• Annals of Surgical Treatment and Research
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• 제95권5호
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• pp.240-248
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• 2018

Purpose: This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2). Methods: Western blot analysis was performed to assess expression levels of Bcl-2 family proteins and caspase-related molecules. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry analysis. Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (z-VAD-fmk) was used for pretreatment to assess the role of caspases. Results: Cell viability of MDA-MB-231 after combination treatment with ABT-737 and docetaxel was significantly lower than that after docetaxel or ABT-737 monotherapy based on MTT assay (both P < 0.001), with a combination index of 0.41. The proportion of sub-G1 population after combination treatment was significantly higher than that after docetaxel or ABT-737 monotherapy (P = 0.001, P = 0.003, respectively). Pretreatment with z-VAD-fmk completely restored cell viability of MDA-MB-231 from apoptotic cell death induced by combination therapy (P = 0.001). Although pro-caspase-8 or Bid did not show significant change in expression level, pro-casepase-9 showed significantly decreased expression after combination treatment. Cleaved caspase-3 showed increased expression while poly (ADP-ribose) polymerase cleavage was induced after combination treatment. However, hypoxia-inducible factor 1-alpha and aldehyde dehydrogenase 1 totally lost their expression after combination treatment. Conclusion: Combination of ABT-737 with docetaxel elicits synergistic therapeutic effect on MDA-MB-231, a TNBC cell line overexpressing Bcl-2, mainly by activating the intrinsic pathway of apoptosis. Therefore, adjunct of ABT-737 to docetaxel might be a new therapeutic option to overcome docetaxel resistance of TNBCs overexpressing Bcl-2.

• 한국분말재료학회지
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• 제28권5호
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• pp.396-402
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• 2021

Stainless steel, a type of steel used for high-temperature parts, may cause damage when exposed to high temperatures, requiring additional coatings. In particular, the Cr₂O₃ product layer is unstable at 1000℃ and higher temperatures; therefore, it is necessary to improve the oxidation resistance. In this study, an aluminide (Fe₂Al₅ and FeAl₃) coating layer was formed on the surface of STS 630 specimens through Al diffusion coatings from 500℃ to 700℃ for up to 25 h. Because the coating layers of Fe₂Al₅ and FeAl₃ could not withstand temperatures above 1200℃, an Al₂O₃ coating layer is deposited on the surface through static oxidation treatment at 500℃ for 10 h. To confirm the ablation resistance of the resulting coating layer, dynamic flame exposure tests were conducted at 1350℃ for 5-15 min. Excellent oxidation resistance is observed in the coated base material beneath the aluminide layer. The conditions of the flame tests and coating are discussed in terms of microstructural variations.

• 한국철학논집
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• 제50호
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• pp.139-169
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• 2016

조선 후기 집권 노론의 낙학파는 성리학의 이념으로 국정을 이끌면서 종래의 '정신적' 측면에 급급했던 데서 벗어나 '물질'에 대한 관심으로 정계와 학계의 분위기를 전환했다. 이런 움직임을 주도했던 세력이 김원행(金元行)을 중심으로 한 석실서원(石室書院) 계통의 학인들이었다. 그러나 소수의 진보적 학자-북학론자들을 제외한 대다수 낙학파 학자들은 청나라의 실체를 내심 인정하면서도 종래의 성리학적 전통에서 벗어 나지는 못하였다. 그들은 정권의 존립 기반을 위태롭게 하는 북학론을 수용하기 어려웠다. 종래의 성리학적 전통과 조선중화주의의 이념을 지키면서도 청나라의 문화 수준에 이를 방안을 모색하였고, 그 과정에서 "성리대전"에 집약된 경세학 체계의 복구를 대안으로 인식하였다. 황윤석은 낙학파의 이런 대응논리를 대변하였던 성리학자다. 그는 성리학의 범주 안에 들어 있는 상수학의 가치를 재발견하였고, "성리대전"의 중요성을 다시 부각했다.

• 문화기술의 융합
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• 제5권3호
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• pp.209-214
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• 2019

이 연구는 가설적으로써, 하나의 감정을 어떻게 잘라내어 긍정적으로 활성화시킬 수 있는지에 대한 것이다. 이 연구는 AI를 통한 문학치료에 활용될 수 있을 것이다. 이번 연구에서, 황진이의 시조 "동짓달 기나긴 밤을"을 연구하였다. 왜냐하면 이 작품이 감정의 잘라냄과 이어놓음에 대한 연구에 아주 적절하기 때문이다. 이 시조에는 이러한 치유의 셈법이 활용되었다. 황진이의 이 작품은 초장에서 '동짓달 기나긴 밤'을 잘라낸다. 그리고 그 잘라낸 그리움의 시간들을 '춘풍 이불' 아래에 잇대어 놓으면서 감정의 재생산을 꿈꾼다. 그리고 종장에서 그리움의 시간들을 아주 잘게 무한대로 펼쳐낸다. 펼쳐지는 그리움의 시간들은 '춘풍 이불'에 덧대어 놓았던 것이다. 그리움의 시간들을 펼쳐내면서, 종장에서는 끊임없는 사랑에의 그리움 즉 영원한 사랑을 꿈꾼다. 이러한 문학적 행위는 인체의 신경 계통에 많은 변화를 유도할 수 있을 것으로 예측된다. 이것이 문학으로 감정의 치료를 꿈꾸는 사랑법이다. 임은 떠났지만 보내지 않은 임의 사랑이 기쁨의 감정을 증폭시키게 된다. 이러한 감정의 셈법은 앞으로 전개될 AI를 통한 문학치료에 매우 유용하게 사용될 수 있을 것으로 사료된다.

• 자원환경지질
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• 제6권2호
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• pp.115-122
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• 1973

The writer intended to observe the relative mobility of elements in weathering process of granite, on the outskirts of IRI city at Jeollabukdo KOREA. He analysed fresh granites and weathered ones of Hwang-Dung granite mass and had following conclusions by the triangular diagrams and the oxidized variation diagrams of the analysis. 1) The increasing phenomena of $H_2O$ observed clearly in early and late stage of weathering processes. 2) Granites was weathered by physical weathering in early stage, and it was weathered by chemical weathering in late stage. 3) The ratio of $FeO/Fe_2O_3$, FeO/MgO, and $SiO_2/Al_2O_3$ decreased uniformly from early to late stage of weathering processes. 4) It was proved that weathering potential of granite was larger than that of basaltic rock. 5) The order of mobility in major elements was Ca, Na, K>Si>Mg>Fe, Al.

• 대한치과의사협회지
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• 제52권9호
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• pp.550-557
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• 2014

The restorative treatment with dental implants in edentulous patients has been a well documented treatment modality proven in experimental studies and long-term clinical investigations. The aim of this paper is to introduce the implant mediated drug delivery system as a novel application of endosseous implants. The system is composed of hollow cylindric implants which has multiple microholes for drug delivery. For this purpose, the general outlines of drug delivery system and drug delivery route is discussed briefly. In addition, this paper deals with the results of experiments done up to now and the future perspective of the system.

• 한국CDE학회논문집
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• 제15권3호
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• pp.234-242
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• 2010

3D CAD technology has been extended to a medical area including dental clinic beyond industrial design. The 2D images obtained by CT(Computerized Tomography) and MRI(Magnetic Resonance Imaging) are not intuitive, and thus the volume rendering technique, which transforms 2D data into 3D anatomic information, has been in practical use. This paper has focused on a method and its implementation for forming 3D geometric surface model from laminated CT images of the pubis. The implemented system could support a dental clinic to observe and examine the status of a patient's pubis before implant surgery. The supplement of 3D implant model would help dental surgeons settle operation plans more safely and confidently. It also would be utilized with teaching materials for a practice and training.

• 대한산업공학회지
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• 제7권2호
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• pp.19-26
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• 1981

A special case of the probabilistic multi-location problem is studied in a two-echelon logistic system for deteriorating items. The objective is to determine the location of the minimum number of supply centers among a discrete set of location sites of supply centers, such that the probability each retailer being covered by some supply center is not less than a specified value. A logistic cost is introduced as performance measure of the system, and leads us to analyze the impact of deterioration rate on the location problem. The results obtained from numerical examples are discussed, which provides effective guidelines that can be used for the logistic managerial decisions.

• 아동학회지
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• 제30권6호
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• pp.75-84
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• 2009

Recently, low birthrate has been recognized as a social problem, which is expressed as catastrophy of population. There are several reasons why low birth rate has occurred directly and indirectly, generating total economic and social burden for our society. That is, low birthrate should not be simply regarded as reduction of population. The present study identified the reasons of low birthrate and the current status of infertility, and examined practical and theoretical issues in terms of low birthrate. It is our contention that low birthrate and infertility is one of the most important governmental issue to enhance quality of life of the public. Thus, integrated and systematic policy must be developed and implemented to effectively meet the issues.

• 대한약침학회지
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• 제9권1호
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• pp.103-107
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• 2006

Objective : The purpose of this study is to estimate the effects of spiral taping treatment on low back pain. Methods : 420 low back pain patients were treated with spiral taping or spiral taping plus herbal medicine, and no other treatments such as acupuncture, herbal acupuncture, and chiropractic therapy were added. We evaluated the improvement by physical examination and pain. Results : 364 patients felt no pain or inconvenience of daily life and 43 patients showed improvement of pain or symptom after 1 month of treatment. 13 patients showed same pain with before treatment. Conclusion : These results suggest spiral taping treatments contribute to the improvement of low back pain. Further study is needed for the confirmation of this effect of spiral taping treatments on low back pain.