Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 8 Issue 2
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- Pages.143-146
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- 1998
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Rectal Absorption of Acetaminophen from Polyethylene Glycol and Witepsol Suppositories
아세트아미노펜의 Polyethylene glycol 및 Witepsol 좌제의 직장흡수 - 병원제제를 목적으로 한 아세트아미노펜좌제의 조제 및 유용성 검토-
- Lee, Hye Suk (College or Pharmacy, Ewha Womans University, Department or Pharmacy, Seoul National University Hospital) ;
- Jin, Sun Kyung (College or Pharmacy, Ewha Womans University) ;
- Choi, Jung Hwa (College or Pharmacy, Ewha Womans University) ;
- Ku, Young Soon (College or Pharmacy, Ewha Womans University)
- Published : 1998.12.01
Abstract
Acetaminophen (APAP) suppositories with active ingredients, i.e., polyethylene glycol (PEG), Witepsol H-15 (WH), were prepared for hospital use and investigated on their drug release characteristics and pharmacokinetics. WH was employed as oil-soluble base with an aim of reducing fragility and mucosa irritancy that are common drawbacks found in PEG suppositories. Also hollow type suppository was tried as compared with conventional type suppository. Drug release tests revealed that in most formulations, more than
Keywords
- Acetaminophen;
- Suppository;
- Polyethylene glycol;
- Witepsol H-15;
- Drug release;
- AUC;
- Hollow type;
- Hospital use