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Brachytherapy: A Comprehensive Review

  • Lim, Young Kyung;Kim, Dohyeon
    • 한국의학물리학회지:의학물리
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    • 제32권2호
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    • pp.25-39
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    • 2021
  • Brachytherapy, along with external beam radiation therapy (EBRT), is an essential and effective radiation treatment process. In brachytherapy, in contrast to EBRT, the radiation source is radioisotopes. Because these isotopes can be positioned inside or near the tumor, it is possible to protect other organs around the tumor while delivering an extremely high-dose of treatment to the tumor. Brachytherapy has a long history of more than 100 years. In the early 1900s, the radioisotopes used for brachytherapy were only radium or radon isotopes extracted from nature. Over time, however, various radioisotopes have been artificially produced. As radioisotopes have high radioactivity and miniature size, the application of brachytherapy has expanded to high-dose-rate brachytherapy. Recently, advanced treatment techniques used in EBRT, such as image guidance and intensity modulation techniques, have been applied to brachytherapy. Three-dimensional images, such as ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography are used for accurate delineation of treatment targets and normal organs. Intensity-modulated brachytherapy is anticipated to be performed in the near future, and it is anticipated that the treatment outcomes of applicable cancers will be greatly improved by this treatment's excellent dose delivery characteristics.

종합병원 다인병실의 치유환경 개선을 위한 건축 계획적 연구 (A Study on the Architectural Planning for Improvement of the Healing Environment in Multi-bed Room of General Hospitals)

  • 김용우;양내원
    • 한국실내디자인학회논문집
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    • 제36호
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    • pp.76-83
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    • 2003
  • The purpose of this study is to know how to improve environment of multi-bed room by investigating and analysing factors influencing to patients. 1 measured stress and satisfaction degrees about patient room for 4ㆍ5ㆍ6ㆍ7 men of domestic general hospital wards. The results of research show that patients of 4 bed room appeared the fewest stress and highest satisfaction degree among patients of other room styles. The patients positioned between two beds can give us more stress and fewer satisfaction than others. These results have proven that 4 bed room patients are offering comfortable environment than any other room types as a healing environment. When patient room area are more than 7.3$M^2$ per 1 person, bed interval space is more than 120cm, there is curtain between bed, transit space such as a toilet were established in patient room, patients' satisfaction appeared high.

양파로부터 추출한 천연염료의 피부자극성 시험 (Skin Irritation of Natural Dyes Extracted from Onion (Allium cepa))

  • 배순이;오태광;박승춘
    • Toxicological Research
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    • 제13권1_2호
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    • pp.161-165
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    • 1997
  • This study was conducted to investigate the skin irritation by transdermal administration of the three dyes. These dyes were originated from onion by using extraction method. By the order of extraction from onion, A-dye was obtained from onion by using water at 90-100$\circ$C. B-dye was extracted from A-dye with ethylacetate. After ethylacetate extraction from A-dye, the lower layer named as C-dye. Twenty-four New Zealand white rabbits were divided into three groups. The each groups was consisted of two subgroups according to high dose (extracted dyes) and low dose (the 100-fold dilutions of A-, Band C-dye). In primary skin irritation test of male New Zealand White rabbits, body temperature and weights were not significantly changed and blood cells were positioned in normal blood cell ranges of health rabbits. Primary irritation index was "0" in the test and control sites of all animals used in this study. By the results obtained in the present test, all dyes were evaluated as a non-irritant on the basis of the criteria of Draize.of Draize.

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A Linear Beacon System Featuring an Internal Deoxyguanine Quencher Allows Highly Selective Detection of Single Base Mismatches

  • Lee, Young-Ae;Hwang, Gil-Tae
    • Bulletin of the Korean Chemical Society
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    • 제31권7호
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    • pp.2011-2014
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    • 2010
  • The fluorescence intensity of a single-stranded oligonucleotide containing a fluorene-labeled deoxyuridine $(U^{Fl})$ unit increases by only 1.5-fold upon formation of its perfectly matched duplex. To increase the fluorescence signal during hybridization, we positioned a quencher strand containing a deoxyguanine (dG) nucleobase, functioning as an internal quencher, opposite to the $U^{Fl}$ unit to reduce the intrinsic fluorescence upon hybridization with a probe. From an investigation of the optimal length of the quencher strand and the effect of the neighboring base sequence, we found that a short strand (five-nucleotide) containing all natural nucleotides and dG as an internal quencher was effective at reducing the intrinsic fluorescence of a linear beacon; it also exhibited high total discrimination factors for the formation of perfectly matched and single base-mismatched duplexes. Such assays that function based on clear changes in fluorescence in response to single-base nucleotide mutations would be useful tools for accelerating diagnoses related to various diseases.

전파 흡수체에 의한 구형 공동 공진기의 방사노이즈 억제 방법에 관한 연구 (A Study on the Method to Suppress Radiation-Noise with Electromagnetic Wave Absorber in the Rectangular Cavity Resonator)

  • 김경용;김왕섭
    • 전자공학회논문지A
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    • 제28A권12호
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    • pp.19-23
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    • 1991
  • A method for suppressing unwanted resonance modes by attaching an electromagnetic wave absorber onto a metal case was studied to prevent performance deterioration of electronic devices. The electromagnetic wave absorber fabricated for this study had an attenuation characteristics above 20dB in the frequency band from 450MHz, 1150MHz. A rectangular cavity resonator whose resonance frequencies of TE$_{101}$, TE$_{102}$ modes were 900MHz, 1250MHz, respectively, was made to measure attenuation for the electromagnetic wave absorber-metal assembly. The result showed that the resonance mode for high attenuation was sensitive to the location of electromagnetic wave absorber, and the attenuation characteristics above 20dB could be obtained when electromagnetic wave absorber was properly positioned.

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The Effects of a Massage and Oro-facial Exercise Program on Spastic Dysarthrics' Lip Muscle Function

  • Hwang, Young-Jin;Jeong, Ok-Ran;Yeom, Ho-Joon
    • 음성과학
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    • 제11권1호
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    • pp.55-64
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    • 2004
  • This study was to determine the effects of a massage and oro-facial exercise program on spastic dysarthric patients' lip muscle function using an electromyogram (EMG). Three subjects with Spastic Dysarthria participated in the study. The surface electrodes were positioned on the Levator Labii Superior Muscle (LLSM), Depressor Labii Inferior Muscle (DLIM), and Orbicularis Oris Muscle (OOM). To examine lip muscle function improvement, the EMG signals were analyzed in terms of RMS (Root Mean Square) values and Median Frequency. In addition, the diadochokinetic movements and the rate of sentence reading were measured. The results revealed that the RMS values were decreased and the Median Frequency moved to a high frequency area. Diadochokinesis and sentence reading rates were improved.

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무용동작을 위한 밑위길이에 관한 연구 (A Study on the Crotch Length for Dance Movement)

  • 윤성화;이영주
    • 한국생활과학회지
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    • 제11권1호
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    • pp.45-58
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    • 2002
  • The purpose of this study was to offer a more functional slacks by analyzing its crotch length. The result of the study were as follows : Regarding the feeling of wearing and appearance, the P2 b style which measures the crotch length starting from the waist line passing around the iliac spine was the most highly evaluated. This suggested that the functionality of dance movement was more influenced by the position of the waist line not by the crotch length measurement. Since the front and rear center lines of the crotch could not be flown if the waist line of slacks was positioned high, both the crotch and abdominal part might be clogged or tightened when dancers made large dance movements or bended their upper bodies forward. In conclusion, slacks for more functional dance movement should be manufactured focusing on the location of the waist line rather than on the crotch length.

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선삭에서 회절격자를 이용한 크레이터마모 측정장치 개발에 관한 연구 (A Study on the Development of Measurement Setup for Crater Wear by Diffraction Grating in Turning)

  • 김영일;김세진
    • 한국정밀공학회지
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    • 제9권1호
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    • pp.82-95
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    • 1992
  • There is the high interest for sensing of tool wear with the aim of controlling machine tools productivity from the point of view of qualitity. Difficulties in this measurement are also known. This study is on the development of measurement setup for crater wear by CCD image inturning. In this study, the crater wear measurement system consists of the He-Ne gas laser, diffraction grating. CCD camera, noise filter, slit, microcomputer, diverging lens, converging lens and so on. He-Ne laser beam passes through a diverging lens and a diffraction grating is positioned properly. A converging lens focuses so that the interference fringes can be obtained on the crater wear. Performance test revealed that the developed image technique provides precise, absolute tool-wear quantification and reduces human measurement errors. The results obtained are as follows 1. The digitizing of one image requires less than 2ses. 2. It can give detailed information on crater wear with limited times and errors 3. All parameters required by specification are easily obtained for several points of the cutting edge.

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COMPARISON OF FLUX AND RESIDENT CONCENTRATION BREAKTHROUGH CURVES (BTCs) IN STRUCTURED SOIL COLUMNS

  • Kim, Dong-Ju
    • 한국지하수토양환경학회:학술대회논문집
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    • 한국지하수토양환경학회 1997년도 총회 및 춘계 학술발표회 논문집
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    • pp.25-29
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    • 1997
  • In many solute transport studies, either flux or resident concentration has been used. Choice of the concentration mode was dependent on the monitoring device in solute displacement experiments. It would be questionable, however. to accept the equivalency in the solute transport parameters between flux and resident concentrations in structured soils exhibiting preferential movement of solute. In this study, we investigate how they differ in the monitored breakthrough curves (BTCs) and transport parameters for a given boundary and flow condition by performing solute displacement experiments on a number of undisturbed soil columns. Both flux and resident concentrations have been simultaneously obtained by monitoring the effluent and resistance of the Horizontally-positioned TDR probes. The study reveals that soil columns having relatively high flux densities exhibited great differences in the degree of peak concentration and travel time of peak between flux and resident concentrations. The peak concentration in flux mode was several times higher than that in resident one. This was mainly due to the bypassing of solute through soil macropores.

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Optimization of H-IPS Structure for High Aperture Ratio.

  • Lee, Do-Young;Kim, Do-Sung;Kang, Byung-Goo;Kim, Eui-Tae;Kim, Bo-Ram;Kim, Jung-Han;Lim, Byung-Ho;Ahn, Byung-Chul
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2006년도 6th International Meeting on Information Display
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    • pp.290-293
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    • 2006
  • We designed the H-IPS that has similar aperture ratio to the AS-IPS with organic insulator. To improve the aperture ratio without organic insulator, we positioned the pixel electrode over the preceding gate on the base of the H-IPS structure, and minimized the width of pixel and common electrodes. Without the additional process, we could obtain the similar brightness with that of AS-IPS in 15inch SXGA+ Panel.

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