Proceedings of the Korean Society of Sericultural Science Conference (한국잠사학회:학술대회논문집)

Korean Society of Sericultural Science (한국잠사학회)
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Deoxynojirimycin extracted from the Korean Mulberry Plant and Silkworm Exhibits Antiviral Activity in Surrogate Hepatitis C Virus Assays

  • James R. Jacob (Department of Clinical Sciences, College of Veterinary Medicine, Cornell University) ;
  • Keith Mansfield (Division of Primate Resources, New England Regional Primate Research Center, Harvard Medical School, Southboroug) ;
  • You, Jung-Eun (Department of Life Sciences, The University of Suwo) ;
  • Bud C. Tennant (Department of Clinical Sciences, College of Veterinary Medicine, Cornell University) ;
  • Kim, Young-Ho (Department of Life Sciences, The University of Suwon)
  • Published : 2003.10.01
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Abstract

Over 100 million people worldwide are chronic carriers of hepatitis C virus (HCV)(1). Chronic viral infections of the liver can prouess to cirrhosis, which may ultimately lead to hepatic failure or the development of hepatocellular carcinoma. There are a limited number of antiviral drugs on the market approved fur clinical management of chronic HCV infections; interferon-alpha (IFN$\alpha$) and the nucleoside analog ribavirin. However, whether used as monotherapy or in combination, adverse side-effects are associated with each drug and better therapeutic regimens are needed. (omitted)

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