• Title/Summary/Keyword: HPL

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Development of Quality Control Method for a Novel Herbal Medicine, HPL-1 using UHPLC (UHPLC를 이용한 새로운 한약제제 HPL-1의 품질관리법 개발)

  • Kim, Se-Gun;Lamichhane, Ramakanta;Lee, Kyung-Hee;Jung, Hyun-Ju
    • The Korea Journal of Herbology
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    • v.30 no.3
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    • pp.19-24
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    • 2015
  • Objectives : HPL-1, a novel herbal medicine which is composed of five herbs such as Kalopanacis Cortex, Chaenomelis Fructus, Raphani Semen, Atractylodis Rhizoma and Pulvis Aconiti Tuberis Purificatum, was developed for treatment of osteoarthritis. This study is aimed to develop analytical method for consistent quality control of HPL-1 and validate chromatographic method. Methods : Chromatographic analysis was performed using ultra-high performance liquid chromatography - diode array detector (UHPLC-DAD) equipped with RP-amide column, column oven, and auto sampler. Marker compounds [protocatechuic acid, chlorogenic acid, liriodendrin, 3,5-dicaffeoylquinic acid, ${\beta}$-D-(3-O-sinapoyl)-fructofuranosyl-$\alpha$-D-(6-O-sinapoyl)glucopyranoside and benzoylmesaconine] were separated by step gradient elution of acetonitrile and 0.1% phosphoric acid/water. The method validation was evaluated by quantitative validation parameters of linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) according to KFDA guideline.Results : An optimized method for six marker compounds in HPL-1 was established by UHPLC-DAD. The correlation coefficient (R2) with each calibration curve was greater than 0.99. The LOD and LOQ were within the range of 0.008-0.090 and $0.023-0.274{\mu}g/mL$, respectively. The relative standard deviation (RSD) of intra- and inter-day variability were less than 4.0%. The result of recovery test was range from 93.3-106.3% with RSD < 4.0%.Conclusions : These results suggest that the quantitative UHPLC method is precise, accurate, effective for quality evaluation of HPL-1. The method may also contribute to improve quality of crude drug preparations used for treatment of various diseases.

The Correlational Study of Health Promotion Lifestyle and Body Composition in a University Students (일개 대학생의 건강증진 생활양식과 신체조성간의 관계 연구)

  • Park, Yeon-Suk;Lee, Hye-Gyeong
    • Journal of the Korean Society of School Health
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    • v.19 no.1
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    • pp.67-78
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    • 2006
  • Purporse : The purpose of this study was to examine the relationship between a health promoting lifestyle and body composition in university students. The study subjects were 194 university students who attended K-university located in Chungnam. Methods : The data was collected between March 2 and May 31, 2004. The instrument used for this study was the modified Health Promoting Lifestyle Profile(HPLP) developed by Walker, Sechrist, & Pender(1987). The body composition was measured by In Body 3.0, a Bioelectrical Impedance Analyzer. The data was analyzed using the SPSS/WIN 10.0 program by t-test, ANOVA and pearson correlation coefficients. Results : The results of this study are as follows: 1) The scores of the Health Promoting Lifestyle(HPL) ranged from 79 to 170, with a mean score of 110(±15.8). The mean scores of sub-categorical HPL were self-actualization 31.8(±4.9), health responsibility 17.0(±4.0), exercise 8.3(±3.2), nutrition 15.4(±3.7), interpersonal relationships 20.3(±3.5) and stress management 17.2(±3.4). 2) The HPL according to the subjects' general characteristics had significant correlation to exercise amount(F=8.09, p<.01), drinking amount(F=6.56, p<.01), perceived health status(F=19.2, p<.01) and perceived health knowledge (F=15.9, p<.01). 3) The total HPL did not significantly correlate with any categories in body composition. The exercise area of sub-categorical HPL had significant positive correlation to height (r=.199, p<.01), weight(r=.181, p<.05) and soft lean mass(r=.257, p<.01), and negative correlation to percent body fat(r=-.255, p<.01) in body composition. Conclusion : The results suggest that the exercise area of sub-categorical HPL was an important variable for an exercise program's development such as nursing intervention for the health promotion of university students.

An Exploratory Study for the Church Setting-Centered Health Promoting Program (교회 기반 건강증진 사업 기획을 위한 탐색연구)

  • Park, In-Hyae;Joo, Ae-Ran
    • Journal of agricultural medicine and community health
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    • v.34 no.3
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    • pp.324-333
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    • 2009
  • Objectives: The purpose of this study was to examine the health promoting lifestyle(HPL) practices and to provide the baseline data for development of church setting-centered health promotion program. Methods: For the study, 315 adults were selected from a church in G city by convenient sampling method. The data were analyzed using frequencies, ANOVA, t-test, Duncan test, and Pearson's correlation coefficient with the SPSS/PC program. Results: The mean score on HPL was 3.3. The item of the lowest score HPL was smoking. In the mean score of knowledge, behavior, and practice on HPL, the highest score of knowledge on HPL was drinking, but the highest score of practice was smoking. On the other hand, the highest score of behavior was: exercise, nutrition, stress respectably. Analysis of HPL according to the demographic characteristics showed there was a statistically significant difference by age. Subcategories of HPL showed positive correlations statistically significant: Exercise with nutrition, stress and drinking. Nutrition with stress and drinking. Drinking with stress and smoking. Conclusions: Based on the above findings, it is suggested to develop church setting-centered health promotion program with areas focused on management of stress, antismoking, sobriety, practice in nutrition and exercises.

Study of Soluble Organic Matter of Livestock Wastewater Treated by Ionized Gas and Coagulation after Ionized Gas (이온화가스와 응집공정을 조합한 축산폐수의 처리시 용존 유기물의 특성에 관한 연구)

  • Lee, Eun-Ju;Chung, Paul-Gene;Kim, Min-Jeong;Hyun, Mi-Hee
    • Journal of Korean Society on Water Environment
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    • v.20 no.6
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    • pp.708-713
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    • 2004
  • This study was performed to investigate the variations of hydrophilic and hydrophobic organic matter fractions in soluble organic matter according to livestock wastewater treatment by ionized gas and coagulation effect to these fractions after ionized gas contact. As a result of experiment, because of ionized gas contact, particle in the surface of livestock wastewater was more smaller and the result was consisted of particle size analysis and the amount of small size was increased. Also, we confirmed that organic matters in livestock wastewater by ionized gas contact were removed. The relation equation between ionized gas contact time(X) and $TCOD_{cr}$(Y) was shown as yscale(y)=3.748-0.431* xscale(X). That between ionized gas contact time(X) and $TCOD_{cr}$(Y) was yscale(y)=3.283-0.463* xscale(X). As respects the HPL(hydrophilic matter)and HPO(hydrophobic matter) fractions of raw in livestock wastewater treatment plant, HPL fraction was 53.2% and HPO fraction was 46.8%. But, HPO fraction according to ionized gas treatment was increased at 30min and after that time, HPL fraction was increased. Also, when we performed coagulation process after ionized gas treatment of raw wastewater, the removal efficiency of organic matter was the highest at 30min of ionized gas treatment because of the variation of HPL and HPO fractions in organic matter by ionized gas. In coagulation process following after ionized gas process, HPO was removed more effective than HPL.

The Analysis of Thermal Conductivity and Basic Quality Performances of Decoration Wood-based Flooring Board Laminated with PVC Surface Decoration Materials (PVC 표면치장재를 적층한 치장목질마루판의 열특성 및 기초 품질성능 분석)

  • Park, Cheul-Woo
    • Journal of the Architectural Institute of Korea Structure & Construction
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    • v.34 no.1
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    • pp.53-60
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    • 2018
  • For test on flooring board laminated with PVC decoration materials in order to replace the current surface materials such as HPL in decoration wood-based flooring board. the Results of comparison and analysis are as follows: For thermal conductivity, flooring board decorated with PVC did not show huge differences when temperature was rising and lowering compared to the flooring materials laminated with the existing HPL surface materials. It seems the most meaningful results for using it as indoor flooring materials. That is, in Korea where there is the culture focusing on ondol heating, use amount of heat energy and efficiency of flooring materials are very important and sensitive issues, involving immediately with household economy of final consumers, and it might be a criteria to judge basic performances required as flooring materials. As a result of the analysis on mandatory durability test items such as abrasion resistance, absorption width expansion rate, impact resistance, surface hardness, and impact absorption for flooring materials, compared to flooring board laminated with general HPL surface decoration materials, decoration wood-based flooring board laminated with PVC surface decoration materials which is higher abrasion resistance with smaller transformation and has better durability and impact absorption of the surface, is available for actual application as indoor flooring board, and for replacing surface decoration materials impregnated with heat-hardened resion such as HPL.

Mechanism of Morphological Transition from Lamellar/Perforated Layer to Gyroid Phases

  • Ahn, Jong-Hyun;Zin, Wang-Cheol
    • Macromolecular Research
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    • v.11 no.3
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    • pp.152-156
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    • 2003
  • We investigated epitaxial relations of phase transitions between the lamellar (L), hexagonally perforated layers (HPL), and gyroid (G) morphologies in styrene-isoprene diblock copolymer (PSI) and polyisoprene (PI)/PSI blend using rheology and small angle X-ray scattering (SAXS) techniques. In HPLlongrightarrowG transitions, six spot patterns of G phase were observed in two-dimensitional SAXS pattern. On the other hand, in direct L-longrightarrowG transition without appearance of HPL phase, the polydomain patterns of G phase were observed. From present study, it was understood that direct LlongrightarrowG transition of blend may be suppressed by high-energy barrier of transition and mismatches in domain orientation between epitaxially related lattice planes.

Interlaminar Fracture Toughness of GFRP Composites for Insulating Structure of Magnet System (전자석 시스템의 절연 구조물용 유리섬유강화 복합재료의 층간 파괴인성)

  • Song, Jun Hee;Kim, Hak Kun;Kim, Yonjig
    • Korean Journal of Metals and Materials
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    • v.49 no.10
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    • pp.754-759
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    • 2011
  • In this study, the interlaminar fracture behaviors of laminated GFRP composites were investigated, and the results could be used for damage tolerance design based on fracture mechanics. Three types of laminated GFRP composites that can be used as high voltage insulating materials in magnet systems were fabricated in order to study the interlaminar fracture behavior according to the molding process. The values of interlaminar fracture toughness for the VPI, prepreg, and HPL laminate were $1.9MPa{\cdot}^{1/2}$, $1.7MPa{\cdot}^{1/2}$, and $2.2MPa{\cdot}^{1/2}$, respectively. HPL laminate showed the best fracture resistance. The failure modes of HPL and VPI were similar to that of an adhesive joint, and prepreg laminates showed partial cohesive failure mode due to internal voids.

Performance Evaluation on the Parallel Processing System with the Raspberry Pi 4 (라즈베리파이 4 기반 병렬처리 시스템의 성능 평가)

  • Han, Hyeonseung;Kim, Kyungha;Jung, Seungwoo;Chang, Yunseok
    • Proceedings of the Korea Information Processing Society Conference
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    • 2022.11a
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    • pp.6-8
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    • 2022
  • 병렬처리시스템이 설계와 구축에서 가장 중요한 관점 중의 하나는 비용 대비 성능이다. 본 연구에서는 라즈베리파이 4를 클러스터 방식으로 연결하여 병렬처리 시스템을 구축하였을 때, 클러스터의 병렬처리 성능이 다른 병렬처리 시스템과 유사한 확장성과 병렬처리 성능을 보여주는지를 HPL 벤치마크를 통하여 검증하였다. 실험 결과 라즈베리파이 기반의 병렬처리 시스템이 클러스터의 크기에 따른 병렬 확장성이 있고, 다른 병렬처리 시스템들과 유사한 처리 성능을 가질 수 있음을 확인하였으며, 이를 통하여 라즈베리파이와 같은 저가의 처리장치로도 충분한 크기의 클러스터를 구성할 경우 높은 성능을 기대할 수 있음을 알 수 있다.

Hardware Abstraction Architecture for Low Cost Flash Memories in Wireless Sensor Nodes (무선 센서 노드상의 저가형 플래시 메모리를 위한 하드웨어 추상화 구조)

  • Kim, Chang-Hoon;Kwon, Young-Jik
    • Journal of Korea Society of Industrial Information Systems
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    • v.14 no.2
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    • pp.72-80
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    • 2009
  • In this parer, we propose a hardware abstraction architecture(HAA) for low cost flash memories that can be applicable to wireless sensor nodes. The proposed HAA consists of three layers. The three layers are 1) HHL(Hardware Interlace Layer), HAL(Hardware Adaption Layer), and HPL(Hardware Presentation Layer), where HIL provides a platform independent interlace to applications of upper layers, HAL performs hardware resource management, program status control, and generation of logical instructions as main core of the HAA, and HPL initializes hardware and communicates data between MCU and flash memory. We implemented our HAA on AT45DB flash memory, and the HAA used 4,384 bytes program memory and 195 bytes data memory respectively. Since the proposed HAA is composed of well defined three layers and shows a low utilization of memory, it can provides a high efficiency in terms of flexibility, scalability, and re-usability, and thus the HAA is well suited for wireless sensor nodes.

Development of Analytical Method for Quality Control from New Herbal Medicine(HPL-4) (새로운 생약복합제제(HPL-4)의 품질관리를 위한 분석법 개발)

  • Kim, Se-Gun;Sharma, Dipak Kumar;Lamichhane, Ramakanta;Lee, Kyung-Hee;Han, Sang-Mi;Jung, Hyun-Ju
    • Korean Journal of Pharmacognosy
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    • v.45 no.4
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    • pp.338-345
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    • 2014
  • HPL-4 is a new herbal formulation developed for the treatment of osteoarthritis. In this study, we took HPL-4 to develop a method for simultaneous determination of nine marker compounds (protocatechuic acid, chlorogenic acid, liriodendrin, nodakenin, ${\beta}$-$\small{D}$-(3-O-sinapoyl)frucofuranosyl-${\alpha}$-$\small{D}$-(6-O-sinapoyl)glucopyranoside, quercitrin, 6-gingerol, decursin and decursinol angelate) present in the formulation. The analytes were separated by UPLC system consisting of diode array detector at 205 nm and RP-amide column, and solvent system of $ACN/0.1%H_3PO_4$. Analytical method was validated to evaluate its linearity, limit of detection (LOD), limit of quantification (LOQ), precision, and accuracy. All standards showed good linearity ($R^2$ >0.99) in the rage of $0.25-400.0{\mu}g/mL$. The LOD and LOQ were within the range of 0.021-0.148 and $0.070-0.448{\mu}g/mL$, respectively. Intra- and inter-day precision was less than RSD 4.0% and the accuracy was range from 92.00-104.81% with RSD<4.2%. The results suggest that the developed UPLC method is precise, accurate and effective, and could be applied for quality control of HPL-4 formulation.