• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.1332-1335
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• 1996

It is very important to predict the future position for the heavy vehicle with evasive maneuvering. In this paper, we considered for the manual image tracking system. The vehicle images are received from gyro stabilized mirror system, pass through the optical lens, processed, and displayed on the TV monitor. The operator try to lay the reticle to the center of vehicle image. When the vehicle is moving, the mirror platform (actually the line of sight) should follow the vehicle and the angular rate information is picked up from the mirror stabilized system. This rate signal should be used to predict the future vehicle position. The problem is that the visual system of the human operator is in the closed loop system. The rate signals are disturbed by the operator. In addition, there are some non linearities concerned with the control handle bar and the servo control system. The proposed Kalman filter, combined with some modifications for operator disturbance rejection, improved the predication of the future vehicle position when compared with the conventional passive filter used.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1993.10a
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• pp.1137-1146
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• 1993

In order to analyze lateral control in the forward manuever of a tractor- trailer combination , a human operator model and a kinematic vehicle model were utilized for the operator/vehicle system. By combining the vehicle and operator models, a mathematical model of the closed-loop operator/vehicle system was formulated. A computer program was developed so as to simulate the motion of the tractor-trailer combination . In order to verify the operator/vehicle system model, the results of the field trials were compared with the simulated results. There was found to be reasonably good agreement between the two.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.10a
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• pp.524-527
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• 1995

In most cases, a crane is controlled by an open-loop technique. That is, the controller tries to follow a given velocity profile that is designed to minimize the swing of rope and the transfer time. But such a system is not capable of handling various disturbances such as changing rope length and wind effect. In order to overcome this kind of difficulty, this research focuses on the design of a feedback controller using intelligent techniques such as fuzzy logic and neural network. These intelligent techniques has been emplyoyed in order to represent human knowledge and to imitate human learning. The deveped controllers have been evaluated via computer simulation

• Journal of Ginseng Research
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• v.48 no.2
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• pp.171-180
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• 2024

Background: Epimers of ginsenoside Rg3 (Rg3) have a low bioavailability and are prone to deglycosylation, which produces epimers of ginsenoside Rh2 (S-Rh2 and R-Rh2) and protopanaxadiol (S-PPD and R-PPD). The aim of this study was to compare the efficacy and potency of these molecules as anti-cancer agents. Methods: Crystal violet staining was used to study the anti-proliferatory action of the molecules on a human epithelial breast cancer cell line, MDA-MB-231, and human umbilical vein endothelial cells (HUVEC) and compare their potency. Cell death and cell cycle were studied using flow cytometry and mode of cell death was studied using live cell imaging. Anti-angiogenic effects of the drug were studied using loop formation assay. Molecular docking showed the interaction of these molecules with vascular endothelial growth factor receptor-2 (VEGFR2) and aquaporin (AQP) water channels. VEGF bioassay was used to study the interaction of Rh2 with VEGFR2, in vitro. Results: HUVEC was the more sensitive cell line to the anti-proliferative effects of S-Rh2, S-PPD and R-PPD. The molecules induced necroptosis/necrosis in MDA-MB-231 and apoptosis in HUVEC. S-Rh2 was the most potent inhibitor of loop formation. In silico molecular docking predicted a good binding score between Rh2 or PPD and the ATP-binding pocket of VEGFR2. VEGF bioassay showed that Rh2 was an allosteric modulator of VEGFR2. In addition, SRh2 and PPD had good binding scores with AQP1 and AQP5, both of which play roles in cell migration and proliferation. Conclusion: The combination of these molecules might be responsible for the anti-cancer effects observed by Rg3.

• Journal of the Korea Society for Simulation
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• v.23 no.4
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• pp.171-180
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• 2014

Our Automatic Replanning enables simulation entities to execute goal oriented behavior planning by dynamic behavior linking. Existing methods especially in Semi-Automated Forces (SAF) are mainly executing strict plans which are given at initial stage, thus they are not effective to cope with contingencies especially in a human in the loop simulation where humans interrupt. Moreover, those usually suffer from explosion of behavior combination in attempt to describe all possible countermeasures, and such combinations may be prone to being inconsistent to the situations. Our method generates behavior sequence in which behavior are linked from the goal in the manner of back-propagation. Each behavior has tags of pre/post-conditions. The tags are linked dynamically according to a certain contingency. The method is being applied to a national defense research project to show feasibility.

• Molecules and Cells
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• v.43 no.4
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• pp.350-359
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• 2020

Pathogenic aminoacyl-tRNA synthetases (ARSs) are attractive targets for anti-infective agents because their catalytic active sites are different from those of human ARSs. Mupirocin is a topical antibiotic that specifically inhibits bacterial isoleucyl-tRNA synthetase (IleRS), resulting in a block to protein synthesis. Previous studies on Thermus thermophilus IleRS indicated that mupirocin-resistance of eukaryotic IleRS is primarily due to differences in two amino acids, His581 and Leu583, in the active site. However, without a eukaryotic IleRS structure, the structural basis for mupirocin-resistance of eukaryotic IleRS remains elusive. Herein, we determined the crystal structure of Candida albicans IleRS complexed with Ile-AMP at 2.9 A resolution. The largest difference between eukaryotic and prokaryotic IleRS enzymes is closure of the active site pocket by Phe55 in the HIGH loop; Arg410 in the CP core loop; and the second Lys in the KMSKR loop. The Ile-AMP product is lodged in a closed active site, which may restrict its release and thereby enhance catalytic efficiency. The compact active site also prevents the optimal positioning of the 9-hydroxynonanoic acid of mupirocin and plays a critical role in resistance of eukaryotic IleRS to anti-infective agents.

• Journal of Advanced Navigation Technology
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• v.27 no.4
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• pp.473-480
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• 2023

This study evaluated a novel method of defining the automatic flight path of unmanned aerial vehicles (UAVs) for search and rescue missions in a VR environment. The developed VR content reserves miniature digital twins of a building in the fire and a steep mountain terrain site. The users drow the UAV's scanning path using hand gestures on the surface of digital twins, and then the UAV make an automatic flight along the defined path. According to human-in-the-loop simulation tests comparing the novel method with a conventional manual flight task with 19 participants, the novel method did not improve the mission performance but participants felt a lower mental workload. The designer may need to consider the automation support on the vulnerable points of the SAR mission environment while maintaining experts' mapping capability.

• ETRI Journal
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• v.37 no.2
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• pp.204-211
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• 2015

For this study, we designed an implantable rectangular spiral antenna for medical biotelemetry in the Medical Implant Communications Service band (402 MHz to 405 MHz). The designed antenna has a U-shaped loop for impedance matching. The antenna impedance is easily adjusted by controlling the shape and length of the U-shaped loop. Significant design parameters were studied to understand their effects on the antenna performance. To verify the potential of the antenna for the desired applications, we fabricated a prototype and measured its performance in terms of the resonant characteristics and gain radiation patterns of the antenna. In the testing phase, the prototype antenna was embedded in human skin tissue-emulating gel, which was developed to simulate a real operation environment. The measured resonant characteristics show good agreement with the simulations, and the -10 dB frequency band is within the range of 398 MHz to 420 MHz. The antenna exhibits a maximum gain of -22.26 dBi and an antenna efficiency of 0.215%.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.4
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• pp.414-419
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• 2019

JC polyomavirus (JCPyV) is a human pathogenic virus belonging to the family Polyomaviridae, a viral group containing dsDNA nucleic acid. A recent recommendation is to apply the presence of JCPyV as a fecal indicator for water contamination in environments like sewage, and techniques to monitor JCPyV in water are being proposed. To date, the conventional PCR system has been applied as a diagnostic method for detecting JCPyV. There is a need for a more rapid and sensitive JCPyV diagnostic detection method in clinical and environmental samples. In this study, we developed a loop-mediated isothermal amplification (LAMP) primer set for the detection of JCPyV. Our results indicate that the LAMP method using a specific primer set shows about 10-fold higher detection sensitivity than the conventional PCR system. The effectiveness of the LAMP method developed in this study has been validated by PCR product digestion using the HaeIII restriction enzyme. We, therefore, propose that the LAMP method using a specific primer set can be applied as a rapid and sensitive detection method for monitoring JCPyV in clinical and environmental samples.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.44 no.3
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• pp.51-57
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• 2007

Without human dynamics effects, the manually operated target tracking system has poor performance or instability in real environments. The tracking system is invalid when a human is added to the control loop as a real time delay, because input signals are generated by human operator to reduce the errors between target and gun. In this paper, we consider the human operator as a part of controller and modeling the human operator as a first-order model to generate the intentional force. But it is known that human modeling is not easy because of disturbance or noise of the vehicle while moving for the target. We performed a variety of experiments with real plant to identify the model's parameters and verify the proposed operator model's efficiency.