• The Korean Journal of Archival Studies
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• no.24
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• pp.73-112
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• 2010

With progress of the sound and moving picture recording technology, sound and moving picture have been a tool for evidence and memory on human activities. Accordingly, in archival science the importance of oral history as a record is disseminating and the production of oral record is carried out actively. But for producing oral record in archival institutions, the identity of oral record need to be established more firmly. Archival science is the task which delivers the current appearance of life to future through records. Therefore producing oral record in archival science must have unique characters. And archival science is the task which is building current memory. Therefore the identity of oral more firmly. This article intends to explore the meaning and role of oral record from a perspective of archival science. All these days, the theories and methodologies had been developed focusing on written records mainly in the deep-rooted influence of positivism. But as it is enabled the creation and preservation of records through 'speech', it need to be noted that oral record is the very core of tool for delivering the current society shape and collective memory. Therefore this article will intend to explore the meaning and role of oral record as a part of effort to establish the identity of oral record.

• Journal of the Korean Medical Association
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• v.61 no.11
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• pp.649-654
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• 2018

Although the dermoscopy had very long history since its introduction in 17th century, only recently it has been possible to see the widespread application of dermoscopy in the dermatology clinic. One of the most promising areas where the dermoscopy can be applied is the diagnosis of skin cancer, especially malignant melanoma. Due to its inherent limitation to obtain in-depth information-literally, from more than skin-deep and more importantly, from microscopic structures-of skin cancers, dermoscopy cannot replace the present gold-standard 'biopsy' in the diagnosis of skin cancer. However, several advantages of dermoscopy over biopsy merit further considerations. For example, as a non-invasive tool, dermoscopy is best suited for the follow-up of suspicious skin lesions, and as an all-at-a-glance tool, dermoscopy can aid the selection of the best biopsy-site to obtain the most meaningful pathological information from the minimal tissue specimen. There goes a saying that 'it takes two to tango,' similarly, we might need the two (biopsy and dermoscopy) to cope rhythmically with the varying tempos of everprogressing skin tumorigenesis and to reveal the true face of skin cancers usually hidden in various disguises.

• Journal of Periodontal and Implant Science
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• v.26 no.1
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• pp.161-175
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• 1996

There were many reports that elevations in the levels of active and latent collagenase in gingival crevicular fluid(GCF) have been correlated positively with periodontal disease activity. To provide a simple diagnostic approach for testing GCF collagenolytic activity, the detection limit of enzyme activity was compared using radiofibril assay(Sodek et.al.1981) and spectrophotometric collagenolytic assay(Nethery et al. 1986). The detection limits of both assay for standard bacterial enzyme were similar and the radiofibril assay showed a little (1/2) lower detection limit for tad pole collagenase. To evaluate the relationship between periodontal tissue destruction and the collagenolytic activity, GCF was collected, and latent and active enzyme activities were measured by a spectrophotometric collagenolytic assay. Twelve subjects showing progressive lesions were selected according to the presence of immediate tissue destruction, frequent abscess formation, and increasing need for tooth extraction, and the absence of underlying systemic disease and previous antibiotic medication history within 6 months. Comparisons were made between sites with either: 1) inflammation with a previous history of progressive loss of periodontal tissue and bone support(2l progressive sites): 2) previous history of bone loss and periodontal destruction but now clinically stable(12 comparably stable sites); or 3) no loss of periodontal tissue and bone support(11 control sites including 5 gingivitis sites and 6 healthy sites). Active collagenase activity was the highest in the progressive sites and decreased in the order of the gingivitis sites, the stable sites, and the healthy sites. The total enzyme activity was $2{\sim}3$ fold higher in the progressive sites and the gingivitis sites, compared to the stable and the healthy sites. The ratio of active to total collagenolytic activity was twice in the progressive sites. Analysis of active collagenase level(5mU) and the ratio of active to total collagenolytic activity(0.8) as a diagnositic test indicates that these measurements have the sensitivity of 0.81 and 0.86, the specificity of 0.70 and 0.65, and the overall agreement of 0.75 and 0.73, respectively. Thus, this method has significant merits as a diagnostic tool to determine wherher the site is in a state of remission or progression.

• The Journal of the Korea Contents Association
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• v.15 no.5
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• pp.582-591
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• 2015

Late-Koryeo people networks were constructed from four different history books that were written by various historic aspects in the period from king Kongmin to the final king of the Koryeo, Kongyang. All networks constructed in this study show scale free network properties as if most social networks do. Tajo-sillok preface is one of subjectively written history book that described personal history of the Lee Seong-gye and his ancestors. It is confirmed that the book is one of the most biased-written history books through network study. Jeong Do-jeon known as a Chosun dynasty projector is not greatly contributed for founding of a Chosun dynasty in network study and various historical documents as well. In this network study, we provide objective historical information in the historical situations of the late-Koryeo and during establishment procedure of Chosun dynasty. Hub nodes in network is denoted highly linked nodes, called degree. Stress centrality is a unit to measure positional importancy in the network. If we employ two factors, degree and stress centrality to determine hub node, it represents high connectivity and importancy as well. As comparing values of the degree and stress centrality, we elucidate more objective historical facts from late-Koryeo situations in this study. If we further develop and employ a new algorithm that is considered both degree and stress centrality, it is a very useful tool for determining hub node.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.861-865
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• 2014

Background: High risk HPV (HR-HPV) testing has been recommended as an effective tool along with cytology screening in identification of cervical intraepithelial lesions (CINs) and prevention of their progress towards invasive cervical cancer. The aim of this study was to assess the HR-HPV DNA status by Hybrid Capture 2 (HC2) assay in healthy asymptomatic women of North-East India. Materials and Methods: This study examined cervical cell samples of forty three (n=43) healthy women by HC2 assay. A High Risk HPV DNA kit (Qiagen) was used which can detect 13 high risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68. Results: The mean relative light units (RLU) for samples was in the range of 141-5, 94, 619. HR-HPV DNA was confirmed in 16% (7/43) of participant women samples. Among demographic and clinical parameters, menstrual irregularity (p=0.039) and infection history (p=0.028) has shown statistically significant differences between the HR-HPV-positive and negative groups. In the HR-HPV positive group, two women were confirmed for CINs after colposcopy and histopathologic examination. Conclusions: We suggest that there may be an association between irregular menstruation and infection history of the urogenital tract with HR-HPV DNA prevalence in North-East Indian asymptomatic women. HC2 assay can be a valuable tool for HR-HPV screening.

• BMB Reports
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• v.53 no.7
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• pp.341-348
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• 2020

The targeted nuclease clustered, regularly interspaced short palindromic repeats/CRISPR-associated proteins (CRISPR/Cas) system has recently emerged as a prominent gene manipulation method. Because of its ease in programming targeted DNA/protein binding through RNA in a vast range of organisms, this prokaryotic defense system is a versatile tool with many applications in the research field as well as high potential in agricultural and clinical improvements. This review will present a brief history that led to its discovery and adaptation. We also present some of its restrictions, and modifications that have been performed to overcome such restrictions, focusing specifically on the most common CRISPR/Cas9 mediated non-homologous end joint repair.

• Journal of the Korean Society of Costume
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• v.20
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• pp.63-72
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• 1993

The concept of style provides a useful structure in history of Art. In aspect of formative art, dress and art work are alike, so style is a useful concept in the historical methodology on dress. The main purpose of this study was to apply the art criticism to the historical methodology on dress. For this purpose, documentary studies about style as a tool of historical research were proceeded. The results were as follows : 1. The concept of style consists of the external form and the internal meaning as double roots. Therefore, it's indispensable that the two asp-ects of style, form and meaning, must to be harmonized to describe the historical phenomena in dress. 2. The change pattern of style in dress is not always predeterminate and regular according to the cyclical theory. From the alternative point of view, the change pattern of style could be to describe the continuous theory proposed by kroeber, Brodsky. The whole change of style is considered "liked solution" by this theory.is theory.

• Journal for History of Mathematics
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• v.20 no.1
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• pp.57-72
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• 2007

Recently, dissection puzzles such as pentominoes have been used in mathematics education. But they are not actively applicable as a tool of problem solving or introducing mathematical concepts since researches about the historical background and developments of mathematical applications of such puzzles have not been effectively accomplished. In this article, in order to use pentominoes in mathematical teaming effectively, we first investigate geometric problems related to dissection puzzles and the historic background of development of pentominoes. And then we collect and classify data related to pentomino activities which can be applicable to mathematics classes based on the 7th elementary school national curriculum. Finally, we suggest several basic materials and directions to develop more systematic learning materials about pentominoes.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.47 no.11
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• pp.803-811
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• 2019

Water rocket is a non-chemical rocket mechanically powered by pressurized gas and liquid (water) propellants. Since water rockets share many engineering commonalities with liquid propellant rockets for space launch vehicles, it is as a education tool for rocket engineering. Present paper investigated the availability of water rocket as an engineering education model by surveying the history of water rocket and making examples from K-12 education, commercial products and club activities. Finally, a way of improvement is suggested for water rocket competitions make changes in the perception on water rockets by examining the limitations of present competitions.

• BMB Reports
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• v.56 no.2
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• pp.71-77
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• 2023

Cancers are one of the most dreaded diseases in human history and have been targeted by numerous trials including surgery, chemotherapy, radiation therapy, and anti-cancer drugs. Adult stem cells (ASCs), which can regenerate tissues and repair damage, have emerged as leading therapeutic candidates due to their homing ability toward tumor foci. Stem cells can precisely target malicious tumors, thereby minimizing the toxicity of normal cells and unfavorable side effects. ASCs, such as mesenchymal stem cells (MSCs), neural stem cells (NSCs), and hematopoietic stem cells (HSCs), are powerful tools for delivering therapeutic agents to various primary and metastatic cancers. Engineered ASCs act as a bridge between the tumor sites and tumoricidal reagents, producing therapeutic substances such as exosomes, viruses, and anti-cancer proteins encoded by several suicide genes. This review focuses on various anti-cancer therapies implemented via ASCs and summarizes the recent treatment progress and shortcomings.