• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3587-3592
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• 2014

Burden of cancer is progressively increasing in developing countries like India which has also led to a steep rise in toxicity due to anti-cancer therapy. A cross-sectional analysis was here conducted for patients with different malignancies (except leukaemia) who while undergoing radical anti-cancer therapy were admitted to our oncology ward from January-July 2013. In a total of 280 patients, the total number of toxicity events was 473. Nine patients expired over this time period. Among the events, grade 2 anaemia the most common (n=189) while the most common grades of neutropenia and thrombocytopenia were grade 4 (n=114) and grade 2 (n=48), respectively. Among the tracable microbial etiologies, gram negative bacteria were the most commonly found pathogens. Treatment interruptions took place in 240 patients (median duration=8.8 days). Prolonged hospital admission, intensive care and artificial ventilation support was needed to be given in 48, 7 and 13 patients respectively. Advanced NSCLC, KPS <70, pancytopenia and artificial ventilation requirement were found to have a significant impact on death. Such studies show the prevailing practice from institutes of our country and may guide us formulating a guideline for managing such toxicities for this part of the world.

• The Journal of Korean Academic Society of Nursing Education
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• v.23 no.4
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• pp.419-429
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• 2017

Purpose: The purpose of this study was to investigate the effect of the development and application of the new nurses' core skill program on the clinical skill, confidence, knowledge and performance of new nurses. Methods: This study was a nonequivalent control group post-test design on 46 new nurses with 3 to 6 months work experience in a general hospital. Data were collected from August 2015 to August 2016. A training program of core fundamental nursing skills was applied on 23 new nurses from 2016 in the experiment group, and an existing training method was applied on 23 new nurses from 2015 in the comparison group. The collected data were analyzed using SPSS/WIN 23.0. Results: The experimental group ($89{\pm}4.29$) showed higher score in practical skill assessment compared to the control group ($85.09{\pm}3.99$) and showed a statistically significant difference (p<001). Conclusion: A training program of core fundamental nursing skills for new nurses proved effective in improving practical skills. Further research on the development of a systemic training program that can improve clinical nursing knowledge and work ability for new nurses according to the extended enforcement of a Nursing Care Integrated Service ward is needed.

• Journal of Breast Cancer
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• v.21 no.4
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• pp.371-381
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• 2018

Purpose: Immune suppression is common in patients with advanced breast cancer but the mechanisms underlying this phenomenon have not been sufficiently studied. In this study, we aimed to identify B7 family members that were able to predict the immune status of patients, and which may serve as potential targets for the treatment of breast cancer. We also aimed to identify microRNAs that may regulate the expression of B7 family members. Methods: The Cancer Genome Atlas data from 1,092 patients with breast cancer, including gene expression, microRNA expression and survival data, were used for statistical and survival analyses. Polymerase chain reaction and Western blot were used to measure messenger RNA and protein expression, respectively. Luciferase assay was used to investigate direct microRNA target. Results: Bioinformatic analysis predicted that microRNA (miR)-93, miR-195, miR-497, and miR-340 are potential regulators of the immune evasion of breast cancer cells, and that they exert this function by targeting CD274, PDCD1LG2, and NCR3LG1. We chose CD274 for further investigations. We found that miR-195, miR-497, and CD274 expression levels were inversely correlated in MDA-MB-231 cells, and miR-195 and miR-497 expressions mimic inhibited CD274 expression in vitro. Mechanistic investigations demonstrated that miR-195 and miR-497 directly target CD274 3' untranslated region. Conclusion: Our data indicated that the level of B7 family members can predict the prognosis of breast cancer patients, and miR-195/miR-497 regulate CD274 expression in triple negative breast cancer. This regulation may further influence tumor progression and the immune tolerance mechanism in breast cancer and may be able to predict the effect of immunotherapy on patients.

• Korea Journal of Hospital Management
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• v.25 no.1
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• pp.46-57
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• 2020

Objectives: The purpose of this study is to evaluate the factors affecting patient satisfaction for the nursing service of comprehensive nursing care service unit in Tertiary hospital Methods: This study employed a descriptive survey to investigate the nursing satisfaction and the study data was collected from 74 patients among 83 patient who were admitted to the nursing care integration service ward of an tertiary hospital for 10 days from May 9, 2018 to May 19, 2018. Data was analyzed by descriptive statistics, t-test, ANOVA, and multiple linear regression using SPSS 21 program. Results: The average with nursing satisfaction was significantly different according to marriage type and KPCS level. It was found that physical factor and educational factor have statistically significant effect on nursing satisfaction. As physical care increase by one unit, patient satisfaction increase by 0.226(95% CI; 0.061-0.390) and also satisfaction increase by 0.443(95% CI; 0.070-0.816) as education care increase by one unit. Conclusions: As a result of study, it was found that it is necessary to provide patients with more careful nursing service in physical and educational perspective, in order to improve the service quality of comprehensive nursing care service unit.

• Journal of Korean Academy of Nursing
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• v.35 no.5
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• pp.896-903
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• 2005

Purpose: This study was designed to exam me the effects of an assertive training program on interpersonal relations, and psychiatric symptoms in patients with a mental disorder. Method: The study employed a quasi experimental design. The subjects included 44 patients with a mental disorder, 20 in the experimental group, and 24 in the control group. Data was collected using structured questionnaires over a 3 month period. Results: There were greater significant increases in scores of interpersonal relations and content of communication in the experimental group than the control group. Also, there was a greater significant decrease in the score of psychiatric symptoms in the experimental group than the control group. Conclusion: Assertive training has an effect on increasing content of communication and decreasing psychiatric symptoms.

• Journal of Digital Convergence
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• v.16 no.3
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• pp.363-373
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• 2018

The purpose of this study was investigates the Autonomy and job satisfaction of the nurses in the hematopoietic stem cell transplantation ward. The data was collected by distributing structured questionnaires to 79 nurses at the hematopoietic stem cell transplantation ward at 7 university hospitals in D, B and U Metropolitan cites, from May 20 to June 4, 2013 and analyzed by t-test, ANOVA, Pearson correlation coefficient. The average autonomy level of nursing professionals was $165.47{\pm}19.56points$. The average nurse's job satisfaction was $3.15{\pm}0.35points$. The correlation between autonomy and nurse's job satisfaction showed to be not correlated. The correlation between autonomy and nurse's job satisfaction of the autonomy category(r=.273) and human interaction category(r=.257) showed to be correlated. It is necessary to developed education and policy programs for nurse's autonomy and nurse's job satisfaction at the hematopoietic stem cell transplantation ward.

• Korean Journal of Adult Nursing
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• v.15 no.4
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• pp.628-638
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• 2003

Purpose: The purpose of this study was to develope a evaluation tool of the quality of nursing care for aneurysmal subarachnoid hemorrhage patients at Hunt & Hess Grade I~III. Method: The data was gathered from April 15, 2002 to June 14, 2002. The tool proceeded in six steps according to Bloch's framework. Result: The results of this study are as follows: 1) The quality evaluation tool for neurosurgery ICU consisted of 25 standards and 138 criteria. The quality evaluation tool for ward consisted of 27 standards and 144 criteria.; 2) The content validities of the tools for neurosurgery ICU and ward were 0.96 and 0.98, respectively.; 3) The Pearson coefficients for evaluating the interrated reliability of the tools for neurosurgery ICU and ward were r=0.9106 (p<0.1) and r=0.8807 (p<0.1), respectively.; 4) The ranges of corrected item-total correlations for evaluating the construct validity of the tools for neurosurgery ICU and ward were 0.0279~0.9354 and 0.0174~0.9682, respectively.; And 5) The ranges of Cronbach's ${\alpha}$ reliabilities for evaluating the internal consistency reliability of the tools for neurosurgery ICU and ward were 0.6040~0.8554 and 0.6212~0.9584, respectively. Conclusion: The tools developed in this study seem useful in evaluating the quality of nursing care for aneurismal subarachnoid hemorrhage patients at Hunt & Hess Grade I-III.

• Journal of The Korea Institute of Healthcare Architecture
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• v.22 no.3
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• pp.35-44
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• 2016

Purpose: This study is focus on investigation of user's spontaneous behavior in the public space of ward where chronic patients are hospitalized. Methods: The notion and necessity of social healing environment is analyzed by literature review. User's location and behaviour are investigated for analyzing behavior by visiting the six wards. Results: The result 1) Stay is main behavior of users. 2) The frequency of stay is high in the place where are planned as the dayroom, the program room and the balcony. 3) In the corridor, the users are staying around court and single side corridor. And the users who are staying in the ward planned middle corridor and double corridor are spreaded all over the corridor. As the result of the analysis of correlation between frequency of user for stay and area of public space, 4) The area of the dayroom, the program room and the balcony is bigger, the frequency of users are higher. 5) There is no correlation between area of corridor and frequency of users. 6) When the density of user is highest in the place for stay, one person occupied $1.96m^2$. Implications: Hereafter the public space, which social healing environment is considered, is planned, this study could suggest the directions of architectural planning about area.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.239-244
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• 2015

Background: One of the causes of acute leukemia can be exposure to certain chemicals such as pesticides. This study determined the relationship between exposure to pesticides and the occurrence of acute leukemia in Fars province, south of Iran. Materials and Methods: Between April 2011 and April 2013 in a case-control study conducted in Nemazee Hospital in Shiraz, Southern Iran; 314 subjects diagnosed with acute leukemia (94 pediatric cases and 220 adults) were enrolled to determine any correlation between exposure to pesticides and the occurrence. Controls (n=314) were matched by sex and age. Results: There was a history of exposure to pesticides among 85% of pediatric cases and 69% of their controls and 83% of adult cases and 75% of their controls while 87.5% of pediatric cases and 90% of adult cases reported exposure to intermediate and high doses of pesticides and among the controls, the exposure to low doses of pesticides was 70.5% and 65%, respectively. Exposure to indoor pesticides was seen among most of cases and controls. Being a farmer was at a significantly more increased risk of developing acute leukemia in comparison to other jobs, especially for their children. Conclusions: Exposure to pesticides was shown to be one of the most important causes of acute leukemia. It seems that there is a need to educate the people on public health importance of exposure to pesticides especially during school time to reduce the risk of malignancies during childhood.

• Korean Institute of Interior Design Journal
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• v.18 no.5
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• pp.183-190
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• 2009

Increase in the elderly population has given rise to various social problems throughout Korean society, and what is more, although the greater demand of medical treatment, its development is still in its early stages. Given that Specialized Geriatrics Hospital has stood amid a range of spatial complication and it should faithfully reflect the needs of elderly population, we need a better understanding of Specialized Geriatrics Hospital. This study suggested the foundation to plan of Specialized Geriatrics Hospital through analyzing and evaluating spatial configuration of Specialized Geriatrics Hospital by "Space Syntax" and "J-Graph" The study focused on Specialized Geriatric Hospitals existing in Korea which owned more than 100 beds. The result of this study is summarized as follows; First, the rate of separated convex showed that the portions of the Treatment of outpatients and Supply have increased, but onthe other hand the portion of the The ward has been on the decrease. Second, in the case of Treatment of outpatients, it was structured Tree-shaped and the Tree-shaped could be separated with two types: waiting room and wailing room with lounge. in the case of The ward, it was structured Tree-shaped and also Ring-shaped. The more recently opened Geriatrics Hospital, the closer to Ring-shaped. Third, the access to the Ccentral treatment was low though the access to the core of the each floor was high. Fourth, in the progress of intelligibility, the fact that its value has decreased is becoming a serious problem of medical development for the elderly population finally, according to J-graph's analysis, the hallway made the spatial depth of rooms and public space more deepened. This caused by scattered arrangement of public spaces. As the only planning were considered in this study, It therefore needs more diversified approaches considering physical factors such like real distance and area.