• Title/Summary/Keyword: Herb medicine treatment

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Effect of Ganjeonggyeok Acupuncture and Saengkankunbi-tang Treatment in the Changes of LFT and Lipid-obesity Index Values (간정격 시술 및 생간건비탕 투여가 간기능 및 비만도 변화에 미치는 영향)

  • Lee, Seong-No;Kim, Sang-Joo;Lee, Jin-Seok;Kim, Eun-Geol;Jang, Suk-Geun
    • Journal of Acupuncture Research
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    • v.25 no.6
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    • pp.47-54
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    • 2008
  • Objectives : This study was aimed to figure out how effectively acupuncture treatment and herb-medicine work on patients with elevation of LFT value and lipid-obesity index. Methods : The subject were 23 patients visited to Dept. of Acupuncture and Moxibustion, Kwangdong Oriental Medicine Hospital, who complained chronic fatigue and wandering pain from Oct. 2007. to Oct. 2008. Before treatments, they were tested for LFT, total cholesterol, triglyceride, body fat ratio and obesity index. They were treated with Ganjeonggyeok acupuncture weekly for 1 month. During acupuncture treatments, we applied Sangkankunbi-tang to all patients twice a day. After 1 month, they were retested for LFT, total cholesterol, triglyceride, body fat ratio and obesity index. Results : 1. After treatments, we could get the result of dropping means of AST, ALT and $\gamma$-GTP value. Statistical significance of ALT and $\gamma$-GTP were recognized before and after treatments, but AST was not recognized. 2. After treatments, we also could get the result of dropping means of total cholesterol, triglyceride, body fat ratio and obesity index. Statistical significance of all values were recognized before and after treatments. 3. Among 23 patients, 10 cases were reported that they were not within normal limits at least one in AST, ALT and $\gamma$-GTP. After treatments of those patients, we could get the result of dropping means of AST, ALT and $\gamma$-GTP value. Statistical significance of all values were recognized before and after treatments. 4. Among 23 patients, 19 cases were reported that they were not within normal limits at least one in total cholesterol, triglyceride, body fat ratio and obesity index. After treatments of those patients, we could get the result of dropping means of total cholesterol, triglyceride, body fat ratio and obesity index. Statistical significance of all values were recognized before and after treatments. Conclusions : Though further study is necessary, our finding suggest that the conduction of Ganjeonggyeok acupuncture and Sangkankunbi-tang treatments have helped to decrease the figures of LFT and lipid-obesity index in patients.

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Implement Traditional Korean Medical Information System of Hypertension through Building Database of Advanced Research Articles (선행연구자료 데이터베이스 구축을 통한 한의학 고혈압 정보 시스템 개발)

  • Yea, Sang-Jun;Kim, Chang-Seok;Kim, Chul;Kim, Young-Eun;Jang, Hyun-Chul;Kim, Sang-Kyun;Kim, Bo-Young;Song, Mi-Young
    • Korean Journal of Oriental Medicine
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    • v.18 no.1
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    • pp.35-43
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    • 2012
  • Objectives: Hypertension is the highest ratio among chronic disease in Korea, and the western medical information about hypertension is provided by many web sites. Advanced researches about hypertension have been conducted in Traditional Korean Medicine(TKM) for decades, but the research results are not arranged. So the results have not been utilized in following research nor contributed to the expansion of public knowledge. Methods : We did this study to improve this situation. In this study, we built database about advanced research articles related hypertension in TKM and implemented TKM information system of hypertension. Results : First, we benchmarked hypertension information systems and designed the TKM information system based on the benchmarking results and comments from TKM doctors. And it was composed of introduce, treatment, and etc. Second, we built prescription, herb, acumoxa, qigong, prevention/management, and pill database which is about 600 data extracted from papers and books. Third, we implemented JAVA/JSP based web information system which provides the database. And we created links for the each papers and books to use more easily. Conclusions : If we provide the research results about TKM hypertension diagnosis and combinational medication of western and oriental medicine, this information system will be more useful. And if we add internal and external project report about hypertension, it will be more worthy.

The anti-inflammatory effects of Huang-Lyun (Coptidis Rhizoma, CR) on injured tissue after burn elicitation (황련이 화상조직에 미치는 항산화와 항염증 및 피부재생 효과)

  • Kim, Hee-Kyung;Hong, Seung-Ug
    • The Journal of Korean Medicine
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    • v.32 no.2
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    • pp.1-13
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    • 2011
  • Background and Objective: Coptidis Rhizoma is a medicinal herb known for its antioxidant and anti-inflammatory effect. The purpose of this study was to examine the effects of CR on the experimental burn elicitation in vitro and in vivo. Material and Methods: In order to know the antioxidant effect on skin cell of mice after burn elicitation, superoxide dismutase (SOD) activity was measured. In vitro, the RAW 264.7 macrophage cells were treated with lipopolysaccharides for experimental inflammation. iNOS mRNA expression was observed after CR-treatment. In order to know effects on the skin regeneration in the burned mice, we counted the nitric oxide (NO) in blood. We also observed the histological structure in the epidermal basal layer and the dermal section, and we studied changes of angiogenesis in the capillaries surrounding the basal layer and dermal papilla. The changes of transcription of iNOS mRNA (inducible nitric oxide synthase mRNA) and changes of NF-${\kappa}$B (nuclear factor ${\kappa}$B) p65 positive reaction were also observed to investigate the changes of the stress in the skin. Results: The results indicated that CR has significant effects on the antioxidant effect on skin cells of mice after burn elicitation by increasing SOD activity in the in vitro test. It seemed that CR decreased the amount of NF-${\kappa}$B which induced the iNOS mRNA dose-dependently and suppress activating NO and angiogenesis. Furthermore, CR facilitated the process of skin recovery after experimental burn. Conclusion: CR can be applied for burned skin via antioxidant effect and skin regeneration.

Effect of Herbal Mixture including Lycii Fructus (HML) on Stress Relief and Melatonin in Caffeine and Light induced Stress Animal Model (Caffeine 및 광자극 유발 스트레스 동물모델에서 구기자 복합물이 스트레스 완화 및 혈중 멜라토닌에 미치는 영향)

  • Kim, Ee-Hwa;Hwang, Dong-Suk;Kim, Hee-Taek;Kim, Yong-Min
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.33 no.4
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    • pp.44-54
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    • 2020
  • Objectives : In the present study, we investigated whether or not an herb mixture including Lycii fructus(HML) has attenuation effects on light stress in rats. Methods : Light stress was induced by exposure to 300 lx of constant lifht for 24 h and 1mg/kg of caffeine was injected into the rat. Rats were orally treated with distilled water of HML for 21 days at 100mg/kg/d. The changes of mortality rate, clinical signs, body, blood chemistry, melatonin and IL-2 expression were analyzed after experiment. Results : Normal weight changes were observed in all treatment groups. In addition, no changes were observed in dead animals and general symptoms. At the time of autopsy, the appearance of all groups and gross examination of major organs were observed, and no gross findings were observed. Blood biochemical tests showed that total cholesterol and HDL cholesterol levels were statistically significantly decreased in the group treated with HML compared to the stress-induced group. Melatonin was measured in the blood, but there was no significant difference in the group treated with HML compared to the group with stress-induced group, but it tended to increase. IL-2 was measured in the blood, no significant change was observed in the group treated with HML compared to the stress-induced group. Conclusions : According to the above results, HML maybe help with hematological changes expressed by caffeine and light-induced stress.

Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation

  • Ghaeminia, Mehdy;Rajkumar, Ramamoorthy;Koh, Hwee-Ling;Dawe, Gavin S.;Tan, Chay Hoon
    • Journal of Ginseng Research
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    • v.42 no.3
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    • pp.298-303
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    • 2018
  • Background: Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects. Methods: We investigated the effects of Rg1 on the medial prefrontal cortex (mPFC), a key brain region involved in cognition, information processing, working memory, and decision making. In this study, the effects of systemic administration of Rg1 (1 mg/kg, 3 mg/kg, or 10 mg/kg) on (1) spontaneous firing of the medial prefrontal cortical neurons and (2) long-term potentiation (LTP) in the hippocampal-medial prefrontal cortical (HP-mPFC) pathway were investigated in male Sprague-Dawley rats. Results: The spontaneous neuronal activity of approximately 50% the recorded pyramidal cells in the mPFC was suppressed by Rg1. In addition, Rg1 attenuated LTP in the HP-mPFC pathway. These effects were not dose-dependent. Conclusion: This report suggests that acute treatment of Rg1 impairs LTP in the HP-mPFC pathway, perhaps by suppressing the firing of a subset of mPFC neurons that may contribute to the neurocognitive effects of Rg1.

Rhizoma Coptidis INHIBITS HISTAMINE-INDUCED CONTRACTILE RESPONSES OF AIRWAY SMOOTH MUSCLE (기관지(氣管支) 평골절(平滑筋)에 미치는 황연(黃連)의 효과(效果))

  • O, Kwang-Soo;Han, Jong-Hyun
    • The Journal of Internal Korean Medicine
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    • v.18 no.2
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    • pp.83-93
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    • 1997
  • Rhizoma Coptidis, a traditional herb medicine, has been used in Korea and China for many centuries as a treatment for many disease. The purpose of the present study was to determine the effect of Rhizoma Coptidis on histamine-induced tracheal smooth muscle contraction in guinea pigs and rats. Guinea pigs(500g, male) and rats(250g, male) were killed by $CO_2$ exposure and a segment (8-10mm) of the thoracic trachea from each guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for histamine ($10^{-7}-10^{-3}M$). Contractions evoked by histamine($ED_{50}$) were inhibited significantly by Rhizoma Coptidis. The mean percent inhibition was 33.2% after 1.5mg/ml Rhizoma Coptidis, and 69.5% after 5.0mg/ml Rhizoma Coptidis in guinea pigs, and the mean percent inhibition was 25.3% after 1.5mg/ml Rhizoma Coptidis, and 65.8% after 5.0mg/ml Rhizoma Coptidis in rats. Indomethacin ($10^{-7}M$) slightly but significantly attenuated the inhibitory effects of Rhizoma Coptidis. But propranolol and methylene blue ($10^{-7}M$) did not significantly alter the inhibitory effect of Rhizoma Coptidis. These results indicate that Rhizoma Coptidis can relax histamine-induced contraction of guinea pig and rat tracheal smooth muscle, and that this inhibition involves, in part, cyclooxygenese inhibitor.

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Effects of Scutellaria baicalensis on Surgically Induced Endometriosis in Rats after Oral or Rectal Administration (황분(黃芬)의 경구와 직장투여가 실험적으로 유발된 자궁내막증에 미치는 영향)

  • Lee, Hyun-Hee;Kim, Yoon-Sang;Lim, Eun-Mee
    • The Journal of Korean Obstetrics and Gynecology
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    • v.21 no.3
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    • pp.1-17
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    • 2008
  • Purpose: Scutellaria baicalensis is a herb which has effect of eliminating heat, drying dampness, purging away fire, detoxicating. Clinically, has been used to remove fever and control of inflammation. We have studied in series to investigate the effective traditional oriental medicines of treatment for endometriosis. In this study, the effects of Scutellaria baicalensis administrated orally or rectally on surgically induced endometriosis in rat were investigated. Methods: The endometrial tissues of rats were autografted to their small intestine. Rats with surgically induced endometriosis were administered with Scutellaria baicalensis extracts for 40 days orally or rectally. We observed the tissue size of ectopic uterine implants at the mesenteric with the naked eye and examined the concentration of estradiol, progesterone, $TNF-{\alpha}$ and IL-2, IL-4, IL-6 and IL-10 in serum. Also, we inquired which was more effective between oral administration groups and rectal administration groups. Results: The size of ectopic uterine implants of orally or rectally treated groups was much smaller than those of control groups. The concentrations of estradiol, progesterone, $TNF-{\alpha}$, IL-2 and IL-6 were significantly decreased in oral administration experimental group compared with the control group. The concentrations of progesteron, $TNF-{\alpha}$, IL-2 and IL-6 were significantly decreased in rectal administration experimental group compared with the control group. The efficiency of oral administration group was better than that of rectal administration group at the serum concentration of estradiol and IL-4. Conclusion: Our data suggest that Scutellaria baicalensis inhibit the inflammation induced from ectopic uterine implants at the mesenteric wall and inhibit the growth of ectopic uterine implants. Judging from the above results, it can be suggested that Scutellaria. baicalensis should be a useful agent for inhibiting the inflammation induced from ectopic uterine implants and the proliferation of endometriosis. Maybe, oral administration of Scutellaria baicalensis is more effective than rectal administration.

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The Comparative Study of Oriental Medicine in Korea, Japan and China (한국(韓國)과 일본(日本) 및 중국(中國)의 동양의학(東洋醫學)에 대한 비교연구(比較硏究))

  • Cho, Ki-Ho
    • The Journal of Korean Medicine
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    • v.19 no.1
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    • pp.271-298
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    • 1998
  • During these days of new understanding, western medicine has developed remarkably and a revaluation of traditional medicine has been achieved. This appears to have resulted from the sound criticisms of what western medicine has achieved up to now; excessive subdivisions of clinical medicine, severe toxicity of chemical drugs, lack of understanding about patients complaints which cannot be understood objectively, and etc. It is thought that the role of traditional medicine will be more important in the future than it is now. Someone said that the research methods of traditional medicine depends on the way of experimental science too much. That there was no consideration of a system for traditional medicine and the critic also went so far as to assert that in some cases the characteristics of eastern ideas is to permit irrationalism itself. In view of this thinking, the term traditional medicine seems to have been used somewhat too vaguely. However, traditional medicine is a medical treatment which has existed since before the appearance of modern medicine and it was formed from a traditional culture with a long history. One form of traditional medicine, oriental medicine based upon ancient Chinese medicine, was received in such countries as Korea, Japan, Thailand, Vietnam, Tibet, and Mongolia. Oriental medicine then developed in accordance with its own environment, race, national characteristics, and history. Although there are some simultaneous differences between them, three nations in Eastern Asia; Korea, Japan, and China, have especially similar features in their clinical prescriptions and medical literature. These three nations are trying to understand each others unique traditional medicines through numerous exchanges. Even though many differences in their ways of studying have developed over history exist, recent academic discussions have been made to explore new ways into oriental medicine. Therefore a comparative study of oriental medicine has gradually been thought to be more important. In Korea the formation of a new future-oriented paradigm for oriental medicine is being demanded. The purpose of the new paradigm is to create a new recognition of traditional culture which creates an understanding of oriental medicine to replace the diminished understanding of oriental medicine that was brought about by the self-denial of traditional culture in modem history and cultural collisions between oriental and occidental points of view. Therefore, to make a new paradigm for oriental medicine which is suitable for these days, and fortifies the merit of oriental medicine while compensating its defects, the author has compared the characteristics of oriental medicines in Korea, Japan, and China. The conclusions of this research are as follows: 1. The fundamental differences of the traditional medicines of these three nations are caused by the differences in the systems of Naekyung and Sanghannon. 2. The pattern-identification of illnesses is generally divided into two categories; the pattern identification of Zang-Fu and the pattern identification of prescription. 3. There are many differences in the definition of terms, such as Yin and Yang, Deficiency and Excess, and etc. 4. Chinese traditional medicine has some new concepts about pattern identification and epidemic febrile disease. 5. Japanese traditional medicine has some characteristics about pattern identification of the whole bodys condition and signs of abdominal palpation. 6. In terms of the effects of herbal drugs, Chinese traditional medicine attaches great importance to the experiential efficacy of the herb, and Japanese traditional medicine is taking a serious view of the effects of experimental medical actions.

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A study on a terms of "The Jung pung(中風) therories of JuJinHyoung(朱震亨)" (주진형(朱震亨)의 중풍론(中風論)에 관한 고찰(考察))

  • Ko, Kyeong-Deok;Lee, Dong-Won;Jung, Seung-Hyun;Shin, Gil-Cho;Lee, Won-Chul
    • The Journal of Dong Guk Oriental Medicine
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    • v.6 no.1
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    • pp.129-136
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    • 1997
  • We inquired into tile origins, pathologies, theraphies and prescriptions of Jungpung(中風) especially on the ground of Keokchiyeron(格致餘論) Dangeosimbub(丹溪心法) written by JuJinHyoung(朱震亨) as medical books, from this study we could get that conclusions. 1. According to special feature of the theroies of JuJinHyoung's(朱震亨) Jungpung(中風) he thought pathologies of Jungpung(中風) as "sub seong dam dam seong yeol yeol seong pung 濕生痰痰生熱 熱生風" through studying stress on regional characteristics and thought much of dam(痰) as one of major elements of internal causes. 2. He suggested chi-dam(治痰) in the first place in the treatment of Jungpung(中風) and emphasises the treatment using Succus Pyllostachyos(竹瀝), waterly extracted Rhizoma Zingiberis(薑汁) in that they had the virtues of sodam-ganghwa(消痰降火), geo-gyeongrak(開經絡), haeng-heolgi(行血氣) 3. He treated differently whether a man in fat and thin, and have right or left hemiplegia, but he prescribed herb-medications on the principle that that medications should have the virtues of chi-dam(治淡).

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Systemic review: Herbal Medicines in the Treatment of Osteoarthritis in Pubmed and Chinese Medical Journals (퇴행성관절염(退行性關節炎) 한방치료(韓方治療)에 대(對)한 최근(最新) 연구(硏究) 동향(動向) - 임상연구(臨床硏究) 방법론(方法論)을 중심(中心)으로 -)

  • Seo, Byung-kwan;Ryu, Seong-ryong;Lee, Song-shil;Huh, Jeong-eun;Baek, Yong-hyeon;Lee, Jae-dong;Choi, Do-young;Cho, Yoon-je;Kim, Nam-jae;Park, Dong-suk
    • Journal of Acupuncture Research
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    • v.21 no.3
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    • pp.265-282
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    • 2004
  • Objective : The aim of this study was to review systemically clinical trials on the effectiveness and safety of herbal medicines in the treatment of osteoarthritis. Methods : Computerized literature searches were carried out on seven electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Trial data were extracted in a standardized, predefined manner and assessed independently. Results : 1. Thirty reports of clinical trials and two reports of meta-analyses concerning herbal medicine were collected and reviewed. Among these reports three medical herbs were applied as topical medicine and others as internal medicine. 2. The western studies established NSAIDs or placebo as their control group. Five chinese reports established formulated herb pill(Ruanshnagshenjin pill) as their control group and Six did not establish a control group at all. 3. ACR was the most highly used diagnostic criteria in the western studies while the Chinese used their official criteria established by their government or the criteria of their text books. 4. 20 reports chose the Lequesne functional index, SHAQ, WOMAC OA index, AIMS, and their own unique scoring system as the criteria of analysing the effect. Others chose clinical symptoms, articular functions, and lab finding as their criteria. 5. 7 single herbs and 19 formulated herbs were studied. Among the formulated herbs, Achyranthes japonica was studied in 10 of the studies and Angelica gigantis Radix in 8, making them the most often studied herbs among the studies.

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