• 약학회지
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• 제43권2호
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• pp.150-159
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• 1999

Hollow type suppositories inserted polyvinyl alcohol (PVA) hydrogel capsule containing propranolol·HCI (PPH) were prepared using different bases, polyethylene glycol (PEG), Witepsol H-15 (WH-15) and Witepsol W-35 (WW-35) to improve the controlled release of PPH. The release of PPH from the hollow type suppository inserted PVA hydrogel capsule was retarded than that from PEG, WH-15, or WW-35 hollow type suppositories in rat rectal cavity. When the suppositories were administered to rats, the controlled release of PPH was proved by the plasma concentration-time-profiles of PPH. No significant difference (p〈0.05) among the three different hollow type suppositories was observed in terms of AUC and MRT of PPH. WH-15 hollow type suppository inserted 12% of PVA hydrogel capsule caused irritation to rat rectal mucosa. However, the WH-15 hollow type suppository inserted PVA hydrogel capsule caused no severe irritation on rectal mucosa. The application of the hollow type suppositories using PVA in sustained rectal delivery of drugs might be feasible.

• 약학회지
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• 제35권3호
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• pp.197-202
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• 1991

In order to study drug release from the suppository, three types of hollow suppositories and one conventional suppository were prepared using indomethacin(IDM) as a model drug and Witepsol H-15 as a base. The 4 types of suppository prepared are as follows: type I, conventional suppository containing 50 mg of IDM powder, type II, hollow supository containing 50 mg of IDM powder in the cavity, type III, hollow suppository containing 25 mg of IDM powder in the base and IDM microcapsules (25 mg as IDM powder) in the cavity, and type IV, hollow suppository containing IDM microcapsules (25 mg as IDM powder) in the base and 0.5 ml of 5%(w/v) IDM-PEG 300 solution in the cavity. The drug amount released(%) from type II and I within 24 hrs was 46.7% and 66.9%, respectively. Comparing with the drug amount released from four types of suppository within initial 2 hrs and 24 hrs, that of type IV was high as 32.7% and 76.6%, respectively. IDM-ethycellulose microcapsules passed through 270 mesh sieve and the IDM content was 20.95%.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2010년도 춘계 학술대회 제22권1호
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• pp.31-32
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• 2010

본 연구는 중공 형성체의 형상이 중공 슬래브의 휨 성능에 미치는 영향에 관하여 살펴보기 위하여 실험적 연구를 수행하였다. 사전 해석적 연구를 통하여 도출한 최적 중공 형성체 형상인 도넛형 중공형성체를 적용한 중공 슬래브의 일방향 휨 성능 평가를 수행하였다. 그리고 이를 통하여, 중공 형성체의 형상이 중공 슬래브에 미치는 영향을 확인하고, 그 성능을 파악하였다.

• 한국임상약학회지
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• 제8권2호
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• pp.143-146
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• 1998

Acetaminophen (APAP) suppositories with active ingredients, i.e., polyethylene glycol (PEG), Witepsol H-15 (WH), were prepared for hospital use and investigated on their drug release characteristics and pharmacokinetics. WH was employed as oil-soluble base with an aim of reducing fragility and mucosa irritancy that are common drawbacks found in PEG suppositories. Also hollow type suppository was tried as compared with conventional type suppository. Drug release tests revealed that in most formulations, more than $80\%$ of loaded APAP were released within 20 minutes, except for APAP-WH hollow type suppositories. Significant differences in the plasma concentration profile were observed among four type suppositories. $T_{max}$ of APAP-PEG and APAP-WH suppositories were 90 and 60 minutes, respectively, in hollow types. APAP-WH hollow type suppositories demonstrated fast absorption rates of APAP as compared with those of APAP-PEG suppositories. No burst effect was observed from APAP-WH suppository in contrast to APAP conventional type suppository, whereas AUCs of all the suppositories were similar. APAP-WH hollow type suppository may be an useful dosage form for hospital use.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 춘계학술발표회논문집(2)
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• pp.427-432
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• 1998

중수속의 삼중수소 제거 공정인 액상 촉매 교환 반응에서 중수의 촉매 표면 응축에 의한 성능 저하가 큰 문제의 하나로서 성능 저하를 감소시키기 위한 여러 가지 형태의 촉매탑이 고안 되었다. 본 연구에서는 membrane을 사용하여 중수와 촉매를 분리시킴으로써 촉매 성능 저하를 감소시킬 수 있는 촉매탑의 설계를 시도하였다. 세 가지 촉매탑이 고안되었는데 sheet type의 membrane을 사용한 multilayered type 과 double spiral type, hollow fiber membrane을 사용한 hollow fiber cartridge type 등이다. multilayered type은 구조가 단순하여 scale-up이 용이하고 double spiral type은 다른 type보다 유로의 blocking 문제가 작고 hollow fiber cartridge type은 최대의 비표면적을 가질 수 있다.

• 콘크리트학회논문집
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• 제25권2호
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• pp.155-163
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• 2013

이 연구는 도넛형 이방향 중공슬래브에 매입된 이형철근의 부착특성 및 부착강도 산정을 위한 기초적인 연구이다. 도넛형 이방향 중공슬래브의 철근 부착특성 및 부착강도 산정을 위해 pull-out test를 수행하였다. 도넛형 중공형성체는 슬래브 내부에 배치되어 철근과 중공형성체 사이에 내부의 피복이 형성된다. 이러한 내부피복두께는 외부피복두께보다 상대적으로 작은 피복두께를 가지며 중공형상에 따라 $2.5d_b$보다 작은 내부피복두께가 형성되기 때문에 철근의 부착에 영향을 미치게 된다. 또한 중공형성체가 일정 간격으로 떨어져 배치되어 있으므로 인장철근을 감싸고 있는 피복두께의 조건이 철근의 길이방향으로 변하게 된다. 따라서 도넛형 이방향 중공슬래브의 부착특성을 알아보기 위해서 중공형성체 형상에 따라 부착구간을 구분하였다. 구간별로 내부피복두께에 따른 부착응력-슬립 관계를 확인하였으며, 중공형성체 전 구간에 걸친 부착응력분포를 확인하여 철근의 길이방향에 따른 부착응력의 발현정도를 확인하였다. 또한 구간별 부착응력-슬립 관계를 기반으로 하여 도넛형 중공슬래브의 부착강도를 산정할 수 있는 부착강도 산정 방법을 제안하였다.

• 한국환경보건학회지
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• 제27권3호
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• pp.27-34
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• 2001

This paper discussed the shape effect of ceramic support carrier in order to facilitate biomass immobilization. The shape of ceramic support carrier was modified hollow pipe type into hollow gear type. After seeding, microorganisms were attached in crevices where protection from shear forces or surfaces where easy to contact with support carrier surface. In case of hollow gear type carrier, initial attachment rate was faster than that of hollow pipe type and obtained thick biofilm. Synthetic wastewater(COD:75~880 mg/L, organic loading rate:0.36~4.22 kgCOD/㎥.d) was treated aerobic fixed bed biofilm reactor where 100% of the volume was filled with the ceramic carrier. COD removal efficiency of reactor filled with gear type support carrier was a little high withing 70 days, and then showed similar removal efficiency. It was found that highly loaded operation with up to 4.22 kgCOD/㎥.d was possible in both reactor. Total biomass amounts of pipe type was higher than gear type, however, attached biomass of gear type was higher than that of pipe type.

• Journal of Chest Surgery
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• 제25권5호
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• pp.451-457
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• 1992

The hollow fiber oxygenator is the most advanced one for the cardiopulmoanry bypass. They have two different types of the hollow fiber systems according to the way how the blood go through the fibers. One is inside blood flow type and the other outside type. In order to find out which is better to prevent blood cell destruction, we selected 40 valve replacing patients and divided them into 2 groups prospectively. In group I [n=20], inside blood flow type[BCM-7a], CO2 excretion is more effective than group II, that is partly because of the relative large surface area of the BCM-7. In group II [n=20], outside blood flow type [MAXIMAa], they have better quality to preserve platelet count. We also studied about several other items such as SaO2, Hemoglobin and RBC, WBC, fibrinogen, LDH, plasma hemoglobin, haptoglobulin and so on. But we cannot find any differences between two groups with any statistical meanings [p<0.05]. We conclude that both of two oxygenators are excellent in the aspects of gas exchange and blood cell preservation.

• 한국가스학회지
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• 제20권3호
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• pp.73-77
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• 2016

본 연구에서는 여러 가지의 절단면 형상을 구비한 중공축이 동등한 최적을 갖는 경우에 대한 변위거동 안전성을 유한요소법으로 해석하였다. FEM 해석결과에 의하면, 외측튜브, 중간튜브, 내측튜브와 이들 튜브 사이를 연결하기 위해 X-타입 또는 Y-타입의 칼럼을 설치하였을 때 중공축 길이의 중간부에서 발생하는 최대 변위량을 줄여주는 것으로 나타났다. 특히, 하중을 지지하기 위해 구비된 X-타입 또는 Y-타입의 칼럼을 위상차 없이 외측튜브와 내측튜브를 중심축을 향해 직접 연결하면 중공축의 변위량을 줄이는 효과가 있는 것으로 나타났다. 그리고 동등한 체적을 갖는 중공축에서 발생하는 수직 변위량을 줄여주고, 변위거동 안전성을 높이기 위해서는 하중을 지지하기 위한 칼럼의 두께를 두껍게 설계하는 것이 바람직함을 알 수 있다.

• 반도체디스플레이기술학회지
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• 제11권2호
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• pp.23-26
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• 2012

The monodispersed polystyrene spheres were prepared by emulsion polymerization in aqueous alcohol system. They coated with silver by reduction of silver ion percolated on the surface of them. The spherical hollow type silver has been prepared by dissolving polystyrene with toluene. Epoxy resin compositions with spherical hollow type silver were manufactured, which were composed of a bisphenol F type epoxy resin (RE-304S), amine type hardener (Kayahard AA), and 1-benzyl 2-methyl imidazole (1B2MI) as catalyst. The electrical conductivity with silver content ratio were investigated after cure, the percolation threshold weight ratio for conductance in this epoxy resin system was obtained above the 70 wt% of silver.