• 한국발생생물학회지:발생과생식
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• 제15권1호
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• pp.53-59
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• 2011

Sex steroid hormones are key molecules to prepare the decidual response and their levels are important in this process. Imbalances of the levels of steroid hormones are cause of implantation failure and other diseases including physical weakness. Androgen replacement therapy or selective androgen receptor modulator are used to overcome various diseases but long-term use may cause of side effects. In previous report, it is suggested that the steroid hormonal complexes derived from pig enhance the proliferation of satellite cell. Therefore, to evaluate the possible usage of steroid hormonal complex derived from pig testis (tS-C), the effects of tS-C on uterine response were studied using the model of artificial decidua. tS-C did not disturb the rhythmical estrus cycle. Artificial-induced decidual response was normally induced in tS-C administered mice. The histological characters of the decidua of tS-C administered mice were not different from the vehicle. The expression patterns of molecular markers of decidua were not different between vehicle and tS-C group. Collectively these results suggested that tS-C does not disturb the uterine responsibility to the embryo. In addition, our results suggested that tS-C can be applied to overcome the various problems such as loss of muscle mass and anemia.

• 대한화장품학회지
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• 제22권2호
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• pp.141-152
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• 1996

Many eastern females concern themselves about the condition and the color of their skin. The purpose of the present study is to classify the skin trouble and the change of the facial color due to hormonal cycle in female. We examined the actual cricumstances by questionnaires, and made patch tests of methyl nicotinate, representing rubefacient, to estimate the epidermal penetratin rate, and measured the facial color change during the menstrual cycle period to invest the correlation factors between skin trouble due to cosmetics and facial color change. Fifty-two percent of subjects had skin trouble relating to cosmetics. One second of subjects with skin trouble due to cosmetic complained the change of sysptom by menstrual cycle. The changes of systptom were related on premenstrual period. The skin trouble developed mainly on the first trimester of the pregnancy. In patch test of methyl nicotinate, most cases showed decreased threshold of the reaction on minstruation, and other cases showed increased reactivity of the skin of menstruation. In facial color measurements, it proves in the appearance of red spot, darkness, increasing the value and turning the hue to yellowish, Also it demonstrates that premenstruation hue turn red and value level decrease. During the period, facial color turns pale and hue progress to yellow. This fact coincides with the questionnaire. We have quqntified through questionnaire, which demonstrates it has good correlation with done to the subjects among the internal environment factors hormonal cycle influences the facial color change and the skin trouble due to cosmetics. Through this paper the development of an more fragmented make-up and skin care products is required to increase the interest to females, to make true the creation of beauty.

• Journal of Nutrition and Health
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• 제35권2호
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• pp.207-212
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• 2002

Acetyl-CoA carboxylase (ACC) is the enzyme that controls no devo fatty acid biogynthesis, and this enzyme catalyzes the carboxylation pathway of acetyl-CoA to malonyl-CoA. Acetyl-CoA carboxylase gene expression was regulated by nutritional and hormonal status. The present study was performed to identify the regulation mechanism of ACC gene promoter I. The fragments of ACC promoter I -1.2-kb region wert recombined to pGL3-Basic vector with luciferase as a reporter gene. The primary hepatocytes from the rat were used to investigate the hormonal regulation of ACC promoter I activity. ACC PI (-1.2)/Luc plasmid was trtransferred into primary hepatocytes using lipofectin. Activity of luciferase was increased two-fold by 10-9M, three-fold by 10-8M, 10-6M, 3.5-fold by 10-6M, and 4.5-fold by 10-7M insulin treatment, respectively. In the presence of dexamethasone (1 $\mu$M), the effects of insulin increased about 1.5-fold, showing the additional effects of dexamethasone. Moreover, the activity of luciferase increased with insulin+dexamethasone, insulin+T3, dexamethasone+T3, and dexamethasone+insulin+T3 treatment approximately 6-, 4-, 6.5-, and 10-fold, respectively. Therefore it can be postulated that 1) these hormones coordinately regulate acetyl-CoA caroxylase gene expression via regulation of promoter activity, 2) the -1.2-kb region of ACC promoter I may have the response element sequences for insulin, dexamethasone, and T3.

• Toxicological Research
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• 제26권4호
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• pp.301-313
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• 2010

Growth promoters including hormonal substances and antibiotics are used legally and illegally in food producing animals for the growth promotion of livestock animals. Hormonal substances still under debate in terms of their human health impacts are estradiol-$17\beta$, progesterone, testosterone, zeranol, trenbolone, and melengestrol acetate (MGA). Many of the risk assessment results of natural steroid hormones have presented negligible impacts when they are used under good veterinary practices. For synthetic hormonelike substances, ADIs and MRLs have been established for food safety along with the approval of animal treatment. Small amounts of antibiotics added to feedstuff present growth promotion effects via the prevention of infectious diseases at doses lower than therapeutic dose. The induction of antimicrobial resistant bacteria and the disruption of normal human intestinal flora are major concerns in terms of human health impact. Regulatory guidance such as ADIs and MRLs fully reflect the impact on human gastrointestinal microflora. However, before deciding on any risk management options, risk assessments of antimicrobial resistance require large-scale evidence regarding the relationship between antimicrobial use in food-producing animals and the occurrence of antimicrobial resistance in human pathogens. In this article, the risk profiles of hormonal and antibacterial growth promoters are provided based on recent toxicity and human exposure information, and recommendations for risk management to prevent human health impacts by the use of growth promoters are also presented.

• Journal of Preventive Medicine and Public Health
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• 제48권6호
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• pp.280-286
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• 2015

Objectives: Approximately 10% to 15% of lung cancer cases occur in never-smokers. Hormonal factors have been suggested to lead to an elevated risk of lung cancer in women. This systematic review (SR) aimed to investigate the association between hormonal replacement therapy (HRT) and the risk of lung cancer in women using cohort studies. Methods: We first obtained previous SR articles on this topic. Based on these studies we made a list of refereed, cited, and related articles using the PubMed and Scopus databases. All cohort studies that evaluated the relative risk of HRT exposure on lung cancer occurrence in women were selected. Estimate of summary effect size (sES) with 95% confidence intervals (CIs) were calculated. Results: A total of 14 cohort studies were finally selected. A random effect model was applied due to heterogeneity (I-squared, 64.3%). The sES of the 14 articles evaluating the impact of HRT exposure on lung cancer occurrence in women indicated no statistically significant increase in lung cancer risk (sES, 0.99; 95% CI, 0.90 to 1.09). Conclusions: These results showed that HRT history had no effect on the risk of lung cancer in women, even though the sES of case-control studies described in previous SR articles indicated that HRT had a protective effect against lung cancer. It is necessary to conduct a pooled analysis of cohort studies.

• 한국양식학회지
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• 제9권1호
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• pp.19-23
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• 1996

Hormonal induction of sex reversal was examined by using sex steroid hormones in serranid fish, Epinephelus septemfasciatus. Young fish were collected from the coastal area of Cheju Island, and reared for 2 years before fish were used for the experiments. Without any hormonal treatment, gonads of fish ($1,000\~2,800$ g in body weight) were occupied by oocytes of the perinucleolus stage and bundles of protogonial cells in the area of germinal epithelium. When the induction of sex reversal was attempted by daily oral administration of $17\alpha$-methyltestosterone (0.5 mg/kg fish) for 90 days, active spermatogenesis was induced, and spermatogonia and spermatocytes and spermatids were appeared in all gonads we examined. However, after daily, oral treatment of $17\beta$-estradiol (0.5 mg/kg fish) to. 50 days with the following injection of human chorionic gonadotrophin ($1,000\~1,500$ IU/kg fish) mature oocytes were not induced in fish gonad.

• International Journal of Industrial Entomology and Biomaterials
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• 제5권1호
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• pp.1-12
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• 2002

Ecophysiologically diapause represents a syndrome of physiological and biochemical characteristics, all of which ensure survival during a long period of dormancy. Since, silkworm enters diapause as embryo at the early embryonic stage, the duration of egg life depends on the duration of embryonic diapause. The nature of diapause in silkworm, Bombyx mori, is primarily determined by genetic characters and endocrinologicnl mechanisms, mediated by environmental factors such as temperature and photoperiod. Hibernating potency value besides nucleic acid and carbohydrate metabolism, production and utilization of sorbitol are also equally responsible for induction, initiation, determination, maintenance and termination of diapause. Embryonic diapause in Bombyx moir, induced by active secretion of sub-oesophageal ganglion is attributed to hormonal system and metabolic adjustment, which serves to bring about a new physiological state. Metabolic conversion of trehalose to glycogen at induction, glycogen to sorbitol at initiation and sorbitol to glycogen at termination of diapause is correlated and in each metabolic shift a key enzyme becomes active in response to hormonal and environmental stimulation. An attempt has been made in this review article to discuss briefly the nature of embryonic diapause, influence of various factors on diapause nature, hormonal mechanism of diapause besides biochemical composition of egg, nucleic acid and carbohydrate metabolism, production and utilization of sorbitol in relation to induction, determination, maintenance, initiation and termination of diapause in the silkworm, Bombyx mori.

• 한국과학교육학회지
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• 제32권6호
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• pp.1063-1071
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• 2012

The purpose of this study is to investigate the relation between the classification ability quotient and cortisol-hormonal change of middle school students. Thirty-three students, second graders in middle school, performed the classification task that can be an indicator of students' classification ability. And then amount of the secreted hormone was analyzed during task performance. The study results were as follows: First, the classification methods of students mostly utilized visual, qualitative. Their classification patterns for each subject were static, partial, and non-comparative. Second, the amount of stress-hormone was secreted from students during the experiment decreased in overall after the free classification. It seemed that student-centered activity relieved stress. Third, the classification ability quotient turned out to be significantly correlated to the stress hormone, which means that there was a close relationship between classification ability and stress level. It was also considered that stress had a positive effect on the improvement of classification ability. This study provided physiologically more accurate information on the stress increased in the learning process than other conventional studies based on reports or interviews. Finally, researchers could recognize the effect of stress in the cognitive activity and the need to find an appropriate level of stress in learning processes.

• 대한한의학회지
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• 제19권2호
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• pp.391-400
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• 1998

This study was to investigate the effects of Bo-Jung-Chi-Seub-Tang administration on body composition, blood biochemistrical factors and hormonal changes during 2 weeks Weight Reduction in TaeKwonDo Athletes. 10 subjects were belong to be in elite athletes of KNUPE. They were divided two groups(administration group and non-administration) by 5 subjects in each group randomly. they were measured about body composition(% Fat, Fat Wt, LBM, TBW), Blood Biochemistrical Factors(glucose, TG, total protein, albumin, BUN, Uric acid, Ca, Pi, Mg) and Hormonal Changes(Renin, Aldosteron). As the results of the experiment, conclusions were made as follows: In terms of % Fat, Fat W.T., Mg, TG, Renin, it was shown significant differences between two groups. Although there were no significant differences, rate of weight reduction and levels of LBM, BUN in Bo-Jung-Chi-Seub-Tang administration group were changed more lower than non-administration group.

• 한국가축번식학회지
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• 제20권3호
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• pp.225-232
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• 1996

The purpose of this study was to evaluate effects of hormonal treatments on corpus lutea, follicles and development stage of embryos for enhancing the production efficiency of in vivo porcine embryos suitable to introduce fo foreign genes. Hundred and twenty gilts were allocated to 6 experimental group in different combinations of hormones PG 600, PMSG, hCG and altrenogest. When gilts were treated with chorionic gonadotrophin 200 IU and serum gonadotrophin 200 IU(PG 600), altrenogest, serum gonadotrophin (PMSG) 1,000 IU, and chorionic gonadotrophin(hCG) 750 IU (PAPh), the numbers of corpus luteum (30.4) were significantly higher than those of other treatment groups (P<0.05). The number of corpus luteum from ovary in either right (9.1) or left (10.1) side was not significantly changed with hormone treatments. Number of follicles in control was 20.7, which was higher than those of hormonal treatment groups. The average numbers of 1, 2, 4 and 8 cell staged embryos were 8.1, 1.4, 1.6 and 1.0 in control, but the numbers of 1-cell stage in PAPh treatment group was 24.2, which was significantly higher than those of treatment groups (P<0.05). Therefore, these data indicated that hormonal treatment, especially PAPh, enhanced the developments of follicles, corpus lutea and embryos and increased the collection rate of the 1-cell stage embryos to introduce of foreign genes.