The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Rhizoma Coptidis INHIBITS HISTAMINE-INDUCED CONTRACTILE RESPONSES OF AIRWAY SMOOTH MUSCLE

기관지(氣管支) 평골절(平滑筋)에 미치는 황연(黃連)의 효과(效果)

  • O, Kwang-Soo (College of Oriental Medicine, Wonkwang University) ;
  • Han, Jong-Hyun (Medicinal Resources Research Center of Wonkwang University)
  • Published : 1997.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Rhizoma Coptidis, a traditional herb medicine, has been used in Korea and China for many centuries as a treatment for many disease. The purpose of the present study was to determine the effect of Rhizoma Coptidis on histamine-induced tracheal smooth muscle contraction in guinea pigs and rats. Guinea pigs(500g, male) and rats(250g, male) were killed by $CO_2$ exposure and a segment (8-10mm) of the thoracic trachea from each guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for histamine ($10^{-7}-10^{-3}M$). Contractions evoked by histamine($ED_{50}$) were inhibited significantly by Rhizoma Coptidis. The mean percent inhibition was 33.2% after 1.5mg/ml Rhizoma Coptidis, and 69.5% after 5.0mg/ml Rhizoma Coptidis in guinea pigs, and the mean percent inhibition was 25.3% after 1.5mg/ml Rhizoma Coptidis, and 65.8% after 5.0mg/ml Rhizoma Coptidis in rats. Indomethacin ($10^{-7}M$) slightly but significantly attenuated the inhibitory effects of Rhizoma Coptidis. But propranolol and methylene blue ($10^{-7}M$) did not significantly alter the inhibitory effect of Rhizoma Coptidis. These results indicate that Rhizoma Coptidis can relax histamine-induced contraction of guinea pig and rat tracheal smooth muscle, and that this inhibition involves, in part, cyclooxygenese inhibitor.

Keywords

References

  1. 日藥理誌 v.72 Berberine型 알칼로이드의 行動藥理學的 硏究(第1報) 黃連 및 그의 含有成分의 中樞抑制作用 山原條二
  2. 日藥理誌 v.72 Berberine型 알칼로이드의 行動藥理學的 硏究(第2報) Tetrahydroberberine 및 그의 關聯化合物의 中樞 抑制作用 山原條二
  3. 和漢藥 심포지움 記錄 v.9 實驗的胃潰瘍에 대한 和漢藥 處方의 效果 渡邊和夫;渡邊裕司;後藤義明
  4. 和漢藥심포지움 v.9 生物試驗法에 의한 和漢藥의 品質評價 澤田德之助;山原條二
  5. 日藥理誌 v.53 베르베린의 藥理作用 知見補遺 內炭精一
  6. Chem. Pharm. Bull. v.18 Some Observations on the Cardiovascular Effects of 9-Substituted Berberines Fukuda, H.;Watanabe, K.;Kudo, Y.
  7. 日藥理誌 v.53 Berberine의 抗 curare 作用 島本暉郞;內炭精一;井上邦夫
  8. 生藥學 雜誌 v.24 黃連 및 그 成分의 藥理 桑野重昭
  9. Am. J. Physiol. v.241 Reversal of choleratoxin-induced secretion in rat ileum by luminal berberine Swabb, E.A.;Tai, Y.H.;Jordan, L.
  10. 和漢藥 赤松金芳
  11. 藥誌 v.90 生藥 및 植物成分의 抗炎症 스크리닝 藤村一;澤田德之助;後藤實
  12. Pflugers Arch, ges. : Physiol.
  13. Br. J. Pharmac. v.91 The obligatory role of calcium in the delelopment of antigen-induced airway hyperreactivity to cold provocation in the rat isolated trachea Chand, N.;Diamantis, W.;Sofia, R.D.
  14. Statistical Methods Snedecor, G.H.;Cochran, W.G.
  15. 黃帝內經 張馬合
  16. 丹溪心法附餘 朱震亨
  17. 醫學入門 李挺
  18. 中醫內科學 上海中醫學院
  19. 傳統老年醫學 李聰甫
  20. 藥理學講義 李宇柱
  21. The Pharmacological Basic of Therapeutics Alfred Goodman Gilman
  22. Current Medical Diagnosis and Treatment Werdegar, Krupp Chatton
  23. Eur. J. of Pharmacol. v.157 ${\beta}$-Adrenoceptor desensitization in guinea-pig isolated trachea Fernandes, Lynette B.;Knight, Darryl A.;Rigby, Paul J.;Spina, Domenico;Paterson, James W.;Goldie, Roy G.
  24. Pharmacol. Res. Commun. v.18 Arachidonic acid metabolites and lung ${\beta}$-adrenoceptor desensitization Abbrachio, M.P.;Daffonchio, I.;Omini, C.
  25. J. Aulon. pharmacol. v.2 Desensitization of ${\beta}$-adrenoceptor in guinea-pig trachea : A prostaglandin mediated phenomenon Berti, F.;Daffonchio, L.;Folco, G.C.;Omini, C.;Vigano, T.
  26. Br. J. Pharmacol. v.85 Pharmacological moculation of responses guinea-pig airways contracted with arachidonic acid Bruka, John F.
  27. Prostaglandins v.22 Immunolgical and non-immunological synthesis and release of prostaglandines and thromboxanes from isolated guinea-pig trachea Burka, J.F.;Ali, M.;Mcdonald, J.W.D.;Paterson, N.A.M.
  28. Br. J. Pharmac. v.81 Mediators of arachidonic acid-induced contraction of indomethacine-treated guinea-pig airways : Leukotrienes C4 and D4 Burka, J.F.;Saad, M.H.
  29. Prostaglandins v.28 Metabolism of arachidonic acid by 5-lipoxygenase in guinea-pig lung Burka, J.F.;Saad, M.H.
  30. Am. Rev. Respir. Dis. v.130 Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure O'Byrne, P.M.;Watlters, E.H.;Gold, B.D.;Aizawa, H.A.;Fabbri, L.M.;Alpert, S.E.;Nadel, J.A.;Holtzman, M.J.