Development and Reproduction (한국발생생물학회지:발생과생식)

The Korean Society of Developmental Biology (한국발생생물학회)
권호 표지

Non-disturbing of Decidual Response by Steroid Hormonal Complexes of Pig Testis

  • Yoo, Ja-Hyun (School of Biosciences and Chemistry, Center for NanoBio Applied Technology, Institute of Basic Sciences, Sungshin Women's University) ;
  • Byun, Jee-Hyun (School of Biosciences and Chemistry, Center for NanoBio Applied Technology, Institute of Basic Sciences, Sungshin Women's University) ;
  • Jeon, So-Ra (School of Biosciences and Chemistry, Center for NanoBio Applied Technology, Institute of Basic Sciences, Sungshin Women's University) ;
  • Lee, Dong-Mok (School of Biotechnology, Yeungnam University) ;
  • Chun, Tae-Hoon (School of Life Sciences and Biotechnology, Korea University) ;
  • Lee, Ki-Ho (Dept. of Biochemistry and Molecular Biology, Eulji University School of Medicine) ;
  • Choi, In-Ho (School of Biotechnology, Yeungnam University) ;
  • Cheon, Yong-Pil (School of Biosciences and Chemistry, Center for NanoBio Applied Technology, Institute of Basic Sciences, Sungshin Women's University)
  • Received : 2011.02.14
  • Accepted : 2011.03.17
  • Published : 2011.03.31
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Abstract

Sex steroid hormones are key molecules to prepare the decidual response and their levels are important in this process. Imbalances of the levels of steroid hormones are cause of implantation failure and other diseases including physical weakness. Androgen replacement therapy or selective androgen receptor modulator are used to overcome various diseases but long-term use may cause of side effects. In previous report, it is suggested that the steroid hormonal complexes derived from pig enhance the proliferation of satellite cell. Therefore, to evaluate the possible usage of steroid hormonal complex derived from pig testis (tS-C), the effects of tS-C on uterine response were studied using the model of artificial decidua. tS-C did not disturb the rhythmical estrus cycle. Artificial-induced decidual response was normally induced in tS-C administered mice. The histological characters of the decidua of tS-C administered mice were not different from the vehicle. The expression patterns of molecular markers of decidua were not different between vehicle and tS-C group. Collectively these results suggested that tS-C does not disturb the uterine responsibility to the embryo. In addition, our results suggested that tS-C can be applied to overcome the various problems such as loss of muscle mass and anemia.

Keywords

References

  1. Bazer FW, Wu G, Spencer TE, Johnson GA, Burghardt RC, Bayless K (2010) Novel pathways for implantation and establishment and maintenance of pregnancy in mammals. Mol Hum Reprod 16:135-152. https://doi.org/10.1093/molehr/gap095
  2. Brosens JJ, Hayashi N, White JO (1999) Progesterone receptor regulates decidual prolactin expression in differentiating human endometrial stromal cells. Endocrinology 140:4809-4820. https://doi.org/10.1210/en.140.10.4809
  3. Carson DD, Bagchi I, Dey SK, Enders AC, Fazleabas AT, Lessey BA, Yoshinaga (2000) Embryo implantation. Dev Biol 223:217-237. https://doi.org/10.1006/dbio.2000.9767
  4. Cheon YP, Lee DM, Chun T, Lee KH, Choi I (2009) Androgen in the uterus a compensator of estrogen and progesterone. Dev Reprod 13:133-143.
  5. Cheon YP, Li Q, Xu X, DeMayo FJ, Bagchi IC, Bagchi MK (2002) A genomic approach to identify novel progesterone receptor regulated pathways in the uterus during implantation. Mol Endocrinol 16:2853-2871. https://doi.org/10.1210/me.2002-0270
  6. Cheon YP, DeMayo FJ, Bagchi MK, Bagchi IC (2004) Induction of cytotoxic T-lmphocyte antigen-2beta, a cysteine protease inhibitor in deciduas: a potential regulator of embryo implantation. J Biol Chem 279:10357-10363. https://doi.org/10.1074/jbc.M309434200
  7. Clark AS, Henerson LP (2003) Behavioral and physiological responses to anabolic-androgenic steroids. Neurosci Biobehav Rev 27:413-436. https://doi.org/10.1016/S0149-7634(03)00064-2
  8. Clark AS, Costine BA, Jones BL, Kelton-Rehkopf MC, Meerts SH, Nutbrown-Greene LL, Penatti A, Porter DM, Yang P, Henderson LP (2006) Sex- and age-specific effects of anabolic androgenic steroids on reproductive behaviors and on GABAergic transmission in neuroendocrine control regions. Brain Res 1126:122-138. https://doi.org/10.1016/j.brainres.2006.08.081
  9. Gellersen B, Brosens IA, Brosens JJ (2007) Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives. Semin Reprod Med 25:445-453. https://doi.org/10.1055/s-2007-991042
  10. Grummer R, Chwalisz K, Mulholland J, Traub O, Winterhager E (1994) Regulation of connexin26 and connexin43 expression in rat endometrium by ovarian steroid hormones. Biol Reprod 51:1109-1116. https://doi.org/10.1095/biolreprod51.6.1109
  11. Grummer R, Reuss B, Winterhager E (1996) Expression pattern of different gap junction connexins is related to embryo implantation. Int J Dev Biol 40:361-367.
  12. Ishak KG, Zimmerman HJ (1988) Drug-induced and toxic granulomatous hepatitis. Bailliere's Clin Gastroenterol 2:463-480. https://doi.org/10.1016/0950-3528(88)90012-7
  13. Ledford BE, Rankin JC, Markwald RR, Baggett B (1976) Biochemical and morphological changes following artificially stimulated deecidualization in the mouse uterus. Biol Reprod 15:529-535. https://doi.org/10.1095/biolreprod15.4.529
  14. Lee DM, Lee KH, Cheon YP, Chun T, Choi I (2010) Effects of anabolic steroids of pork on proliferation and differentiation of myogenic satellite cell. Korean J Food Sci Ani Resour 30:842-850. https://doi.org/10.5851/kosfa.2010.30.5.842
  15. Lukas SE (1993) Current perspectives on anabolic-androgenic steroid abuse. Trends Pharmacol Sci 14:61-68. https://doi.org/10.1016/0165-6147(93)90032-F
  16. Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S, Miyazaki T (2011) Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest 121:318-327. https://doi.org/10.1172/JCI44723
  17. Mustafa R, Hashmi HA (2006) Drug-induced hirsutism. J Coll Physicians Surg Pak 16:485-486.
  18. Ozturk S, Demir R (2010) Particular functions of estrogen and progesterone in establishment of uterine receptivity and embryo implantation 25:1215-1228.
  19. Psychoyos A (1986) Uterine receptivity for nidation. Ann NY Acad Sci 476:36-42. https://doi.org/10.1111/j.1749-6632.1986.tb20920.x
  20. Ramathal CY, Bagchi IC, Taylor RN, Bagchi MK (2010) Endometrial decidualization: of mice and men. Semin Reprod Med 28:17-26. https://doi.org/10.1055/s-0029-1242989
  21. Rockhold RW (1993) Cardiovascular toxicity of anabolic steroids. Annu Rev Pharmacol Toxicol 33:497-520. https://doi.org/10.1146/annurev.pa.33.040193.002433
  22. Witte DP, Wiginton DA, Hutton JJ, Aronow BJ (1991) Coordinate developmental regulation of purine catabolic enzyme expression in gastrointestinal and postimplantation reproductive tracts. J Cell Biol 115:179-190. https://doi.org/10.1083/jcb.115.1.179