibited the active response of mast cell populations and modulated its characteristics.

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Samsoeum inhibits systemic anaphylaxis and release of histamine, cytokine in vivo and in vitro

  • Kim, Su-Jin;Kim, Na-Hyung;Moon, Phil-Dong;Myung, Noh-Yil;Kim, Min-Chol;Lee, Ki-Taek;Jo, Hyung-Mook;Kim, Na-Hyun;Rim, Hong-Kun;Seo, Min-Jun;Kim, Jin-Man;Lee, Seung-Eun;An, Nyeon-Hyung;Lee, Kang-Min;Lee, Si-Hyung;Park, Yun-Jum;Jeong, Hyun-Ja;Um, Jae-Young;Kim, Hyung-Min;Hong, Seung-Heon
    • Advances in Traditional Medicine
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    • v.9 no.2
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    • pp.115-127
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    • 2009

  • Samsoeum (SSE) is used in traditional oriental medicine for various medicinal purposes. However, the exact mechanism that accounts for the anti-allergy and anti-inflammatory effects of the SSE is still not fully understood. The aim of the present study is to elucidate whether and how SSE modulates the allergic reactions in vivo, and inflammatory reaction in vitro. In this study, we showed that SSE significantly decreased compound 48/80-induced systemic anaphylaxis, ear-swelling response, histamine release from preparation of rat peritoneal mast cells and anti-dinitropheny IgE-induced passive cutaneous reaction. Also, SSE inhibited the expression of inflammatory cytokine and cyclooxygenase-2 in PMA plus A23187-stimulated human mast cells (HMC-1). In addition, we showed that anti-inflammatory mechanism of SSE is through suppression of nuclear factor-${\kappa}B$ activation and $I{\kappa}B-{\alpha}$ phosphorylation/degradation in HMC-1. These results provided new insight into the pharmacological actions of SSE as a potential molecule for therapy of inflammatory allergic diseases.

  • https://doi.org/10.3742/OPEM.2009.9.2.115 인용 PDF