• 한국정보통신학회논문지
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• 제18권12호
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• pp.3029-3034
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• 2014

이 논문은 사람 눈의 공막컬러코드와 공막혈관징후패턴코드 생성에 의한 공막진단시스템 구현에 관한 연구이다. 시스템은 고성능 DSP 영상처리 프로세서를 기반으로 PGC 프로그램어불 게인제어 선처리 및 RISC SD프레임저장 메모리 등으로 구성된다. PGC는 RGB신호를 최적화하고 그래리 영상에서 에지가 검출된다. 판별 및 매칭 처리알고리듬은 공막컬러코드화 및 혈관징후패턴코드 생성을 실행된다. 공막컬러코드는 메모리 맵의 위치에서 YCbCr값을 구하고 허용오차 범위를 적용하여 생성된다. 혈관징후패턴코드는 24시간등분과 13환형등분 구역에 의해 디지털화 되고 중첩매칭과 허용오차 적용에 의해 코드화된다. 실험결과 성능에서 시스템은 40ms로 동작하고 진단오차는 컬러판별이 평균 약20%, 혈관징후패턴 매칭이 약 24%이다. 이 시스템 및 기술은 세분화와 환자데이터베이스화 하면 공막진단 의용시스템으로 사용 할 수 있다.

• Molecules and Cells
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• 제45권6호
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• pp.403-412
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• 2022

Hypoxia leads to significant cellular stress that has diverse pathological consequences such as cardiovascular diseases and cancers. MicroRNAs (miRNAs) are one of regulators of the adaptive pathway in hypoxia. We identified a hypoxia-induced miRNA, miR-34c, that was significantly upregulated in hypoxic human umbilical cord vein endothelial cells (HUVECs) and in murine blood vessels on day 3 of hindlimb ischemia (HLI). miR-34c directly inhibited BCL2 expression, acting as a toggle switch between apoptosis and autophagy in vitro and in vivo. BCL2 repression by miR-34c activated autophagy, which was evaluated by the expression of LC3-II. Overexpression of miR-34c inhibited apoptosis in HUVEC as well as in a murine model of HLI, and increased cell viability in HUVEC. Importantly, the number of viable cells in the blood vessels following HLI was increased by miR-34c overexpression. Collectively, our findings show that miR-34c plays a protective role in hypoxia, suggesting a novel therapeutic target for hypoxic and ischemic diseases in the blood vessels.

• Applied Microscopy
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• 제23권1호
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• pp.91-108
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• 1993

The relationship of cartilage canals to initial osteogenesis of primary ossification center of developing vertebrae in human fetuses ranging from 50mm to 260mm in crown rump length was studied by light and electron microscopy. The cartiage canals of the thoracic vertebrae were first observed at 60mm fetus. Cartilage canals were identified as vascular channels arising from perichondrium surfaces. A number of cartilage canals were observed around the primary center of ossification at 80mm fetus. At 120mm fetus, cartilage canals of the bodies of vertebra were increased. Eventually the canals were eroded from the main medullary cavity and remained at only peripheral regions of growth cartilage. Superficial, intermediate, and deep canals were identified by the characteristics of cartilage cells. Fibroblasts, undifferentiated mesenchymal cells, and vacuolated macrophages were observed adjacent to the matrix of resting cartilage cells in the superficial canal. Fibroblasts and mesenchymal cells were densely packed at the tip of canal, giving an epithelial appearance to the clustered cell in the intermediate canal. Vacuolated macrophages were in contact with matrix of hypertrophied cartilage. The thick-walled vessels in the intermediate and deep canals consisted of typical endothelial cells, but in the newly formed vessels contained mesenchymal cells and fibroblasts incorporated into the vessel wall. During lengthening of cartilage canal, the matrix of cartilage cells were invaded by newly formed capillaries and vacuolated macrophages. At the deep canal, the lateral wall of the canal terminated in matrix containing calcified cartilage. The mesenchymal cells began to differentiate into osteoblasts adjacent to the calcified matrix. The results indicate that the connective tissue cells within the cartilage canals proliferate and differentiate into osteoblasts at the site of primary ossification center.

• BMB Reports
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• 제50권10호
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• pp.504-509
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• 2017

Ischemia is a serious disease, characterized by an inadequate blood supply to an organ or part of the body. In the present study, we evaluated the effects of the anti-microbial peptide SR-0379 on the stem cell-mediated therapy of ischemic diseases. The migratory and tube-forming abilities of human endothelial progenitor cells (EPCs) were enhanced by treatment with SR-0379 in vitro. Intramuscular administration of SR-0379 into a murine ischemic hindlimb significantly enhanced blood perfusion, decreased tissue necrosis, and increased the number of blood vessels in the ischemic muscle. Moreover, co-administration of SR-0379 with EPCs stimulated blood perfusion in an ischemic hindlimb more than intramuscular injection with either SR-0379 or EPCs alone. This enhanced blood perfusion was accompanied by a significant increase in the number of CD31- and ${\alpha}$-SMA-positive blood vessels in ischemic hindlimb. These results suggest that SR-0379 is a potential drug candidate for potentiating EPC-mediated therapy of ischemic diseases.

• 수산해양교육연구
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• 제6권2호
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• pp.190-197
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• 1994

1989년부터 1993년까지 5년동안 우리 나라 주변해역에서 발생한 2513건의 해난사고(海難事故)를 유형(類型), 원인(原因) 및 선종(船種)에 따라 21의 인자(因子)로 분류하고, 이를 주요분분석법(主成分分析法)에 의해 분석(分析)한 결과를 요약하면 다음과 같다. 1. 해난사고(海難事故)의 주된 원인(原因)은 운항부주의(運航不主意), 기관취급불량(機關取扱不良) 등 인적요인(人的要因)에 있으며, 사고(事故) 유형(類型)으로서는 기관고장(機關故障)이, 선종(船種)으로서는 어선(漁船)이 특히 해난사고(海難事故)의 큰 비중을 차지한다. 2. 어선(漁船)의 경우에는 기관고장(機關故障) 등 경미(輕微)한 해난사고(海難事故)가 많은데 비해 화물선(貨物船), 여객선(旅客船), 유조선(油槽船)의 경우에는 좌초(坐礁), 추돌(衝突), 침수(浸水) 등 재산(財産)과 인명(人命)의 피해가 큰 대형해난사고(大型海難事故)가 많은 경향이다. 3. 대형해난사고(大型海難事故)중 좌초(坐礁)와 충돌(衝突)은 그 주된 원인(原因)이 운항부주의(運航不主意) 등 인적요인(人的要因)에 있고, 침수(浸水)와 전복(顚覆)은 인적요인(人的要因)이외에도 기상악화(氣象惡化)나 재질구조결함(材質構造缺陷) 등에 기인(起因)하는 바가 크다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.119-120
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• 2003

One of the most frequent defects in human cancer is the uncontrolled activation of the ras-signaling pathways. Elevated p21 ras expression is associated with tumor aggressiveness in breast cancer including the extent of invasion into fat tissues. infiltration into lymphatic vessels and tumor recurrence, We demonstrate that H-ras, but not N-ras, upregulates matrix metalloproteinase(MMP)-2 expression and induces invasive phenotype in MCF10A human breast epithelial cells. (omitted)

• 대한수의학회지
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• 제6권1호
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• pp.76-81
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• 1966

This study was conducted to observe the condition of the ramification of the bronchus and pulmonary blood vascular system by injection of vinylite into the bronchial tree and pulmonary blood vessels in normal adult swines. The results obtained were summarized as follows. 1. Lungs of swine were composed of the same pulmonary territories as in lungs of human and dog. 2. Bronchial tree of swine also were axial divergency in the patterns. 3. Ramification of the left and right apical lobes are especially complex patterns but cardiac and diaphragmatic lobes are a little monotonous. 4. Intermediate lobe corresponding to mediobasalis branch of human lungs formed only one lobe in swine lung. 5. Pulmonary artery of right apical lobe was mono branch form in all case by authors observation. 6. $B._2$ streched into the seg. dorsalis of the right apical lobe was especially developed compare to $B._1$, $B._3$ of the seg, apicalis and seg, ventralis.

• Journal of Advanced Marine Engineering and Technology
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• 제32권1호
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• pp.42-49
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• 2008

Most of vessels are not evaluated for their vibration and noise effects to human body. The vibration and noise generated by engine and auxiliary machine in vessel is a negative element for seamen. Therefore, in this paper, the diagnosis and evaluation of vibration and noise from vessel is accomplished by a shipbuilding corporation. The vibration and noise transferred from engine room and auxiliary machine was measured during the steady-state operation, and the vibration and noise map of vessel was made. Also, in order to evaluate the ship environment for human, the diagnosis is carried out on the base of measurement results.

• 대한인간공학회지
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• 제29권4호
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• pp.693-699
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• 2010

Korea has been took the top ranking in the global shipbuilding industry in terms of new orders, order backlogs and the volume of vessels for several years. However, the domestic small- and medium-scale shipbuilders currently face imminent threat from China and new challenge to focus on development of high value-added ships. So far, the marine leisure industry of Korea has been showed weak global competitiveness and there were few attempts to design and develop leisure boats and yachts. We describe the digital design process of leisure boat exterior that could reflect user's sensibilities and feelings of entire forms of the products. This design process contains stepwise sensibility evaluation via web and provides designers with various and fast feedbacks about their design outputs in each design stage.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
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• pp.544-544
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• 2000

From ancient times. the diagnosis method of the oriental medicine has been Performed by curing diseases by means of rectifying and adjusting the unbalance in the Physiological function of the five viscera and the six bowels of a human body. Diseases have been diagnosed by the condition of blood circulation that cycles a human body through blood vessels by dint of the vitality of the heart, Based on such a systematic pulse diagnosis method, the article presents parameters that will be beneficial to clinical application on the basis of its analysis of the filtering for eliminating noises from pulse signals inputted from sensor group the digital hardware dealing with signals necessary for recognition algorithm. and the structure of diagnosis algorithm and components of pulse waveform.