• Korean Journal of Plant Resources
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• v.34 no.5
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• pp.478-490
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• 2021

We aimed to generate basic breeding data for melon (Cucumis melo L.). A total of 219 melon accessions conserved at the National Agrobiodiversity Center (NAC) in Rural Development Administration (RDA) were used in this study, of which 72 (33%) were collected from India. The majority of accessions showed orange (42%) and white (36%) flesh color. In addition to phenotypic evaluations, the accessions were genotyped using a molecular marker for the carotenoid biosynthesis gene CmOr. DNA fragments of the expected size were amplified in 205 out of 219 accessions. Digestion of the PCR products with HinfI restriction endonuclease showed 100% concordance between phenotype and genotype in green-fleshed accessions, but 98%, 97%, and 80% concordance in orange-, white-, and creamy-fleshed accessions, respectively. Sequence analysis revealed single nucleotide changes in the three positions of SNP1, SNP2 and SNP1int in the CmOr gene among accessions. These newly found alleles suggest that there are multiple mechanisms in determining fruit flesh color in melon. Also, the phenotype data of diverse accessions obtained in this study will be a valuable source for melon breeding.

• Journal of Applied Biological Chemistry
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• v.63 no.4
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• pp.327-334
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• 2020

Oxidative stress is common cause of neurodegenerative diseases. The purpose of this study is to investigate the in vitro free radical scavenging activity and protective effect of three Glycyrrhiza species including Glycyrrhiza uralensis, G. glabra, and a new variety of Glycyrrihza (Shinwongam, SW) against hydrogen peroxide-induced oxidative stress in C6 glial cells. In vitro assays, radical scavenging activities of G. uralensis, G. glabra, and SW against 2,2-diphenyl-1-picrylhydrazyl, ·OH, and O2- increased as concentration-dependent manner. In addition, the SW was found to contain the highest polyphenol and flavonoid contents. The treatment of H2O2 to C6 glial cell induced oxidative stress, whereas G. uralensis, G. glabra, and SW significantly increased the cell viability as dose-dependent manner. In particular, SW exerted stronger protective effect on H2O2-induced cytotoxicity, than G. uralensis and G. glabra. Furthermore, reactive oxygen species (ROS) formation was significantly elevated by H2O2 in C6 glial cells. However, treatments of G. uralensis, G. glabra, and SW decreased ROS formation. In addition, SW decreased pro-inflammatory related protein expression levels such as inducible nitric oxide synthase and cyclooxygenase-2, compared to H2O2-treated control group. These results indicated that G. uralensis and G. glavra, especially SW, may be useful for preventing from oxidative stress-induced neuronal damage by regulating inflammatory reaction.

• Journal of Applied Biological Chemistry
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• v.64 no.1
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• pp.69-74
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• 2021

Chronic alcohol is responsible for oxidative stress and neurodegenerative diseases such as dementia. In the present study, we investigated the antioxidant activity and protective effects of seed of Carthamus tinctorius L. on ethanol-induced C6 glial cells. Antioxidant effect of seed of C. tinctorius L. was measured by scavenging activity of 1,1-diphenyl-2-prcrylhydrazy (DPPH), hydroxyl radical (·OH), superoxide radical, and nitric oxide. The seed of C. tinctorius L. extract showed significant radical scavenging activities in a concentration-dependent manner. In particular, it revealed strong DPPH and ·OH scavenging activity, displaying more than 80% at 500 and 100 ㎍/mL, respectively. Treatment of 500 mM ethanol to C6 glial cell led to decline of cell viability and elevation of reactive oxygen species (ROS) generation. However, seed of C. tinctorius L.-treated groups significantly increased cell viability and decreased ROS levels, compared to ethanol-induced control group. These results suggest that seed of C. tinctorius L. would have protective effect against neuronal oxidative stress induced by alcohol.

• Journal of Service Research and Studies
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• v.12 no.2
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• pp.38-47
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• 2022

The user interface is a very important factor in application usability. The user interface of a typical application has a navigation system and the selection of the item takes place to move the movement. In this study, we would like to see if there are differences in user satisfaction depending on the location of the navigation and the number of items. The methods of in this study, a random group of 135 adult men and women who randomly selected four to six items as independent variables was conducted on the top, bottom, side, and three locations of navigation in a typical application. As a result, the navigation system rejected the null hypothesis of 0.000 and 0.008 respectively, with a significant probability of 0.05 or less than 0.000 and 0.008, respectively. It was also confirmed that the study theory of whether the interaction of navigation location and number of items creates a difference in satisfaction was significant with a significant probability of 0.016. In the post-analysis (Schefe), there were significant differences in the position of navigation, as each group was classified as a new group at the top <bottom <, and in the number of items, there were significant differences between the two groups of six <4 . Conclusion of this research, depending on the results of some significant differences in satisfaction with the location of the navigation and the number of items, it can be seen that the satisfaction of the interface increases when the navigation position is located at the bottom. However, follow-up research is needed on whether side-type navigation is suitable for different mobile sizes.

• Journal of Service Research and Studies
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• v.13 no.1
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• pp.159-175
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• 2023

Mass production has long been the most important production paradigm in establishing a company's strategy as a method of producing various products. However, mass production cannot now be the most important paradigm as companies' competitive environment and consumer needs diversify. In particular, consumers' needs are becoming more diverse and rapidly changing, making it difficult for companies to respond to consumers' needs. Mass customization is the most notable paradigm reflecting this trend, and mass customization aims to produce a variety of products tailored to the needs of customers at a low cost. In this study, the theory and concept of a product architecture system were used to specify a method of realizing mass-customized services, and a case study was conducted focusing on the internal furniture model of a camping car. In particular, unlike previously when companies developed product platforms and modules focusing on productivity, a method of developing and configuring product platforms and modules was suggested by reflecting consumer requirements first, and its effectiveness was considered. As a result of the study, it was confirmed that it was effective in replacement, recyclability, line-up, and chargeability by designing through internal factors of the product architecture system and verifying the effectiveness of the results with external factors. It is expected that further empirical research will be led through a design process using a product architecture system in the future.

• Journal of the Daesoon Academy of Sciences
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• v.22
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• pp.387-432
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• 2014

In this paper, I want to compare the mantra of Korean Buddhism with the jumun(呪文) of Daesoonjinrihoe in rites and cultivation. Regarding the mantra of Buddhism there are some researches, but there are few studies with regard to the jumun of Daesoonjinrihoe. The mantra of Buddhism and jumun of Daesoonjinrihoe look similar in pronouncing Hangul characters, but the religious and historical context around these seems to be different. The mantra of Korean Buddhism is associated with the introduction and diffusion process of esoteric Buddhism. In the early period of Buddhism some mantras were allowed by Buddha and the mantras were certified as a educational teaching in the period of Early Buddhist schools. In Mahayana school, the dharani that was abstracted from the vast Mahayana scriptures was developed. As Mahayana Buddhism develops, esoteric Buddhism was born in India. Esoteric Buddhism was introduced into China and was imported into Korea in Silla dynasty. In Koryo dynasty various rituals of esoteric Buddhism flourished and Jineunjong(眞言宗) and Chongjijong(總持宗) school were formed. In Chosun dynasty Buddhism was suppressed by government and the esoteric school was discontinued. But in rituals and cultivation the mantra and dharani were flourished in the latter part of Chosun dynasty. In modern period several esoteric schools were formed and developed. In present context the mantra was recited by many people in Korea. Main mantras are 'Om mani padme hum', 'Dharani of Avalokitesvara(神妙章句大陀羅尼)', 'neungumju(楞嚴呪)', 'Gwangmyung mantra(光明眞言) etc. The jumun of Daesoonjinrihoe was started by Kang Jeungsan(姜甑山) who was believed to be a God by Daesoonjinrihoe believers. Jeungsan used several existed mantras in creating new heaven and earth and made new jumuns by himself and taught them to his followers. Cho Jungsan(趙鼎山) who succeeded to the doctrines has received the jumuns by Jeungsan. He selected the jumuns to recite and determined the method how to spell these. Park Hankyung(朴漢慶) who opened Daesoonjinrihoe succeeded the rituals and doctrines. Every day ritual of Daesoonjinrihoe is chanting the jumun and the cultivation and gongbu(工夫) is practiced through jumun. Important jumuns of Daesoonjinrihoe are Taeulju(太乙呪) and Kidoju(祈禱呪). In the aspects of ritual, the mantra of Buddhism and the jumun of Daesoonjinrihoe perform a similar function. The mantra of Buddhism has the context of the doctrines of Buddhism and the method of Buddhistic practicing but the jumun of Daesoonjinrihoe is related to Jeungsan's teaching and the doctrines of Daesoonjinrihoe. But it is same that the mantra and jumun are used in communicating or uniting with ultimate reality. So the mantra and jumun are important vehicles for homo religius to meet the sacred and unite with the sacred and is regarded as the sacred word by the faithful which has a lot of symbols and meanings.

• Journal of Aerospace System Engineering
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• v.18 no.4
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• pp.81-88
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• 2024

The payload BioCabinet of CAS500-3 is designed for 3D stem cell differentiation, culture, and analysis utilizing bio 3D printing techniques in space. The 3D printing technique was initially developed for orbital use; however, it lacks separate validation for extreme launch vibration environments, necessitating a design that mitigates the launch load on the payload. This paper proposes a passive vibration isolator with a low-stiffness elastic support structure and high damping characteristics to reduce the launch loads affecting the BioCabinet. We explore the high-damping characteristics through the superelastic effects of SMA (Shape Memory Alloys) and a multi-layered structure incorporating viscoelastic tape. The effectiveness of the proposed vibration isolation system was confirmed via launch vibration tests on a qualification model.

• Korea Journal of Hospital Management
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• v.8 no.3
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• pp.32-48
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• 2003

Korea is to open its medical markets to foreign hospitals starting in the year 2006 regardless of our will(DDA, Doha Development Agenda). To accurately understand the characteristics of Korean medical users, their detailed and various needs, their attitudes toward the opening of Korean medical markets, and factors affecting these users in choosing foreign medical service providers would be first step needs to be taken by the Korean medical facilities that need to survive and develope through the fiercely competitive era coming with the opening of Korean medical markets to foreign medical service providers and would be very important in hospital management. The subjects of this study were 500 patients randomly selected from the outpatients who visited one of university hospitals in Seoul on the 14th-16th days of April 2003, and conducted a self-completion questionnaire. The answers of 463 respondents among the selected patients(93% of a responding rate)were analyzed through the Excel and statistics programs. The attitudes on the opening of the medical markets were shown in agreement 56.5%(247 persons), disagreement 6.9%(30 persons), and no idea 36.6%(160 persons). In consideration of only the answers as agreement and disagreement exclusive of the answer as no idea, 89.2% of the respondents agreed to the opening of the medical markets while 10.8% objected to the opening. The approval rate was higher with the higher education and income levels. Moreover, The approval rate for the opening of the medical markets was relatively high regardless of the satisfaction in the medical service, and the most important reason of the agreement was the guarantee of the patients(national)option. The main reason of the disagreement was high medical fee(50.5%), and the other reasons showing low rates were outflow of the domestic fund to the foreign countries(13.6%), damage of medical influences on the public(11.4%), lack of competition of the domestic medical industry(9.1%)and so on. As for the factors of selecting the foreign hospitals in the opening of the medical markets, the patients considered the authority(competency)of doctors firstly, and the other principal factors were worldwide fame and reliance, specific explanation of doctors, modernized medical instruments, convenient consultation procedure, etc. The patients agreed to the opening of the medical markets at a high rate regardless of the satisfaction in the medical service, and the most principal reason of the agreement was the guarantee of the patients(national)option for the medical care. Connected with the factors to select the hospitals, the approval reasons for the opening of the medical markets were the authority(competency)of the doctors as the first one, and then fame and tradition, reliance, overall diagnosis and modernized medical instruments, doctors specific explanation, and so on. However, these factors are actually associated with the Quality of the medical care, and consequently the approval reasons for the opening of the medical markets are connected with the security of the medical care. Accordingly, the guarantee of the patients(national)option answered as the main reason of the agreement can be also understood as the awareness of the right to have a variety of options for the security of the medical quality.

• Tuberculosis and Respiratory Diseases
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• v.39 no.2
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• pp.159-166
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• 1992

Background:Sulfiting agents are widely used as preservatives and antioxidants in foods, beverages and drugs including bronchodilators. There have been reports of sulfite-related reactions such as anaphylaxis, urticaria, angioedema, abdominal discomfortness as well as bronchospasm. Several investigators reported that sulfite-sensitive asthmatic patients comprised from 3.9% to 8.2% of all asthmatic patients and its prevalence was higher in steroid-dependent group than in steroid-independent group. Subjects and Method:We performed oral provocation test with sodium bisulfite and aspirin in 17 asthmatic patients who have experienced aggravation of their symptoms after administration of drugs or foods. All of them were steroid dependent asthmatics. We observed clinical symptoms and steroid requirements from 1 to 18 months. Result:Ten of them showed severe bronchoconstriction after the ingestion of sodium bisulfite (50 to 200 mg) within 30 minutes. Concurrent aspirin intolerance was noted by oral provocation test in four cases (40%). Three of them showed positive responses on skin prick test with sulfite (10 or 100 mg/ml). Mean total eosinophil counts was $844/mm^3$ at asthmatic attack. And there was no significant responses on skin prick test and IgE-RAST to common inhalant allergens. After complete avoidance from sulfite containing foods and drugs as well as antiasthmatic medication for 1 to 18 months, nine of them (90%) could stop or reduce the steroid requirements. ConcIusion:It was suggested that severe steroid dependent and intrinsic type of asthmatic patients should be evaluated for sulfite-sensitivity.

• Korea Journal of Hospital Management
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• v.13 no.1
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• pp.24-41
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• 2008

This research is aimed at analyzing and understanding the perception and attitudes of inpatients in a general hospital in Seoul towards the activation of private health insurance. Survey was conducted against 231 inpatients, results of which were analyzed in the methods of frequency analysis, chi square test, and logistic regression. The results are summarized as follows; First, better-educated population who finished college education at least, higher-income population, and people who had more knowledge about private health insurance showed more perception about activation of private health insurance. Second, better-educated population who finished college education at least, higher-income population, those who are insured in existing private insurance, oncological patients, and people who had more knowledge about private health insurance showed more positive attitude towards private health insurance paying for actual damages, long-term care insurance, and income security insurance. Third, age and education were the factors affecting perception about activation of private health insurance. The older the age is, perception was 1.035 times positive towards activation of private health insurance, and those who finished college education or above showed 3.148 times positive perception towards the same. Forth, surgical patients showed 1.087 times more positive attitude towards private health insurance paying for actual damages than internal medicine patients, while oncological patients showed 2.314 times more positive attitude than internal medicine patients. Further, understanding on the activation of private health insurance was 6.014 times higher in the higher understanding group than in the lower understanding group. Intention to use long-term care insurance was 2.692 times stronger in the male group than in the female group, and 3.616 times stronger in the oncological patients group than in internal medicine patients group. Further, understanding on the activation of private health insurance was 3.881 times deeper in the higher understanding group than in the lower understanding group. Intention to use income security insurance was 3.185 times stronger in those who have academic background of under the high school than those over the college, and 4.175 times higher in the group those whose monthly average income is over 4 million won than those under 4 million won. Also, intention to use income security insurance was 4.323 times higher in the group those who are insured by existing private insurances than those who are not insured by those insurances and it was 5.234 times higher in the group of oncological patients than in the group of internal medicine patients. Further, intention to use income security insurance was 3.559 times higher in the group those who thought that out-of-pocket money of the National Health Insurance is too much to bear than those it is quite endurable. Understanding on the activation of private health insurance was 4.875 times deeper in the higher understanding group than in the lower understanding group. There were some suggestions could be made based on the results of this research. First, reinforced publicity and education is needed for the low-educated or low-income group, as there are gaps in the understanding on the activation of private health insurance depending on the degree of education and income. Second, government should prepare administrative complementary measures to solve the problem of adverse selection by the consumer which is foreseen when private health insurances are activated. Third, government should suggest the desirable course of development of private health insurance items to ensure efficient use of enormous fund of private insurance market for health security of the people. Further, institutional complementary measures are needed to convert existing cancer insurances or specific disease insurances to private health insurances paying for actual damages guaranteeing against every kind of disease. Forth, it judged that, not only private health insurances paying for actual damages, but also long-term care insurances and income security insurances are prospective as fields to create fresh demand for insurance industry.