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Deoxynojirimycin extracted from the Korean Mulberry Plant and Silkworm Exhibits Antiviral Activity in Surrogate Hepatitis C Virus Assays

  • James R. Jacob;Keith Mansfield;You, Jung-Eun;Bud C. Tennant;Kim, Young-Ho
    • Proceedings of the Korean Society of Sericultural Science Conference
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    • 2003.10a
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    • pp.28-33
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    • 2003
  • Over 100 million people worldwide are chronic carriers of hepatitis C virus (HCV)(1). Chronic viral infections of the liver can prouess to cirrhosis, which may ultimately lead to hepatic failure or the development of hepatocellular carcinoma. There are a limited number of antiviral drugs on the market approved fur clinical management of chronic HCV infections; interferon-alpha (IFN$\alpha$) and the nucleoside analog ribavirin. However, whether used as monotherapy or in combination, adverse side-effects are associated with each drug and better therapeutic regimens are needed. (omitted)

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Structural Analysis of e-Government in India

  • Basettihalli, Rangamani;Kim, Hee-Woong;Lee, Hyun-Lyung;Noh, Seung-Eui
    • Asia pacific journal of information systems
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    • v.20 no.2
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    • pp.1-21
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    • 2010
  • e-Government is an innovative phenomenon around the globe for refurbishing public administration. Research to date, however, has been deficient in empirical studies of the factors that emerge out of the interplay of structure and human interactions responsible for successful implementation of e-Government projects. From the perspective of structuration theory, this study examines and explains the impact of this interplay in the implementation of an e-Government system, eSeva for local administration at one of the Indian state, The results suggest that the success of implementation of e-Government projects can be conceptualized as the outcome of persisting constructive interrelationships among the human, programmatic and institutional elements of e-Government and the critical learning and adaptation as a result of efforts at the structuration level.

Magnetic Fields of the Youngest Protostellar System L1448 IRS 2 revealed by ALMA

  • Kwon, Woojin;Stephens, Ian W.;Tobin, John J.;Looney, Leslie W.;Li, Zhi-Yun;Crutcher, Richard M.;Kim, Jongsoo;van der Tak, Floris F.S.
    • The Bulletin of The Korean Astronomical Society
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    • v.43 no.1
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    • pp.44.3-45
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    • 2018
  • Magnetic fields affect star formation in a broad range of scales from parsec to hundreds au. In particular, interferometric observations and ideal magneto-hydrodynamic (MHD) simulations have reported that formation of a rotation-supported disk at the earliest young stellar objects (YSOs) is largely suppressed by magnetic fields aligned to the rotational axis of YSOs: magnetic braking. Our recent ALMA observations toward L1448 IRS 2, which has a rotation detected and its magnetic fields aligned to the rotation axis (poloidal fields) in ~500 au scales, show that the fields switch to toroidal at the center in ~100 au scales. This result suggests that magnetic braking may not be so catastrophic for early disk formation even in YSOs with magnetic fields aligned to the rotational axis.

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Multi-Channel Vibrotactile Display for Teleoperated Assembly

  • Thomas Debus;Jang, Tae-Jeong;Pierre Dupont;Robert Howe
    • International Journal of Control, Automation, and Systems
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    • v.2 no.3
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    • pp.390-397
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    • 2004
  • This paper presents the design and testing of a multi-channel vibrotactile display. It is composed of a cylindrical handle with four embedded vibrating elements driven by piezoelectric beams. Vibrations are transmitted to the hands through arrays of pins. The device was tested in sensory substitution for conveying force information during a teleoperated peg insertion. Results show that the device is effective in reducing peak forces during the insertion task.

Phosphorus in the Young Supernova Remnant Cassiopeia A

  • Koo, Bon-Chul;Lee, Yong-Hyun;Moon, Dae-Sik;Yoon, Sung-Chul;Raymond, John C.
    • The Bulletin of The Korean Astronomical Society
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    • v.39 no.1
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    • pp.59.1-59.1
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    • 2014
  • Phosphorus ($^{31}P$), which is essential for life, is thought to be synthesized in massive stars and dispersed into interstellar space when these stars explode as supernovae (SNe). Here we report on near-infrared spectroscopic observations of the young SN remnant Cassiopeia A, which show that the abundance ratio of phosphorus to the major nucleosynthetic product iron ($^{56}Fe$) in SN material is up to 100 times the average ratio of the Milky Way, confirming that phosphorus is produced in SNe. The observed range is compatible with predictions from SN nucleosynthetic models but not with the scenario in which the chemical elements in the inner SN layers are completely mixed by hydrodynamic instabilities during the explosion.

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Acupuncture Stimulation for Motor Cortex Activities: Evidence from 3T Functional MRI Study

  • Choe, Bo-Young;Kang, Sei-Kwon;Chul, Myung-Ja;Jeun, Sin-Soo;Yoo, Seung-Schik;Park, Gi-Soon;Park, Sang-Dong;Lim, Eun-Chul;Chung, Sung-Taek
    • Proceedings of the KSMRM Conference
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    • 2002.11a
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    • pp.132-132
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    • 2002
  • Purpose: To investigate whether or not acupuncture of GB34 produces a significant response of the modulation of somatomotor areas by functional magnetic resonance imaging (fMRI) study. The acupoint, GB34, located in the back of the knee, is known to be effective in recovering motor function after stroke.

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Partial Necrosis of the Mandibular Proximal Segment Following Transoral Vertical Ramus Osteotomy

  • Kim, Somi;Kim, Sang Yoon;Kim, Gi-Jung;Jung, Hwi-Dong;Jung, Young-Soo
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.36 no.3
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    • pp.131-134
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    • 2014
  • Transoral vertical ramus osteotomy (TOVRO) procedure can result in a variety of complications. Complications commonly reported include extensive bleeding due to major blood vessel injury, unpredictable fracture, postoperative infection, neurosensory deficit related Inferior alveolar nerve, insufficient osteosynthesis, and temporomandibular joint problem. The authors describe a case of partial necrosis of the mandibular proximal segment following TOVRO, a rarely reported complication. A 37-year-old otherwise healthy woman underwent Lefort l osteotomy and TOVRO to correct mandibular prognathism. Postoperatively, she developed pain and swelling in the right submandibular region and was found to have a partial necrosis of proximal segment.

OGLE-2019-BLG-0362Lb: A SUPER-JOVIAN-MASS PLANET AROUND A LOW-MASS STAR

  • Chung, Sun-Ju;Yee, Jennifer C.;Udalski, Andrej;Gould, Andrew;Albrow, Michael D.;Jung, Youn Kil;Hwang, Kyu-Ha;Han, Cheongho;Ryu, Yoon-Hyun;Shin, In-Gu;Shvartzvald, Yossi;Zang, Weicheng;Cha, Sang-Mok;Kim, Dong-Jin;Kim, Seung-Lee;Lee, Chung-Uk;Lee, Dong-Joo;Lee, Yongseok;Park, Byeong-Gon;Pogge, Richard W.;Poleski, Radek;Mroz, Przemek;Pietrukowicz, Pawel;Skowron, Jan;Szymanski, Michal K.;Soszynski, Igor;Kozlowski, Szymon;Rybicki, Krzysztof A.;Iwanek, Patryk;Wrona, Marcin;Gromadzki, Mariusz;Ulaczyk, Krzysztof
    • Journal of The Korean Astronomical Society
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    • v.55 no.4
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    • pp.123-130
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    • 2022
  • We present the analysis of a planetary microlensing event OGLE-2019-BLG-0362 with a shortduration anomaly (~0.4 days) near the peak of the light curve, which is caused by the resonant caustic. The event has a severe degeneracy with ∆𝜒2 = 0.9 between the close and the wide binary lens models both with planet-host mass ratio q ≃ 0.007. We measure the angular Einstein radius but not the microlens parallax, and thus we perform a Bayesian analysis to estimate the physical parameters of the lens. We find that the OGLE-2019-BLG-0362L system is a super-Jovian-mass planet $M_p=3.26^{+0.83}_{-0.58}M_J $ orbiting an M dwarf $M_h=0.42^{+0.34}_{-0.23}M_{\odot}$ at a distance $D_L=5.83^{+1.04}_{-1.55}kpc$. The projected star-planet separation is ${\alpha}_{\bot}= 2.18^{+0.58}_{-0.72}AU$, which indicates that the planet lies beyond the snow line of the host star.

Microbial Subversion of Heparan Sulfate Proteoglycans

  • Chen, Ye;Gotte, Martin;Liu, Jian;Park, Pyong Woo
    • Molecules and Cells
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    • v.26 no.5
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    • pp.415-426
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    • 2008
  • The interactions between the host and microbial pathogen largely dictate the onset, progression, and outcome of infectious diseases. Pathogens subvert host components to promote their pathogenesis and, among these, cell surface heparan sulfate proteoglycans are exploited by many pathogens for their initial attachment and subsequent cellular entry. The ability to interact with heparan sulfate proteoglycans is widespread among viruses, bacteria, and parasites. Certain pathogens also use heparan sulfate proteoglycans to evade host defense mechanisms. These findings suggest that heparan sulfate proteoglycans are critical in microbial pathogenesis, and that heparan sulfate proteoglycan-pathogen interactions are potential targets for novel prophylactic and therapeutic approaches.

CHANDRA SPECTROSCOPY OF SUPERNOVA REMNANT 3C 391

  • CHEN YANG;SU YANG;SLANE PATRICK O.;WANG Q. DANIEL
    • Journal of The Korean Astronomical Society
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    • v.38 no.2
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    • pp.211-214
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    • 2005
  • We performed a spatially resolved spectroscopic study of the thermal composite supernova remnant 3C 391 by the Chandra observation. Broad- and narrow-band X-ray images show a southeast-northwest elongated morphology and unveil a highly clumpy structure of the remnant. The spectral analysis for. the small-scale features indicates normal metal abundance and uniform temperature for the interior gas. The properties of the hot gas are largely in agreement with the cloudlet evaporation model as a main mechanism for the 'thermal composite' X-ray appearance, though radiative rim and thermal conduction may also be effective. An unresolved X-ray source, with a power-law spectrum, is observed on the northwest border. The equivalent width images reveal a faint finger-like protrusion in Si and S lines out of the southwest radio border.