• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2004.05b
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• pp.792-795
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• 2004

Digital watermarking technology is one of method of protecting property from the illegal reproduction of digital data. This technology inserts the specific data in a certain file to identify the property, that is an author and rights, not for human to be seen and heard. In this paper, the watermarking technology which inserts a RGB rotor watermark in a JPEG2000 color image using the visual characteristics of wavelet coefficient was proposed. After applying various attack at a watermarked image according to proposed technology, the likeness between the original image, the watermark and the extracted watermark was measured and investigated. As a result, the PSNR value of image was varied depending on perceptual parameter, but we can obtain 32㏈ as a whole.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.8
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• pp.1755-1759
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• 2004

Digital watermarking technology is one of method of protecting property from the illegal reproduction of digital data. This technology inserts the specific data in a certain file to identify the property, that is an author and rights, not for human to be seen and heard. In this paper, the watermarking technology which inserts a RGB color watermark in a JPEG2000 color image using the visual characteristics of wavelet coefficient was proposed. After applying various attack at a watermarked image according to proposed technology, the likeness between the original image, the watermark and the extracted watermark was measured and investigated. As a result, the PSNR value of image was varied depending on perceptual parameter, but we can obtain 32dB as a whole.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3817-3825
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• 2015

Background: The human protein methyl-transferase DOT1L catalyzes the methylation of histone H3 on lysine 79 (H3K79) at homeobox genes and is also involved in a number of significant processes ranging from gene expression to DNA-damage response and cell cycle progression. Inhibition of DOT1L activity by shRNA or small-molecule inhibitors has been established to prevent proliferation of various MLL-rearranged leukemia cells in vitro, establishing DOT1L an attractive therapeutic target for mixed lineage leukemia (MLL). Most of the drugs currently in use for the MLL treatment are reported to have low efficacy, hence this study focused on various natural compounds which exhibit minimal toxic effects and high efficacy for the target receptor. Materials and Methods: Structures of human protein methyl-transferase DOT1L and natural compound databases were downloaded from various sources. Virtual screening, molecular docking, dynamics simulation and drug likeness studies were performed for those natural compounds to evaluate and analyze their anti-cancer activity. Results: The top five screened compounds possessing good binding affinity were identified as potential high affinity inhibitors against DOT1L's active site. The top ranking molecule amongst the screened ligands had a Glide g-score of -10.940 kcal/mol and Glide e-model score of -86.011 with 5 hydrogen bonds and 12 hydrophobic contacts. This ligand's behaviour also showed consistency during the simulation of protein-ligand complex for 20000 ps, which is indicative of its stability in the receptor pocket. Conclusions: The ligand obtained out of this screening study can be considered as a potential inhibitor for DOT1L and further can be treated as a lead for the drug designing pipeline.

• Korean Institute of Interior Design Journal
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• v.13 no.5
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• pp.162-172
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• 2004

Architects and designers of the 20th Century made various efforts to establish new design languages reflecting the changes of society, the times, and environment. They used furniture, especially chairs, as controversial items of aesthetic value, society and ideology. Le Corbusier and Alvar Aalto are furniture designers as well as architects, who adopted this ‘spirit of the times’ actively and have greatly contributed to modernism. This study will help us to understand the diversity of design since modernism, by comparing these two designers' furniture design. It also covers the common factors In modern furniture design, and analyses their individuality and likeness In design. The following is a comparison of furniture design by Le Corbusier and Alvar Aalto. Le Courbusier linked International design and Aalto linked Rational design and Organic concept design to their furniture, just as they did in their architecture. They were able to establish the base of modern furniture design by adapting new concepts and pursuing humanism. In structure, Le Corbusier's furniture Is simple and proportional. It demonstrates a sophisticated geometric composition, mechanical beauty. On the other hand, Aalto rationally linked nature with human requirements and his furniture is organic and in harmony with geometric structure. In function, Le Corbusier's furniture is standardized and prefabricated. He designed for the user so they could choose to use the furniture efficiently to suit their needs. In comparison with Le Corbusier, Aalto Invented the ‘Stacking Chair’ which allows a more effective use of space and reflected the structure of the human body to improve the user's comfort. In materials and techniques, Le Corbusier used new materials like metal or leather, and attempted new ways such as welding, prefabrication, and standardization for production. On the contrary, Alto mainly used birch, which is the traditional material in Finland, and tried new bent wood techniques and joining methods.

• Journal of the Korea Convergence Society
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• v.13 no.3
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• pp.11-22
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• 2022

Recently, research and development using various Artificial Intelligence (AI) technologies are being conducted in the field of education. Among the AI in Education (AIEd), conversational agents are not limited by time and space, and can learn more effectively by combining them with various AI technologies such as voice recognition and translation. This paper conducted a trend analysis on platforms that have a large number of users and used conversational agents for English learning among commercialized application. Currently commercialized educational platforms using conversational agent through trend analysis has several limitations and problems. To analyze specific problems and limitations, a comparative experiment was conducted with the latest pre-trained large-capacity dialogue model. Sensibleness and Specificity Average (SSA) human evaluation was conducted to evaluate conversational human-likeness. Based on the experiment, this paper propose the need for trained with large-capacity parameters dialogue models, educational data, and information retrieval functions for effective English conversation learning.

• Journal of the Korean association of regional geographers
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• v.9 no.2
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• pp.153-168
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• 2003

Since 1945, geography textbooks of South Korea and North Korea have been developed differently. Taking both geography textbooks of South Korea(printed in 1996 and 1997) and them of North Korea(printed in 1995), this study compares and analyse geography textbooks of South and North Korea systematically, then to show their likeness and difference. Results of this study are as follows: First, Most of contents in South Korean textbooks consist of explations and many tables, graphs and photographs leading to inquiry activities, whereas those in North Korean textbooks consist of mostly sentences that explain topics, diagrams and sketches. Second, Geographical education in South Korea puts strong emphasis on human geography and regional geography, whereas that in North Korea does strong emphasis on physical geography, economic geography and education of cartography. Third, The geographical words of South Korean textbooks contain words written in Chinese character and words of English origin, whereas Those of North Korean textbooks do many pure Korean words.

• Biomolecules & Therapeutics
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• v.28 no.4
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• pp.311-319
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• 2020

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a newly emerging viral disease with fatal outcomes. However, no MERS-CoV-specific treatment is commercially available. Given the absence of previous structure-based drug discovery studies targeting MERS-CoV fusion proteins, this set of compounds is considered the first generation of MERS-CoV small molecule fusion inhibitors. After a virtual screening campaign of 1.56 million compounds followed by cell-cell fusion assay and MERS-CoV plaques inhibition assay, three new compounds were identified. Compound numbers 22, 73, and 74 showed IC₅₀ values of 12.6, 21.8, and 11.12 µM, respectively, and were most effective at the onset of spike-receptor interactions. The compounds exhibited safe profiles against Human embryonic kidney cells 293 at a concentration of 20 µM with no observed toxicity in Vero cells at 10 µM. The experimental results are accompanied with predicted favorable pharmacokinetic descriptors and drug-likeness parameters. In conclusion, this study provides the first generation of MERS-CoV fusion inhibitors with potencies in the low micromolar range.

• Journal of the HCI Society of Korea
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• v.14 no.1
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• pp.15-22
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• 2019

The purpose of this study is to investigate the users' expectation and expectation gap about the attributes of smart speaker as an intelligent agent, ie autonomy, sociality, responsiveness, activeness, time continuity, goal orientation. To this end, semi-structured interviews were conducted for smart speaker users and analyzed based on ground theory. Result has shown that people have huge expectation gap about the sociality and human-likeness of smart speakers, due to limitations in technology. The responsiveness of smart speakers was found to have positive expectation gap. For the memory of time-sequential information, there was an ambivalent expectation gap depending on the degree of information sensitivity and presentation method. We also found that there was a low expectation level for autonomous aspects of smart speakers. In addition, proactive aspects were preferred only when appropriate for the context. This study presents implications for designing a way to interact with smart speakers and managing expectations.

• Science of Emotion and Sensibility
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• v.19 no.1
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• pp.95-110
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• 2016

Uncanny valley refers to the condition where the affinity of a human-like object decreases dramatically if the object becomes extremely similar to human, and has been hypothesized to derive from the cognitive load of categorical conflict against an uncanny object. According to the hypothesis, the present study ran an oddball task consisting of trials each displaying one among a non-human, human and uncanny face, and measured event-related potentials (ERPs) for each trial condition. In Experiment 1, a non-human face was presented in 80% of the trials (standard) whereas a human face for another 10% trials (target) and an uncanny face for the remaining 10% trials (uncanny). Participants' responses were relatively inaccurate and delayed in both the target and uncanny oddball trials, but neither P3 nor N170 component differed across the three trial conditions. Experiment 2 used 3-D rendered realistic faces to increase the degree of categorical conflict, and found the behavioral results were similar to Experiment 1. However, the peak amplitude of N170 of the target and uncanny trials were higher than the standard trials while P3 mean amplitudes for both the target and uncanny trials were comparable but higher than the amplitude for the standard trials. P3 latencies were delayed in the order of the standard, target, and uncanny trials. The changes in N170 and P3 patterns across the experiments appear to arise from the categorical conflict that the uncanny face must be categorized as a non-target according to the oddball-task requirement despite its perceived category of a human face. The observed increase of cognitive load following the added reality to the uncanny face also indicates that the cognitive load, supposedly responsible for the uncanny experience, would depend on the increase of categorical conflict information subsequent to added stimulus complexity.