• 제어로봇시스템학회논문지
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• 제17권7호
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• pp.659-667
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• 2011

The study of bipedal robot is towards similar shape and function with human. In this paper, we propose a human-like walking pattern compatible to the flexible foot with toe and heel structure. The new walking pattern for a bipedal robot consists of ZMP, center of mass (CoM), and ankle trajectory and is drawn by considering human kinesiology. First, the ZMP trajectory moves forward without stopping at a point even in the single support phase. The corresponding CoM trajectory to the ZMP one is derived by solving differential equations. As well, a CoM trajectory for the vertical axis is added by following the idea of human motion. The ankle trajectory closely mimics the rotational motion of human ankles during taking off and landing on the ground. The advantages of the proposed walking pattern are demonstrated by showing improved stability, decreased ankle torque, and the longer step length capability. Specifically, it is interesting to know that the vertical CoM motion is able to compensate for the initial transient response.

• 산업경영시스템학회지
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• 제1권1호
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• pp.11-26
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• 1978

Economic development is usually identified with the increased of G.N.P and capital formation connected directly wi:11 the net increase of land, structure, commodity, stocks and foreign claims, etc. The increase of G.N.P. is driving at capital formation. The usual concept of capital formation for economic development misses the important productivity factor of human capital. Because it is now increasingly realized that a massive injection of material into production will 11 not necessarily explain a successful productivity unless that country already possesses 1 suitable human capital. Human capital is built of educational investment which is related to the physical capital. Many statistical investigations identified this reality. Of late years, a great crowd of economists studying an the problem of economic development have turned their attention towards human capital. Thereupon, this paper has dealt with the fact that educational investment affects physical capital and employment. The qualitative increment of human capital will increase the productivity but excessive expenditure on human capital will squander a physical capital. In designing a strategy of human capital for economic development, one needs to consider tile level of educational investment because educational investment of developing countries will be accasionaly made or marred by investment level and direction.

• Biomolecules & Therapeutics
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• 제3권4호
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• pp.251-255
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• 1995

DA-3002 is a genuine human growth hormone produced by Dong-A Pharm. Co. Ltd. research laboratory using recombinant DNA technic. In this study, antigenic potential of DA-3002 was examined by active systemic anaphyaxis(ASA) in guinea pigs, mouse-rat passive cutaneous anaphylaxis(PCA) and passive hemagglutination(PHA) test as a part of safety research. DA-3002 induced anaphylactic shock in ASA test using guinea pigs Immunized with DA-3002 alone or DA-3002 incoporated into Freund's complete adjutant(FCA) when challenged with 10 times higher dose of anticipated clinical dose of DA-3002. In the mouse-rat PCA and PHA test, DA-3002 also showed positive results. DA-3002, therfore, was considered to produce IgE, IgG, and/or IgM in mice. The results of this study were similar to those of the other human growth hormones and these positive results were thought to be caused due to the fact that both DA-3002 and the other human growth hormones were heterogenous proteins to guinea pigs and mice. Considering the fact that DA-3002 is a genuine human growth hormone of which structure is identical with indigenous human growth hormone, DA-3002 is thought not to cause immunological problems in clinical use.

• BMB Reports
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• 제54권6호
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• pp.329-334
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• 2021

Collagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effective domain (CED) which promotes collagen type I synthesis. Recombinant hCOL1A1-CED effectively induces cell proliferation and collagen biosynthesis in HDFs, as well as increased cell migration and elastin production. Based on these results, hCOL1A1-CED may be explored further for its potential use as a preventative agent against skin aging.

• Biotechnology and Bioprocess Engineering:BBE
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• 제7권3호
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• pp.150-154
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• 2002

Monoclonal antibodies (Mabs) have been used as diagnostic and analytical reagents since hybridoma technology was invented in 1975. In recent years, antibodies have become increasingly accepted as therapeutics for human diseases, particularly for cancer, viral infection and autoimmune disorders. An indication of the emerging significance of antibody-based therapeutics is that over a third of the proteins currently undergoing clinical trials in the United States are antibodies. Until the late 1980's, antibody technology relied primarily on animal immunization and the expression of engineered antibodies. However, the development of methods for the expression of antibody fragments in bacteria and powerful techniques for screening combinatorial libraries, together with the accumulating structure-function data base of antibodies, have opened unlimited opportunities for the engineering of antibodies with tailor-made properties for specific applications. Antibodies of low immunogenicity, suitable for human therapy and in vivo diagnosis, can now be developed with relative ease. Here, antibody structure-function and antibody engineering technologies are described.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
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• 제2권2호
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• pp.123-133
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• 1998

As the results of investigation, the noise level was between 60 dB and 80 dB in the area of explosion. The residents living within 1 Km would feel uncomfortable. However, hearing loss is not happened by this range. The maximum range that the human can hear is 20,000 Hz and the maximum range that the dog can hear is between 20 Hz and 40,000 Hz. The auditory range for humans to be uncomfortable toward noise is between 1,000 Hz and 2,000 Hz. As the result of this experiment, the auditory range of dog is more wide than of a human. The change of hair cells in the Corti's organ occurred when the dog was exposed to 1,000 Hz at 100 dB for 1 month. Therefore, the structure change of the ear could happen by hearing loss because of noise, but the structure change of hair cells is the worst symptom by hearing loss because of noise.

• 대한의생명과학회지
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• 제15권2호
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• pp.105-112
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• 2009

The screening of the anti-cancer activity of the chemical library provided 2-thio-4-aminopyrimidine as the initial hit. The confirmation of structure and biological effect of hit was performed by synthesis and biological evaluation. The optimization of hit was performed by derivatization of substituents while keeping the core structure. The evaluation of growth inhibitory activity was carried out using SRB assay against 6 human cancer cell lines and human fibroblast. The growth inhibitory activity of compounds showed substituent dependency and more than 5 compounds showed complete growth inhibition of cancer cell lines at 10 ${\mu}M$ concentration. Chemical library screening followed by synthetic modification provided possibility that 2-thio-4-aminopyrimidine can be used as a new scaffold for the development of anti-cancer agent.

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 1997년도 제9회 한글 및 한국어 정보처리 학술대회
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• pp.360-363
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• 1997

코퍼스 속의 언어적 규칙을 직접적으로 사용하여 한국어 의존 구조를 분석하기 위해, 본 한국어 의존 구조 분석기는 의존 구조가 나타나 있는 코퍼스로부터 변환 규칙 학습기로 규칙을 자동적으로 학습하고 그 규칙을 적용함으로써 한국어 의존 구조를 분석한다. 이를 위해 기존의 연구된 구구조 문법의 규칙 틀과는 다른 한국어 의존 구조에 맞는 규칙 틀을 연구하였고 또 의존 구조에서 발생할 수 있는 교차구조(Crossing structure)를 방지하는 연산을 고안하였다.

• 간호행정학회지
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• 제18권4호
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• pp.452-459
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• 2012

Purpose: This study was a descriptive study conducted to investigate the effects of intellectual capital on organizational performance of nurses in medium and small hospitals. Methods: Data were collected from 241 nurses working in medium and/or small hospitals located in G City from August 10 to September 17, 2011. The measurement tools were the Intellectual Capital scale and Organizational Performance scale. Data were analyzed using frequency, percentage, mean, standard deviation, t-test, one way ANOVA, Pearson correlation, and hierarchical regression with SPSS WIN 18.0 PC. Results: Intellectual capital composed of human, customer, and structure capital had significant effects on organizational performance of nurses working in medium and small hospitals and explained 50.4% of the variance. Conclusion: In order to promote organizational performance of nurses, nursing managers and administrators need to invest more resources into the intellectual capital of the system including human, customer, and structure capital.

• 한국건축시공학회지
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• 제5권4호
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• pp.165-171
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• 2005

Nowadays, a source of all water, which has been spent by a lot of people, is the rainwater The rainwater is directly relating human being' life. According to how to use rainwater. human being' life is abundant or poor. Due to the lack of underground filtration quantity, the water circulation of the city is discontinued and the underground ecosystem is destroyed. This study suggest that the unused underground space of building and temporary structure can be used into rainwater storage tank in the facility to use rainwater. Moreover, in this study, while the building is constructed, It is showed that the water used in construction can be replaced in the rainwater.