The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Yukmijihwangtang on the Biochemical Changes in Brain Tissue

육미지황탕(六味地黃湯)이 뇌조직(腦組織)의 생화학적(生化學的) 변화(變化)에 미치는 영향(影響)

  • Lee, Young-Goo (Dept. of internal Medicine, College of Oriental Medicine WonKwang University) ;
  • Lee, In (Dept. of internal Medicine, College of Oriental Medicine WonKwang University) ;
  • Moon, Byung-Soon (Dept. of internal Medicine, College of Oriental Medicine WonKwang University)
  • 이영구 (원광대학교 한의과대학 내과학교실) ;
  • 이인 (원광대학교 한의과대학 내과학교실) ;
  • 문병순 (원광대학교 한의과대학 내과학교실)
  • Published : 1997.12.30
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Abstract

The present experiment was designed to examine catecholamines, serotonine, amino acids, malondialdehyde and free radical scavenging activity, by administering Yukmijihwangtang extract of a variety of concentraction to senile brain. The results were summarized as followings: 1. Yukmijihwangtang significantly increased noradrenaline in the striatum, hypothalamus, midbrain and pons-medulla oblongota of the brain tissue of senile rats, and even though Yukmijihwangtang increased noradrenaline also in other brain tissue, there was no significance. 2. Yukmijihwangtang significantly increased dopamine in the striatum, hypothalamus and midbrain of the brain tissue of senile rats, and even though Yukmijihwangtang increased dopamine also in other brain tissue, there was no significance. 3. Yukmijihwangtang significantly increased serotonine in the pons- medulla oblongata and cerebellum of the brain tissue of senile rats, and even though Yukmijihwangtang increased serotonine also in the other brain tissue except hypothalamus and midbrain, there was no significance. 4. Yukmijihwangtang significantly increased amino acid in the brain tissue of senile rats. 5. Yukmijihwangtang significantly decresed malondialdehyde and free radical in the brain tissue of senile rats. According to the above results, Yukmijihwangtang is assumed to improve brain function by reacting on biochemical of the senile brain, and that Yukmijihwangtang can be used to treat regressive brain disease carrying symptoms of psychoactive disorders.

Keywords

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