• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.4
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• pp.85-94
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• 2011

Purpose: Hominis placenta have used widely for women's disease like climacteric syndrome, dysmenorrhea, infertility, but we don't have enough evidence with it. This study is to investigate efficacy and safety of Hominis Placenta on women by investigating papers. Methods: We searched for papers which had Hominis placenta, placental extract associated with women's disease in the Pubmed and Korean journals. Results: 20 papers were found. 15 papers were associated with menopausal disorder. Hominis placenta could have the efficacy on osteoporosis and climacteric syndrome induced by menopause. And each 2 papers were relevant to postpartum symptoms and menses. 1 papers was relevant to pregnancy. Most of studies have shown that Hominis placenta is useful for female disorders. Conclusions: Hominis placenta could be a good treatment for female disorder like climacteric syndrome, dysmenorrhea, infertility. But evidence is not enough with Hominis placenta, so more research will be needed.

• Journal of Pharmacopuncture
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• v.16 no.3
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• pp.52-57
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• 2013

Objectives: The main purpose of this research is to investigate the effect of treatment with Hominis Placental pharmacopuncture (HPP) for 32 patients with hemifacial spasm. Methods: We treated facial spasm patients with acupuncture and HPP at Sabaek (ST2), Seung-eup (ST1), Gwallyeo (SI18), Chanjuk (BL2), Sajukgong (TE23), Hagwan (ST7), Hyeopgeo (ST6), Jichang (ST4), Wan-gol (SI4) and Yepung (TE17), and we investigated the effect by using Scott's scale. The data were analyzed by using the SPSS/10.0 for windows program with descriptive statistics, the paired t-test, and the Shapiro-Wilk normality test. Results: After treatment, the grade of the spasm's intensity based on Scott's description were decreased significantly. About 72% of the patients felt that the combination treatment had produced excellent results. Conclusion: These data suggested that HPP can be useful for treating facial spasm patients.

• Korean Journal of Acupuncture
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• v.25 no.2
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• pp.87-94
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• 2008

Objectives : The aim of this study was to find out some rationales for using Hominis placental extract(HPE) pharmaco-acupuncture on asthmatic patients, and to suggest an appropriate clinical research of HPE pharmaco-acupuncture on asthma. Methods : Articles regarding immunologic experiments about HPE and clinical reports about HPE-contained pharmaco-acupuncture on asthmatic patients were reviewed by on-line and off-line searching. Results and Conclusions : HPE is suggested to have several pharmacological effects on allergic diseases including asthma as well as autoimmune diseases. There are some observational studies of HPE-contained pharmaco-acupuncture on asthmatic patients. However, the designs of these studies are not sufficient to investigate the exact effect of HPE pharmaco-acupuncture on asthma. To investigate HPE pharmaco- acupuncture as a novel asthma therapy, it will be needed to perform further experiments about HPE's pharmacological mechanism on asthma and to try further advanced clinical researches such as well-designed randomized controlled trial of HPE pharmaco-acupuncture.

• The Journal of Internal Korean Medicine
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• v.38 no.5
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• pp.668-674
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• 2017

Objective: This case report describes the effects of Korean medicine treatment on chronic peroneal nerve palsy. Methods: One patient with peroneal nerve palsy was treated 6 months after onset with various Korean medicine treatments, such as acupuncture, cupping, herbal medicine (Bojungikki-tang and Palmijihwang-tang), and Hominis Placental pharmacopuncture for 14 days. The Manual Muscle Test (MMT), range of motion (ROM) of the ankle, and a numerical rating scale (NRS) were used to evaluate the effectiveness of treatment. Results: After 14 days of treatment, the scores for all 3 scales were improved. The MMT grade increased from 1-3 to 4-4+. The ankle ROM was restored to a nearly normal range. The NRS showed a considerable improvement, decreasing from 7 to 2. No side effects were noted. Conclusions: Korean medicine may be effective for the treatment of chronic peroneal nerve palsy, but further studies are needed.

• Journal of Pharmacopuncture
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• v.15 no.3
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• pp.13-18
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• 2012

Objectives: The purpose of this study is to examine whether Hominis Placental pharmacopuncture solution (HPPS) combined with zinc-oxide nanoparticles (ZnO NP) activates RAW 264.7 cells. Methods: We soaked ZnO nanoparticles in the Hominis Placenta pharmacopuncture solution, thereby making a combined form (ZnO NP HPPS). The effect of ZnO NP HPPS on the intracellular reactive oxygen species (ROS) production was measured by 2', 7'-dichlorofluorescin diacetate (DCFH-DA) assay. The effect of ZnO NP HPPS on NF-${\kappa}B$ was measured by using a luciferase assay. The effect of ZnO NP HPPS on the cytokine expression was assessed by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR). The cellular uptake of ZnO NP HPPS was measured by using a flow cytometric analysis, and cellular structural alterations were analyzed by using transmission electron microscopy (TEM). Results: Neither the HPPS nor the ZnO NPs induced intracellular ROS production in RAW 264.7 cells. Neither of the materials activated NF-${\kappa}B$ or it's dependent genes, such as TNF-${\alpha}$, IL-1, and MCP-1. However, ZnO NP HPPS, the combined form of ZnO NPs and HPPS, did induce the intracellular ROS production, as well as prominently activating NF-${\kappa}B$ and it's dependent genes. Also, compared to ZnO NPs, it effectively increa-sed the uptake by RAW 264.7 cells. In addition, cellular structural alterations were observed in groups treated with ZnO NP HPPS. Conclusions: Neither ZnO NP nor HPPS activated RAW 264.7 cells, which is likely due to a low cellular uptake. The ZnO NP HPPS, however, significantly activated NF-${\kappa}B$ and up-regulated its dependent genes such as TNF-${\alpha}$, IL-1, and MCP-1. ZnO NP HPPS was also more easily taken into the RAW 264.7 cells than either ZnO NP or HPPS.

• The Journal of Internal Korean Medicine
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• v.38 no.2
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• pp.289-300
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• 2017

Objectives: This case report describes the effect of Hominis placenta pharmacopuncture (HPP) on multiple sclerosis. Methods: A multiple sclerosis patient with gait disturbances, tremors, spasms of both lower limbs, and diplopia was treated with only HPP for two weeks. To evaluate the effects of HPP on the balance ability of the patient, the Functional System (FS) scale, Expanded Disability Statue Scale (EDSS), visual analog scale (VAS), manual muscle test (MMT), and Berg Balance Scale (BBS) were used. Results: The HPP treatment reduced the patient's gait disturbance, tremors, spasms of the lower limbs, and diplopia. According to the FS scale, the patient's cerebellar and optic functions were enhanced. In addition, the patient's performance on the EDSS improved from 4.0 to 3.0.3. As shown by the MMT, the lower extremities showed a mild improvement (from F+ to G.4). Furthermore, the VAS showed a considerable improvement, decreasing from 9 to 6.5 post-treatment. The patient's performance on the BBS, which denotes balance ability, showed a considerable improvement, increasing from 38 to 49. Conclusion: Treatment with only HPP could help to ameliorate the symptoms of multiple sclerosis.

• Journal of Pharmacopuncture
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• v.3 no.2
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• pp.191-212
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• 2000

Objective: This study was perfomled to examine the therapeutic effect of aqua-acupuncture solution of Hominis Placenta(HP) on kidney and liver intoxicated by $HgCI_2$ in rats. Methods: $10\%$ and $25\%$ HP aqua-acupuncture were carried out everyday for 8 days on corresponding bilateral loci of Shinsu(BL23) and Kansu(BL18), respectively, after mercuric chloride intoxication in rats. Thereafter BUN, creatinine, GOT, GPT, ALP, ${\gamma}$-GT, albumin and total bilirubin were measured before intoxication, and at the 4th and the 8th experimental day. Histopathological and immunochemical observation were also carried out. Results: 1. It showed significant decreases of BUN in the group of $10\%$ HP aqua-acupuncture into Shinsu on the 4th experimental day as compared with the control group. 2. It showed significant decreases of creatinine in the group of $10\%$ HP aqua-acupuncture into Shinsu on the 4th and the 8th experimental days as compared with the control group. 3. There were not any significant changes of GOT, GPT, ALP,${\gamma}$-GT, albumin and total bilirubin in the HP aqua-acupuncture groups compared with the control group. 4. By the histopathological observations on kidney under a light microscope, alt the $10\%$ and $25\%$ HP aqua-acupuncture into Shinsu showed the preventive effect on tubulo-interstitial necrosis and muItifocal calcification in tubular lumen respectively compared with the control group. 5. By the histopathological observations on liver under a light mIcroscope, the groups $10\%$ and $25\%$ HP aqua--acupuncture into Kansu did not show any significant changes in the liver compared with the control group. 6. By the immunochemical analysis of heat shock protein(hsp) and glucose-regulated protein(grp) in rat renal cortex, the expressions of hsp70 and grp78 were decreased in the $10\%$ and $25\%$ HP aqua-acupuncture into Shinsu respectively compared with the control group. Conclusion: These results suggest that Hominis Placenta aqua-acupuncture have an effect on prevention and protection of renal intoxication by $HgCI_2$ in rats.

• Journal of Korean Medicine Rehabilitation
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• v.26 no.4
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• pp.127-136
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• 2016

The purpose of this study is to report a clinical progress of fibromyalgia syndrom patient treated by Korean Medicine treatment. The patient was treated with acupuncture, acupotomy, pharmacopuncture (Bee venom, Hwangryun, Hominis Placental), herbal medicine, moxibustion, cupping treatment. We measured Visual Analogue Scale (VAS), American College of Rheumatology Preliminary Diagnostic Criteria (ACR, 2010), Fibromyalgia Impact Qustionnaire (FIQ), and observed the change in body temperature using Digital Infrared Thermal Imaging (DITI). After Korean Medicine treatment, pain was controlled and VAS, ACR, FIQ were decreased. The result showed that Korean Medicine treatment is effective in fibromyalgia syndrome.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.3
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• pp.119-133
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• 2017

Objectives : This study is designed for analysis of trend and curative effect of Korean medicine for idiopathic external ophthalmoplegia. Methods : Research studies related to objectives were gathered through OASIS and KTKP and analyzed. Results : 21 case reports were selected. 5 korean medicine therapies, Herb, acupuncture, moxibustion, electroacupuncture, and pharmacopuncture, were executed. Restorative herb including Bojungikki-tang was frequently used in herb therapy. Facial and cephalic acupoints and non-facial, non-cephalic acupoints which individually differ were mostly simultaneously executed as acupuncture therapy. Also, moxibustion was partly performed. Electroacupuncture was carried out to affected area with electric stimulation at the strength of 1Hz and 4Hz. Hominis placental pharmacopuncture, 0.1cc or 0.5cc for each acupoint, was injected on disease area. After analyzing number of Korean medicine treatment and period of Korean medicine treatment from 21 case reports, the recovery period of idiopathic external ophthalmoplegia, 36.6 treatment session/36.69 days, was assessed to be more than one month shorter than previously known recovery period. Number of treatment sessions and treatment period for 11 cases when pharmacopuncture or electroacupunture was applied were 10/29, 35/29.96, which was 15 days shorter in terms of treatment period and 10 times less in terms of number of treatment sessions compared to cases when pharmacopuncture or electroacupunture was not applied. Conclusions : Korean medicine treatment can be effective for recovery of idiopathic external ophthalmoplegia.