• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.1951-1956
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• 2003

It is known that HIV (Human Immunodeficiency Virus) infection, which causes AIDS after some latent period, is a dynamic process that can be modeled mathematically. Effects of available anti-viral drugs, which prevent HIV from infecting healthy cells, can also be included in the model. In this paper we illustrate control theory can be applied to a model of HIV infection. In particular, the drug dose is regarded as control input and the goal is to excite an immune response so that the symptom of infected patient should not be developed into AIDS. Finite horizon optimal control is employed to obtain the optimal schedule of drug dose since the model is highly nonlinear and we want maximum performance for enhancing the immune response. From the simulation studies, we find that gradual reduction of drug dose is important for the optimality. We also demonstrate the obtained open-loop optimal control is vulnerable to parameter variation of the model and measurement noise. To overcome this difficulty, we finally present nonlinear receding horizon control to incorporate feedback in the drug treatment.

• Journal of Ginseng Research
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• 제27권3호
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• pp.115-119
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• 2003

There has been continuing interest in the development of synthetic and natural compounds that modify the immune response particularly for the treatment of AIDS and cancer. During the past fifty years, numerous scientific studies have been published on ginseng. Modem human studies have investigated preventive effect of ginseng on several kinds of cancer, its long term immunological effect on HIV patients, its effect on cell mediated immune functions in healthy volunteers. Similarly non clinical studies on animal model system have studied the chemopreventive action of ginseng on cancer and immunological properties of ginseng. The precise mechanism of action of ginseng, however, not clearly understood. Considering its wide-ranging therapeutic effects, this study is being undertaken to elucidate the general mode of action of ginseng, especially to test our hypothesis that its biological action may be mediated by the immune system.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2935-2941
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• 2012

Biological response modifiers (BRMs) can alter interactions between the immune system and cancer cells to boost, direct, or restore the body's ability to fight disease. Mice with ethylnitrosourea- (ENU) induced leukemia were here used to monitor the therapeutic efficacy of lipopolysaccaride (LPS), Bacillus Calmette Guerin (BCG) and sheep erythrocytes (SRBC). Flow cytometry based CD34+ positivity analysis, clonogenicity, proliferation and ultrastructure studies using scanning electron microscopy (SEM) of stem cells in ENU induced animals with and without BRMs treatment were performed. BRMs improved the stem-stromal relationship structurally and functionally and might have potential for use as an adjunct in human stem cell therapy.

• 경영과학
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• 제29권2호
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• pp.105-125
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• 2012

As medical service industry is transformed into the market centered on consumers, medical service quality patients recognize is emphasized as the powerful means to ensure competitive advantage among hospitals in the fierce medical markets. Many researches have been done on the definition of medical service quality, developing a scale to measure it, patient satisfaction, hospital repurchase and oral transmission intention, but integrated studies have not been done sufficiently on the patient' cognitive emotional aspects. For these research purposes, based on service relation, service quality, physical surroundings, human services, corporate reputation, service value, emotional response, customer satisfaction and repurchase intention, this paper suggests a theoretical modeling composed of hypotheses on the relations of each theoretical variable. In addition, the moderating effect of service relationships is investigated based on the structural equation model.

• 대한의용생체공학회:의공학회지
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• 제25권5호
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• pp.369-376
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• 2004

이명 재훈련 치료법은 백색 잡음을 이용하여 이명 환자를 치료하는 효과적인 방법이다. 이 치료법은 광대역의 청각 세포를 자극하기 위하여 백색 잡음을 이용한다. 본 논문에서는 열 잡음을 이용한 소형의 백색 잡음 발생기와 인간의 외이와 중이 시스템에 의해 변형된 주파수 응답을 보상할 수 있는 주파수 응답 조절부를 제안하였다. 실험 결과, 제안된 시스템이 기존의 백색 잡음 발생기에 비하여 이명 재훈련 치료의 목적에 보다 적합한 형태임을 알 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제29권3호
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• pp.249-253
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• 2008

The indirect-contact ECG (IDC-ECG) was introduced by a prior study for daily non-intrusive measurements. To improve the signal quality and to extend the application area of IDC-ECG, close study of the frequency characteristics of the IDC-ECG is necessary. In this study, the frequency response of the active electrode for several sample clothes was measured under conditions of actual IDC-ECG measurement with human body. Higher gain in low frequency range than expected by prior study was observed. In addition to it, wide variation in gain according to the cloth type in the low frequency range was observed. Variation in gain caused by moisture variation in the clothes was also observed. This study shows that the parallel R-C connection is proper for electrode model and the resistive factor is influenced by moisture in the clothes. This study is the first that provides the frequency response of the electrode in the actual indirect-contact ECG measurement and it is expected that the results will be helpful to improve the indirect-contact ECG method.

• 한국정보과학회논문지:정보통신
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• 제28권4호
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• pp.489-497
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• 2001

차세대 정보전에서는 자신의 정보 시스템에 대한 침해방지, 복구 등의 수동적인 형태의 보호뿐만 아니라 상대방의 정보 기반구조(Information Infrastructure)에 대한 공격과 같은 적극적인 형태의 보호가 요구된다. 침입이 발생함과 동시에 시스템에 대한 피해를 최소화하고 침입자 추적 등의 즉각적인 대응을 하기 위해 정보보호시스템이 인간의 개입없이 자동적으로 대응하는 기능을 제공할 필요가 있다. 본 논문에서는 자기확장 모니터링 기법과 이를 기반으로 설계된 침입자동대응 모델을 제시한다. 또한 제안된 모델에 의해 설계, 구현된 침입자동대응 시스템인 ARTEMIS(Advanced Realtime Emergency Management Identification System)를 소개한다. 자기보호 기능을 가진 모니터링과 복제를 이용한 자기확장 모니터링은 모니터링 정보수집과 침입자 추적에 대한 공간적인 제약을 최소화하여 침입탐지와 침입자 추적의 정확도를 높인다.

• Wind and Structures
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• 제32권2호
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• pp.143-159
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• 2021

The 246.8-m-tall Beijing Olympic Tower (BOT) is a new landmark in Beijing City, China. Its unique architectural style with five sub-towers and a large tower crown gives rise to complex dynamic characteristics. Thus, it is wind-sensitive, and a double-stage pendulum tuned mass damper (DPTMD) has been installed for vibration mitigation. In this study, a finite-element analysis of the wind-induced responses of the tower based on full-scale measurement results was performed. First, the structure of the BOT and the full-scale measurement are introduced. According to the measured dynamic characteristics of the BOT, such as the natural frequencies, modal shapes, and damping ratios, an accurate finite-element model (FEM) was established and updated. On the basis of wind measurements, as well as wind-tunnel test results, the wind load on the model was calculated. Then, the wind-induced responses of the BOT with the DPTMD were obtained and compared with the measured responses to assess the numerical wind-induced response analysis method. Finally, the wind-induced serviceability of the BOT was evaluated according to the field measurement results for the wind-induced response and was found to be satisfactory for human comfort.

• Toxicological Research
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• 제17권
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• pp.293-297
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• 2001

The international pharmaceutical and regulatory communities had been recognizing the limited utility of conventional rodent carcinogenicity study particularly on the second species, mouse, after intense investigation of carcinogenicity data base worldwide, and a new scheme for carcinogenicity testing for pharmaceuticals was proposed at the Expert Working Group on Safety in the International Conference on Harmonization (ICH) in 1996. CB6F 1-Tg rasH2 mouse carrying human prototype c-Ha-ras gene with its own promoter/enhancer is one oj the new carcinogenicity assay model for human cancer risk assessment. Studies have been conducted since 1992 to validate the transgenic (Tg) mice for rapid carcinogenicity test-ing, short term (26 weeks) studies with genotoxic (by Salmonella), non-genotoxic carcinogens, genotoxic non-carcinogens, non-genotoxic non-carcinogens revealed relatively high concordance oj the response of the Tg mouse with classical bioassay across classes of carcinogenic agents. Mechanistic basis for carcinogensis in the model are being elucidated in terms of the role of overexpression and/or point mutation of the transgene. This report review the initial studies of validation of the model and preliminary results of on-going ILSI HESI ACT project will be presented.

• 품질경영학회지
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• 제30권2호
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• pp.11-25
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• 2002

This paper is to find how does service orientation of organization and human resource job satisfaction affect its customer orientation, that is, its service attitude and behavior toward customer. Purpose of this study is also to measure the level of employees' customer orientation more systemic. Consequently, the correlation between service orientation and performance can be identified and more effective guideline for service quality management can be draw through this study. The findings of this paper are as followings; Firstly, it is found that reward system and CEO's vision toward service orientation affect employee's job satisfaction positively, It's analyzed on Gap analysis model of PZB. Secondly, in point of inner marketing, employee who is satisfied with his job shows higher customer orientation. Thirdly, strategy change of organization in response to environment change in hospital industry influences on performance positively.