The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Water Extracts from Lagocephalus wheeleri with Several Herbs on Hyperlipemia and Liver Damage Induced by Alcohol

은복과 한약재 복합물이 알콜 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향

  • Seo, Bu-Il (Dept. of Oriental Medicine, Daegu Haany University) ;
  • Park, Ji-Ha (Dept. of Oriental Medicine, Daegu Haany University) ;
  • Choi, Hong-Sik (Dept. of Oriental Medicine, Daegu Haany University) ;
  • Kim, Seung-Mo (Dept. of Oriental Medicine, Daegu Haany University) ;
  • Gu, Deok-Mo (Dept. of Oriental Medicine, Daegu Haany University) ;
  • Kim, Mi-Ryeo (Dept. of Oriental Medicine, Daegu Haany University) ;
  • Park, Jin-Hyun (Food Science, P&I Cosulting Bioinformatics R&D Center)
  • 서부일 (대구한의대학교 한의학과) ;
  • 박지하 (대구한의대학교 한의학과) ;
  • 최홍식 (대구한의대학교 한의학과) ;
  • 김승모 (대구한의대학교 한의학과) ;
  • 구덕모 (대구한의대학교 한의학과) ;
  • 김미려 (대구한의대학교 한의학과) ;
  • 박진현 (푸드사이언스 피앤아이컨설팅 Bioinformatics 연구소)
  • Published : 2008.03.30
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Abstract

Objectives : This study was performed to investigate the effect of water extracts from Lagocephalus wheeled with several herbs(LW) on hyperlipemia and liver damage induced by alcohol. Methods : Except for the normal group, we fed rat on 25% alcohol for 55 days. And each extract was administrated for the same period. We measured the serum component in rat's blood, body weight and weight of liver. Results : At first, we observed effects of LW on hyperlipemia induced by alcohol. LW group didn't show significant increase of total cholesterol in comparison with those of the control group. LW group didn't show significant increase of HDL(High-Density lipoprotein) cholesterol in comparison with those of the control group. LW group showed significant decrease of triglyceride in comparison with those of the control group. LW group showed significant increase of body weight in comparison with those of the control group in 4weeks and 8weeks. LW group showed significant increase of liver weight in comparison with those of the control group. At second, we observed effects of LW on liver damage induced by alcohol. LW group showed significant decrease of ALP, GOT, GPT and LDH in comparison with those of the control group. Conclusions : Reviewing these experimental results, it appears that water extracts from Lagocephalus wheeleri with several herbs have pharmaceutical efficacy on hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of this.

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