• Childhood Kidney Diseases
• /
• v.14 no.1
• /
• pp.1-9
• /
• 2010

Slowing the progression of chronic kidney disease is much more important in children and adolescents with a relatively longer remaining life span. A practical way to assess the rate of progression of chronic kidney disease is to measure the change of GFR estimated by formulae. To slow the progression, hypertension and proteinuria have to be controlled strictly, and hypoplastic anemia must be treated with erythropoietin. If not contraindicated, ACE inhibitor or angiotensin receptor blocker is recommended with monitoring of the side effects. Trials to slow the progression should be commenced as soon as the chronic kidney disease is confirmed and needs to be continued until renal transplantation as long as residual renal function remains. An online system, the Korean Pediatric Chronic Kidney Disease Registry (http://pedcrf.or.kr/), provides tools that are useful in evaluation and management of the children and adolescents with chronic kidney diseases.

• Molecules and Cells
• /
• v.28 no.5
• /
• pp.463-472
• /
• 2009

Although the possible cellular roles of several ubiquitin-specific proteases (UBPs) were identified in Arabidopsis, almost nothing is known about UBP homologs in rice, a monocot model plant. In this report, we searched the rice genome database (http://signal.salk.edu/cgi-bin/RiceGE) and identified 21 putative UBP family members (OsUBPs) in the rice genome. These OsUBP genes each contain a ubiquitin carboxyl-terminal hydrolase (UCH) domain with highly conserved Cys and His boxes and were subdivided into 9 groups based on their sequence identities and domain structures. RT-PCR analysis indicated that rice OsUBP genes are expressed at varying degrees in different rice tissues. We isolated a full-length cDNA clone for OsUBP6, which possesses not only a UCH domain, but also an N-terminal ubiquitin motif. Bacterially expressed OsUBP6 was capable of dismantling K48-linked tetra-ubiquitin chains in vitro. Quantitative real-time RT-PCR indicated that OsUBP6 is constitutively expressed in different tissues of rice plants. An in vivo targeting experiment showed that OsUBP6 is predominantly localized to the nucleus in onion epidermal cells. We also examined how knock-out of OsUBP6 affects developmental growth of rice plants. Although homozygous T3 osubp6 T-DNA insertion mutant seedlings displayed slower growth relative to wild type seedlings, mature mutant plants appeared to be normal. These results raise the possibility that loss of OsUBP6 is functionally compensated for by an as-yet unknown OsUBP homolog during later stages of development in rice plants.

• The Korea Journal of Herbology
• /
• v.36 no.5
• /
• pp.1-14
• /
• 2021

Objectives : From January 2020, when the first confirmed case of COVID-19 in Korea, the use of health information using the Internet is expected to increase. It is expected that there will be a significant change in the general public's interest in Korean herbal medicines for health care. Therefore, in this study, we tried to confirm the change in the search trend of Korean herbal medicines after the COVID-19 epidemic. Methods : Using the "Naver DataLab (http://datalab.naver.com)" service of a Korean portal site Naver, search volume was investigated with 606 Korean herbal medicines as keywords. The search period was from January 2020, right after the onset of COVID-19, to June 2021. The search results were sorted by the peak search volume and the total search volume. Results : 'Cheonsangap (천산갑, 穿山甲, Manitis Squama)' was the most searched Korean herbal medicine in the peak search volume and total search volume with least bias. Conclusions : The problem of supply and demand of Korean herbal medicines of high public interest was identified. Broadcasting and media exposure were the factors that had a big impact on the search volume for Korean herbal medicines. As it was confirmed that the search volume for Korean herbal medicines increased rapidly due to media exposure, it is necessary to provide correct information about Korean herbal medicines, improve public awareness, and manage stable supply and demand based on continuous search trend monitoring.

• Journal of Climate Change Research
• /
• v.8 no.2
• /
• pp.171-175
• /
• 2017

The purpose of the farmstead-specific early warning service system for weather risk management is to develop custom-made risk management recommendations for individual farms threatened by climate change and its variability. This system quantifies weather conditions into a "weather risk index" that is customized to crop and its growth stage. When the risk reaches the stage where it can cause any damage to the crops, the system is activated and the corresponding warning messages are delivered to the farmer's mobile phone. The messages are sent with proper recommendations that farmers can utilize to protect their crops against potential damage. Currently, the technology necessary to make the warning system more practical has been developed, including technology for forecasting real-time weather conditions, scaling down of weather data to the individual farm level and risk assessments of specific crops. Furthermore, the scientific know-how has already been integrated into a web-based warning system (http://new.agmet.kr). The system is provided to volunteer farmers with direct, one-on-one weather data and disaster warnings along with relevant recommendations. In 2016, an operational system was established in a rural catchment ($1,500km^2$) in the Seomjin river basin.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.12 no.3
• /
• pp.15-22
• /
• 2002

Java applet, executed in user's web browsers which is via proxy server on web sever, can approach client files or resources, so it is necessary to secure against malicious java applet. Currently, the previous security countermeasures against malicious java applet use two ways: one is making a filter system to detect malicious java applet hewn in proxy, the other is that establishes another security java virtual machine. However, the first one can not detect unknown malicious java applet, and the other one nay increase loads, because it decides whether there is malicious or not after implementing java applet on proxy server. In this paper, after inserting monitoring function to java applet on proxy server using java-methods substitution and transfer it to user to detect malicious java applet, we propose a technique for detecting malicious java applet that can detect the unknown malicious java applet with reducing loads

• The Korean Journal of Nuclear Medicine Technology
• /
• v.27 no.2
• /
• pp.95-98
• /
• 2023

Purpose: The precision error of a bone density meter reflects the equipment and reproducibility of results by an examiner. Precision error values can be expressed as coefficient of variation (CV), CV%, and root mean square-SD (RMS-SD). The International Society for Clinical Densitometry (ISCD) currently recommends using RMS-SD as the precision error value. When a 95% confidence interval is applied, the least significant change (LSC) value is calculated by multiplying the precision error value by 2.77. Exceeding the LSC value reflects a significant difference in measured bone density. Therefore, the LSC value of a bone density equipment is an essential factor for accurately determining a patient's bone density. Accordingly, we aimed to calculate the LSC value of a bone density meter (Lunar iDXA, GE) and compare it with the value recommended by the ISCD. We also assessed whether the value measured by the iDXA equipment was below the LSC value recommended by ISCD. Material and Methods: The bone densities of the lumbar spine and thighs of 30 participants were measured twice, and the LSC values were calculated using the precision calculation tool provided by the ISCD (http://www.iscd.org). To check the reproducibility of the measurement, patients were asked to completely dismount from the equipment after the first measurement; the patient was then repositioned before proceeding with the second measurement. Results: The LSC values derived using the CV% values recommended by the ISCD were 5.3% for the lumbar spine and 5.0% for the thigh. The LSC values measured using our bone density equipment were 2.47% for the lumbar spine and 1.61% for the thigh. The LSC value using RMS-SD was 0.031 g/cm² for the lumbar spine and 0.017 g/cm² for the thigh. Conclusion: that the findings confirm that the CV% value measured using our bone density meter and the LSC value using RMS-SD were maintained very stably. This can be helpful for obtaining accurate measurements during bone density follow-up examinations.

• Herbal Formula Science
• /
• v.32 no.3
• /
• pp.277-296
• /
• 2024

Objective : Dyspepsia is one of the most common ailments among Koreans, leading to a continuously expanding market for liquid digestive solutions. These products are popular due to their convenience and low risk of side effects. However, there is a lack of research on the basic prescription composition of these ingredients and their precise indications according to Korean Medicine. Methods : Drugs were selected from the Korea Pharmaceutical Information Service website (http://www.health.kr), focusing on oral and liquid products classified under the Ministry of Food and Drug Safety's category of stomach and digestive aids (category 233). Frequency analysis was conducted to determine the occurrence and combinations of herbal ingredients within each product. Additionally, the four properties and five flavors of each product were calculated using their herbal ingredient composition ratios, and Pearson correlation coefficients were employed to verify the linear relationships between the composition ratios of the ingredients. Results : A comparative analysis of 33 liquid digestive medicines revealed that Zingiberis Rhizoma was the most frequently used herb. The most common dual-herb combination was Zingiberis Rhizoma and Citri Unshius Pericarpium, and the most prevalent tri-herb combination was Zingiberis Rhizoma, Citri Unshius Pericarpium, and Cinnamomi Cortex. Pearson correlation coefficient analysis showed a strong positive correlation between the composition ratios of Zingiberis Rhizoma and Cinnamomi Cortex. The analysis of four properties and five flavors indicated that products with warm and bitter flavors were the most common. Conclusions : The most frequently used herbal combination in liquid digestive solutions was Zingiberis Rhizoma, Citri Unshius Pericarpium, and Cinnamomi Cortex. This composition is suitable for treating dyspepsia caused by cold-dampness in the digestive system.

• KIISE Transactions on Computing Practices
• /
• v.21 no.10
• /
• pp.658-669
• /
• 2015

The paradigm of game development changes with technological trends. If the system can analyze and determine undefined inputs, users' input choices are not restricted. Therefore, game scenarios can have multifarious flows depending upon the user's input data. In this paper, we propose a method of including an output plan in the game system that is based on the user's input but is not restricted to predefined choices. We have implemented an experimental game on the Android platform by combining network communication and APIs. The game interface works as follows: first, the user's input data is transmitted to the server using HTTP protocol; then, the server carries out an analysis on the input data; and finally, the server returns the decision result to the game device. The game can provide users a scenario that corresponds to the decision results. In this paper, we used an image file for the user's input data format. The server calculates similarities between the user's image file and reference images obtained from the Naver Image Search API and then returns determination results. We have confirmed the value of integrating the game development framework with other computing technologies demonstrating the potential of the proposed methods for application to various future game interfaces.

• The korean journal of orthodontics
• /
• v.30 no.2 s.79
• /
• pp.245-260
• /
• 2000

The Objective of this research was to construct the multimedia database system that was necessary for the education of the practitioners and the students. To establish this system, there were technical problems as follows 1) The processing of the images, 2) The rapid processing of the information with the computer network, 3) The development of diagnosis tools, 4) The technique to establish the database system, 5) The link between the database system and the internet, and 6) The method to educate through many cases. The analysis for diagnosis and treatment planning were provided as two parts : model analysis and cephalometric analysis. As a model analysis, arch length discrepancy and Bolton tooth ratio were provided for the part of patient information. Cephalometric analyses were provided in the part of initial diagnosis. The Cephalometric analysis ver 2.0 and the PowerCeph pro 3.3.5 were used to show Tweed, Steiner and Jarabak analysis. In the main part, Kim's analysis and some measurements were added. In the post-treatment or retention part, we show the superimposition of the cephalometrics with which you can find the effectiveness of the various orthodontic treatment The address of this home page is "http://damis.snu.ac.kr/orthodontics"

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2017.06a
• /
• pp.135-135
• /
• 2017

The Gramene database (http://www.gramene.org) is a powerful online resource for agricultural researchers, plant breeders and educators that provides easy access to reference data, visualizations and analytical tools for conducting cross-species comparisons. Learn the benefits of using Gramene to enrich your lectures, accelerate your research goals, and respond to your organismal community needs. Gramene's genomes portal hosts browsers for 44 complete reference genomes, including crops and model organisms, each displaying functional annotations, gene-trees with orthologous and paralogous gene classification, and whole-genome alignments. SNP and structural diversity data, available for 11 species, are displayed in the context of gene annotation, protein domains and functional consequences on transcript structure (e.g., missense variant). Browsers from multiple species can be viewed simultaneously with links to community-driven organismal databases. Thus, while hosting the underlying data for comparative studies, the portal also provides unified access to diverse plant community resources, and the ability for communities to upload and display private data sets in multiple standard formats. Our BioMart data mining interface enable complex queries and bulk download of sequence, annotation, homology and variation data. Gramene's pathway portal, the Plant Reactome, hosts over 240 pathways curated in rice and inferred in 66 additional plant species by orthology projection. Users may compare pathways across species, query and visualize curated expression data from EMBL-EBI's Expression Atlas in the context of pathways, analyze genome-scale expression data, and conduct pathway enrichment analysis. Our integrated search database and modern user interface leverage these diverse annotations to facilitate finding genes through selecting auto-suggested filters with interactive views of the results.