• The Journal of Internal Korean Medicine
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• v.21 no.4
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• pp.583-590
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• 2000

Objective : The major risk factors of stroke are hyperlipemia, ateriosclerosis, hypertension, diabetis mellitus, smoking, drinking, age, personal history, family history etc. Hypertension, smoking and hyperlipemia are very important factor to promote stroke. We intended to observe the serum lipid density of 51 patients come to Joongpoong & Chronic Disease Center of Conmaul Oriental hospital, comparing with already reported study. Methods : We studied 51 stroke-patients( 38 cerebral infarction, 13 intracerebral hemorrhage) of Conmaul Oriental hospital, Department of oriental internal medicine, Joongpoong & Chronic Disease Center from January 1. 1999 to August 31. 2000, which examined by neurologic test, brain-CT, brain-MRI. . We used DOSHISA TBA-30FR(Japan) as instrument for measuring total cholesterol and triglyceride of serum. Results and conclusions : The results are as follows 1. The rate of hyperlipemia and presumed-hyperlipemia is higher in female patient-group than male patient-group. 2. The rate of hyperlipemia and presumed-hyperlipemia is higher in drinking group than non-drinking group. 3. The rate of hyperlipemia and presumed-hyperlipemia is higher in hypertension group than normotention group.

• The Journal of Internal Korean Medicine
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• v.19 no.2
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• pp.60-80
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• 1998

In 123 examples of admission patients at Dongshin university oriental medical hospital circulatory internal medicine, we sequently investigated serum lipid, at admission state, 2th and 4th weeks. The results were as follows; 1. In the case of 123 stroke patients, only 12cases were related to Hyperlipemia. So stroke was not related to Hyperlipemia significantly. 2. According to sex, woman has more significant results in the T-cholesterol and LDL-cholesterol. 3. According to the living Zone, Triglyceride of the city zone group washigher than that of the contryside zone significantly. 4. According to the history of drinking and smoke, the patients who have the history of drinking and smoke had a significant remark in T-cholesterol and LDL-cholesterol. 5. In the case of patients like eating meat, it was significant gain of HDL-cholesterol. 6. In the patients who had past history of Hypertension, the value of Triglyceride is significantly low, and sequently as blood pressure decreased, serum lipid value decreased too. 7. In the patients who had past history of D.M., the value of Triglyceride is significantly high, and sequently as blood sugar value decreased, serum lipid value decreased too. 8. In the case of patients treated He-Ne laser, Triglyceride was decreased significantly. 9. In the case of treating the stroke patients, serum lipid had non-significant decrease value.

• The Journal of the Korea Contents Association
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• v.10 no.8
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• pp.301-307
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• 2010

The purpose of this study was to find out how diagnosis of hyperlipemia differed for according to BMI and %Fat. The included subjects were 224 adult women, they performed physical measurement and BMI measured %Fat by BIA. Blood pressure and lipid profiles were measured in the NPO state. The LDL calculated in using a formula of Friedwald and an atherogenic index was calculated using the serum TC lever divided by th HDL level As a results, HDL decreases so that BMI and %Fat increase and TC, TG, LDL, AI appeared by increasing. There was significant correlation(r=.585) between BMI and %Fat, and lipid profile correlation with BMI is higher than %Fat. In conclusion, diagnosis results of hyperlipemia according to BMI and %Fat could become different conclusively. In study it seems that BMI's diagnosis ability on hyperlipemia is high but the most desirable method uses BMI and %Fat together and evaluates lipid profile.

• Korean Journal of Clinical Laboratory Science
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• v.36 no.1
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• pp.49-54
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• 2004

The purpose of this study was to investigate the effects of Lycii fructus extract on the serum lipids in hyperlipemia rats. The rats were divided five groups including negative control, positive control and treated L. fructus extract at dose of 50, 100, 200 mg/kg. To induce the hyperlipemia, 4 groups of rats, not including the negative control group, were fed experimental diets consisting of cholesterol, lard, corn oil, and normal diet for experiment period. As a result, the L. fructus extract decreased total cholesterol(T. Cho), trigryceride(TG), low density lipoprotein cholesterol(LDL-C), and free fatty acid(FFA) significantly compared with positive control. However, no significant difference was found in high density lipoprotein(HDL-C) and phospholipid(PPL) level. Otherwise, in serum lipid level including, T-Cho, TG, LDL-C, FFA and PPL was decreased dose dependently by treatment of L. fructus extract. But HDL-C was increased by L. fructus extract too. Thereby having beneficial effect on hyperlipermia by influencing the serum lipid change, it is expected that Lycii fructus extract can suppress arteriosclerosis and obesity.

• Journal of Haehwa Medicine
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• v.15 no.1
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• pp.19-31
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• 2006

KJST is the oriental herbal medicine of hyperlipemia which consisted of a herb of 17. We induced hyperlipemia to Spontaneous Hypertensive Rat(SHR) and studied the treatment effect by KJST. Hyperlipidemia was induced by hyper-lipidemic diet fed for 4weeks. Total cholesterol, LDL-cholesterol, HDL-cholesterol, Triglyceride, Total bilirubin, Lactic dehydrogenase(LDH), Glucose and Total protein were measured on the serum after an oral administration of KJST. Total cholesterol, LDL-cholesterol, Glucose and LDH was significantly lower in the KJST treated animals, and HDL was significantly raised in the KJST treated animals. These results suggest that KJST is effective for the treatment of hyperlipidemia.

• Archives of Pharmacal Research
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• v.14 no.1
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• pp.44-47
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• 1991

Blood lipid levels in rats with high fat-fed hyperlipemia were determined after intraperitoneal administration of a methanolic extract of Prunus davidiana Fr. stems. Administration of the methanolic extract for 6 days produced a significant decrease of blood triglyceride and total cholesterol, and the atherogenic index was also improved. In addition to the hypolipemic effect, the methanolic extract was also shown to be effective in reducing an elevated level of glucose in rats with hyperlipemia resulting from high-fat feeding. On the other hand, blood triglyceride and total cholesterol in rats fed with stock diet were not affected by administration of the methanolic extract even if there was a tendency to decrease. No significant change was also found in the level of glucose. Thus, it is suggested that this methanolic extract probably may increase the metabolic utilization only when fed with excess fat.

• Journal of Society of Preventive Korean Medicine
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• v.15 no.1
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• pp.29-36
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• 2011

The hypoglycemic and hypolipidemic effects of Allium victorialis (AV) leaf methanol extract were evaluated in a high fat diet (HFD) supplied mice. Changes on the serum glucose, total cholesterol, triglyceride, low density lipoprotein and high density lipoprotein were examined. The effects were compared with those of a group given 250 mg/kg of metformin. After 91 days of a continuous HFD supply, the mice were showed marked hyperglycemia and hyperlipemia. However, these hyperglycemia and hyperlipemia induced by the HFD were inhibited by the AV extract treatment at the three different doses (62.5, 125 and 250 mg/kg). The results suggest that the AV methanol extract is beneficial for improving the diet-induced hyperlipidemia and hyperglycemia in humans.

• The Korea Journal of Herbology
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• v.23 no.1
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• pp.9-15
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• 2008

Objectives : This study was performed to investigate the effect of water extracts from Lagocephalus wheeled with several herbs(LW) on hyperlipemia and liver damage induced by alcohol. Methods : Except for the normal group, we fed rat on 25% alcohol for 55 days. And each extract was administrated for the same period. We measured the serum component in rat's blood, body weight and weight of liver. Results : At first, we observed effects of LW on hyperlipemia induced by alcohol. LW group didn't show significant increase of total cholesterol in comparison with those of the control group. LW group didn't show significant increase of HDL(High-Density lipoprotein) cholesterol in comparison with those of the control group. LW group showed significant decrease of triglyceride in comparison with those of the control group. LW group showed significant increase of body weight in comparison with those of the control group in 4weeks and 8weeks. LW group showed significant increase of liver weight in comparison with those of the control group. At second, we observed effects of LW on liver damage induced by alcohol. LW group showed significant decrease of ALP, GOT, GPT and LDH in comparison with those of the control group. Conclusions : Reviewing these experimental results, it appears that water extracts from Lagocephalus wheeleri with several herbs have pharmaceutical efficacy on hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of this.

• Korean Journal of Acupuncture
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• v.24 no.1
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• pp.113-129
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• 2007

Objectives : This research was performed to investigate the effect of acupuncture using invasive low level laser therapy (LLLT) at Yolgyol (LU7) + Yogu (LR5) on weight gain, food intake, food efficiency, lipid metabolism, atherogenic index, HTR (HDL-cholesterol to total cholesterol ratio) and morphological change of hepatic tissue in hyperlipdemia rats. Methods : Experimental groups were divided into high fat diet group (Control group), high fat diet and acupuncture therapy group at LU7 + LR5 (AT group), high fat diet and acupuncture group using 10 mW LLLT at LU7 +LR5 (LA10 group), high fat diet and acupuncture group using 20 mW LLLT at LU7+LR5(LA20 group), high fat diet and acupuncture group using 60 mW LLLT at LU7 + LR5 (LA60 group), once per 3 days during 9 weeks. Results : Body weight was decreased significantly in AT and LA20 groups compared with Control group. Food intake was increased significantly in LA60 group compared with Control group. Food efficiency was decreased significantly in LA10, LA20 and LA60 groups compared with control group. In the lipid metabolism, total cholesterol was decreased significantly in AT, LA10, LA20 and LA60 groups, triglyceride was decreased significantly in LA10, LA20 and LA60 groups, TG/HDL-cholesterol ratio was decreased significantly in LA 60 group compared with control group. In the morphological change, hepatic tissue were not showed balloning degeneration and irregular arrangement of hepatic cell in LA10 and LA20 groups with control group. Conclusions : Acupuncture using LLLT at LU7+LR5 can manage hyperlipemia by controlling body weight, food intake, food efficiency ratio and lipid metabolism.

• Korean Journal of Pharmacognosy
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• v.23 no.2
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• pp.96-105
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• 1992

The studies were attempted to evaluated the therapeutic effects of various fractions(ether, methanol, butanol) of Caragana chamlagu roots on the hyperlipemia induced by feeding the diet containing 1%, cholesterol and 0.5%, cholic acid in rats, and on the hyperglycemia induced by streptozotocin in rats. Also the preventive effects of these fractions were studies on the liver damage in $CCl_4-intoxicated$ rats. The followings were obtained as the results: 1.The butanol fraction was significantly shown to down the serum lipid level in 1%, cholesterol and 0.5%, cholic acid diet-feeding rats and streptozotocin-induced hyperglycemic rats. Cholesterol level in $CCl_4-intoxicated$ rats was reduced in the case of all pre-treated groups. 2.The serum glucose level of streptozotocin-induced hyperglycemic rats was significantly decreased by the administration of various fractions of C. chamlagu roots, and the lipid-peroxidation of pancreas was significantly decreased in the case of administration of these fractions. 3.The activates of s-GOT and s-GPT were decreased by the administration of various fractions, especially in butanol fraction, of C. chamlagu roots in the $CCl_4-intoxicated$ rats. The liver lipid-peroxidation was decreased by administration of 200mg/kg of these fractions in the $CCl_4-intoxicated$ rats. In histological observation, hepatic cellular necrosis and fatty acid deposit were increased remarkably by $CCl_4-intoxication$, but the pretreatment of various fractions of C. chamlagu roots improved the pathological change of parenchymatous cell necrosis and fatty change around centrilobular area of the control.