• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3219-3226
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• 2014

Chemotherapy continues to be a mainstay of cancer treatment, although drug resistance is a major obstacle. Lipid metabolism plays a critical role in cancer pathology, with elevated ether lipid levels. Recently, alkylglyceronephosphate synthase (AGPS), an enzyme that catalyzes the critical step in ether lipid synthesis, was shown to be up-regulated in multiple types of cancer cells and primary tumors. Here, we demonstrated that silencing of AGPS in chemotherapy resistance glioma U87MG/DDP and hepatic carcinoma HepG2/ADM cell lines resulted in reduced cell proliferation, increased drug sensitivity, cell cycle arrest and cell apoptosis through reducing the intracellular concentration of lysophosphatidic acid (LPA), lysophosphatidic acid-ether (LPAe) and prostaglandin E2 (PGE2), resulting in reduction of LPA receptor and EP receptors mediated PI3K/AKT signaling pathways and the expression of several multi-drug resistance genes, like MDR1, MRP1 and ABCG2. ${\beta}$-catenin, caspase-3/8, Bcl-2 and survivin were also found to be involved. In summary, our studies indicate that AGPS plays a role in cancer chemotherapy resistance by mediating signaling lipid metabolism in cancer cells.

• Nuclear Engineering and Technology
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• v.52 no.4
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• pp.835-840
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• 2020

A position-sensitive CsI(Tl) crystal array coupled with the multi-anode position sensitive photomultiplier tube (PS-PMT), Hamamatsu H8500C, has been developed at the Institute of Modern Physics. An effective, fast, and economical readout circuit based on discretized positioning circuit (DPC) bridge was designed for the 64-channel multi-anode flat panel PSPMT. The horizontal and vertical position resolutions are 0.58 mm and 0.63 mm respectively for the 1.0 × 1.0 × 5.0 ㎣ CsI(Tl) array, and the horizontal and vertical position resolutions are 0.86 mm and 0.80 mm respectively for the 2.0 × 2.0 × 10.0 ㎣ CsI(Tl) array. These results show that the CsI(Tl) crystal array with low cost could be applied in the fields of medical imaging and high-resolution gamma camera.

• Nuclear Engineering and Technology
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• v.54 no.6
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• pp.2120-2134
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• 2022

A hypothetical core destructive accident (HCDA) has received widespread attention as one of the most serious accidents in sodium-cooled fast reactors. This study combined recent advantages in numerical methods to realize realistic modeling of the complex fluid-structure interactions during HCDAs in a full-scale sodium-cooled fast reactor. The multi-material arbitrary Lagrangian-Eulerian method is used to describe the fluid-structure interactions inside the container. Both the structural deformations and plug rises occurring during HCDAs are evaluated. Two levels of expansion energy are considered with two different reactor models. The simulation results show that the container remains intact during an accident with small deformations. The plug on the top of the container rises to an acceptable level after the sealing between the it and its support is destroyed. The methodology established in this study provides a reliable approach for evaluating the safety feature of a container design.

• (The)Study of the Eastern Classic
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• no.63
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• pp.141-168
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• 2016

This paper studies Zhu Xi's critical comprehension about the theories of gewu zhizhi of senior Confucian scholars, focusing on the Daxue Zhangju, Daxue huowen, and Daxue huowen yulei of Zhuzi yulei. Zhu Xi described in depth the theory of gewu zhizhi of Sima Guang, disciples of the Cheng Yi(Lu Dalin, Xie Liangzuo, Yin Ch'un, Yang Shi), scholars of Hu-Xing province(Hu An-guo, Hu hong), Li Dong in the Daxue huowen and Daxue huowen yulei, by his understanding through a criticism of the theory of gewu zhizh, thereby formulating a theory of gewu zhizhi on the basis of Cheng Yi's theory. Through this criticism of senior Confucian scholars, Zhu Xi explained that the theory of gewu zhizhi was departed from a positive affirmation of things. Zhu Xi claimed that the crux of gewu zhizhi was a thorough understanding like a sudden release achieved by accumulating Li of things. This plan of Zhu Xi with respect to "Supplementary Chapter on the Gewu Zhizhi" showed that the theory of gewu zhizhi which was set up by himself corresponded to the theory of Cheng Yi's, and it was based on the Confucian tradition firmly.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.7
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• pp.3401-3420
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• 2018

Pixel expansion and contrast are two major performance parameters for visual cryptography scheme (VCS), which is a type of secret image sharing. Random Grid (RG) is an alternative approach to solve the pixel expansion problem. Chen and Tsao proposed the first (k, n) RG-based VCS, and then Guo et al., Wu et al., Shyu, and Yan et al. significantly improved the contrast in recent years. However, the investigations on improving the contrast of threshold RG-based VCS are not sufficient. In this paper, we develop a contrast-improved algorithm for (k, n) RG-based VCS. Theoretical analysis and experimental results demonstrate that the proposed algorithm outperformers the previous threshold algorithms with better visual quality and a higher accuracy of contrast.

• Transactions on Electrical and Electronic Materials
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• v.15 no.3
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• pp.125-129
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• 2014

A dataset can be clustered by merging the bucket indices that come from the random projection of locality sensitive hashing functions. It should be noted that for this to work the merging interval must be calculated first. To improve the feasibility of large scale data clustering in high dimensional space we propose an enhanced Locality Sensitive Hashing Clustering Method. Firstly, multiple hashing functions are generated. Secondly, data points are projected to bucket indices. Thirdly, bucket indices are clustered to get class labels. Experimental results showed that on synthetic datasets this method achieves high accuracy at much improved cluster speeds. These attributes make it well suited to clustering data in high dimensional space.

• International Journal of High-Rise Buildings
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• v.10 no.2
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• pp.137-147
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• 2021

The principle of energy dissipation technology is to dissipate or absorb the seismic energy input through the deformation or velocity change of dampers installed in the main structure of high-rise buildings, so as to reduce the seismic response of the buildings. With the development of energy dissipation technology, recognized as an effective and new measurement for reducing seismic effects, its application in high-rise buildings has become more and more popular. The appropriate energy dissipation devices suitable for high-rise buildings are introduced in this paper. The effectiveness of energy-dissipation technology for reducing the seismic response of high-rise buildings with various structural forms is demonstrated with a number of actual examples of high-rise buildings equipped with various energy dissipation devices.

• Nuclear Engineering and Technology
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• v.56 no.4
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• pp.1153-1164
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• 2024

In recent years, unmanned ground vehicles (UGVs) have been used to search for lost or stolen radioactive sources to avoid radiation exposure for operators. To achieve autonomous localization of radioactive sources, the UGVs must have the ability to automatically determine the next radiation measurement location instead of following a predefined path. Also, the radiation field of radioactive sources has to be reconstructed or inverted utilizing discrete measurements to obtain the radiation intensity distribution in the area of interest. In this study, we propose an effective source localization framework and method, in which UGVs are able to autonomously explore in the radiation area to determine the location of radioactive sources through an iterative process: path planning, radiation field reconstruction and estimation of source location. In the search process, the next radiation measurement point of the UGVs is fully predicted by the design path planning algorithm. After obtaining the measurement points and their radiation measurements, the radiation field of radioactive sources is reconstructed by the Gaussian process regression (GPR) model based on machine learning method. Based on the reconstructed radiation field, the locations of radioactive sources can be determined by the peak analysis method. The proposed method is verified through extensive simulation experiments, and the real source localization experiment on a Cs-137 point source shows that the proposed method can accurately locate the radioactive source with an error of approximately 0.30 m. The experimental results reveal the important practicality of our proposed method for source autonomous localization tasks.

• Journal of Microbiology and Biotechnology
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• v.31 no.12
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• pp.1672-1683
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• 2021

Vibrio parahaemolyticus is recognized as one of the most important foodborne pathogens responsible for gastroenteritis in humans. The bla_CARB-17 gene is an intrinsic β-lactamase gene and a novel species-specific genetic marker of V. parahaemolyticus. In this study, a loop-mediated isothermal amplification (LAMP) assay combined with a lateral flow dipstick (LFD) was developed targeting this bla_CARB-17 gene. The specificity of LAMP-LFD was ascertained by detecting V. parahaemolyticus ATCC 17802 and seven other non-V. parahaemolyticus strains. Finally, the practicability of LAMP-LFD was confirmed by detection with V. parahaemolyticus-contaminated samples and natural food samples. The results showed that the optimized reaction parameters of LAMP are as follows: 2.4 mmol/l Mg²⁺, 0.96 mmol/l dNTPs, 4.8 U Bst DNA polymerase, and an 8:1 ratio of inner primer to outer primer, at 63℃ for 40 min. The optimized reaction time of the LFD assay is 60 min. Cross-reactivity analysis with the seven non-V. parahaemolyticus strains showed that LAMP-LFD was exclusively specific for V. parahaemolyticus. The detection limit of LAMP-LFD for V. parahaemolyticus genomic DNA was 2.1 × 10^-4 ng/μl, corresponding to 630 fg/reaction and displaying a sensitivity that is 100-fold higher than that of conventional PCR. LAMP-LFD in a spiking study revealed a detection limit of approximately 6 CFU/ml, which was similar with conventional PCR. The developed LAMP-LFD specifically identified the 10 V. parahaemolyticus isolates from 30 seafood samples, suggesting that this LAMP-LFD may be a suitable diagnostic method for detecting V. parahaemolyticus in aquatic foods.

• Steel and Composite Structures
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• v.20 no.4
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• pp.869-887
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• 2016

The socket-spigot template supporting system is widely used in engineering applications in China. As a newer type of support structure, there has been growing research interest in its bearing capacity. In this paper, four vertical bearing capacity tests were carried out on the basic mechanical unit frame of a socket-spigot template supporting system. The first goal was to explore the influence of the node semi-rigid degree and the longitudinal spacing of the upright tube on the vertical bearing capacity. The second objective was to analyze the displacement trend and the failure mode during the loading process. This paper presents numerical analysis of the vertical bearing capacity of the unit frames using the finite element software ANSYS. It revealed the relationship between the node semi-rigid degree and the vertical bearing capacity, that the two-linear reinforcement model of elastic-plastic material can be used to analyze the socket-spigot template supporting system, and, through node entity model analysis, that the load transfer direction greatly influences the node bearing area. Finally, this paper indicates the results of on-site application performance experiments, shows that the supporting system has adequate bearing capacity and stability, and comments on the common work performance of a socket and fastener scaffold.