• 대한임상약리학회:학술대회논문집
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• 2006.11a
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• pp.70-70
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• 2006

• Interdisciplinary Bio Central
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• v.3 no.3
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• pp.11.1-11.5
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• 2011

The MRI (magnetic resonance imaging) volumetric analysis of the brain was performed in 59 healthy elderly Koreans (aged 62-76 years; 34 male, 25 female) to investigate whether the previously reported significant correlations between body height and brain volumes in the young aged Koreans (20's) still exist in the old aged Koreans (60's and 70's). Unlike previously reported significant correlations in the young aged Koreans, neither the correlation between whole brain volume and body height in male nor the correlation between cerebellar volume and body height in female show any significance in the old aged Koreans. The significant correlation between body height and whole brain volume was still observed when both male and female data were combined (r=0.27, P<0.05), but the correlation coef-ficient and the level of significance markedly decreased from those of previously reported Korean youth data (r=0.67, P<0.01). Simple linear regression analysis shows decrease of explanatory power of height (measured in $r^2$) from 44% in the youth group to 7% in the old age group on the variance of whole brain volume. Multiple linear regression analysis shows that age and sex, rather than height, are major explanatory variables for whole brain volume in the old aged Koreans. The loss of correlations in the aged group is suspected to be mainly due to age related brain volume changes.

• Journal of Dairy Science and Biotechnology
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• v.23 no.2
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• pp.99-106
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• 2005

Chronic diseases such as cancer, cardiovascular diseases, are the leading cause of death and disability in Korea since 1970 due to lifestyle change introduced by urbanization & industrialization. The type of cancer and cardiovascular diseases changes as lifestyle becomes westernized. These diseases account for 4 of every 10 deaths and affect the quality of lift of Koreans. Although chronic diseases are among the most common and costly healthy problems, they are also preventable. Adopting healthy behaviors such as quitting smoking, being physically active, eating right with moderate alcohol drinking, and maintaining healthy weight can prevent or control the effect of these diseases.

• 한국유가공학회:학술대회논문집
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• 2005.06a
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• pp.1-12
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• 2005

Chronic diseases such as cancer, cardiovascular diseases, are the leading cause of death and disability in Korea since 1970 due to lifestyle change introduced by urbanization & industrialization. The type of cancer and cardiovascular diseases changes as lifestyle becomes westernized. These diseases account for 4 of every 10 deaths and affect the quality of lift of Koreans. Although chronic diseases are among the most common and costly healthy problems, they are also preventable. Adopting healthy behaviors such as quitting smoking, being physically active, eating right with moderate alcohol drinking, and maintaining healthy weight can prevent or control the effect of these diseases.

• Research in Community and Public Health Nursing
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• v.14 no.4
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• pp.667-675
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• 2003

Purpose: This study was purposed to provide basic data for developing future health promotion programs by comparing health-promoting behavior, life satisfaction and self-esteem between the Korean elderly and the American-Korean elderly. Methods: The subjects were volunteer participants of 120 elders in the Gyeongsan City in Korea and 120 elders in the state of Washington in the U.S. Tools used in this study were Health Promoting Lifestyle Profile (47 items), Life Satisfaction Scale (20 items) and Self-Esteem Scale (10 items). To analyze data, this study used frequency, percentage, chi-square test, t-test, Kendal tau test, Pearson's correlation coefficient with SPSS program. Results: 1) The average score of health-promoting behaviors was 3.21 in Koreans and 3.50 in American-Koreans, showing a significant difference between the two groups. 2) The sub-scales that got the highest score of health-promoting behaviors were self-actualization and nutrition(M=3.41) in Koreans and nutrition(M=3.61) in American-Koreans, and that with the lowest score was exercise in both groups(2.89 in Koreans and 3.02 in American-Koreans). 3) The average score for life satisfaction was 2.76 in Koreans and 3.06 in American-Koreans, showing a significant difference between the two groups. 4) The average score for self-esteem was 3.39 in Koreans and 3.09 in American-Koreans, showing a insignificant difference between the two groups. 5) Health-promoting behaviors were positively related to life satisfaction and self-esteem. Life satisfaction was positively related to self-esteem in both groups. Conclusions: According to the results of this study, the health-promoting behaviors of Korean and American-Korean elders strongly correlated with life satisfaction and self-esteem. Therefore, health promoting programs that enhance life satisfaction and self-esteem should be developed in order to promote the elderly's healthy lifestyle.

• 대한임상약리학회:학술대회논문집
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• 2006.11a
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• pp.90-90
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• 2006

• Korean Journal of Human Ecology
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• v.19 no.6
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• pp.1115-1125
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• 2010

This study investigated how Korean food is perceived within a healthy diet and what kinds of eating habits Korean people have. A Focus Group Interview (FGI) was conducted with participants who were experts on diet. Data were categorized into five groups using content analysis. categories were as follows: 1) Korean food and health assessment, 2) opinion on Koreans' current eating habits, 3) characteristics of Korean food, 4) comparison of Korean food in the past and present, 5) a plan for healthy diet. Results showed that a healthy diet should not only include a lot of vegetables, simple and unprocessed food as well as less spicy food, but that it should also be well-balanced nutritionally.

• Biomedical Science Letters
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• v.14 no.4
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• pp.275-281
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• 2008

Plasma fibrinogen is risk factor of vascular disease including stroke, ischemic heart disease, atherosclerosis and thrombosis. Many studies have confirmed that high plasma fibrinogen levels are related with age, obesity, cholesterol, alcohol consumption, and genotype. This study was carried out to investigate the effect of fibrinogen genotype and other characteristics on the plasma fibrinogen levels in the elderly Koreans. For this study the blood samples were collected from 178 healthy elderly Koreans (102 males and 76 females, $55{\sim}80$ year olds). The blood samples were analyzed by smoking status, cholesterol levels, genotype, age, exercise, drinking, and gender. The plasma fibrinogen was assayed by clotting method, cholesterol being assayed by cholesterol oxidase method. The $\beta$-fibrinogen genotype was detected by PCR of relevant region and digestion with Alu I. The alleres with the restriction site and the non cleavable alleres were designated $A_1$ and $A_2$. In conclusion, genotype $A_1A_2$ and exercise are increased and associated with plasma fibrinogen levels. But, there were no significant differences by smoking, gender, age, drinking and cholesterol.

• Archives of Pharmacal Research
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• v.29 no.12
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• pp.1132-1139
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• 2006

Single nucleotide polymorph isms (SNPs) in the MDR1 gene that are responsible for drug efflux can cause toxicity. Therefore, this study determined the SNPs of the Korean MDR1 gene, and analyzed the haplotypes and a linkage disequilibrium (LD) of the SNPs determined. The frequency of 9 SNPs from the MDR1 gene was determined by PCR-RFLP analyses of 100 to 500 healthy individuals. The frequcies of the SNPs were C3435T (47.7%), G2677T (37.6%), G2677A (4.4%), T1236C (21.7%), T129C (8%), A2956G (2.5%), T307C (1.5%), A41aG (9.2%), C145G (0%), and G4030C (0%). Analyses of the haplotype structure and an estimation of the LD of the combined polymorph isms demonstrated that the frequency of the 1236T-2677G-3435T haplotype is much higher in Koreans (14.1%) than in Chinese and western black Africans and the C3435T SNP in Koreans appears to have LD with T129C in Koreans for the first time. These results provide insight into the genetic variation of MDR1 in Koreans, and demonstrated the possibility of a new LD in this gene.

• Nutrition Research and Practice
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• v.16 no.2
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• pp.233-247
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• 2022

BACKGROUND/OBJECTIVES: The objective of this study was to describe the development process of the Korean Healthy Eating Index (KHEI) based on the Korea National Health and Nutrition Examination Survey (KNHANES). SUBJECTS/METHODS: The components of KHEI were selected based on Dietary Guidelines for Koreans, domestic and overseas dietary quality indices, and results of the analysis of association with chronic diseases. The standards for scoring of KHEI were selected based on the 2015 Dietary Reference Intakes for Koreans (KDRI). The KHEI scores of Korean adults were calculated using a 1-day 24-h recall data in the 2013-2015 KNHANES. RESULTS: The KHEI included eight adequacy components evaluating the proper intake of recommended foods such as fruit, vegetable, and milk and three moderation components evaluating the consumption of food that limit intake such as sodium and saturated fatty acid. In addition, three balance components assessing the balance of energy intake were included. The KHEI score was defined to range from the minimum of 0 point to the maximum of 100 points. Among Korean adults, the total KHEI score was 63.2 out of 100. Gender and age differences were found in the average of total KHEI scores. Women showed higher score than men (61.7 in men and 64.7 in women, respectively). By age group, 20s and 30s showed the lowest scores with 57.4 and 61.1 respectively, and the scores increased with age by peaking at 67.8 in ages 60-69 and slowed down again in ages 70 or over. CONCLUSIONS: The KHEI can be useful for establishing and assessing national nutritional policies and in epidemiological studies to assess the relationship between overall dietary quality and chronic diseases. KHEI will need to be continuously updated to reflect changes in dietary guidelines and the KDRI.