• Journal of Digital Convergence
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• v.11 no.9
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• pp.365-370
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• 2013

This mouse calvarial defected model is frequently used for new scaffold development in the bone regeneration. Most experiments are carried out in this way by measuring the bone regeneration of mouse calvaria defected area. As a next step, hematoxylin and eosin staining is analyzed by sacrificing mice On the other hand, the quantitative analysis for bone regeneration is carried out by micro computed tomography. However, there are several drawbacks with the micro computed tomography. That is, it takes a long time and it is quite expensive for bone regeneration quantitative analysis. This study was performed by simply measuring the quantity of bone regeneration in mouse clavaira defected area on two-dimensional digital x-ray images via Image J. Consequentially, this experimental method by using J program might help bio-technologist researcher regarding new bone regeneration by comparing the quantity of bone regeneration quickly and precisely as well.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.15 no.2
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• pp.144-152
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• 2005

To evaluate the effect of lead biomarkers including bone lead on neurobehavioral test in lead workers, 652 lead workers without any occupational exposure to organic solvent, mercury and arsenic were agreed to participate this study. For the control subjects 102 non-occupationally lead exposed blue collar workers in general manufacturing industries were also joined this study. All study subjects joined this study with written informed consent. The study variables of lead exposure were blood and patella lead. For the general characteristics of study subjects, standardized questionnaire regarding age, sex, past disease history, job duration, body mass index (BMI), drinking and smoking habit were provided. For the past history of neurotoxicity related diseases, all study subjects were interviewed by qualified occupational health physician. The results obtained were as follows: 1. Compared with controls without occupational lead exposure, lead exposed subjects had worse performance on all tests(p<0.05). 2. After adjustment for covariates (age, sex, job duration, education level, BMI, smoking and drinking status), the signs of the regression coefficients for blood lead were negative for 13 of the 14 tests. Blood lead was a significant predictor of poorer scores on 8 tests (simple reaction time(ms & root MSD), Trail-Making Test B, Digit Symbol Substitution, Purdue Pegboard assembly, Digit Span Test, Benton Visual Retention, and Purdue pegboard both hand). 3. After adjustment for covariates (age, sex, job duration, education level, BMI, smoking and drinking status), the signs of the regression coefficients for patella lead were negative for 12 of the 14 tests. Patella lead was a significant predictor of poorer scores on 8 tests (simple reaction time(ms). Purdue Pegboard assembly, Digit Span Test, Benton Visual Retention. Pursuit Aiming rest (no. of correct & no. of incorrect), Purdue pegboard non-dominant hand and both hand). With above results, blood lead and patella lead were associated with poorer performance of neurobehavioral tests. In addition, patella lead was confirmed to be better predictor of manual dexterity test in neurobehavioral test battery in lead workers

• The Korean Journal of Nuclear Medicine
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• v.30 no.1
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• pp.130-138
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• 1996

Bone scan is known to be an effective tool for observing the state of soft tissues and bones of electric burn patients. It is also used for observing the progress of patients after debridement or skin graft as well as deforming to amputate specific body parts. To evaluate bone scan's role in electric burn, we analyzed bone scan 37 patients with electric burn. Among the 37 patients, 8 of 37 were injured in low voltage and 29 of them in high voltage. 27 patients received the electrical input through the hand, 6 through the scalp, 2 through the shoulder, 1 through the left chest wall and 1 through the left inguinal area. Among 29 patients received high voltage, 22 patients had the electrical output through the foot, 3 through the hand, 2 through the shoulder, 1 through the buttock and 1 through the left chest wall. Bone scans revealed cellulitis in 37 patients with 47 sites, osteomyelitis in 15 patients with 15 sites & bone defects in 4 patients with 4 sites. In 4 patients with skin graft or skin flap, follow up bone scan showed improvements of bony uptake in preoperatively bony defect area and all of them were healed without complication. There were 2 cases in which uptake increased in the myocardium, 1 in the liver and 6 in the kidney, however, serum calcium level, EKG, cardiac enzyme, liver and renal function tests were normal. In conclusion, bone scans are helpful in the assessment of injury sites after electrical insult and in differential diagnosis of cellulitis and osteomyelitis. It is also useful tool of assessment after skin graft or skin flap, however, it should be further evaluated about internal organ damage.

• Journal of Periodontal and Implant Science
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• v.39 no.sup2
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• pp.213-222
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• 2009

Purpose: Recently, interest in chitosan has increased due to its excellent biological properties such as biocompatibility, antibacterial effect, and rapid healing capacity. On the other hand, hydroxyapatite is used as a bone substitute in the fields of orthopedics and dentistry. The hydroxyapatite-chitosan (HA-CS) complex containing hydroxyapatite nanoparticles was developed for synergy of both biomaterials. The objective of this study was to evaluate the effect of hydroxyapatite (HA)-chitosan (CS) membrane on bone regeneration in the rat calvarial defect. Methods: Eight-millimeter critical-sized calvarial defects were created in 70 male Sprague-Dawley rats. The animals were divided into 7 groups of 10 animals and received either 1) chitosan (CS) 100% membrane, 2) hydroxyapatite (HA) 30%/CS 70% membrane, 3) HA 30%/CS 70%, pressed membrane, 4) HA 40%/CS 60% membrane, 5) HA 50%/CS 50% membrane, 6) HA 50%/CS 50%, pressed membrane, or 7) a sham . surgery control. The amount of newly formed bone from the surface of the rat calvarial defects was measured using histomorphometry, following 2- or 8- week healing intervals. Results: Surgical implantation of the HA - CS membrane resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. The HA - CS membrane would be significantly more effective than the chitosan membrane in early bone formation. Conclusions: Concerning the advantages of biomaterials, the HA-CS membrane would be an effective biomaterial for regeneration of periodontal bone. Further studies will be required to improve the mechanical properties to develop a more rigid scaffold for the HA-CS membrane.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.387-391
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• 2015

Background: Fluorine-18 deoxyglucose positron emission tomography computed tomography (18F-FDG-PET/CT) and bone scintigraphy (BS) are widely used for the detection of bone involvement. The optimal imaging modality for the detection of bone metastases in hormone receptor positive (+) and negative (-) groups of breast cancer remains ambiguous. Materials and Methods: Sixty-two patients with breast cancer, who had undergone both 18F-FDG-PET/CT and BS, being eventually diagnosed as having bone metastases, were enrolled in this study. Results: 18F-FDG-PET/CT had higher sensitivity and specificity than BS. Our data showed that 18F-FDGPET/CT had a sensitivity of 93.4% and a specificity of 99.4%, whiel for BS they were 84.5%, and 89.6% in the diagnosis of bone metastases. ${\kappa}$ statistics were calculated for 18F-FDGPET/CT and BS. The ${\kappa}$-value was 0.65 between 18F-FDG-PET/CT and BS in all patients. On the other hand, the ${\kappa}$-values were 0.70 in the hormone receptor (+) group, and 0.51 in hormone receptor (-) group. The ${\kappa}$-values suggested excellent agreement between all patient and hormone receptor (+) groups, while the ${\kappa}$-values suggested good agreement in the hormone receptor (-) group. Conclusions: The sensitivity and specificity for 18F-FDG-PET/CT were higher than BS in the screening of metastatic bone lesions in all patients. Similarly 18F-FDG-PET/CT had higher sensitivity and specificity in hormone receptor (+) and (-) groups.

• Journal of Dental Rehabilitation and Applied Science
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• v.28 no.2
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• pp.127-138
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• 2012

This study is to assess the effect of preload level on the stress development at the marginal cortical bone surrounding implant neck. A finite element model was created for a single implant placed in the lower jaw bone. An external load of 100N was applied on the top of abutment at 30 degree with the implant axis in lingo-buccal direction. Five different preloads, i.e. 0, 200, 400, 600, 800N were applied to the abutment stem to investigate if and/or how the preload affects on the marginal bone stress. Differences in the marginal bone stress were recorded depending on the level of preload. On the other hand, the tensile stress on the marginal cortical bone decreased in models of higher preload. Preloads between abutment/fixture can increase compressive stresses in the marginal cortical bone although the amount may be insignificant as compared to those generated by functional forces.

• Archives of Plastic Surgery
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• v.45 no.5
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• pp.470-473
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• 2018

Although breast implants have been in clinical use for almost 6 decades and have undergone considerable development during this time, implant rupture is still a dreaded long-term complication. Some obvious external factors, such as trauma, can lead to implant rupture, but many studies have reported a high rate of "spontaneous" implant rupture. Herein, we present two cases with the aim of raising awareness of a new possible cause of "spontaneous" implant rupture: mechanical irritation by bony protrusions.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.719-722
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• 2003

This paper describes a novel experiment that measures the skin movement of a hand based on MR (magnetic resonance) images in conjunction with surface modeling techniques. The proposed approach consists of 3 phases: (1) MR scanning of a hand with surface makers, (2) 3D reconstruction from the MR images. and (3) registration of the 3D models. The results of registration are used to trace the skin movement with respect to underlying bone motions by measuring the positions of the surface markers.

• Structural Engineering and Mechanics
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• v.83 no.5
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• pp.681-692
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• 2022

The vibrational response of the two bones in a Volleyball player's arm under ball impact is conducted. The two bones in hand, Ulna and Radius, are modeled as two cylindrical shells. The formulations associated with the shells' vibration are obtained using the energy method. Then, the results are extracted with the aid of the two-dimensional form of DQM in conjunction with Runge-Kutta. The results are validated by means of a published paper. Lastly, the role of parameters in determining vibrational frequency as well as deflection is explored through parametric studies. It was shown that the impactor speed and the time of the impact could be essential factors in determining the vibration behavior of the bones. This work can be used in the further investigation of the behavior of bones and physiological structures.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.1 no.1
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• pp.21-27
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• 1971

The author investigated the carpal bone and ephiphyses on the roentgenographic films. Several methods have been used in the study of carpal bones but I have calculated the numbers of ossification center. The subjects consisted of 259 boys and 239 girls from 3 to 13 years of age. The results are summerized as follows; 1. The number of ossification center were increased in aging both boys and girls. 2. Ossification tendency was more faster boys than girls and the difference of left and right hand were non significant. 3. The ossification of ephiphyses was completed in 4 years of age.