Journal of Radiation Protection and Research

The Korean Association for Radiation Protection (대한방사선방어학회)
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ALTERATION OF RADIATION-INDUCED HEMATOTOXICITY BY BU-ZHONG-YI-QI-TANG IN MOUSE

  • Jang, Jong-Sik (Department of Animal Science, Kyungpook National University) ;
  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University)
  • Published : 2008.09.30
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Abstract

The purpose of this study reported here was to investigate the ability of Bu-Zhong-Yi-Qi-Tang (BZYQT), known to elevate hematopoietic functions, to protect mice undergoing treatment with whole body single gamma-irradiation. BZYQT was given (25 mg/kg B.W.) intraperitoneally at 36 and 12 hours before irradiation and 30 minute and 24 hours after irradiation. Recovery of neutrophil and lymphocyte counts was significantly stimulated by extract of BZYQT. Stimulated recovery by the extract from the BZYQT was also observed in thrombocyte. However, the anti-radiation effect of erythrocyte, hemoglobin and hematocrit was not as significant as that of leukocyte. Further studies are needed to better characterize the protective nature of BZYQT extract and its ingredients.

Keywords

References

  1. Patt H, Tyree M and Straube RL. Cystein protects against x-irradiation. Science. 1949;110:213-214 https://doi.org/10.1126/science.110.2852.213
  2. Sweeney TR. A survey of compounds from the antiradiation drug development program of the U.S. army medical research development command. Walter Reed Army Institute of research. 1979
  3. Kligerman MM, Shaw MT, Slavid M and Yudas JM. Phase I clinical studies with WR2721. Cancer Clin Trials. 1980;3(3):217-221
  4. Fujii Y, Imamura M, Han M, Hashino S, Zhu X, Kobayashi H, Imai K, Kassai M, Sakurada K and Miyazaki T. Recipient-mediated effect of a traditional Chinese herbal medicine, ren-shen-yang-rong-tang(Japanese name: ninjinyouei- to), on hematopoietic recovery following lethal irradiation and syngeneic bone marrow transplantation. Int J Immunopharmacol. 1994;16(8):615-622 https://doi.org/10.1016/0192-0561(94)90134-1
  5. Hsu HY, Lian SL and Lin CC. Radioprotective effect Ganoderma lucidum (Leyss. ex. Fr.) Karst after X-ray irradiation in mice. Am J Chin Med. 1990;18(1-2):61-69 https://doi.org/10.1142/S0192415X90000095
  6. Zhang RJ, Quin JK, Yang GH, Wang BZ and Wen XL. Medicinal protection with Chinese herb-compound against radiation damage. Aviat Space Environ Med. 1990;61(8):729-731
  7. Ohnishi Y, Yasumizu R, Fan H, Liu J, Takao-Liu F, Komastu Y, Hosoya E, Good RA and Ikehara S. Effect of juzen-taiho-toh(TJ-48), a traditional Oriental medicine, on hematopoietic recovery from radiation injury in mice. Exp Hematol. 1990;18(1):18-22
  8. Kim SH, Son CH, Nah SY, Jo SK, Jang JS and Shin DH. Modification of radiation response in mice by Panax ginseng and diethyldithiocarbamate. In Vivo. 2001;15(5):407-411
  9. Kim SH, Jeong KS, Ryu SY and Kim TH. Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cell in irradiated mice. In Vivo. 1998;12(2):219-222
  10. Kim SH, Lee SE, Oh H, Kim SR, Yee ST, Yu YB, Byun MW, Jo SK. The radioprotective effects of bu-zhong-yiqi-tang: a prescription of traditional Chinese medicine. Am J Chin Med. 2002;30:127-137 https://doi.org/10.1142/S0192415X02000144
  11. Washburn LC, Carlton JE and Hayes RL. Distribution of WR-2721 in normal and malignant tissue of mice and rats bearing solid tumors: dependence on tumor type, drug dose and species. Radiat Res. 1974;59(2):475-483 https://doi.org/10.2307/3573996
  12. Cairnie AB. Adverse effect of radioprotector WR2721. Radiat Res. 1983;94(1):221-226 https://doi.org/10.2307/3575878
  13. Zhang JS, Sidgdestad CP, Gemmell MA and Grdina DJ. Modification of radiation response in mice by fractionated extracts of Panax ginseng. Radiat Res. 1987;112(1):156-163 https://doi.org/10.2307/3577086
  14. Ohta S, Sakurai N, Sato Y, Inoue T and Shinoda M. Studies on chemical protectors against radiation. XXX. Radioprotective substances of cnidii rhizoma. Yakugaku Zasshi. 1990;110(10):746-754 https://doi.org/10.1248/yakushi1947.110.10_746
  15. Wang Y and Zhu B. The effect of angelica polisaccharide on proliferation and differentiation of hematopoietic progenitor cell. Zhonghua Yi Xue Za Zhi. 1996;76(5):363-366
  16. Miyanomae T and Frindel E. Radioprotection of hemopoiesis conferred by Acanthopanax senticosis Harms (Shigoka) administered before or after irradiation. Exp Hematol. 1988;16(9):801-806
  17. Quan HX and Li HS. Effect of radix Astragali on hemopoiesis in irradiated mice. Chung Kuo Chung Yao Tsa Chin. 1994;19:741-743
  18. Hosokawa Y. Radioprotective effect of Chinese medicinal prescriptions in mice. J Med Pharm Soc for Wakan-Yaku. 1986;3:164-169
  19. Hsu HY, Ho YH, Lian SL and Lin CC. Preliminary study on the anti-radiation effect of jen-sheng-yang-yung-tang. Am J Chin Med. 1993;21(2):187-195 https://doi.org/10.1142/S0192415X93000224
  20. Lee SE, Oh H, Yang JA, Jo SK, Byun MW, Yee ST and Kim SH. Radioprotective effects of two traditional Chinese medicine prescriptions: Si-Wu-Tang and Si-Jun-Zi-Tang. Am J Chin Med. 1999;27(3-4):387-396 https://doi.org/10.1142/S0192415X99000446
  21. Hsu HY, Ho YH and Lin CC. Protection of mouse bone marrow by Si-Wu-Tang against whole body irradiation. J Ethnopharmacol. 1996;52(2):113-117 https://doi.org/10.1016/0378-8741(96)01400-6
  22. Hsu HY and Lin CC. A preliminary study on the radioprotection of mouse hematopoiesis by Dang-Gui-Shao-Yao-San. J Ethnopharmacol. 1996;55(1):43-48 https://doi.org/10.1016/S0378-8741(96)01472-9
  23. Hsu HY, Hau DM and Lin CC. Effect of kuei-pi-tang on cellular immunocompetence of gamma-irradiated mice. Am J Chin Med. 1993;21(2):151-158 https://doi.org/10.1142/S0192415X93000182
  24. Ito H and Shimura K. Studies on the antitumor activity of traditional Chinese medicine. Gan To Kagaku Ryoho. 1985;12(11):2149-2154
  25. Li XY, Takimoto H, Miura S, Yoshikai Y, Matsuzaki G and Nomoto K. Effect of the tradiational Chinese medicine, bu-zhing-yi-qi-tang (Japanese name: Hochu-ekki-to) on the protection against Listeria monocytogens infection in mice. Immunophamacol Immunotoxicol. 1992;14(3):383-402 https://doi.org/10.3109/08923979209005400
  26. Koshikawa N, Imai T, Takahashi I , Yamauchi M, Sawada S and Kansaku A. Effect of Hochu-ekki-to, Yoku-kan-san and Saiko-ka-ryukotsu-borei-to on behavioral despair and acetic acid- induced writhing in mice. Methods Find Exp Clin Phrmacol. 1998;20(1):47-51 https://doi.org/10.1358/mf.1998.20.1.485631
  27. Ikeda S, Kaneko M, Kumazawa Y and Nishimura C. Protective activities of a Chinese medicine, Hochu-ekki-to, to impairment of hematopoietic organs and to microbial infection. Yakugaku Zasshi. 1990;110(9):682-687 https://doi.org/10.1248/yakushi1947.110.9_682
  28. Murakami Y. Clinical effect of hotyuekkito (buzhongyiqitang) on symptoms due to renal ptosis and stress incontinence. Hinyokika Kiyo. 1988;34(10):1841-1843
  29. Ishikawa H, Manabe F, Zhongtao H, Yoshii S and Koiso K. The Hormonal response to HCG stimulation on patients with male infertility before and after treatment with hochuekkito. Am J Chin Med. 1992;20(2):157-165 https://doi.org/10.1142/S0192415X92000163
  30. Floersheim GL, Chiodetti N and Bieri A. Differential radioprotection of bone marrow and tumour cells by zinc aspartate. Br J Radiol. 1988;61(726):501-508 https://doi.org/10.1259/0007-1285-61-726-501