• The Korean Journal of Physiology
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• v.15 no.1
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• pp.53-59
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• 1981

In the present study, an effort was directed to elucidate the effect of osmolality on the absorption of ethanol in rabbits. A single dose of 13.67 ml(2. 16 gm ethanol/kg BW) of hypo-, iso-hyphen and hypertonic ethanol per kg BW was administered into the stomach to albino rabbits and the experiment was performed at 30 th, 60 th and 120 th minute. The blood ethanol level was determined by the method of Williams et al, and hematocrit(Hct) was determined by the conventional Hct centrifuge and reader. The results are summarized as follow. The blood ethanol level showed the highest value at 60 min after the ethanol ingestion in the hypo- and isotonic groups, $171.3{\pm}13.3\;mg%$ and $204.5{\pm}23.0\;mg%$, respectively, but in the hypertonic group, the highest value was observed at 120min after the ingestion. The absorption rate of ethanol between 0 to 30 min after the ingestion of hypo- and isotonic ethanol was $88.54{\pm}12.04$ and $94.73{\pm}8.33\;mg/min$, respectively, but a decreased value of $44.72{\pm}6.69\;mg/min$ was noted after hypertonic ethanol ingestion comparing with hypo- and isotonic groups, The Hct value after hypo- and isotonic ethanol ingestion was decreased at 30 min but returned to the control level at 120 min. In contrast with hypo- and isotonic ethanol ingestion, hypertonic ethanol ingestion produced an increase of the Hct value at 30 min and returned to the control level at 120 min. The heart rate was increased but the respiratory rate was decreased after ethanol ingestion regardless of the osmolality.

• Environmental Analysis Health and Toxicology
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• v.2 no.1_2
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• pp.25-32
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• 1987

The effects of ginseng ethanol extract on the toxicity of lead acetate in mice were examined. Mice were given intraperitoneally daily doses of lead acetate 50 mg/kg with ginseng ethanol extract 50 mg/kg, 100 mg and 200 mg/kg for 3 weeks. The exposure of lead acetate showcd the toxicity at all experimental assay such as the gain of body weight, the ratio of some organs weight to body weight, serum transaminase activity and creatinine value, hematocrit and WBC counts. These toxicities were inhibited significantly by the ginseng ethanol extract administration. The 50 mg/kg and 100 mg/kg administration of ginseng ethanol extract inhibited histopathological changes on kidney by lead acetate, whereas the 200 mg/kg administration of the fraction enhanced histopathological changes.

• Journal of Radiation Protection and Research
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• v.33 no.3
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• pp.93-97
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• 2008

The purpose of this study reported here was to investigate the ability of Bu-Zhong-Yi-Qi-Tang (BZYQT), known to elevate hematopoietic functions, to protect mice undergoing treatment with whole body single gamma-irradiation. BZYQT was given (25 mg/kg B.W.) intraperitoneally at 36 and 12 hours before irradiation and 30 minute and 24 hours after irradiation. Recovery of neutrophil and lymphocyte counts was significantly stimulated by extract of BZYQT. Stimulated recovery by the extract from the BZYQT was also observed in thrombocyte. However, the anti-radiation effect of erythrocyte, hemoglobin and hematocrit was not as significant as that of leukocyte. Further studies are needed to better characterize the protective nature of BZYQT extract and its ingredients.

• Journal of Nutrition and Health
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• v.25 no.7
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• pp.578-585
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• 1992

This study was undertaken to investigate effects of alcohol and dietary protein levels on serum lipids and enzyme activities in 15 week-old male rats given a normal diet. Rats were divided into 8 groups : control group (16% protein 16PC) and 8%(8PE) 16%(16PE) and 24% protein groups(24PE) to which was given 5% ethanol mixed into their drinking water after 4 weeks and 10 weeks. Body weight organ weight and various blood components were determined at 4 and 10 weeks. Body weight gain organ weight hemoglobin concentration and hematocrit value were not influenced by ethanol and dietary protein levels. The levels of total cholesterol HDL-cholesterol and phospholipid in serum were not affected by ethanol consumption. Serum triglyceride concen-trations after 10 weeks were significnatly increased ethanol-treated group compared with that of control group and the effect was greater in low protein group than control group. Serum ALP activity was significantly higher in 8PE group than other group but there was no influence by ethanol consumption.

• Fisheries and Aquatic Sciences
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• v.15 no.3
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• pp.215-220
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• 2012

The effects of inorganic mercury on hematological parameters and hepatic oxidative stress enzyme activity were studied in olive flounder Paralichthys olivaceus. Fish were injected twice intraperitoneally with mercuric chloride (2, 4, or 8 mg Hg/kg BW). The major hematological findings were significant decreases in the red blood cell count, hematocrit value, and hemoglobin level in olive flounder exposed to 8 mg Hg/kg BW. Remarkably low levels of calcium and chloride, and reduced osmolality, were also observed at 8 mg Hg/kg BW. In hepatic tissue, significant increases in glutathione peroxidase and catalase activity were observed above 4 mg Hg/kg BW Inorganic mercury also increased glutathione S-transferase and glutathione reductase activity at 8 mg Hg/kg BW in hepatic tissue. The present findings suggest that exposure to a low concentration (${\geq}4$ mg Hg/kg BW) of inorganic mercury can cause significant changes in hematological and antioxidant parameters.

• Proceedings of the Ginseng society Conference
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• 1978.09a
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• pp.103-108
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• 1978

Ginseng jellies and candies were prepared by adding ginseng extracts as final concentration of $0.5\%\;and\;1\%$ for jellies and $0.7\%$ for candies. Feeding experiments of the diets containing ginseng extract were carried out for evaluation in respects of growth rate, feed efficiency ratio, organ weight change, hematocrit value, and blood cholesterol content by feeding rats for 6 week. The results of ginseng supplemented diets were not significantly different from those for the control. Liver, spleen and kidney cells of ginseng products feeding rats appeared no abnormalities in comparison with the control rats.

• Biomedical Science Letters
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• v.1 no.1
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• pp.73-79
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• 1995

The effect of prior cumulative mixing was evaluated by means of a simple regression model which used as a dependent variable percentage(%) change of each repeated observed value for the initial value. The red blood cell count (RBC), hematocrit (Hct), and mean corpuscular volume(MCV) showed a significant decrease (p<.01), but % of basophils had a significant increase (p<.05). The ratios of rate of change (regression coefficient/SD) were .0012 for RBC, .0020 for Hct, .0024 for MCV, and .0011 for % of basophils. Of the 19 parameters evaluated, 21% changed.

• Biomolecules & Therapeutics
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• v.6 no.3
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• pp.312-316
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• 1998

Efficacy and in vivo bioassay of recombinant human erythropoietin (rho-EPO), was investigated. Efficacy studies were conducted in normal, and cisplatin-induced anemic rats. Normal and anemic animals were treated intravenously with rhu-EPO for 5 days, and the changes in the number of red blood cells (RBC), hemoglobin concentration (Hb), hematocrit value (Hct) and percentage reticulocyte value (Ret, reticulocyte/RBC) were examined. In normal rats, rho-EPO significantly increased RBC, Hb, Hct and Ret at the doses of 50∼ 1,250 lU/kg/day in a dose-dependent fashion. Cisplatin-induced anemic rats showed significant increase of RBC, Hb, Hct and Ret after administration of rho-EPO (50-200 lU/kg/day) in a dose-dependent manner. These changes of hematological parameters disappeared gradually after cessation of the treatment. The in vivo bioassay results in polycythemic mice showed that rho-EPO had 90% of bioactivity compared to NIBSC standard rhu-EPO. These results suggest that rho-EPO might be useful for the therapy of anemia originated from renal failure and chemotherapy-induced anemia.

• Korean Journal of Veterinary Research
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• v.12 no.1
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• pp.7-14
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• 1972

Hemogram and serum composition of pregnant rabbits were studied and the results obtained were as follows: 1. Erythrocyte, hemoglobin concentration and hemotocrit value of pregnant rabbits decreased at the late stage of gestation, and 1 week after delivery the values were recovered to the normal levels. Number of erythrocyte and hematocrit value were not found to be significant, but hemoglobin concentration showed significant differences at the third and fourth week of pregnancy. 2. Total leucocytes of pregnant rabbits increased continuously as gestation progresses and 1 week postpartum the values were returned to normal. Highly significant changes were observed in the third and the fourth week of pregnancy. Neutrophil was revealed highly significant rise at the third and the fourth week of gestation and 1 week postpartum, but lympocyte was decreased highly significantlly. 3. Serum calcium of pregnant rabbits revealed the tendency of decrease as gestation progresses and 1 week after delivery the value was returned to normal, and highly significant decrease was abserved at the fourth week. Serum inorganic phosphorus of pregnant rabbits showed highly significant decrease at the fourth week of gestation, but no differences were observed at the other period of gestation and 1 week postpartum. 4. Serum protein of pregnants rabbits showed the tendency of decrease continuously pregnancy progresses, and 1 week after delivery showed the normal values. Highly significant decrease was found at the fourth week of gestation. the levels of serum lipids in pregnant rabbits was unchanged untill the third week of pregnancy, but at the fourth week and 1 week postpartum, the rise was highly significant. The level of total serum cholesterol in pregnants rabbis was shown the tendency of decrease untill the end of the second week of gestation and significantly dropped at the third week, thereafter, the value was rose significantly at the fourth week of gestation and 1 week postpartum.

• Journal of Nutrition and Health
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• v.11 no.4
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• pp.25-30
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• 1978

The Nutritional Anaemia due to Iron Deficiency is by for the most common variety of anaemia throughout the world, affecting many women in their reproductive years, infant and children. In Korea, several studies reported that most of the female was iron-deficient and anemic. The present study was undertaken to investigate the nutritional anaemic state of the college girls in kwang-ju city area. Seventy-five college girls in child-bearing age (from 17 to 22 years old) were selected and practiced physical examination, hematological and parasitological tests. The results obtained are summarized as follows; 1) The mean body height $(158.6{\pm}3.4cm)$higher tendency compared to other studies, but the mean body weight $(51.1{\pm}5.6kg)$was lighter. 2) The mean red blood cell number was $441.4{\pm}17.7\;10^4/mm^3$, and most of the subjects were included normal criteria. The average hemoglobin level was $12.5{\pm}0.7gm%$, and 25..7% of the subjects was anaemic. (l2gm% below) The average hematocrit value was $39.1{\pm}2.3%$ and 7.0% was anaemic. (below 37%) The average M C.H.C. value was $32.1{\pm}0.9%$, and 86.0% was anaemic. (32% below) These results showed that the incidence of anaemia was high and the anaemia was characterized by hypochromic in general. 3) The mean value of serum total protein and albumin were $6.6{\pm}0.4gm%$ and $4.2{\pm}0.4gm%$. These values were indicated total protein intake was insufficiency, but albumin value was comparatively high. 4) The infestation rate of helminthes was 25.4%, (Ascaris lumbricoides: 20.3%, Trichuris trichiura: 8.5%) and there was no hookworm infected case.