• Journal of the Korea Convergence Society
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• v.12 no.2
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• pp.173-177
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• 2021

In this study, the torsional rigidity and durability of the stabilizer models with the hollow axis of light and large sized cars were compared and investigated each other. Model 1 was applied with the moment more than three times as much as model 2, but the maximum deformation of model 1 was seen to be about 2.6 times larger than that of model 2. Commonly, models 1 and 2 are seen to get the most stress at the neck of stabilizer bar link. Also, the maximum stress of model 1 was about 2.9 times larger than that of model 2. Model 1 at large car showed more than 20 times more deformed energy than model 2 at small car. Overall, it could be examined that the deformation energy of the bracket part on the side where the moment fixing the stabilizer bar was applied was greater than that of the stabilizer. It is thought that the analysis results in this study can be helped at the design of its convergent research as a durable component of the stabilizer at a light or large sized car.

• Journal of the Korea Institute of Military Science and Technology
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• v.24 no.2
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• pp.211-218
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• 2021

This paper deals with the computational work to characterize the formation and pinching of a plasma in an X-pinch configuration. A resistive magnetohydrodynamic model of a single fluid and two temperature is adopted assuming a hollow conical structure in the (r,z) domain. The model includes the thermodynamic parameter of tungsten from the corrected Thomas-Fermi EOS(equation of state), determining the average ionization charge, pressure, and internal energy. The transport coefficients, resistivity and thermal conductivity, are obtained by the corrected Lee & More model and a simple radiation loss rate by recombination process is considered in the simulation. The simulation demonstrated the formation of a core-corona plasma and intense compression process near the central region which agrees with the experimental observation in the X-pinch device at Seoul National University. In addition, it confirmed the increase in radiation loss rate with the density and temperature of the core plasma.

• BMB Reports
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• v.55 no.4
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• pp.175-180
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• 2022

Peptides are gaining substantial attention as therapeutics for human diseases. However, they have limitations such as low bioavailability and poor pharmacokinetics. Periostin, a matricellular protein, can stimulate the repair of ischemic tissues by promoting angiogenesis. We have previously reported that a novel angiogenic peptide (amino acids 142-151) is responsible for the pro-angiogenic activity of periostin. To improve the in vivo delivery efficiency of periostin peptide (PP), we used proteins self-assembled into a hollow cage-like structure as a drug delivery nanoplatform in the present study. The periostin peptide was genetically inserted into lumazine synthase (isolated from Aquifex aeolicus) consisting of 60 identical subunits with an icosahedral capsid architecture. The periostin peptide-bearing lumazine synthase protein cage nanoparticle with 60 periostin peptides multivalently displayed was expressed in Escherichia coli and purified to homogeneity. Next, we examined angiogenic activities of this periostin peptide-bearing lumazine synthase protein cage nanoparticle. AaLS-periostin peptide (AaLS-PP), but not AaLS, promoted migration, proliferation, and tube formation of human endothelial colony-forming cells in vitro. Intramuscular injection of PP and AaLS-PP increased blood perfusion and attenuated severe limb loss in the ischemic hindlimb. However, AaLS did not increase blood perfusion or alleviate tissue necrosis. Moreover, in vivo administration of AaLS-PP, but not AaLS, stimulated angiogenesis in the ischemic hindlimb. These results suggest that AaLS is a highly useful nanoplatform for delivering pro-angiogenic peptides such as PP.

• The Journal of the Acoustical Society of Korea
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• v.41 no.5
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• pp.501-506
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• 2022

Echogenic liposome contains both liquid and gas inside the shell. In ultrasound mediated drug delivery, sonoporation, these new microbubbles can be an attractive drug carrier since they can be loaded water soluble drugs and drug molecules can be unloaded at the specific location with ultrasound sonication. In this paper, the structure of the echogenic liposome was confirmed with EF-TEM and the positive effect of sonoporation with echogenic liposome was comparatively evaluated on MDA-MB-231 cells which is a type of breast cancer cell with Doxorubicin. Control group (Group 1), Doxorubicin only (Group 2), sonoporation with Doxorubicin and hollow microbubbles (Group 3), sonoporation with Doxorubicin loaded echogenic liposome (Group 4) were classified and experiments were conducted. According to the results, Group 4 is at least 1.4 times better in inducing necrosis of cancer cells. Therefore, we conclude echogenic liposome could be one of the most useful form of microbubbles in sonoporation.

• Steel and Composite Structures
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• v.44 no.1
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• pp.33-47
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• 2022

This paper presents a finite element model for predicting the monotonic behaviour of bolted endplate joints connecting steel-concrete composite walls and steel beams. The demountable Hollo-bolts are utilised to facilitate the quick installation and dismantling for replacement and reuse. In the developed model, material and geometric nonlinearities were included. The accuracy of the developed model was assessed by comparing the numerical results with previous experimental tests on hollow/composite column-to-steel beam joints that incorporated endplates and Hollo-bolts. In particular, the Hollo-bolts were modelled with the expanded sleeves involved, and different material properties of the Hollo-bolt shank and sleeves were considered based on the information provided by the manufacture. The developed models, therefore, can be applied in the present study to simulate the wall-to-beam joints with similar structural components and characteristics. Based on the validated model, the authors herein compared the behaviour of wall-to-beam joints of two commonly utilised composite walling systems (Case 1: flat steel plates with headed studs; Case 2: lipped channel section with partition plates). Considering the ease of manufacturing, onsite erection and the pertinent costs, composite walling system with flat steel plates and conventional headed studs (Case 1) was the focus of present study. Specifically, additional headed studs were pre-welded inside the front wall plates to enhance the joint performance. On this basis, a series of parametric studies were conducted to assess the influences of five design parameters on the behaviour of bolted endplate wall-to-beam joints. The initial stiffness, plastic moment capacity, as well as the rotational capacity of the composite wall-to-beam joints based on the numerical analysis were further compared with the current design provision.

• Journal of Biomedical Engineering Research
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• v.42 no.6
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• pp.251-258
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• 2021

Hyaluronic acid (HA) microspheres (MSs) crosslinked with polyethylene glycol diglycidyl ether (PEGDE) are prepared using a simple fluidic device (SFD) to investigate the optimized parameters. A solution mixture of PEGDE in 2-methyl-1-propanol was prepared as a continuous phase in SFD. HA solutions of 1 wt% concentration were introduced into SFD as a discontinuous phase. The HA solution prepared by stirring for more than 48 h exhibited spherical MSs at the needle tip inside the ring cap. As the flow rate of the continuous phase increased from 0.7 to 1.9 mL/min, the diameter of the MS decreased from 173±36 ㎛ to 129±13 ㎛. Although the PEGDE concentration in the range of 0.2 to 1.8 vol% did not affect the diameter of the MS, the microstructure of MS, consisting of inner hollow void and wall, was changed. The inner void and wall size decreased and increased from 79.5 ㎛ to 57.2 ㎛ and from 10.3 ㎛ to 21.4 ㎛, respectively, with increasing PEGDE concentration from 0.2 vol% to 1.8 vol%. FT-IR peaks located around 2867 cm^-1 and 1088 cm^-1 indicated that the HA MS prepared at different PEGDE concentrations were chemically crosslinked. The HA MSs containing different PEGDE concentrations exhibited quantitative cell viability of more than 98%. L-929 cells adhered well to the HA MSs and proliferated continuously with increasing culture time to 48 h regardless of PEGDE concentration, implying that the HA MSs are clinically safe and effective.

• Tunnel and Underground Space
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• v.32 no.4
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• pp.243-253
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• 2022

In this study, the cutting efficiency of TBE (Tunnel Boring Extender) was evaluated by using rotary cutting tester. In the rotary cutting test, a specimen which has a drilled hollow hole at the center was made of rock-like material. The specimen was cut by UDC (undercutting disc cutter) with spiral cutting path to simulate the cutting process of TBE. The cutting forces and specific energy were evaluated under different cutting conditions. The results indicated that the cutter forces of UDC linearly increased with the vertical and radial penetration depths. Among the three directional cutter forces, the normal force is larger than other force components. While the specific energy decreased with the two penetration depths, in particular, it was presumed that the specific energy was minimized at a certain value of the ratio of radial to vertical penetration depth.

• Journal of Aerospace System Engineering
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• v.17 no.4
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• pp.43-57
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• 2023

The hypervelocity impact simulations of space objects and structures are performed using LS-DYNA. Space objects with spherical, conical, and hollow cylindrical shapes are modeled using the Smoothed Particle Hydrodynamics (SPH). The direct and indirect impact zones of a space structure are modeled using the SPH and finite element methods, respectively. The Johnson-Cook material model and Mie-Grüneisen Equation of State are used to represent the nonlinear behavior of metallic materials in hypervelocity impact. In the hypervelocity impact simulations, various impact conditions are considered, such as the shape of the space object, the thickness of the space structure, the impact angle, and the impact velocity. The shapes of debris clouds are quantitatively classified based on the geometric parameters. Conical space objects provide the worst debris clouds for all impact conditions.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.4
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• pp.11-22
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• 2023

In this study, a structural concrete square beam was developed using the centrifugal molding technique. In order to secure the bending stiffness of the cross section, the hollow rate of the cross section was set to 10% or less. Instead of using the current poor mixture of concrete, a special formwork for producing a centrifugal square beam was manufactured, and a concrete mixing ratio with a high slump (150-200) and a design strength of 100 MPa or more was developed and applied. The produced centrifugally formed rectangular beams were subjected to performance tests according to the standard bending and shear test standards for centrifugally formed members. The static load test results for the four specimens exceeded both the nominal bending strength and nominal shear strength, which are design values through structural design, proving the structural reliability of the ultra-high-strength centrifugally formed square beam.

• Steel and Composite Structures
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• v.42 no.1
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• pp.91-106
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• 2022

Concrete-filled square stainless steel tubes (CFSSST), which possess relatively large flexural stiffness, high corrosion resistance and require simple joint configurations and low maintenance cost, have a great potential in constructional applications. Despite that the use of stainless steel may result in high initial cost compared to their conventional carbon steel counterparts, the whole-life cost of CFSSST is however considered to be lower, which offers a competitive choice in engineering practice. In this paper, a comprehensive experimental and numerical program on 24 CFSSST stub column specimens, including 3 austenitic and 3 duplex stainless steel square hollow section (SHS) stub columns and 9 austenitic and 9 duplex CFSSST stub columns, has been carried out. Finite element (FE) models were developed to be used in parametric analysis to investigate the influence of the tube thickness and concrete strength on the ultimate capacities more accurately. Comparisons of the experimental and numerical results with the predictions made by design guides ACI 318, ANSI/AISC 360, Eurocode 4 and GB 50936 have been performed. It was found that these design methods generally give conservative predictions to the ultimate capacities of CFSSST stub columns. Improved calculation methods, developed based on the Continuous Strength Method, have been proposed to provide more accurate estimations of the ultimate resistances of CFSSST stub columns. The suitability of these proposals has been validated by comparison with the test results, where a good agreement between the predictions and the test results have been achieved.