• Journal of Korean Neurosurgical Society
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• 제63권2호
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• pp.237-247
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• 2020

Objective : Fixation of the C1-2 segment is challenging because of the complex anatomy in the region and the need for a high degree of accuracy to avoid complications. Preoperative 3D-computed tomography (CT) scans can help reduce the risk of complications in the vertebral artery, spinal cord, and nerve roots. However, the patient may be susceptible to injury if the patient's anatomy does not match the preoperative CT scans. The intraoperative 3D image-based navigation systems have reduced complications in instrument-assisted techniques due to greater accuracy. This study aimed to compare the radiologic outcomes of C1-2 fusion surgery between intraoperative CT image-guided operation and fluoroscopy-guided operation. Methods : We retrospectively reviewed the radiologic images of 34 patients who underwent C1-2 fusion spine surgery from January 2009 to November 2018 at our hospital. We assessed 17 cases each of degenerative cervical disease and trauma in a study population of 18 males and 16 females. The mean age was 54.8 years. A total of 139 screws were used and the surgical procedures included 68 screws in the C1 lateral mass, 58 screws in C2 pedicle, nine screws in C2 lamina and C2 pars screws, four lateral mass screws in sub-axial level. Of the 34 patients, 19 patients underwent screw insertion using intraoperative mobile CT. Other patients underwent atlantoaxial fusion with a standard fluoroscopy-guided device. Results : A total of 139 screws were correctly positioned. We analyzed the positions of 135 screws except for the four screws that performed the lateral mass screws in C3 vertebra. Minor screw penetration was observed in seven cases (5.2%), and major pedicle screw penetration was observed in three cases (2.2%). In one case, the malposition of a C2 pedicle screw was confirmed, which was subsequently corrected. There were no complications regarding vertebral artery injury or onset of new neurologic deficits. The screw malposition rate was lower (5.3%) in patients who underwent intraoperative CT-based navigation than that for fluoroscopy-guided cases (10.2%). And we confirmed that the operation time can be significantly reduced by surgery using intraoperative O-arm device. Conclusion : Spinal navigation using intraoperative cone-beam CT scans is reliable for posterior fixation in unstable C1-2 pathologies and can be reduced the operative time.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.73-73
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• 2018

Bacterial leaf blight(BLB), caused by X. oryzae pv. oryzae(Xoo), is one of the most destructive diseases of rice due to its high epidemic potential. Understanding BLB resistance at a genetic level is important to further improve the rice breeding that provides one of the best approaches to control BLB disease. In the present investigation, a collection of 192 accessions was used in the genome-wide association study (GWAS) for BLB resistance loci against four Korean races of Xoo that were represented by the prevailing BLB isolates under Xoo differential system. A total of 192 accessions of rice germplasm were selected on the basis of the bioassay using four isolated races of Xoo such as K1, K2, K3 and K3a. The selected accessions was used to prepare 384-plex genotyping by sequencing (GBS) libraries and Illumina HiSeq 2000 paired- end read was used for GBS sequencing. GWAS was conducted using T ASSEL 5.0. The T ASSEL program uses a mixed linear model (MLM). T he results of the bioassay using a selected set of 192 accessions showed that a large number of accessions (93.75%) were resistant to K1 race, while the least number of accessions (34.37%) resisted K3a race. For races K2 and K3, the resistant germplasm proportion remained between 66.67 to 70.83%. T he genotypic data produced SNP matrix for a total of 293,379 SNPs. After imputation the missing data was removed, which exhibited 34,724 SNPs for association analysis. GWAS results showed strong signals of association at a threshold of [-log10(P-value)] more than5 (K1 and K2) and more than4 (K3 and K3a) for nine of the 39 SNPs, which are plausible candidate loci of resistance genes. T hese SNP loci were positioned on rice chromosome 2, 9, and 11 for K1 and K2 races, whereas on chromosome 4, 6, 11, and 12 for K3 and K3a races. The significant loci detected have also been illustrated, NBS-LRR type disease resistance protein, SNARE domain containing protein, Histone deacetylase 19, NADP-dependent oxidoreductase, and other expressed and unknown proteins. Our results provide a better understanding of the distribution of genetic variation of BLB resistance to Korean pathogen races and breeding of resistant rice.

• Journal of Dental Anesthesia and Pain Medicine
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• 제20권4호
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• pp.203-212
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• 2020

Background: This research evaluated the numbness produced by lignocaine at an equal or higher concentration than that of 4% articaine through a single point of injection for maxillary third molar surgery. This randomized double-blind study was conducted to compare the anesthetic efficiency of 4% lignocaine with that of 4% articaine in impacted maxillary third molar surgery using a single buccal infiltration alone. Methods: The study participants were 30 healthy patients requiring the bilateral surgical removal of symmetrically-positioned maxillary third molars. Using a split-mouth design, each patient randomly received buccal infiltration of 1.7 ml of 4% lignocaine and 1.7 ml of 4% articaine during two separate appointments. After 15 minutes of anesthetic injection, surgery was performed by the same surgeon using a consistent technique on both sides. Pinprick test pain scores of the buccal and palatal gingiva of the maxillary third molar after 10 minutes and 15 minutes latencies, pain scores during the surgery, the need for supplemental anesthesia, and patients' satisfaction with anesthetic efficiency were recorded. Surgery performed without supplemental anesthesia was categorized as successful. Results: The success rates of 4% lignocaine and 4% articaine (83.34% vs. 86.67%, P = 1.00) were not significantly different. Only 5 cases (4 cases in the articaine group and 1 case in the lignocaine group) reported mild pain and pressure sensation (NRS ≤ 1) on probing at the palatal side after 15 minutes of latency (P = 0.25). The pain scores of maxillary third molar surgery in the two groups were not significantly different (P > 0.05). Moreover, the statistical analysis confirmed the comparable patient satisfaction of two study groups (P = 0.284). Conclusion: This study provides evidence that single buccal infiltrations of 4% lignocaine and 4% articaine have comparable anesthetic efficacy and success rates for impacted maxillary third molar surgery. Both 4% lignocaine and 4% articaine can produce effective palatal anesthesia and pain control using buccal infiltration alone after 15 minutes of latency.

• 통상정보연구
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• 제13권2호
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• pp.51-73
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• 2011

선진국의 경제성장률 둔화로, 신흥국이 글로벌 수요의 새로운 시장으로 부상하고 있다. 세계 각국은 금융위기로 증발한 선진국의 수입수요를 대체할 시장으로서 신흥국 BOP 시장을 그 대안으로 주목하고 있다. 이미 유럽과 일본기업들은 이러한 BOP 시장의 잠재력을 높게 보고 가장 발 빠르게 시장공략에 나서고 있다. 우리나라도 신흥국가의 BOP 시장의 가능성을 인식하고, 진출을 위한 신흥대상국 분석과 전략수립과 대응이 필요한 시점이다. 중국과 함께 인도는 아시아 신흥국으로 BOP 시장규모와 잠재성이 가장 높게 평가되고 있다. 우리나라는 인도와 CEPA체결로 시장진입이 한층 용이한 가운데, 정부와 대기업들은 기존의 진출 전략과 함께, 중장기적인 관점에서 인도 BOP 시장 접근을 위한 효과적인 진출모델을 구축할 필요가 있다. 즉, 인도 전 계층에 대한 밀착형 맞춤형 전략으로 우리기업들의 마케팅력, 현지 적응력, 빠른 의사결정 등으로 인도 소비시장 전체를 대상으로 하는 TMB모델을 구축해 가야할 것이다. 이러한 인도에서의 BOP 시장 진입의 성공 여부가 중장기적으로 인접국가로의 진출을 위한 교두보 및 세계 시장 확대로 이어질 수 있도록 하여야 할 것이다.

• 한국언론정보학보
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• 제77권
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• pp.36-72
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• 2016

정치적 산물로서 출범한 지 5년을 넘어선 종합편성채널의 영향력과 방송 영역에서의 지위가 상승하고 있다. 종편의 안정화는 저널리즘의 물량 공세에 기초한다. 끊임없이 반복적으로 쏟아 내는 뉴스와 시사토론 프로그램들이 '종편 타임대'라 불리는 오후 시간대를 점유한다. 시사토크쇼는 종편이 만들어 낸 대표적인 프로그램 형식이자 상품으로 독특한 종편 스타일 저널리즘을 이끌고 있다. 시사토크쇼의 주인공은 평론과 토론을 위해 모인 출연자들이다. 이 연구는 이들을 정치 매개 엘리트라는 개념적 위치화와 함께 TV조선, 채널A, MBN, JTBC의 대표적인 시사토크쇼에서 이들이 벌이는 텔레비전 정치의 풍경들을 살펴본다. 이 연구는 종편의 시청률을 상승시키고 시청자들의 이목을 집중시키는 시사토크쇼에서 정치 매개 엘리트들이 자신들의 정치적 편향성과 감정을 과감하게 드러내고 독특한 규정과 서술적 발화들을 통해 특정 대상들을 형상화하는 텔레비전 정치의 효과들을 읽어 내고자 한다. 이 연구에서 출연자로 불리는 정치 매개 엘리트들은 주로 극우, 보수, 중도보수적 정치 성향들을 가지며, 특정한 정당이나 정치 집단과 밀착된 관계를 형성한다. 정치 매개 엘리트들은 종편 시사토크쇼에서 수행하는 텔레비전 정치를 통해 대중들에게 영향을 미치는 자산을 확보하면서 정치 집단과 정치적 교환 혹은 거래 관계를 형성한다. 이 같은 정치적 동원, 교환, 거래의 관계 속에 종편의 시사토크쇼가 위치하며, 시사토크쇼는 정치적 전장으로 존재할 수밖에 없다는 점을 이 연구는 강조한다.

• 생태와환경
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• 제41권3호
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• pp.360-366
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• 2008

본 연구는 심수층의 고정 취수구를 통해 방류하는 안동댐을 대상으로 1일 최대 99.4 mm, 총 299.1 mm인 단일사상의 강우로 유입된 고탁수의 호소 내 시 공간적인 거동과 방류수의 탁도가 감소하는 경향을 조사하였다. 유입된 고탁수는 중류지점부터 호소 바닥에서 이탈되어 중층 밀도류로 최하류까지 이동하였다. 강우 이전의 호소 내 탁도는 10 NTU 이하의 균일한 분포를 보였으나 강우에 의해 수심 16 m에 최고 290 NTU의 고탁수대가 형성되었다. 고탁수는 강우 후 3일부터 방류수의 탁도를 상승시켰으며 5일째에 129 NTU로 최고 탁도를 보였다. 댐까지 이동한 탁수층은 취수구 상부 5 m 이내의 수심에 최고 농도로 분포하였으며 하류 방류에 의해 탁수층의 두께와 농도가 감소하였다. 방류수의 탁도가 30 NTU까지 감소하는데 38일, 강우 이전의 상태로 회복되는데 87일이 소요되었으며, 감소경향의 상관계수는 각각 0.96, 0.97이었다. 중층에서 밀도류를 형성한 고탁수는 취수구 직상부에 분포하면서 취수구 방향으로 점차 유인되어 하류로 배출되었으며 호소 바닥으로의 침강은 일어나지 않았다. 안동호로 유입된 고탁수는 심층에 위치한 취수구를 통해 효과적으로 배출되므로 취수구 위치는 고탁수 배제에 적정한 것으로 판단된다.

• Investigative Magnetic Resonance Imaging
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• 제6권2호
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• pp.166-172
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• 2002

목적: 척수경색의 진단에서 현성확산계수 값의 측정을 포함한 확산강조자기공명영상의 유용성을 평가하고자하였다. 대상 및 방법: 척수 경색으로 진단받은 6명의 환자를 대상으로 후향적으로 분석하였다. 경색증상 발현 후 평균 5.4일이 지난 후에 1.5 T 초전도체 자기공명영상 기기를 이용하여 자기공명영상을 얻었다. 확산강조자기공명영상은 고식적인 b값($1000s/\textrm{mm}^2$)으로 하여 multi-shot echo planar imaging 기법을 이용하여 영상을 획득하였으며 개인용 컴퓨터로 옮겨져 현성확산계수 지도를 얻어 정상부위와 병변부위의 현성확산계수 값을 측정하였다. 자기공명영상에서 병변의 위치와 T1 과 T2 강조영상, 그리고 확산강조자기공명영상에서 나타나는 각각의 신호강도를 알아 보았고, 병변부위와 정상부위에서 측정한 현성확산계수 값을 비교하였다. 결과: T1강조영상에서 6예 중 4예에서 등신호강도를, 2예에서 저신호 강도를 보였고, T2강조 영상에서 6예 모두 고신호강도를 보였다. 또한 확산강조자기공명영상에서 6예 모두 고신호강도를 보였다. 현성확산계수 지도는 6예 전예에서 성공적으로 얻을 수 있었다. 현성확산계수 지도에서 6예 모두 정상과 뚜렷한 차이를 보이는 색조변화를 보였으며, 6예 모두 병변부위의 현성확산계수 값은 정상 부위의 현성확산계수의 값보다 더 낮았으며 통계적으로 유의하였다 (p＜0.05 ). 결론: 척수경색 환자에서 척수병변의 확산강조자기공명영상과 현성확산계수 값의 측정이 가능하였다. 따라서 확산강조자기공명영상은 척수경색의 조기진단과 국재화(localization)에 유용하리라 보여진다.

• 한국임상수의학회지
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• 제29권1호
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• pp.12-17
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• 2012

많은 약물들이 개의 진정 및 마취를 위해 근육내 투여를 통해 사용되고 있다. 개 마취를 위한 많은 근육내 병용투여 방법이 정립되었으나 xylazine-diazepam-ketamine 병용투여에 대한 연구는 미흡하다. 따라서 본 연구의 목적은 개에서 xylazine-diazepam-ketamine 병용투여의 영향을 연구하는 것이다. 12 마리의 혼혈 종 개를 사용하였으며 diazepam (0.5 mg/kg), xylazine (1.1 mg/kg)에 두 가지 용량의 ketamine (5 mg/kg; group 1, 10 mg/kg; group 2)을 근육내로 투여하여 비교하였다. 마취 시간은 group 2에서 group 1과 비교 시 유의적으로 길었으며 혈압은 약물 투여 후 두 군에서 모두 유의적으로 증가 하였다. $S_aO_2$ 수준도 약물 투여 후 두 군에서 모두 유의적으로 감소 하였다. 마취는 두 군에서 모두 적절히 이루어졌다. 본 실험 결과 diazepam (0.5 mg/kg), xylazine (1.1 mg/kg)에 두 가지 용량의 ketamine (5 mg/kg, 10 mg/kg)의 병용투여는 개에서 짧은 시간의 깊은 진정 및 마취 시에 사용할 수 있는 효과적인 방법으로 생각된다.

• Journal of Chest Surgery
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• 제12권3호
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• pp.281-288
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• 1979

For years, physicians and anatomists have been interested in the heart that has one functioning ventricle. Various terms have been suggested for this entity including single ventricle, common ventricle, double-inlet left ventricle, cor biatriatum triloculare, and primitive ventricle. In this report, the term "single ventricle" is utilized as suggested by Van Praagh, and is defined as that congenital cardiac anomaly in which a common or separate atrioventricular valves open into a ventricular chamber from which both great arterial trunks emerge. An outlet chamber, or infundibulum, may or may not be present and give rise to the origin of either of the great arteries. This definition excludes the entity of mitral and tricuspid atresia. An 11 year old cyanotic boy was admitted chief complaints of exertional dyspnea and frequent upper respiratory infection since 2 weeks after birth. He was diagnosed as inoperable cyanotic congenital heart disease, and remained without any corrective treatment up to his age of 11 year when he suffered from aggravation of symptoms and signs of congestive heart failure for 2 months before this admission. On 22nd of May 1979, he was admitted for total corrective operation under the impression of tricuspid atresia suggested by a pediatrician. Physical check revealed deep cyanosis with finger and toe clubbing, and grade V systolic ejection murmur with single second heart sound was audible at the left 3rd intercostal space. Development was moderate in height [135 cm] and weight[28Kg]. Routine lab findings were normal except increased hemoglobin [21.1gm%], hematocrit [64 %], and left axis deviation with left ventricular hypertrophy on EKG. Cardiac catheterization and angiography revealed 1-transposition of aorta, pulmonic valvular stenosis, double inlet of a single ventricle with d-loop, and normal atriovisceral relationship [Type III C solitus according to the classification of Van Praagh]. At operation, longitudinal incision at the outflow tract of right ventricle in between the right coronary artery and its branch [LAD from RCA] revealed high far anterior aortic valve which had fibrous continuity with mitral annulus, and pulmonic valve was stenotic up to 4 mm in diameter positioned posterolaterally to the aorta. Ventricular septum was totally defective, and one markedly hypertrophied moderator band originated from crista supraventricularis was connected down to the imaginary septum of the ventricular cavity as a pseudoseptum of the ventricle. Size of the defect was 3X3 cm2 in total. Patch closure of the defect with a Teflon felt of 3.5 x 4 cm2 was done with interrupted multiple sutures after cut off of the moderator band, which was resutured to the artificial septum after reconstruction of the ventricular septum. Pulmonic valvotomy was done from 4 mm to 11 mm in diameter thru another pulmonary arteriotomy incision, and right ventriculotomy wound was closed reconstructing the right ventricular outflow tract with pericardial autograft of 3 x 4 cm2. Atrial septal defect of 2 cm in diameter was closed with 3-0 Erdeck suture, and atrial wall was sutured also when rectal temperature reached from 24`C to 35.5`C. Complete A-V block was managed with temporary external pacemaker with a pacing rate of 110/min. thru myocardial wire, and arterial blood pressure of 80/50 mmHg was maintained with Isuprel or Dopamine dripping under the CVP of 25-cm saline. Consciousness was recovered one hour after the operation when his blood pressure reached 100 /70 mmHg, but vital signs were not stable, and bleeding from the pericardial drainage and complete anuria were persisted until his heart could not capture the pacemaker impulse, and patient died of low output syndrome 320 min after the operation.

• Journal of Chest Surgery
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• 제12권3호
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• pp.289-296
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• 1979

For years, physicians and anatomists have been interested in the heart that has one functioning ventricle. Various terms have been suggested for this entity including single ventricle, common ventricle, double-inlet left ventricle, cor biatriatum triloculare, and primitive ventricle. In this report, the term "single ventricle" is utilized as suggested by Van Praagh, and is defined as that congenital cardiac anomaly in which a common or separate atrioventricular valves open into a ventricular chamber from which both great arterial trunks emerge. An outlet chamber, or infundibulum, may or may not be present and give rise to the origin of either of the great arteries. This definition excludes the entity of mitral and tricuspid atresia. An 11 year old cyanotic boy was admitted chief complaints of exertional dyspnea and frequent upper respiratory infection since 2 weeks after birth. He was diagnosed as inoperable cyanotic congenital heart disease, and remained without any corrective treatment up to his age of 11 year when he suffered from aggravation of symptoms and signs of congestive heart failure for 2 months before this admission. On 22nd of May 1979, he was admitted for total corrective operation under the impression of tricuspid atresia suggested by a pediatrician. Physical check revealed deep cyanosis with finger and toe clubbing, and grade V systolic ejection murmur with single second heart sound was audible at the left 3rd intercostal space. Development was moderate in height [135 cm] and weight[28Kg]. Routine lab findings were normal except increased hemoglobin [21.1gm%], hematocrit [64 %], and left axis deviation with left ventricular hypertrophy on EKG. Cardiac catheterization and angiography revealed 1-transposition of aorta, pulmonic valvular stenosis, double inlet of a single ventricle with d-loop, and normal atriovisceral relationship [Type III C solitus according to the classification of Van Praagh]. At operation, longitudinal incision at the outflow tract of right ventricle in between the right coronary artery and its branch [LAD from RCA] revealed high far anterior aortic valve which had fibrous continuity with mitral annulus, and pulmonic valve was stenotic up to 4 mm in diameter positioned posterolaterally to the aorta. Ventricular septum was totally defective, and one markedly hypertrophied moderator band originated from crista supraventricularis was connected down to the imaginary septum of the ventricular cavity as a pseudoseptum of the ventricle. Size of the defect was 3X3 cm2 in total. Patch closure of the defect with a Teflon felt of 3.5 x 4 cm2 was done with interrupted multiple sutures after cut off of the moderator band, which was resutured to the artificial septum after reconstruction of the ventricular septum. Pulmonic valvotomy was done from 4 mm to 11 mm in diameter thru another pulmonary arteriotomy incision, and right ventriculotomy wound was closed reconstructing the right ventricular outflow tract with pericardial autograft of 3 x 4 cm2. Atrial septal defect of 2 cm in diameter was closed with 3-0 Erdeck suture, and atrial wall was sutured also when rectal temperature reached from 24`C to 35.5`C. Complete A-V block was managed with temporary external pacemaker with a pacing rate of 110/min. thru myocardial wire, and arterial blood pressure of 80/50 mmHg was maintained with Isuprel or Dopamine dripping under the CVP of 25-cm saline. Consciousness was recovered one hour after the operation when his blood pressure reached 100 /70 mmHg, but vital signs were not stable, and bleeding from the pericardial drainage and complete anuria were persisted until his heart could not capture the pacemaker impulse, and patient died of low output syndrome 320 min after the operation.