• Title/Summary/Keyword: Herpes Virus

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Herpes Infection (임상가를 위한 특집 3 - 헤르페스 감염)

  • Lee, Sang-Shin;Lee, Suk-Keun
    • The Journal of the Korean dental association
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    • v.48 no.5
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    • pp.365-370
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    • 2010
  • Herpes virus family is highly infectious to patients, their families and dentists. The diagnosis of herpes infection is based on the characteristic clinical appearance and the location of the lesions. Herpes Simplex Virus(HSV) usually acquired through direct contact with infected lesions or body fluids, and the prevalence of HSV infection increases progressively from childhood. Primary infections provoke herpetic gingivostomatis typically affects the tongue, lips, gingival, buccal mucosa and palate. Recurrent infections give rise to vesiculo-ulcerative lesions at vermilion border of lip(herpes labialis). In the form of chickenpox, Varicella Zoster Virus(VZV) usually is infected in childhood. VZV spreads in the affected primary afferent nerve to the skin and produces a vesicular rash and pain. Epstein-Barr Virus(EBV) infects B cells and cause infectious mononucleosis. Latent EBV infection has also been implicated in Burkitt lymphoma, nasopharyngeal carcinoma. Cytomegalovirus(CMV) is associated with immune-compromised patient such as organ transplantation and AIDS patients.

Neonatal Meningoencephalitis caused by Herpes Simplex Virus Type 2 (Herpes simplex virus type 2에 의한 신생아 수막뇌염)

  • Kim, Dae Eun;Pae, Ramee;Bae, E Young;Han, Ji Yoon;Han, Seung Beom;Jeong, Dae Chul;Lee, In Goo;Kang, Jin Han
    • Pediatric Infection and Vaccine
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    • v.21 no.2
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    • pp.150-156
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    • 2014
  • Despite its rare occurrence, early diagnosis and appropriate treatment for neonatal herpes simplex virus infection are mandatory due to its high morbidity and mortality. In Korea, there has been no epidemiologic data on neonatal herpes simplex virus infection, and even case reports are rare. We observed a 16-day-old neonate who presented with fever and seizures. We diagnosed her with meningoencephalitis caused by herpes simplex virus type 2 based on the polymerase chain reaction test, and treated her with intravenous acyclovir and anticonvulsants. The seroprevalence of herpes simplex virus type 2 sharply increases in women in their 30s, and the average age for childbirth has increased to older than 30 years of age in Korea; we therefore expect that the incidence of neonatal herpes simplex virus type 2 infection will rise in Korea, and more attention should be directed to neonatal herpes simplex virus type 2 infection. We report this newborn patient's case along with a literature review.

Demyelination of Myelinated Neuronal cells by Infection of Herpes Simplex Virus-1 (Herpes Simplex Virus-1감염에 의한 수초화 뉴우런의 탈수초)

  • Kim, Hyun Joo;Kim, Ji-Young;Sa, Young-Hee;Hong, Seong-Karp
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2016.10a
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    • pp.919-922
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    • 2016
  • Neuronal cells and Schwann cells from dorsal root ganglion (DRG) in embryos of rat were isolated and cultured in vitro respectively. The purified neuronal cells added with anti-mitotic agents and purified Schwann cells were co-cultured and then accomplished myelination processing. This myelinated co-culture system was infected by herpes simplex virus-1 and then accomplished demyelination processing in this myelinated co-culture. We identified myelination and demyelination processing using antibody of neuropeptide Y meaning presence of myelinated neuron.

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Effect of Cholera Toxin, Dibutyryl cAMP and Adenosine on the In Vitro Reactivation of Latent Herpes Simplex Virus

  • Cheong, D.K.;Park, N.H.
    • Toxicological Research
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    • v.4 no.1
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    • pp.47-53
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    • 1988
  • Cholera toxin and dibutyryl cyclic adenosine 3', 5'-monophosphate(db-cAMP) increased the rate and number of infections units produced in the in vitro reactivation of latent herpes simplex virus, whereas adenosine diminished them. cAMP concentration in latently infected trigeminal ganglia of mice was greatly increased by cholera toxin but was not affected by adenosine.

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Electron Microscopic Observations on BHK-21 Cells Infected with Herpes Simplex Type 2 Virus (Herpes Simplex 2형 바이러스의 BHK-21 세포내에서의 전자현미경적 관찰)

  • Ko, Kwang-Kjune;Lee, Yun-Tai;Lee, Chong-Hoon
    • The Journal of the Korean Society for Microbiology
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    • v.16 no.1
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    • pp.71-82
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    • 1981
  • An electron microscopic study was carried out on the morphogenesis of herpes simplex type 2 virus in BHK-21 cells BHK-21 cells was found susceptible to infection and replication of herpes simplex type 2 virus cytopathic effects of the herpes type appeared at approximately 1 day postinoculation. Foci consisting of rounded refractile cells and syncytia were observed. Projection of the nuclear membrane in the infected cells was also seen, Several infected cells showed a track-shaped structure which apparently consisted of multiple layered membranes of the nucleus.

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Screening of Microorganisms having Antiviral Activity against HIV Virus from Soil (토양으로부터 HIV 바이러스에 항바이러스 활성을 나타내는 미생물의 탐색)

  • 김성욱;이상한;정태숙;문석식;이종교;이항우;이원영;복성해
    • Microbiology and Biotechnology Letters
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    • v.21 no.5
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    • pp.399-405
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    • 1993
  • For screening of the antiviral agent from soil, about 520 strains of microorganisms were evaluated for their antiviral activity, About 6.9% of strains showed more than 95% antiviral activity against Herpes Simples Virus (HSV)-1. Two strains among 30 strains active against HSV-1 virus showed a quite strong activity against human immunodeficiency virus.

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A Case of Herpes simplex Esophagitis in an Immunocompetent Boy (건강했던 남아에서 발생된 헤르페스 식도염 1예)

  • Yeo, Joong-Suk;Jeon, Je-Deok;Chang, Soo-Hee
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.11 no.1
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    • pp.70-74
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    • 2008
  • Herpes simplex virus has rarely been identified as a cause of esophagitis in immunocompetent children. This virus affects predominantly males presenting with symptoms of fever, odynophagia, dysphagia, and retrosternal pain of acute onset. Esophagoscopy typically reveals exudative well-circumscribed ulcerations of the distal and/or mid-esophagus. Further investigations using biopsy, viral culture, polymerase chain reaction (PCR), and seroconversion of antibodies to Herpes simplex are recommended to assist with a definitive diagnosis. This esophagitis is often a self-limited infection in immunocompetent children. Nevertheless, antiviral treatment may expedite symptom relief with Herpes simplex virus infection. It is imperative to document herpes esophagitis in cases with subsequent severe odynophagia in immunocompetent children. Here we present the case of a 12-year-old immunocompetent boy with herpes esophagitis.

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Inhibition of Herpes Simplex Viruses, Types 1 and 2, by Ginsenoside 20(S)-Rg3

  • Wright, Stephen M.;Altman, Elliot
    • Journal of Microbiology and Biotechnology
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    • v.30 no.1
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    • pp.101-108
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    • 2020
  • Infections by herpes simplex viruses have an immense impact on humans, ranging from self-limiting, benign illness to serious, life-threatening diseases. While nucleoside analog drugs are available, resistance has been increasing and currently no vaccine exists. Ginsenosides derived from Panax ginseng have been documented to inhibit several viruses and bolster immune defenses. This study evaluated 12 of the most relevant ginsenosides from P. ginseng for toxicities and inhibition of herpes simplex viruses types 1 and 2 in Vero cells. The effects of test compounds and virus infection were determined using a PrestoBlue cell viability assay. Time course studies were also conducted to better understand at what points the virus life cycle was affected. Non-toxic concentrations of the ginsenosides were determined and ranged from 12.5 μM to greater than 100 μM. Ginsenoside 20(S)-Rg3 demonstrated the greatest inhibitory effect and was active against both HSV-1 and HSV-2 with an IC50 of approximately 35 μM. The most dramatic inhibition-over 100% compared to controls-occurred when the virus was exposed to 20(S)-Rg3 for 4 h prior to being added to cells. 20(S)-Rg3 holds promise as a potential chemotherapeutic agent against herpes simplex viruses and, when used together with valacyclovir, may prevent increased resistance to drugs.

A Case of Type 1 Herpes Simplex Virus Encephalitis Detected by Polymerase Chain Reaction (중합효소연쇄반응으로 확진된 Herpes Simplex virus 뇌염 1례)

  • Park, Dae Young;Lee, Joon Soo;Lee, Young Ho;Sohn, Young Mo
    • Pediatric Infection and Vaccine
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    • v.3 no.2
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    • pp.207-213
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    • 1996
  • Herpes simplex virus(HSV) infections of the CNS are associated with significant morbidity and mortality even when appropriate antiviral therapy is administered. HSV infections of the brain can be subdivided into two categories : neonatal HSV infections, which usually are caused by HSV type 2, and herpes simplex encephalitis(HSE), which occur in patients over 3 months old and is nearly uniformly caused by HSV type 1. The clinical presentation of HSE is one of the focal encephalopathic process associated with altered levels of consciousness, fever, focal seizures and hemiparesis. But because of the lack of pathognomic clinical presentation and diagnostic procedure, the efforts to develop alternative diagnostic procedure have led to the use of new diagnostic technique such as polymerase chain reaction(PCR). We report a case of HSV type 1 encephalitis in 13 month old male infant who presented with altered level of consciousness, fever and focal seizures. With the use of the PCR, HSV-1 DNA was detected in cerebrospinal fluid from the patient. The symptoms and signs of encephalitis subsided by treatment with acyclovir in 14 days.

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