• Journal of Ginseng Research
• /
• v.46 no.6
• /
• pp.750-758
• /
• 2022

Background: Mild cognitive impairment (MCI) is a transitional condition between normality and dementia. Ginseng is known to have effects on attenuating cognitive deficits in neurogenerative diseases. Ginsenosides are the main bioactive component of ginseng, and their protein targets have not been fully understood. Furthermore, no thorough analysis is reported in ginsenoside-related protein targets in MCI. Methods: The candidate protein targets of ginsenosides in brain tissues were identified by drug affinity responsive target stability (DARTS) coupled with label-free liquid chromatography-mass spectrometry (LC-MS) analysis. Network pharmacology approach was used to collect the therapeutic targets for MCI. Based on the above-mentioned overlapping targets, we built up a proteineprotein interaction (PPI) network in STRING database and conducted gene ontology (GO) enrichment analysis. Finally, we assessed the effects of ginseng total saponins (GTS) and different ginsenosides on mitochondrial function by measuring the activity of the mitochondrial respiratory chain complex and performing molecular docking. Results: We screened 2526 MCI-related protein targets by databases and 349 ginsenoside-related protein targets by DARTS. On the basis of these 81 overlapping genes, enrichment analysis showed the mitochondria played an important role in GTS-mediated MCI pharmacological process. Mitochondrial function analysis showed GTS, protopanaxatriol (PPT), and Rd increased the activities of complex I in a dose-dependent manner. Molecular docking also predicted the docking pockets between PPT or Rd and mitochondrial respiratory chain complex I. Conclusion: This study indicated that ginsenosides might alleviate MCI by targeting respiratory chain complex I and regulating mitochondrial function, supporting ginseng's therapeutic application in cognitive deficits.

• Journal of The Korean Association For Science Education
• /
• v.42 no.4
• /
• pp.449-475
• /
• 2022

The purpose of this study is to critically examine science content and science education from the 'essential-holistic' perspective, in particular, among the core disciplines constituting the teacher education curriculum. In this study, we first, analyzed the definition of the 'essential-holistic' perspective, the philosophical background, and the relationship with the practices in-depth, and then, from the 'essential-holistic' perspective, conducted an inquiry into the essence of science content and science education. The results of this study are as follows: first, according to the 'essential-holistic' perspective, science content is a study that explores the science practices and systematizes the results of that inquiry. Major activities of science content include the establishment and implementation of 'science for teachers' and participation in the development of science curriculum (textbook). Second, science education according to the 'essential-holistic' perspective is a study about in-depth exploration of essential problems in science education phenomena rooted in the science practices and the practice of good teaching. More specifically, science education is a field that carries out work related to inviting, participating, and guiding students to grow into science practices (i.e. initiating into practices). The main activities of science education related to this include activities ranging from the development of the science curriculum (textbook) to teaching and evaluation (recording). In this study, we discussed important tasks to be carried out in the future based on the results of the study.

• Research in Community and Public Health Nursing
• /
• v.27 no.1
• /
• pp.60-71
• /
• 2016

Purpose: This study was to present education and holistic care of Elizabeth J. Shepping (1880~1934), a nursing missionary and a founder of the Chosun Nursing Association who visited Korea during the Japanese colonial period. Methods: Primary and secondary sources were collected and analyzed. Results: This study provides important implications regarding Shepping's holistic nursing as follows: First, she came to Korea after studying nursing and bibliology and being trained for nursing missionary works. Second, she cared for many Koreans, especially Korean women, to protect them from poverty, oppression, ignorance, and illnesses. Third, she continued to spread holistic care in hospitals and other local communities. She trained nurses, developed nursing education, and produced a large number of domestic nursing leaders by establishing women's Bible school. Fourth, she founded the Chosun Nursing Association, serving as its first president for 10 years and applied to join the International Council of Nurses (ICN). Conclusion: Finally, suggestions were provided for future research, and it will be necessary to study thoroughly nursing achievements by nurses from other countries who practiced their nursing activities in Korea, and such studies are expected to lead to analysis of nursing missionaries' experiences.

• Journal of Industrial Convergence
• /
• v.13 no.3
• /
• pp.57-76
• /
• 2015

The purpose of this paper is to examine the moderate effects of self monitoring and the ways of thinking on the relationships and the moderate effects of brand credibility and brand attachment on the relationships between the negative information about a brand and the customer attitude holistic and analytic on the relationships between the negative information about a brand and customer attitude. To accomplish these purposes, this research divided negative information about a brand into corporate ability and corporate social responsibility. In addition, research also divided product type into functional product and symbolic product. participants are classified as having Low or High self monitoring. and the ways of thinking divided into holistic and analytic on the relationships between the negative information about a brand and customer attitude. The following are the summary of hypothesis test: (1)the consumers with low(high) level of self monitering are more likely to reveal high level of preference for negative information of corporate ability. (2)the consumers with analytic(holistic) ways of thinking are more likely to reveal high level of preference for negative information of corporate ability. (3)the consumers with low(high) level of self monitering are more likely to reveal high level of preference for functional product. (4)the consumers with analytic(holistic) ways of thinking aren't more likely to reveal high level of preference for functional(symbolic) product.

• Journal of the Daesoon Academy of Sciences
• /
• v.19
• /
• pp.1-20
• /
• 2005

In spite of the ethics of sangsaeng is based on Daesoon thoughts, we can regard it as a moral theory independent on religion. Like other reasonable moral theories, It has three levels, moral standard, moral rules and moral acts or judgements. Sangsaeng is moral standard in the ethics of sangsaeng. moral rules are derived from it and could justify many particular moral judgements and acts. The ethics of sangsaeng belongs to metaphysical ethics and holistic ethics because it is derived holistic, sangsaeng's world view of Daesoon thoughts. The ethics of sangsaeng, first of all, extends the realm of moral community to all beings of world. Therefore it might works well on as a solution for environmental problem recently issued. Secondly, because beings are fundamentally all equal in holistic world, the principle of equality is basic principle in the ethics of sangsaeng. Finally, in relation to the principle of equality, the ethics of sangsaeng needs 'Haewon' as the first moral rule because it is a practical method for solution to various social inequality - racism, sexism, regionalism and so on.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.31 no.4
• /
• pp.25-38
• /
• 2003

The main problems of disordered and congested urban landscape are due to the lack of holistic management that can control various elements of forming a city. Especially, the color of urban landscape is problematic because it is related to individual and social characteristics as well as to physical characteristics. Therefore, temporary expedients that can solve only visualized problems can not be a proper solution for color problems of urban landscape. This study originated from the question about why the color of disordered and congested urban landscape has not been improved. This study aims at directly improving the urban environmental color by finding out what the actual problems related to color are, and what the solutions would be. The goal of this study is to find a holistic systematic problem-solving method. Problems of urban environmental color are identified from both literature review and questionnaires to the expert group, such as environmental planning, design group, and the landscape executive group. Through mapping of relationships among these problems, the intellectual map was made to layout the structures of problems. Based on this method, the structures of problems of urban environmental color were classified into 5 categories: 1) the items related to the administrative structure, 2) the items related to the color management goal and system, 3) the items related to the color planning and design phase, 4) the items related to the color consulting committee, and 5) the items related to the present state of color use. Thus, in order to solve the color problem in urban landscape, practical strategy is strongly required. It is not a temporary expedient but a holistic approach. The solution for the problems of urban environmental color could be divided into 6 types; ‘regulations amendment’,‘color standard amendment’,‘color management plan’,‘color education’, and ‘advertisement for the goal of color management’. Regulations amendment among these types was proposed as the most effective method due to the close relationship with problem categories. Thus, as the solution for the problems of urban environmental color, the ‘color management system’ was suggested. Detailed contents the suggested color management system were divided into three parts; 1) legislation by regulations, ordinance and acts, 2) management by controling the level of guidelines, and 3) the standards for execution of this system.

• Journal of Korea Multimedia Society
• /
• v.18 no.7
• /
• pp.834-842
• /
• 2015

We propose a method to construct composite feature vector based on discriminant analysis for face recognition. For this, we first extract the holistic- and local-features from whole face images and local images, which consist of the discriminant pixels, by using a discriminant feature extraction method. In order to utilize both advantages of holistic- and local-features, we evaluate the amount of the discriminative information in each feature and then construct a composite feature vector with only the features that contain a large amount of discriminative information. The experimental results for the FERET, CMU-PIE and Yale B databases show that the proposed composite feature vector has improvement of face recognition performance.

• Archives of design research
• /
• v.20 no.2 s.70
• /
• pp.65-76
• /
• 2007

The primary purpose of this study was to evolve integrated design process for Experiential Design which is based on the former study, 'The Influence of Cognitive Factors on the Creative Abilities in Design'. Experience is a transformation factor to all of the design processes, which has three phase of problem solving; Input, Process, and Output. We regard Experiential Design is a transforming process from concept to experience, and set up a mode) of Holistic Design Process (HDP), which consists of four domains: Four Causes, Thinking Modes, Sensory Modalities, and Creative Abilities. Revolving Sensory Modalities (SM), Creative Abilities (CA), and Thinking Modes (TM) around Product Design Specification (PDS) through a design process, Design Concepts ripen and mature into Externalization. Each component of Experiential Design (TM, SM, and CA) turns around the PDS. Here, experience is first perceived by the five senses. Then, the knowledge is formed, and the CA works for a problem solving. And TM controls all of these procedures. We regard these are a phenomenon of Experiential Design. The HDP can be helpful to develop valuable solutions and create a good experience.

• Journal of The Korea Institute of Healthcare Architecture
• /
• v.13 no.3
• /
• pp.47-55
• /
• 2007

The theme of this study is holistic healing environment of children's library and it was researched on the basis of anthroposophy theory of Rudolf Steiner. According to Steiner's theory, human being consists of body, spirit, and soul. Especially, children are sensitive ones, and through synthetic function of 12 kinds of senses, they can be holistically healed (healing of body, spirit, and soul). As the sense independently functions or it is a element that cannot be described, it needs spatial plan to support synthetic function of it. We classified the healing space's meaning of children library by motion (including art and music), reading, & landscape healing activities and analyzed spatial characteristic to support each activity.

• Journal of Information Technology Applications and Management
• /
• v.28 no.5
• /
• pp.1-16
• /
• 2021

This paper attempts to explore the need and importance of values integration in educational activities to mitigate learning crisis and promote sustainable learning achievement. The traditional approach, commercial motive, focus on instrumental knowledge coupled with many other contemporary issues have collectively smothered the fundamental humanistic principles of education. To avert the situation and execute the core objectives, we need to shift our focus: a shift from instrumental knowledge to humanistic-transformational knowledge; a shift from the traditional approach of supplying and storing information to learning to deal with the real-world problems; a shift from head to heart. Values integration is an attempt to initiate and promote this shift. Rather than teaching values and moral principles under a particular subject heading, values need to be a part of everyday in-school and out-school activities. To concretize this concept, a model is proposed in this study as a holistic model of values integration via whole school ambiances and community support.